Exog (exo/endonuclease G) - Rat Genome Database

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Gene: Exog (exo/endonuclease G) Rattus norvegicus
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Symbol: Exog
Name: exo/endonuclease G
RGD ID: 1304628
Description: Predicted to enable 5'-3' exonuclease activity; RNA endonuclease activity; and single-stranded DNA endodeoxyribonuclease activity. Predicted to be involved in apoptotic DNA fragmentation. Predicted to be located in membrane and mitochondrion. Predicted to be part of protein-containing complex. Predicted to be active in mitochondrial inner membrane and nucleus. Orthologous to human EXOG (exo/endonuclease G); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-sulfonyldiphenol; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: endo/exonuclease (5'-3'), endonuclease G-like; Endogl1; endonuclease G-like 1; LOC301062; nuclease EXOG, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88128,062,688 - 128,082,529 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8128,059,126 - 128,083,460 (+)EnsemblGRCr8
mRatBN7.28119,184,974 - 119,204,819 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8119,185,136 - 119,204,672 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8124,766,920 - 124,786,632 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,965,942 - 122,985,654 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,799,635 - 120,819,356 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08128,133,398 - 128,153,110 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,133,431 - 128,153,110 (+)Ensemblrn6Rnor6.0
Rnor_5.08127,340,128 - 127,360,069 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48124,410,416 - 124,430,163 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8118,336,037 - 118,355,751 (+)NCBICelera
RGSC_v3.18124,430,195 - 124,446,969 (+)NCBI
Cytogenetic Map8q32NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18187503   PMID:18614015   PMID:25378300   PMID:27417117   PMID:33515431  


Genomics

Comparative Map Data
Exog
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88128,062,688 - 128,082,529 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl8128,059,126 - 128,083,460 (+)EnsemblGRCr8
mRatBN7.28119,184,974 - 119,204,819 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8119,185,136 - 119,204,672 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx8124,766,920 - 124,786,632 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08122,965,942 - 122,985,654 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08120,799,635 - 120,819,356 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.08128,133,398 - 128,153,110 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,133,431 - 128,153,110 (+)Ensemblrn6Rnor6.0
Rnor_5.08127,340,128 - 127,360,069 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.48124,410,416 - 124,430,163 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera8118,336,037 - 118,355,751 (+)NCBICelera
RGSC_v3.18124,430,195 - 124,446,969 (+)NCBI
Cytogenetic Map8q32NCBI
EXOG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38338,496,340 - 38,526,303 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl338,496,127 - 38,542,161 (+)Ensemblhg38GRCh38
GRCh37338,537,831 - 38,567,794 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,512,837 - 38,541,183 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34338,512,836 - 38,541,183NCBI
Celera338,473,645 - 38,503,721 (+)NCBICelera
Cytogenetic Map3p22.2NCBI
HuRef338,580,009 - 38,610,042 (+)NCBIHuRef
CHM1_1338,489,402 - 38,519,435 (+)NCBICHM1_1
T2T-CHM13v2.0338,489,424 - 38,532,347 (+)NCBIT2T-CHM13v2.0
Exog
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,274,026 - 119,294,584 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9119,274,009 - 119,294,583 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm389119,444,925 - 119,465,518 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,444,943 - 119,465,517 (+)Ensemblmm10GRCm38
MGSCv379119,354,041 - 119,374,636 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv369119,293,658 - 119,312,928 (+)NCBIMGSCv36mm8
Celera9119,915,149 - 119,935,877 (+)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.33NCBI
Exog
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542725,394,019 - 25,426,930 (-)Ensembl
ChiLan1.0NW_00495542725,394,019 - 25,426,930 (-)NCBIChiLan1.0ChiLan1.0
EXOG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2238,448,631 - 38,479,076 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1338,453,395 - 38,483,840 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0338,392,968 - 38,422,990 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1338,674,970 - 38,703,750 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl338,674,970 - 38,703,750 (+)EnsemblpanPan2panpan1.1
EXOG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1238,231,469 - 8,260,572 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl238,231,484 - 8,258,710 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha238,271,601 - 8,300,194 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0238,520,487 - 8,549,097 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl238,520,502 - 8,549,097 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1238,334,334 - 8,362,914 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0238,474,827 - 8,503,623 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0238,468,262 - 8,496,874 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Exog
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118194,696,462 - 194,724,401 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647327,835,050 - 27,865,067 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647327,835,065 - 27,862,966 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EXOG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1323,278,932 - 23,307,566 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11323,278,458 - 23,330,540 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21325,463,770 - 25,510,239 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EXOG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.115892,860 - 920,371 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl15893,055 - 919,994 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660639,623,778 - 9,650,559 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Exog
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247312,514,513 - 2,550,617 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247312,515,294 - 2,550,531 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Exog
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v18110,680,566 - 110,701,390 (+)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:334
Count of miRNA genes:193
Interacting mature miRNAs:245
Transcripts:ENSRNOT00000020174
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)8105462581132782436Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8103375781129871912Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)8102413464132782436Rat
634332Pia18Pristane induced arthritis QTL 184joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)884192326132782436Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)885348065130348065Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)879394435132782436Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)891340911131690273Rat
10450865Bw175Body weight QTL 1754.1total fat pad mass (VT:0015008)adipose tissue molecular composition measurement (CMO:0000484)884192326129192326Rat

Markers in Region
RH128550  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28119,202,560 - 119,202,756 (+)MAPPERmRatBN7.2
Rnor_6.08128,150,854 - 128,151,049NCBIRnor6.0
Rnor_5.08127,357,813 - 127,358,008UniSTSRnor5.0
RGSC_v3.48124,427,907 - 124,428,102UniSTSRGSC3.4
Celera8118,353,491 - 118,353,686UniSTS
RH 3.4 Map81287.3UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 91 59 6 355 191 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000020174   ⟹   ENSRNOP00000020174
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8128,062,876 - 128,083,460 (+)Ensembl
mRatBN7.2 Ensembl8119,185,136 - 119,204,672 (+)Ensembl
Rnor_6.0 Ensembl8128,133,431 - 128,153,110 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000125917   ⟹   ENSRNOP00000107451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8128,059,126 - 128,080,521 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000131964   ⟹   ENSRNOP00000111424
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl8128,062,640 - 128,080,521 (+)Ensembl
RefSeq Acc Id: NM_001106866   ⟹   NP_001100336
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88128,062,850 - 128,082,529 (+)NCBI
mRatBN7.28119,185,136 - 119,204,819 (+)NCBI
Rnor_6.08128,133,431 - 128,153,110 (+)NCBI
Rnor_5.08127,340,128 - 127,360,069 (+)NCBI
RGSC_v3.48124,410,416 - 124,430,163 (+)RGD
Celera8118,336,037 - 118,355,751 (+)RGD
Sequence:
RefSeq Acc Id: XM_006244088   ⟹   XP_006244150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88128,062,688 - 128,080,519 (+)NCBI
mRatBN7.28119,184,974 - 119,202,807 (+)NCBI
Rnor_6.08128,133,398 - 128,151,899 (+)NCBI
Rnor_5.08127,340,128 - 127,360,069 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039081300   ⟹   XP_038937228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88128,065,613 - 128,080,519 (+)NCBI
mRatBN7.28119,187,847 - 119,202,807 (+)NCBI
RefSeq Acc Id: NP_001100336   ⟸   NM_001106866
- UniProtKB: D3ZTW9 (UniProtKB/TrEMBL),   A6I3W9 (UniProtKB/TrEMBL),   A6I3W8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244150   ⟸   XM_006244088
- Peptide Label: isoform X1
- UniProtKB: A6I3W8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020174   ⟸   ENSRNOT00000020174
RefSeq Acc Id: XP_038937228   ⟸   XM_039081300
- Peptide Label: isoform X2
- UniProtKB: A6I3X3 (UniProtKB/TrEMBL),   A6I3X2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000111424   ⟸   ENSRNOT00000131964
Ensembl Acc Id: ENSRNOP00000107451   ⟸   ENSRNOT00000125917
Protein Domains
DNA/RNA non-specific   ENPP1-3/EXOG-like endonuclease/phosphodiesterase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZTW9-F1-model_v2 AlphaFold D3ZTW9 1-368 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696373
Promoter ID:EPDNEW_R6898
Type:multiple initiation site
Name:Exog_1
Description:exo/endonuclease G
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08128,133,446 - 128,133,506EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304628 AgrOrtholog
BioCyc Gene G2FUF-28786 BioCyc
Ensembl Genes ENSRNOG00000014801 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000020174 ENTREZGENE
  ENSRNOT00000020174.7 UniProtKB/TrEMBL
  ENSRNOT00000125917.1 UniProtKB/TrEMBL
  ENSRNOT00000131964 ENTREZGENE
  ENSRNOT00000131964.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.570.10 UniProtKB/TrEMBL
  6.10.250.1250 UniProtKB/TrEMBL
InterPro DNA/RNA_non-sp_Endonuclease UniProtKB/TrEMBL
  DNA/RNA_non-sp_Endonuclease_sf UniProtKB/TrEMBL
  Exog_C UniProtKB/TrEMBL
  Extracellular_endonuc_su_A UniProtKB/TrEMBL
  His-Me_finger_sf UniProtKB/TrEMBL
  Non-specific_endonuclease UniProtKB/TrEMBL
KEGG Report rno:301062 UniProtKB/TrEMBL
NCBI Gene 301062 ENTREZGENE
PANTHER NUCLEASE EXOG, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR13966 UniProtKB/TrEMBL
Pfam Endonuclease_NS UniProtKB/TrEMBL
  Exog_C UniProtKB/TrEMBL
PhenoGen Exog PhenoGen
RatGTEx ENSRNOG00000014801 RatGTEx
SMART Endonuclease_NS UniProtKB/TrEMBL
  NUC UniProtKB/TrEMBL
Superfamily-SCOP SSF54060 UniProtKB/TrEMBL
UniProt A0ABK0LA92_RAT UniProtKB/TrEMBL
  A0ABK0LY75_RAT UniProtKB/TrEMBL
  A6I3W8 ENTREZGENE, UniProtKB/TrEMBL
  A6I3W9 ENTREZGENE, UniProtKB/TrEMBL
  A6I3X2 ENTREZGENE, UniProtKB/TrEMBL
  A6I3X3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZTW9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-10-05 Exog  exo/endonuclease G  Exog  endo/exonuclease (5'-3'), endonuclease G-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-02-23 Exog  endo/exonuclease (5'-3'), endonuclease G-like  Endogl1  endonuclease G-like 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Endogl1  endonuclease G-like 1   Endogl1_predicted  endonuclease G-like 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Endogl1_predicted  endonuclease G-like 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED