Dis3 (DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease) - Rat Genome Database

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Gene: Dis3 (DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease) Rattus norvegicus
Analyze
Symbol: Dis3
Name: DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
RGD ID: 1304646
Description: Predicted to enable 3'-5'-RNA exonuclease activity; endonuclease activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in CUT catabolic process; RNA processing; and rRNA catabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Orthologous to human DIS3 (DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease); PARTICIPATES IN ribosome biogenesis pathway; RNA degradation pathway; INTERACTS WITH methamphetamine; paracetamol; tetrachloromethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DIS3 exosome endoribonuclease and 3'-5' exoribonuclease; DIS3 mitotic control; DIS3 mitotic control homolog; DIS3 mitotic control homolog (S. cerevisiae); exosome complex exonuclease RRP44; LOC306103; RGD1304646; similar to mitotic control protein dis3 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81582,231,922 - 82,258,299 (-)NCBIGRCr8
mRatBN7.21575,820,040 - 75,850,450 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1575,823,436 - 75,850,642 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1579,808,848 - 79,835,406 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01580,885,466 - 80,912,024 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01577,833,009 - 77,859,568 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01583,466,330 - 83,494,107 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1583,466,428 - 83,494,423 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01586,975,865 - 87,005,393 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41582,855,389 - 82,881,767 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11582,871,188 - 82,897,665 (-)NCBI
Celera1575,064,436 - 75,090,827 (-)NCBICelera
Cytogenetic Map15q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. An overview of pre-ribosomal RNA processing in eukaryotes. Henras AK, etal., Wiley Interdiscip Rev RNA. 2015 Mar-Apr;6(2):225-42. doi: 10.1002/wrna.1269. Epub 2014 Oct 27.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:9562621   PMID:12477932   PMID:19056938   PMID:19946888   PMID:20368444   PMID:20531386   PMID:20531389  


Genomics

Comparative Map Data
Dis3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81582,231,922 - 82,258,299 (-)NCBIGRCr8
mRatBN7.21575,820,040 - 75,850,450 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1575,823,436 - 75,850,642 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1579,808,848 - 79,835,406 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01580,885,466 - 80,912,024 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01577,833,009 - 77,859,568 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01583,466,330 - 83,494,107 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1583,466,428 - 83,494,423 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01586,975,865 - 87,005,393 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41582,855,389 - 82,881,767 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11582,871,188 - 82,897,665 (-)NCBI
Celera1575,064,436 - 75,090,827 (-)NCBICelera
Cytogenetic Map15q21NCBI
DIS3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381372,752,169 - 72,781,900 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1372,752,169 - 72,782,096 (-)EnsemblGRCh38hg38GRCh38
GRCh371373,326,307 - 73,356,038 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361372,227,541 - 72,254,007 (-)NCBINCBI36Build 36hg18NCBI36
Build 341372,227,541 - 72,254,007NCBI
Celera1354,228,002 - 54,254,806 (-)NCBICelera
Cytogenetic Map13q21.33NCBI
HuRef1354,026,857 - 54,053,683 (-)NCBIHuRef
CHM1_11373,297,230 - 73,324,057 (-)NCBICHM1_1
T2T-CHM13v2.01371,973,643 - 72,003,383 (-)NCBIT2T-CHM13v2.0
Dis3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391499,314,070 - 99,337,217 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1499,312,642 - 99,337,206 (-)EnsemblGRCm39 Ensembl
GRCm381499,076,634 - 99,099,780 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1499,075,206 - 99,099,770 (-)EnsemblGRCm38mm10GRCm38
MGSCv371499,475,853 - 99,498,989 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361497,960,404 - 97,982,874 (-)NCBIMGSCv36mm8
Celera1497,752,393 - 97,775,528 (-)NCBICelera
Cytogenetic Map14E2.2NCBI
cM Map1449.25NCBI
Dis3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540433,897,237 - 33,924,069 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540433,897,681 - 33,924,069 (+)NCBIChiLan1.0ChiLan1.0
DIS3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21474,335,657 - 74,362,392 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11372,931,207 - 72,953,629 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01353,982,914 - 54,011,076 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11372,760,610 - 72,787,325 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1372,760,610 - 72,787,325 (-)Ensemblpanpan1.1panPan2
DIS3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12226,908,502 - 26,935,368 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2226,909,409 - 26,935,033 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2226,761,433 - 26,791,766 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02227,236,965 - 27,267,364 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2227,236,861 - 27,266,597 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12226,899,065 - 26,929,340 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02226,938,509 - 26,968,828 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02227,009,909 - 27,040,201 (-)NCBIUU_Cfam_GSD_1.0
Dis3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945132,665,787 - 132,687,976 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365118,082,406 - 8,108,233 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365118,082,909 - 8,105,203 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DIS3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1145,044,508 - 45,075,963 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11145,046,040 - 45,075,973 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21149,594,714 - 49,614,004 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DIS3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1351,890,033 - 51,916,628 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl351,888,707 - 51,916,643 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660467,984,139 - 8,013,994 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dis3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475127,760,776 - 27,785,613 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475127,760,665 - 27,786,403 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dis3
114 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:67
Count of miRNA genes:60
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000037588
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)155380615298806152Rat
61477Aia4Adjuvant induced arthritis QTL 43joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)155559608991365858Rat
631516Gluco31Glucose level QTL 317blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)155559608995018120Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1558156477101769107Rat
731177Uae26Urinary albumin excretion QTL 262.40.025urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1567588667101769107Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1568327165100062518Rat
1331724Bp223Blood pressure QTL 2233.53715arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)157369051895018228Rat
1641889Colcr6Colorectal carcinoma resistance QTL 62.90.0126intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)157369051899794247Rat
70182BpQTLcluster12Blood pressure QTL cluster 123.53arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)157369065795018120Rat
2317055Aia10Adjuvant induced arthritis QTL 103.41joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1575788062101769107Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1575788062101769107Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 20 32 16 19 16 1 1 69 29 41 11 1
Low 1 23 25 25 25 7 10 5 6 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000037588   ⟹   ENSRNOP00000029411
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1575,823,436 - 75,850,642 (-)Ensembl
Rnor_6.0 Ensembl1583,466,428 - 83,494,423 (-)Ensembl
RefSeq Acc Id: NM_001127483   ⟹   NP_001120955
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81582,231,922 - 82,258,299 (-)NCBI
mRatBN7.21575,824,075 - 75,850,450 (-)NCBI
Rnor_6.01583,467,064 - 83,494,107 (-)NCBI
Rnor_5.01586,975,865 - 87,005,393 (-)NCBI
RGSC_v3.41582,855,389 - 82,881,767 (-)RGD
Celera1575,064,436 - 75,090,827 (-)RGD
Sequence:
RefSeq Acc Id: XM_008770869   ⟹   XP_008769091
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81582,231,935 - 82,258,213 (-)NCBI
mRatBN7.21575,820,040 - 75,850,402 (-)NCBI
Rnor_6.01583,466,330 - 83,494,046 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599715   ⟹   XP_017455204
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81582,231,935 - 82,258,119 (-)NCBI
mRatBN7.21575,820,040 - 75,850,331 (-)NCBI
Rnor_6.01583,466,330 - 83,493,929 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039093378   ⟹   XP_038949306
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81582,231,935 - 82,257,926 (-)NCBI
mRatBN7.21575,820,040 - 75,850,077 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001120955   ⟸   NM_001127483
- UniProtKB: B2RYL7 (UniProtKB/TrEMBL),   F7EPZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008769091   ⟸   XM_008770869
- Peptide Label: isoform X3
- UniProtKB: F7EPZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455204   ⟸   XM_017599715
- Peptide Label: isoform X1
- UniProtKB: A6HU57 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000029411   ⟸   ENSRNOT00000037588
RefSeq Acc Id: XP_038949306   ⟸   XM_039093378
- Peptide Label: isoform X2
- UniProtKB: A6HU57 (UniProtKB/TrEMBL)
Protein Domains
PIN   Ribonuclease II/R

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7EPZ4-F1-model_v2 AlphaFold F7EPZ4 1-1025 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304646 AgrOrtholog
BioCyc Gene G2FUF-12788 BioCyc
Ensembl Genes ENSRNOG00000009125 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037588 ENTREZGENE
  ENSRNOT00000037588.7 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.140 UniProtKB/TrEMBL
  2.40.50.690 UniProtKB/TrEMBL
  2.40.50.700 UniProtKB/TrEMBL
  5'-nuclease UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8370691 IMAGE-MGC_LOAD
InterPro Dis3_CSD2 UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/TrEMBL
  PIN_dom UniProtKB/TrEMBL
  PIN_domain-like UniProtKB/TrEMBL
  RNase_II/R UniProtKB/TrEMBL
  RNase_II/R_CS UniProtKB/TrEMBL
  Rrp44_CSD1 UniProtKB/TrEMBL
  RRP44_S1 UniProtKB/TrEMBL
KEGG Report rno:306103 UniProtKB/TrEMBL
MGC_CLONE MGC:188706 IMAGE-MGC_LOAD
NCBI Gene 306103 ENTREZGENE
PANTHER EXOSOME COMPLEX EXONUCLEASE RRP44 UniProtKB/TrEMBL
  RIBONUCLEASE UniProtKB/TrEMBL
Pfam OB_Dis3 UniProtKB/TrEMBL
  PIN_4 UniProtKB/TrEMBL
  RNB UniProtKB/TrEMBL
  Rrp44_CSD1 UniProtKB/TrEMBL
  Rrp44_S1 UniProtKB/TrEMBL
PhenoGen Dis3 PhenoGen
PROSITE RIBONUCLEASE_II UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009125 RatGTEx
SMART PINc UniProtKB/TrEMBL
  RNB UniProtKB/TrEMBL
Superfamily-SCOP SSF50249 UniProtKB/TrEMBL
  SSF88723 UniProtKB/TrEMBL
UniProt A6HU57 ENTREZGENE, UniProtKB/TrEMBL
  B2RYL7 ENTREZGENE, UniProtKB/TrEMBL
  F7EPZ4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-09 Dis3  DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease  Dis3  DIS3 exosome endoribonuclease and 3'-5' exoribonuclease  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-03-12 Dis3  DIS3 exosome endoribonuclease and 3'-5' exoribonuclease  Dis3  DIS3 mitotic control homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Dis3  DIS3 mitotic control homolog (S. cerevisiae)  RGD1304646_predicted  similar to mitotic control protein dis3 homolog (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1304646_predicted  similar to mitotic control protein dis3 homolog (predicted)  LOC306103_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC306103_predicted  similar to mitotic control protein dis3 homolog (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL