Zfp169 (zinc finger protein 169) - Rat Genome Database

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Pathways
Gene: Zfp169 (zinc finger protein 169) Rattus norvegicus
Analyze
Symbol: Zfp169
Name: zinc finger protein 169
RGD ID: 1304631
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF169 (zinc finger protein 169); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,5-hexanedione.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC306816; Znf169
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81716,345,569 - 16,379,079 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1716,345,647 - 16,373,928 (+)EnsemblGRCr8
mRatBN7.21716,139,204 - 16,167,242 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1716,139,253 - 16,169,914 (+)EnsemblmRatBN7.2
Rnor_6.01716,443,324 - 16,471,329 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1716,455,026 - 16,470,842 (+)Ensemblrn6Rnor6.0
Rnor_5.01718,499,298 - 18,527,534 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41722,150,391 - 22,175,482 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1715,865,642 - 15,893,659 (+)NCBICelera
RGSC_v3.11722,163,194 - 22,175,482 (+)NCBI
Cytogenetic Map17p14NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
obesity  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IBA,IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Zfp169
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81716,345,569 - 16,379,079 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1716,345,647 - 16,373,928 (+)EnsemblGRCr8
mRatBN7.21716,139,204 - 16,167,242 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1716,139,253 - 16,169,914 (+)EnsemblmRatBN7.2
Rnor_6.01716,443,324 - 16,471,329 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1716,455,026 - 16,470,842 (+)Ensemblrn6Rnor6.0
Rnor_5.01718,499,298 - 18,527,534 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41722,150,391 - 22,175,482 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1715,865,642 - 15,893,659 (+)NCBICelera
RGSC_v3.11722,163,194 - 22,175,482 (+)NCBI
Cytogenetic Map17p14NCBI
ZNF169
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38994,259,298 - 94,301,829 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl994,259,298 - 94,303,967 (+)Ensemblhg38GRCh38
GRCh37997,021,580 - 97,064,111 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36996,061,399 - 96,105,112 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34994,120,594 - 94,143,279NCBI
Celera967,463,117 - 67,506,809 (+)NCBICelera
Cytogenetic Map9q22.32NCBI
HuRef966,699,287 - 66,743,328 (+)NCBIHuRef
CHM1_1997,168,497 - 97,211,917 (+)NCBICHM1_1
T2T-CHM13v2.09106,427,373 - 106,469,821 (+)NCBIT2T-CHM13v2.0
Zfp169
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391348,634,239 - 48,666,969 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1348,641,123 - 48,666,927 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381348,480,763 - 48,513,493 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1348,487,647 - 48,513,451 (-)Ensemblmm10GRCm38
MGSCv371348,583,028 - 48,608,805 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361348,499,596 - 48,525,331 (-)NCBIMGSCv36mm8
Celera1349,577,441 - 49,603,302 (-)NCBICelera
Cytogenetic Map13A5NCBI
cM Map1324.81NCBI
ZNF169
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21145,143,118 - 45,183,757 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1945,145,498 - 45,186,149 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0965,368,373 - 65,408,193 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1993,433,551 - 93,468,404 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl993,443,042 - 93,468,404 (+)EnsemblpanPan2panpan1.1
ZNF169
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1197,811,128 - 97,854,011 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl197,811,274 - 97,853,966 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha198,204,423 - 98,250,305 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0198,428,171 - 98,471,276 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl198,428,253 - 98,471,223 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1198,040,018 - 98,086,270 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0197,769,992 - 97,815,494 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0198,533,818 - 98,576,895 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
ZNF169
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl343,504,685 - 43,558,908 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1343,503,225 - 43,561,299 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2344,956,020 - 44,963,137 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZNF169
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112104,586,491 - 104,626,236 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603892,906,991 - 92,949,022 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znf169
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11467,472,963 - 67,486,281 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Zfp169
246 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:89
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000022932
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17926675540968173Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17436005727233623Rat
8552966Pigfal18Plasma insulin-like growth factor 1 level QTL 188.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)171286094257860942Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920650523859062Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)17622199858177198Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
9589151Insul30Insulin level QTL 308.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)171286094257860942Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17473353449733534Rat
9589057Scfw6Subcutaneous fat weight QTL 68.620.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)171286094257860942Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920650523859062Rat
9590154Scort9Serum corticosterone level QTL 923.570.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)171286094257860942Rat
9590088Insglur7Insulin/glucose ratio QTL 720.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)171286094257860942Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)17122181410Rat
1331720Rf43Renal function QTL 432.881kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)171553702528637951Rat
2317053Aia25Adjuvant induced arthritis QTL 252.69joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)171060469455604694Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171553702560531414Rat
7411666Foco31Food consumption QTL 3111.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)171286094257860942Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17121499218Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17473353449733534Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17798524316523460Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17857434232199534Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920650523859062Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17436005727233623Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17212084322087569Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920650523859062Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122877318Rat

Markers in Region
RH124916  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01484,142,902 - 84,142,993NCBIRnor5.0
Rnor_5.01716,910,297 - 16,910,388NCBIRnor5.0
RGSC_v3.41722,166,351 - 22,166,441UniSTSRGSC3.4
RGSC_v3.41483,850,519 - 83,850,609UniSTSRGSC3.4
Celera1715,885,935 - 15,886,025UniSTS
Celera1477,013,689 - 77,013,779UniSTS
Cytogenetic Map17p14UniSTS
Cytogenetic Map14q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 92 59 6 353 192 10 139 78 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000022932   ⟹   ENSRNOP00000022932
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1716,345,647 - 16,373,928 (+)Ensembl
mRatBN7.2 Ensembl1716,139,253 - 16,169,914 (+)Ensembl
Rnor_6.0 Ensembl1716,455,026 - 16,470,842 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000124749   ⟹   ENSRNOP00000102330
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1716,349,925 - 16,373,604 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000133482   ⟹   ENSRNOP00000111135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1716,345,647 - 16,373,928 (+)Ensembl
RefSeq Acc Id: NM_001427271   ⟹   NP_001414200
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81716,345,647 - 16,373,604 (+)NCBI
RefSeq Acc Id: XM_006253745   ⟹   XP_006253807
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81716,345,569 - 16,379,079 (+)NCBI
mRatBN7.21716,139,204 - 16,167,242 (+)NCBI
Rnor_6.01716,443,324 - 16,471,329 (+)NCBI
Rnor_5.01718,499,298 - 18,527,534 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001414200 (Get FASTA)   NCBI Sequence Viewer  
  XP_006253807 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000022932
  ENSRNOP00000022932.5
  ENSRNOP00000102330.1
  ENSRNOP00000111135
  ENSRNOP00000111135.1
RefSeq Acc Id: XP_006253807   ⟸   XM_006253745
- Peptide Label: isoform X1
- UniProtKB: D3Z9A8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022932   ⟸   ENSRNOT00000022932
RefSeq Acc Id: NP_001414200   ⟸   NM_001427271
Ensembl Acc Id: ENSRNOP00000111135   ⟸   ENSRNOT00000133482
Ensembl Acc Id: ENSRNOP00000102330   ⟸   ENSRNOT00000124749
Protein Domains
C2H2-type   KRAB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z9A8-F1-model_v2 AlphaFold D3Z9A8 1-764 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304631 AgrOrtholog
BioCyc Gene G2FUF-9953 BioCyc
Ensembl Genes ENSRNOG00000017092 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022932 ENTREZGENE
  ENSRNOT00000022932.7 UniProtKB/TrEMBL
  ENSRNOT00000124749.1 UniProtKB/TrEMBL
  ENSRNOT00000133482 ENTREZGENE
  ENSRNOT00000133482.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.140.140 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro KRAB_dom_sf UniProtKB/TrEMBL
  Krueppel-associated_box UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
NCBI Gene 306816 ENTREZGENE
PANTHER ZINC FINGER PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 169 UniProtKB/TrEMBL
Pfam KRAB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Zfp169 PhenoGen
PROSITE KRAB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017092 RatGTEx
SMART KRAB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP Krueppel-associated_box UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0ABK0L1K7_RAT UniProtKB/TrEMBL
  A0ABK0LZU8_RAT UniProtKB/TrEMBL
  D3Z9A8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Zfp169  zinc finger protein 169   Zfp169_predicted  zinc finger protein 169 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Zfp169_predicted  zinc finger protein 169 (predicted)  Znf169_predicted    Symbol updated 1299863 APPROVED
2005-01-12 Znf169_predicted  zinc finger protein 169 (predicted)      Symbol and Name status set to approved 70820 APPROVED