Rasgrp3 (RAS guanyl releasing protein 3) - Rat Genome Database

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Gene: Rasgrp3 (RAS guanyl releasing protein 3) Rattus norvegicus
Analyze
Symbol: Rasgrp3
Name: RAS guanyl releasing protein 3
RGD ID: 1304612
Description: Predicted to enable GTPase regulator activity and enzyme binding activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of guanyl-nucleotide exchange factor complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human RASGRP3 (RAS guanyl releasing protein 3); PARTICIPATES IN B cell receptor signaling pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC313874; RAS guanyl releasing protein 3 (calcium and DAG-regulated); ras guanyl-releasing protein 3; RAS, guanyl releasing protein 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Rasgrp3em1Mcwi ; Rasgrp3em3Mcwi
Genetic Models: SS-Rasgrp3em1Mcwi ; SS-Rasgrp3em3Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8625,647,386 - 25,745,952 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl625,647,386 - 25,710,591 (-)EnsemblGRCr8
mRatBN7.2619,895,361 - 19,993,945 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl619,895,390 - 19,958,578 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx620,225,551 - 20,288,760 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0620,541,387 - 20,604,597 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0620,021,820 - 20,085,037 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0621,072,634 - 21,171,619 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl621,072,634 - 21,135,880 (-)Ensemblrn6Rnor6.0
Rnor_5.0630,966,364 - 31,065,175 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4619,808,453 - 19,871,923 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera619,464,356 - 19,527,205 (-)NCBICelera
RGSC_v3.1619,815,248 - 19,848,714 (-)NCBI
Cytogenetic Map6q12-q13NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
cylindrospermopsin  (ISO)
delta-tocotrienol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
lipopolysaccharide  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methylarsonic acid  (ISO)
nitrates  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP)
pentanal  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
quercetin  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
tert-butyl hydroperoxide  (ISO)
tetraphene  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triphenyl phosphate  (ISO)
triticonazole  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan. Yang HC, etal., PLoS One. 2009;4(5):e5459. Epub 2009 May 7.
Additional References at PubMed
PMID:10934204   PMID:15545601   PMID:15737652   PMID:15894621   PMID:18588530  


Genomics

Comparative Map Data
Rasgrp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8625,647,386 - 25,745,952 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl625,647,386 - 25,710,591 (-)EnsemblGRCr8
mRatBN7.2619,895,361 - 19,993,945 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl619,895,390 - 19,958,578 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx620,225,551 - 20,288,760 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0620,541,387 - 20,604,597 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0620,021,820 - 20,085,037 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0621,072,634 - 21,171,619 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl621,072,634 - 21,135,880 (-)Ensemblrn6Rnor6.0
Rnor_5.0630,966,364 - 31,065,175 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4619,808,453 - 19,871,923 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera619,464,356 - 19,527,205 (-)NCBICelera
RGSC_v3.1619,815,248 - 19,848,714 (-)NCBI
Cytogenetic Map6q12-q13NCBI
RASGRP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38233,436,348 - 33,564,731 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl233,436,272 - 33,586,669 (+)Ensemblhg38GRCh38
GRCh37233,661,415 - 33,789,798 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36233,514,920 - 33,643,162 (+)NCBIBuild 36Build 36hg18NCBI36
Celera233,500,106 - 33,628,502 (+)NCBICelera
Cytogenetic Map2p22.3NCBI
HuRef233,395,400 - 33,523,736 (+)NCBIHuRef
CHM1_1233,590,740 - 33,719,120 (+)NCBICHM1_1
T2T-CHM13v2.0233,482,495 - 33,610,876 (+)NCBIT2T-CHM13v2.0
Rasgrp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391775,742,849 - 75,836,049 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1775,742,891 - 75,836,049 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381775,435,870 - 75,529,054 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1775,435,896 - 75,529,054 (+)Ensemblmm10GRCm38
MGSCv371775,835,245 - 75,928,394 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361775,370,673 - 75,434,104 (+)NCBIMGSCv36mm8
Celera1779,726,720 - 79,821,715 (+)NCBICelera
Cytogenetic Map17E2NCBI
cM Map1746.55NCBI
Rasgrp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554411,679,108 - 1,786,397 (+)Ensembl
ChiLan1.0NW_0049554411,679,258 - 1,786,397 (+)NCBIChiLan1.0ChiLan1.0
RASGRP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21292,937,226 - 93,095,098 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A92,941,198 - 93,004,430 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A33,444,941 - 33,572,829 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A34,156,780 - 34,284,307 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A34,196,421 - 34,284,307 (+)EnsemblpanPan2panpan1.1
RASGRP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11726,560,832 - 26,657,276 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1726,569,488 - 26,655,361 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1726,350,794 - 26,449,397 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01727,127,589 - 27,226,234 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1727,127,678 - 27,226,226 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11726,423,287 - 26,521,834 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01726,496,776 - 26,595,712 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01726,653,466 - 26,752,215 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rasgrp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629270,633,719 - 70,735,839 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936493109,275 - 143,640 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936493103,937 - 205,819 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RASGRP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3106,099,821 - 106,213,728 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.13106,098,541 - 106,213,787 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23112,971,430 - 113,002,767 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RASGRP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11473,871,343 - 73,950,119 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1473,895,534 - 73,946,358 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604537,985,721 - 38,114,455 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rasgrp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473815,130,891 - 15,236,445 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473815,130,709 - 15,237,869 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Rasgrp3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1717,768,127 - 17,829,718 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rasgrp3
689 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:340
Count of miRNA genes:200
Interacting mature miRNAs:255
Transcripts:ENSRNOT00000051239
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6197587946975879Rat
8693699Alc37Alcohol consumption QTL 372.60.224drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)61371716927053860Rat
8693645Alc31Alcohol consumption QTL 313.70.038drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)62328466429732046Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)62265388967653889Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)62228825727729050Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)62009763565097635Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6323998948239989Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6197587946975879Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6197587946975879Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6144788383Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6197587946975879Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6125740059Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6197587946975879Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2301964Bp323Blood pressure QTL 3234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6186868070Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6323998948239989Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6323998948239989Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6140163351Rat
70199Coreg1Compensatory renal growth QTL 111.8kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)61459947363457687Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)61608937261967788Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6144788383Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6323998948239989Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)62228825732981219Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)62228825767288257Rat
8693690Alc35Alcohol consumption QTL 352.20.606drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)61371716927053860Rat

Markers in Region
D6Rat43  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8625,707,912 - 25,708,089 (+)Marker Load Pipeline
mRatBN7.2619,955,899 - 19,956,076 (+)MAPPERmRatBN7.2
Rnor_6.0621,133,292 - 21,133,468NCBIRnor6.0
Rnor_5.0631,026,880 - 31,027,056UniSTSRnor5.0
RGSC_v3.4619,869,334 - 19,869,511RGDRGSC3.4
RGSC_v3.4619,869,335 - 19,869,511UniSTSRGSC3.4
Celera619,524,617 - 19,524,793UniSTS
RGSC_v3.1619,872,287 - 19,872,464RGD
RH 2.0 Map6177.6RGD
FHH x ACI Map621.5799RGD
Cytogenetic Map6q12UniSTS
RH133889  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2619,895,651 - 19,895,833 (+)MAPPERmRatBN7.2
Rnor_6.0621,072,896 - 21,073,077NCBIRnor6.0
Rnor_5.0630,966,626 - 30,966,807UniSTSRnor5.0
RGSC_v3.4619,808,715 - 19,808,896UniSTSRGSC3.4
Celera619,464,618 - 19,464,799UniSTS
Cytogenetic Map6q12UniSTS


Genetic Models
This gene Rasgrp3 is modified in the following models/strains:
SS-Rasgrp3em1Mcwi     SS-Rasgrp3em3Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000051239   ⟹   ENSRNOP00000051116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl625,647,386 - 25,710,591 (-)Ensembl
mRatBN7.2 Ensembl619,895,390 - 19,958,488 (-)Ensembl
Rnor_6.0 Ensembl621,072,634 - 21,135,880 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079819   ⟹   ENSRNOP00000075529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl619,896,695 - 19,958,578 (-)Ensembl
Rnor_6.0 Ensembl621,074,604 - 21,112,734 (-)Ensembl
RefSeq Acc Id: NM_001399544   ⟹   NP_001386473
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,647,386 - 25,710,591 (-)NCBI
mRatBN7.2619,895,361 - 19,958,578 (-)NCBI
RefSeq Acc Id: XM_063261852   ⟹   XP_063117922
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,647,386 - 25,745,952 (-)NCBI
RefSeq Acc Id: XM_063261853   ⟹   XP_063117923
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,647,386 - 25,745,950 (-)NCBI
RefSeq Acc Id: XM_063261854   ⟹   XP_063117924
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,647,386 - 25,710,595 (-)NCBI
RefSeq Acc Id: XM_063261855   ⟹   XP_063117925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,647,386 - 25,710,394 (-)NCBI
RefSeq Acc Id: XM_063261856   ⟹   XP_063117926
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,647,386 - 25,745,509 (-)NCBI
RefSeq Acc Id: XM_063261857   ⟹   XP_063117927
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,647,386 - 25,745,950 (-)NCBI
RefSeq Acc Id: XM_063261858   ⟹   XP_063117928
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,647,386 - 25,745,950 (-)NCBI
RefSeq Acc Id: XM_063261859   ⟹   XP_063117929
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8625,647,386 - 25,710,597 (-)NCBI
Ensembl Acc Id: ENSRNOP00000075529   ⟸   ENSRNOT00000079819
Ensembl Acc Id: ENSRNOP00000051116   ⟸   ENSRNOT00000051239
RefSeq Acc Id: NP_001386473   ⟸   NM_001399544
- UniProtKB: A0A0G2KAU4 (UniProtKB/TrEMBL),   A6H9X0 (UniProtKB/TrEMBL),   D3ZZN2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117922   ⟸   XM_063261852
- Peptide Label: isoform X1
- UniProtKB: A6H9X0 (UniProtKB/TrEMBL),   D3ZZN2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117927   ⟸   XM_063261857
- Peptide Label: isoform X1
- UniProtKB: A6H9X0 (UniProtKB/TrEMBL),   D3ZZN2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117928   ⟸   XM_063261858
- Peptide Label: isoform X1
- UniProtKB: A6H9X0 (UniProtKB/TrEMBL),   D3ZZN2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117923   ⟸   XM_063261853
- Peptide Label: isoform X1
- UniProtKB: A6H9X0 (UniProtKB/TrEMBL),   D3ZZN2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117926   ⟸   XM_063261856
- Peptide Label: isoform X1
- UniProtKB: A6H9X0 (UniProtKB/TrEMBL),   D3ZZN2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117929   ⟸   XM_063261859
- Peptide Label: isoform X1
- UniProtKB: A6H9X0 (UniProtKB/TrEMBL),   D3ZZN2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117924   ⟸   XM_063261854
- Peptide Label: isoform X1
- UniProtKB: A6H9X0 (UniProtKB/TrEMBL),   D3ZZN2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063117925   ⟸   XM_063261855
- Peptide Label: isoform X1
- UniProtKB: A6H9X0 (UniProtKB/TrEMBL),   D3ZZN2 (UniProtKB/TrEMBL)
Protein Domains
N-terminal Ras-GEF   Phorbol-ester/DAG-type   Ras-GEF

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2KAU4-F1-model_v2 AlphaFold A0A0G2KAU4 1-691 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694406
Promoter ID:EPDNEW_R4931
Type:initiation region
Name:Rasgrp3_1
Description:RAS guanyl releasing protein 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0621,135,911 - 21,135,971EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304612 AgrOrtholog
BioCyc Gene G2FUF-38463 BioCyc
Ensembl Genes ENSRNOG00000032703 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000051239 ENTREZGENE
  ENSRNOT00000051239.6 UniProtKB/TrEMBL
Gene3D-CATH 1.10.840.10 UniProtKB/TrEMBL
  3.30.60.20 UniProtKB/TrEMBL
  Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/TrEMBL
InterPro C1-like_sf UniProtKB/TrEMBL
  Prot_Kinase_C-like_PE/DAG-bd UniProtKB/TrEMBL
  Ras-like_GEF UniProtKB/TrEMBL
  Ras-like_Gua-exchang_fac_N UniProtKB/TrEMBL
  Ras_GEF_dom UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/TrEMBL
  RasGRF_CDC25 UniProtKB/TrEMBL
NCBI Gene 313874 ENTREZGENE
PANTHER PTHR23113 UniProtKB/TrEMBL
  PTHR23113:SF178 UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/TrEMBL
  RasGEF UniProtKB/TrEMBL
PhenoGen Rasgrp3 PhenoGen
PROSITE RASGEF_CAT UniProtKB/TrEMBL
  RASGEF_NTER UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000032703 RatGTEx
SMART RasGEF UniProtKB/TrEMBL
  RasGEFN UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
Superfamily-SCOP Ras_GEF UniProtKB/TrEMBL
  SSF57889 UniProtKB/TrEMBL
UniProt A0A0G2KAU4 ENTREZGENE
  A6H9X0 ENTREZGENE, UniProtKB/TrEMBL
  D3ZZN2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-24 Rasgrp3  RAS guanyl releasing protein 3 (calcium and DAG-regulated)  Rasgrp3  RAS, guanyl releasing protein 3   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Rasgrp3  RAS, guanyl releasing protein 3   Rasgrp3_predicted  RAS, guanyl releasing protein 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Rasgrp3_predicted  RAS, guanyl releasing protein 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED