PANK1 (pantothenate kinase 1) - Rat Genome Database

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Gene: PANK1 (pantothenate kinase 1) Canis lupus familiaris
Analyze
Symbol: PANK1
Name: pantothenate kinase 1
RGD ID: 12165233
Description: ENCODES a protein that exhibits acetyl-CoA binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN coenzyme A biosynthetic process (ortholog); PARTICIPATES IN Fanconi syndrome pathway; fructose-1,6-bisphosphatase deficiency pathway; gluconeogenesis pathway; ASSOCIATED WITH genetic disease (ortholog); Nerve Degeneration (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,476,920 - 4,534,501 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha284,711,397 - 4,768,480 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0284,698,818 - 4,755,649 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl284,695,285 - 4,757,129 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1284,449,253 - 4,506,347 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0284,491,681 - 4,548,997 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0284,627,511 - 4,685,087 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cell periphery  (IEA)
cytoplasm  (ISO)
cytosol  (IEA,ISO)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PANK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1284,476,920 - 4,534,501 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha284,711,397 - 4,768,480 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0284,698,818 - 4,755,649 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl284,695,285 - 4,757,129 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1284,449,253 - 4,506,347 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0284,491,681 - 4,548,997 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0284,627,511 - 4,685,087 (-)NCBIUU_Cfam_GSD_1.0
PANK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381089,579,495 - 89,645,242 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1089,579,497 - 89,645,242 (-)EnsemblGRCh38hg38GRCh38
GRCh371091,339,252 - 91,404,999 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361091,332,729 - 91,395,195 (-)NCBINCBI36Build 36hg18NCBI36
Build 341091,332,728 - 91,393,627NCBI
Celera1085,089,566 - 85,152,033 (-)NCBICelera
Cytogenetic Map10q23.31NCBI
HuRef1084,973,212 - 85,039,292 (-)NCBIHuRef
CHM1_11091,621,351 - 91,687,428 (-)NCBICHM1_1
T2T-CHM13v2.01090,463,392 - 90,529,134 (-)NCBIT2T-CHM13v2.0
Pank1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391934,784,335 - 34,862,420 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1934,784,340 - 34,856,855 (-)EnsemblGRCm39 Ensembl
GRCm381934,806,935 - 34,883,423 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1934,806,940 - 34,879,455 (-)EnsemblGRCm38mm10GRCm38
MGSCv371934,885,384 - 34,953,945 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361934,876,891 - 34,943,914 (-)NCBIMGSCv36mm8
Celera1935,587,739 - 35,653,112 (-)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1929.79NCBI
Pank1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81241,737,371 - 241,808,126 (-)NCBIGRCr8
mRatBN7.21232,324,718 - 232,395,445 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1232,328,430 - 232,396,829 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1240,724,470 - 240,789,944 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01247,637,502 - 247,702,944 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01240,475,685 - 240,541,125 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01253,115,400 - 253,189,643 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1253,119,112 - 253,185,533 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01260,338,622 - 260,408,174 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41238,797,912 - 238,857,586 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11238,963,564 - 239,024,786 (-)NCBI
Celera1229,441,874 - 229,506,938 (-)NCBICelera
Cytogenetic Map1q53NCBI
Pank1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554253,384,200 - 3,432,431 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554253,384,023 - 3,433,808 (+)NCBIChiLan1.0ChiLan1.0
PANK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28101,601,436 - 101,722,040 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110101,606,750 - 101,727,618 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01086,302,702 - 86,428,635 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11089,847,888 - 89,912,765 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1089,847,888 - 89,912,765 (-)Ensemblpanpan1.1panPan2
Pank1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721342,945,529 - 43,006,702 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366014,578,394 - 4,638,170 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366014,578,132 - 4,639,305 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PANK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14101,409,253 - 101,473,945 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114101,410,139 - 101,512,498 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214110,396,399 - 110,498,885 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PANK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1982,959,606 - 83,069,759 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl982,961,004 - 83,021,850 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604843,630,697 - 43,753,361 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pank1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624737471,485 - 544,545 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624737474,996 - 544,766 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PANK1
686 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 5 15 6 6 6 6 10 5
Low 3 7 6 2 8 5 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00845050337   ⟹   ENSCAFP00845039464
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl284,695,285 - 4,757,129 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845050383   ⟹   ENSCAFP00845039500
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl284,695,285 - 4,755,619 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845050398   ⟹   ENSCAFP00845039513
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl284,695,285 - 4,755,619 (-)Ensembl
RefSeq Acc Id: XM_038439905   ⟹   XP_038295833
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0284,698,818 - 4,755,649 (-)NCBI
RefSeq Acc Id: XM_038514519   ⟹   XP_038370447
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1284,449,253 - 4,506,347 (-)NCBI
RefSeq Acc Id: XM_038578167   ⟹   XP_038434095
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0284,627,511 - 4,685,087 (-)NCBI
RefSeq Acc Id: XM_038642333   ⟹   XP_038498261
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0284,491,681 - 4,548,997 (-)NCBI
RefSeq Acc Id: XM_843829   ⟹   XP_848922
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1284,476,920 - 4,534,501 (-)NCBI
Dog10K_Boxer_Tasha284,711,397 - 4,768,480 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_848922   ⟸   XM_843829
- UniProtKB: A0A8C0NVC5 (UniProtKB/TrEMBL),   A0A8I3Q0E1 (UniProtKB/TrEMBL),   A0A8C0LHP8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038370447   ⟸   XM_038514519
RefSeq Acc Id: XP_038498261   ⟸   XM_038642333
RefSeq Acc Id: XP_038295833   ⟸   XM_038439905
- UniProtKB: A0A8C0NVC5 (UniProtKB/TrEMBL),   A0A8I3Q0E1 (UniProtKB/TrEMBL),   A0A8C0LHP8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038434095   ⟸   XM_038578167
- UniProtKB: A0A8C0LHP8 (UniProtKB/TrEMBL),   A0A8C0NVC5 (UniProtKB/TrEMBL),   A0A8I3Q0E1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845039500   ⟸   ENSCAFT00845050383
RefSeq Acc Id: ENSCAFP00845039513   ⟸   ENSCAFT00845050398
RefSeq Acc Id: ENSCAFP00845039464   ⟸   ENSCAFT00845050337


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007165 UniProtKB/TrEMBL
  ENSCAFG00030018144 UniProtKB/TrEMBL
  ENSCAFG00040025759 UniProtKB/TrEMBL
  ENSCAFG00845028503 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000011488.5 UniProtKB/TrEMBL
  ENSCAFT00000039603.5 UniProtKB/TrEMBL
  ENSCAFT00000095787.1 UniProtKB/TrEMBL
  ENSCAFT00030033529.1 UniProtKB/TrEMBL
  ENSCAFT00030033573.1 UniProtKB/TrEMBL
  ENSCAFT00030033638.1 UniProtKB/TrEMBL
  ENSCAFT00040048102.1 UniProtKB/TrEMBL
  ENSCAFT00040048105.1 UniProtKB/TrEMBL
  ENSCAFT00040048106.1 UniProtKB/TrEMBL
  ENSCAFT00845050337.1 UniProtKB/TrEMBL
  ENSCAFT00845050383 ENTREZGENE
  ENSCAFT00845050383.1 UniProtKB/TrEMBL
  ENSCAFT00845050398.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.40 UniProtKB/TrEMBL
  3.30.420.510 UniProtKB/TrEMBL
InterPro ATPase_NBD UniProtKB/TrEMBL
  Type_II_PanK UniProtKB/TrEMBL
KEGG Report cfa:486790 UniProtKB/TrEMBL
NCBI Gene PANK1 ENTREZGENE
PANTHER PANTOTHENATE KINASE 1 UniProtKB/TrEMBL
  PTHR12280 UniProtKB/TrEMBL
Pfam Fumble UniProtKB/TrEMBL
Superfamily-SCOP SSF53067 UniProtKB/TrEMBL
UniProt A0A8C0LHP8 ENTREZGENE
  A0A8C0NM59_CANLF UniProtKB/TrEMBL
  A0A8C0NVC5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0NYY3_CANLF UniProtKB/TrEMBL
  A0A8C0TY50_CANLF UniProtKB/TrEMBL
  A0A8C0Z773_CANLF UniProtKB/TrEMBL
  A0A8I3PWY0_CANLF UniProtKB/TrEMBL
  A0A8I3PX49_CANLF UniProtKB/TrEMBL
  A0A8I3Q0E1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0SR10_CANLF UniProtKB/TrEMBL
  A0A8P0TQB2_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:111619 ENTREZGENE