Epha6 (Eph receptor A6) - Rat Genome Database

Name: Epha6
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Epha6 (Eph receptor A6) Rattus norvegicus

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Symbol:

Epha6

Name:

Eph receptor A6

RGD ID:

1304614

Description:

Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axon guidance and ephrin receptor signaling pathway. Predicted to be located in nucleoplasm. Predicted to be active in dendrite and plasma membrane. Orthologous to human EPHA6 (EPH receptor A6); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 6-propyl-2-thiouracil; allethrin; atrazine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

AABR07033882.1; EHK-2; Ehk2; EPH homology kinase 2; ephrin type-A receptor 6; tyrosine-protein kinase receptor EHK-2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	EPHA6 (EPH receptor A6)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OrthoMCL, Panther
Mus musculus (house mouse):	Epha6 (Eph receptor A6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Epha6 (EPH receptor A6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	EPHA6 (EPH receptor A6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	EPHA6 (EPH receptor A6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Epha6 (EPH receptor A6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	EPHA6 (EPH receptor A6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	EPHA6 (EPH receptor A6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Epha6 (EPH receptor A6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CUX2 (cut like homeobox 2)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Epha6 (Eph receptor A6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	EPHA6 (EPH receptor A6)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	epha6 (eph receptor A6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Eph	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	vab-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	epha6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	53,226,784 - 54,178,120 (+)	NCBI		GRCr8
mRatBN7.2	11	39,757,501 - 40,708,901 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	39,757,181 - 40,698,311 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	11	41,867,607 - 42,843,800 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	42,259,761 - 42,843,865 (+)	NCBI	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	45,066,461 - 46,035,688 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	40,551,554 - 41,458,539 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	40,597,889 - 41,024,933 (+)	NCBI
Celera	11	39,606,772 - 40,545,970 (+)	NCBI		Celera
Cytogenetic Map	11	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bardet-Biedl syndrome 3 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

4-hydroperoxycyclophosphamide (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

allethrin (EXP)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

carbamazepine (ISO)

CGP 52608 (ISO)

copper atom (EXP)

copper(0) (EXP)

copper(II) sulfate (ISO)

Cuprizon (EXP)

cyhalothrin (EXP)

cypermethrin (EXP)

dorsomorphin (ISO)

epoxiconazole (ISO)

ethanol (ISO)

fenvalerate (EXP)

genistein (ISO)

glyphosate (EXP)

iron dichloride (ISO)

lipopolysaccharide (ISO)

methoxychlor (EXP)

mono(2-ethylhexyl) phthalate (ISO)

paracetamol (ISO)

permethrin (ISO)

progesterone (EXP)

pyrethrins (EXP)

SB 431542 (ISO)

sodium arsenite (ISO)

titanium dioxide (ISO)

triclosan (ISO)

valproic acid (EXP,ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

axon guidance (IBA)

brain-derived neurotrophic factor receptor signaling pathway (IEA)

cell surface receptor protein tyrosine kinase signaling pathway (IBA)

chromatin remodeling (IEA)

collagen-activated tyrosine kinase receptor signaling pathway (IEA)

ephrin receptor signaling pathway (IBA,IEA)

epidermal growth factor receptor signaling pathway (IEA)

fibroblast growth factor receptor signaling pathway (IEA)

hepatocyte growth factor receptor signaling pathway (IEA)

insulin receptor signaling pathway (IEA)

insulin-like growth factor receptor signaling pathway (IEA)

Kit signaling pathway (IEA)

macrophage colony-stimulating factor signaling pathway (IEA)

platelet-derived growth factor receptor-alpha signaling pathway (IEA)

platelet-derived growth factor receptor-beta signaling pathway (IEA)

vascular endothelial growth factor receptor-1 signaling pathway (IEA)

vascular endothelial growth factor signaling pathway (IEA)

Cellular Component

dendrite (IBA)

membrane (IEA)

nucleoplasm (IEA,ISO)

plasma membrane (IBA)

receptor complex (IBA)

Molecular Function

ATP binding (IEA)

boss receptor activity (IEA)

brain-derived neurotrophic factor receptor activity (IEA)

ephrin receptor activity (IEA)

epidermal growth factor receptor activity (IEA)

fibroblast growth factor receptor activity (IEA)

GPI-linked ephrin receptor activity (IEA)

hepatocyte growth factor receptor activity (IEA)

histone H2AXY142 kinase activity (IEA)

histone H3Y41 kinase activity (IEA)

insulin receptor activity (IEA)

insulin-like growth factor receptor activity (IEA)

macrophage colony-stimulating factor receptor activity (IEA)

placental growth factor receptor activity (IEA)

platelet-derived growth factor alpha-receptor activity (IEA)

platelet-derived growth factor beta-receptor activity (IEA)

protein binding (ISO)

protein tyrosine kinase collagen receptor activity (IEA)

stem cell factor receptor activity (IEA)

transmembrane receptor protein tyrosine kinase activity (IBA)

transmembrane-ephrin receptor activity (IBA,IEA)

vascular endothelial growth factor receptor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

ephrin - ephrin receptor bidirectional signaling axis (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:7504232	PMID:15057822

Genomics

Comparative Map Data

Epha6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	53,226,784 - 54,178,120 (+)	NCBI		GRCr8
mRatBN7.2	11	39,757,501 - 40,708,901 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	39,757,181 - 40,698,311 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	11	41,867,607 - 42,843,800 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	42,259,761 - 42,843,865 (+)	NCBI	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	45,066,461 - 46,035,688 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	40,551,554 - 41,458,539 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	40,597,889 - 41,024,933 (+)	NCBI
Celera	11	39,606,772 - 40,545,970 (+)	NCBI		Celera
Cytogenetic Map	11	q12	NCBI

EPHA6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	96,814,594 - 97,761,532 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	96,814,581 - 97,761,532 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	96,533,438 - 97,480,376 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	98,016,115 - 98,950,476 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	3	94,916,109 - 95,857,365 (+)	NCBI		Celera
Cytogenetic Map	3	q11.2	NCBI
HuRef	3	93,902,924 - 94,837,692 (+)	NCBI		HuRef
CHM1_1	3	96,496,480 - 97,430,819 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	3	99,518,416 - 100,468,755 (+)	NCBI		T2T-CHM13v2.0

Epha6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	59,473,424 - 60,431,196 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	59,473,846 - 60,425,894 (-)	Ensembl		GRCm39 Ensembl
GRCm38	16	59,641,433 - 60,610,911 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	59,653,483 - 60,605,531 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	59,653,309 - 60,605,357 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	59,595,739 - 60,547,503 (-)	NCBI		MGSCv36	mm8
Celera	16	60,004,715 - 60,923,397 (-)	NCBI		Celera
Cytogenetic Map	16	C1.3	NCBI
cM Map	16	34.83	NCBI

Epha6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	400,745 - 1,220,538 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955407	398,415 - 1,220,542 (-)	NCBI	ChiLan1.0	ChiLan1.0

EPHA6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	94,719,146 - 95,674,832 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	94,723,932 - 95,679,616 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	93,881,686 - 94,819,563 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	100,562,841 - 101,504,222 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	100,734,791 - 101,503,805 (+)	Ensembl	panpan1.1		panPan2

EPHA6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	33	3,990,346 - 4,786,070 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	33	4,517,039 - 4,684,336 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	33	4,093,700 - 4,967,547 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	33	4,023,454 - 4,896,341 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	33	3,901,331 - 4,772,858 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	33	3,961,065 - 4,833,214 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	33	4,235,497 - 5,107,565 (+)	NCBI		UU_Cfam_GSD_1.0

Epha6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	152,451,572 - 153,234,891 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936666	2,282,000 - 3,061,944 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936666	2,280,811 - 3,063,601 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EPHA6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	162,569,479 - 163,443,646 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	162,568,835 - 163,445,722 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	173,570,910 - 173,735,724 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EPHA6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	82,960,714 - 83,914,993 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666041	82,679,583 - 83,623,162 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Epha6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624789	9,281,370 - 10,209,495 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624789	9,279,440 - 10,211,840 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Epha6
6998 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	93
Count of miRNA genes:	74
Interacting mature miRNAs:	76
Transcripts:	ENSRNOT00000047310
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300147	Bp187	Blood pressure QTL 187	3.67		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	11	1	69446234	Rat
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	18976208	86241447	Rat
70180	BpQTLcluster10	Blood pressure QTL cluster 10	3.19		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	11	34918041	79918041	Rat
11528648	Bss118	Bone structure and strength QTL 118	6.658	2e-07	femur strength trait (VT:0010010)	femur ultimate displacement (CMO:0002719)	11	40638763	43376331	Rat
8694376	Bw156	Body weight QTL 156	2.25	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	23280456	68280456	Rat
10755497	Bp388	Blood pressure QTL 388	2.76		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	19456205	76331918	Rat
724517	Uae18	Urinary albumin excretion QTL 18	3.7		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	16472047	44285911	Rat
10058952	Gmadr6	Adrenal mass QTL 6	2.29	0.0072	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	22959403	67959403	Rat
1300130	Rf20	Renal function QTL 20	4.44		kidney glomerulus integrity trait (VT:0010546)	kidney glomerulus diameter (CMO:0001166)	11	29528418	60324829	Rat
1558659	Tescar1	Testicular tumor resistance QTL 1	3.9		testis integrity trait (VT:0010572)	percentage of study population developing testis tumors during a period of time (CMO:0001261)	11	1041931	66113562	Rat
2298551	Neuinf10	Neuroinflammation QTL 10	3.7		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	11	31239134	78851519	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	27672410	82846715	Rat
9589032	Epfw10	Epididymal fat weight QTL 10	9.29	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	11	23280456	68280456	Rat
9590313	Scort20	Serum corticosterone level QTL 20	6.51	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	11	23280456	68280456	Rat
8694424	Bw162	Body weight QTL 162	3.8	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	23280456	68280456	Rat
1300110	Stl7	Serum triglyceride level QTL 7	4.64		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	11	29528418	82566702	Rat
1641927	Alcrsp10	Alcohol response QTL 10			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	11	8436674	53436674	Rat

Markers in Region

D11Rat85

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	40,304,169 - 40,304,418 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	42,434,750 - 42,434,998	NCBI	Rnor6.0
Rnor_5.0	11	45,623,663 - 45,623,911	UniSTS	Rnor5.0
RGSC_v3.4	11	41,127,119 - 41,127,368	RGD	RGSC3.4
RGSC_v3.4	11	41,127,120 - 41,127,368	UniSTS	RGSC3.4
RGSC_v3.1	11	41,184,708 - 41,184,957	RGD
Celera	11	40,147,720 - 40,147,968	UniSTS
FHH x ACI Map	11	16.5799	RGD
FHH x ACI Map	11	16.5799	UniSTS
Cytogenetic Map	11	q12	UniSTS

D11Got84

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	40,637,916 - 40,638,019 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	42,783,879 - 42,783,981	NCBI	Rnor6.0
Rnor_5.0	11	45,974,373 - 45,974,475	UniSTS	Rnor5.0
RGSC_v3.4	11	41,399,190 - 41,399,293	RGD	RGSC3.4
RGSC_v3.4	11	41,399,191 - 41,399,293	UniSTS	RGSC3.4
RGSC_v3.1	11	41,456,780 - 41,456,882	RGD
Celera	11	40,479,883 - 40,479,985	UniSTS
RH 3.4 Map	11	295.5	UniSTS
RH 3.4 Map	11	295.5	RGD
RH 2.0 Map	11	315.1	RGD
Cytogenetic Map	11	q12	UniSTS

RH144116

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	40,697,347 - 40,697,570 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	42,843,946 - 42,844,168	NCBI	Rnor6.0
Rnor_5.0	11	46,034,440 - 46,034,662	UniSTS	Rnor5.0
RGSC_v3.4	11	41,458,620 - 41,458,842	UniSTS	RGSC3.4
Celera	11	40,539,323 - 40,539,545	UniSTS
RH 3.4 Map	11	292.6	UniSTS
Cytogenetic Map	11	q12	UniSTS

BF415441

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	39,976,760 - 39,976,874 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	42,104,992 - 42,105,105	NCBI	Rnor6.0
Rnor_5.0	11	45,302,005 - 45,302,118	UniSTS	Rnor5.0
RGSC_v3.4	11	40,770,869 - 40,770,982	UniSTS	RGSC3.4
Celera	11	39,827,166 - 39,827,279	UniSTS
RH 3.4 Map	11	293.4	UniSTS
Cytogenetic Map	11	q12	UniSTS

RH144183

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	39,755,746 - 39,756,006 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	41,866,965 - 41,867,224	NCBI	Rnor6.0
Rnor_5.0	11	45,065,856 - 45,066,115	UniSTS	Rnor5.0
RGSC_v3.4	11	40,549,431 - 40,549,690	UniSTS	RGSC3.4
Celera	11	39,606,130 - 39,606,389	UniSTS
RH 3.4 Map	11	292.7	UniSTS
Cytogenetic Map	11	q12	UniSTS

AU049238

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	40,133,726 - 40,133,900 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	42,258,777 - 42,258,950	NCBI	Rnor6.0
Rnor_5.0	11	45,454,287 - 45,454,460	UniSTS	Rnor5.0
RGSC_v3.4	11	40,953,141 - 40,953,314	UniSTS	RGSC3.4
Celera	11	39,977,135 - 39,977,308	UniSTS
Cytogenetic Map	11	q12	UniSTS

mMECIR525

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	40,691,193 - 40,692,710 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	42,837,784 - 42,839,300	NCBI	Rnor6.0
Rnor_5.0	11	46,028,278 - 46,029,794	UniSTS	Rnor5.0
Celera	11	40,533,155 - 40,534,669	UniSTS
Cytogenetic Map	11	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001419529	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008768648	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008768650	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008776508	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008776514	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008776518	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598105	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598106	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598107	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598108	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017604293	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017604294	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017604295	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017604296	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017604297	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088720	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039088721	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAXUCZ010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000047310 ⟹ ENSRNOP00000049409

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	39,792,624 - 40,698,311 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000097751 ⟹ ENSRNOP00000087819

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	39,757,181 - 40,698,311 (+)	Ensembl

RefSeq Acc Id:

NM_001419529 ⟹ NP_001406458

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	53,226,784 - 54,178,120 (+)	NCBI
mRatBN7.2	11	39,757,501 - 40,708,901 (+)	NCBI

RefSeq Acc Id:

XM_039088720 ⟹ XP_038944648

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	53,261,732 - 54,178,120 (+)	NCBI
mRatBN7.2	11	39,792,037 - 40,708,901 (+)	NCBI

RefSeq Acc Id:

XM_039088721 ⟹ XP_038944649

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	53,261,733 - 54,178,120 (+)	NCBI
mRatBN7.2	11	39,792,040 - 40,708,901 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001406458	(Get FASTA)	NCBI Sequence Viewer
	XP_038944648	(Get FASTA)	NCBI Sequence Viewer
	XP_038944649	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000049409.6
	ENSRNOP00000087819.1
GenBank Protein	P54758	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_038944648 ⟸ XM_039088720
- Peptide Label:	isoform X1
- UniProtKB:	P54758 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038944649 ⟸ XM_039088721
- Peptide Label:	isoform X2
- UniProtKB:	P54758 (UniProtKB/Swiss-Prot), F1LQK6 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000087819 ⟸ ENSRNOT00000097751

Ensembl Acc Id:

ENSRNOP00000049409 ⟸ ENSRNOT00000047310

RefSeq Acc Id:	NP_001406458 ⟸ NM_001419529
- UniProtKB:	A0A8I6A6J8 (UniProtKB/TrEMBL)

Protein Domains

Eph LBD Fibronectin type-III Protein kinase SAM

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P54758-F1-model_v2	AlphaFold	P54758	1-1035	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1304614	AgrOrtholog
BioCyc Gene	G2FUF-21631	BioCyc
Ensembl Genes	ENSRNOG00000029184	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000047310.6	UniProtKB/TrEMBL
	ENSRNOT00000097751.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.150.50	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.60.40.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ephrin a2 ectodomain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Galactose-binding domain-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tumor Necrosis Factor Receptor, subunit A, domain 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	EPH-A6_SAM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Eph_TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EphA6_rcpt_lig-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ephrin_rcpt_lig-bd_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ephrin_rcpt_TKs	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FN3_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FN3_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Galactose-bd-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Growth_fac_rcpt_cys_sf	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Kinase-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Prot_kinase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SAM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SAM/pointed_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ser-Thr/Tyr_kinase_cat_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tyr-kin_ephrin_A/B_rcpt-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tyr_kinase_AS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tyr_kinase_cat_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tyr_kinase_ephrin_rcpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Tyr_kinase_rcpt_V_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	29202	ENTREZGENE
PANTHER	EPH RECEPTOR A5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EPHRIN TYPE-A RECEPTOR 6	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	EphA2_TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ephrin_lbd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ephrin_rec_like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	fn3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PK_Tyr_Ser-Thr	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
	SAM_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Epha6	PhenoGen
PIRSF	TyrPK_ephrin_receptor	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	FNTYPEIII	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TYRKINASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	EGF_2	UniProtKB/Swiss-Prot
	EPH_LBD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FN3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_ATP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PROTEIN_KINASE_TYR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RECEPTOR_TYR_KIN_V_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RECEPTOR_TYR_KIN_V_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SAM_DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000029184	RatGTEx
SMART	EPH_lbd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ephrin_rec_like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	FN3	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SAM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TyrKc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF47769	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF49265	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF49785	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF56112	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF57184	UniProtKB/TrEMBL
UniProt	A0A8I6A6J8	ENTREZGENE, UniProtKB/TrEMBL
	EPHA6_RAT	UniProtKB/Swiss-Prot
	F1LQK6	ENTREZGENE, UniProtKB/TrEMBL
	P54758	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-06-02	Epha6	Eph receptor A6	AABR07033882.1		Data merged from RGD:15003733	737654	PROVISIONAL
2021-09-02	AABR07033882.1		Epha6	Eph receptor A6	Symbol and/or name change	19259462	PROVISIONAL
2021-08-09	Epha6	Eph receptor A6	AABR07033882.1		Symbol and/or name change	19259462	PROVISIONAL
2019-11-08	AABR07033882.1				Symbol and Name status set to provisional	45752	PROVISIONAL
2008-04-30	Epha6	Eph receptor A6	Epha6_predicted	Eph receptor A6 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Epha6_predicted	Eph receptor A6 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - PID (archival)