Advanced Search (OLGA)

Gene: Agr2 (anterior gradient 2, protein disulphide isomerase family member) Rattus norvegicus

Analyze

Symbol:

Agr2

Name:

anterior gradient 2, protein disulphide isomerase family member

RGD ID:

1304606

Description:

Predicted to enable dystroglycan binding activity; epidermal growth factor receptor binding activity; and identical protein binding activity. Predicted to be involved in several processes, including positive regulation of cell-substrate adhesion; positive regulation of protein localization to plasma membrane; and positive regulation of signal transduction. Predicted to act upstream of or within inflammatory response; lung goblet cell differentiation; and mucus secretion. Predicted to be located in extracellular space. Predicted to be active in endoplasmic reticulum. Orthologous to human AGR2 (anterior gradient 2, protein disulphide isomerase family member); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 3,3',5,5'-tetrabromobisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

anterior gradient 2; anterior gradient 2 (Xenopus laevis); anterior gradient 2 homolog; anterior gradient 2 homolog (Xenopus laevis); anterior gradient homolog 2; anterior gradient homolog 2 (Xenopus laevis); anterior gradient protein 2 homolog; LOC298961

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	58,435,908 - 58,456,678 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	58,435,908 - 58,456,677 (+)	Ensembl				GRCr8
mRatBN7.2	6	52,708,602 - 52,729,378 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	52,708,602 - 52,729,371 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	52,999,619 - 53,020,416 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	53,314,493 - 53,335,286 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	52,779,800 - 52,800,569 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	55,465,782 - 55,487,087 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	55,465,782 - 55,487,714 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	65,081,213 - 65,102,524 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	54,695,633 - 54,716,858 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	51,855,174 - 51,875,917 (+)	NCBI		Celera
RGSC_v3.1	6	54,709,609 - 54,719,927 (+)	NCBI
Cytogenetic Map	6	q16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

breast cancer (ISO)

Breast Neoplasms (ISO)

pancreatic ductal adenocarcinoma (ISO)

pancreatic ductal carcinoma (ISO)

Pancreatic Intraepithelial Neoplasia (ISO)

Prostatic Neoplasms (ISO)

RESPIRATORY INFECTIONS, RECURRENT, AND FAILURE TO THRIVE WITH OR WITHOUT DIARRHEA (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (EXP,ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-trinitrobenzenesulfonic acid (ISO)

3,3',5,5'-tetrabromobisphenol A (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3-methylcholanthrene (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

8-Br-cAMP (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bicalutamide (ISO)

bisphenol A (EXP,ISO)

cadmium atom (EXP)

cadmium dichloride (EXP,ISO)

calcitriol (ISO)

capecitabine (ISO)

carbon monoxide (ISO)

carbon nanotube (ISO)

chlordecone (ISO)

chloroprene (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

coumestrol (ISO)

curcumin (ISO)

cyclosporin A (ISO)

dehydroepiandrosterone (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dicrotophos (ISO)

diethylstilbestrol (ISO)

dimethyl sulfoxide (ISO)

disodium selenite (ISO)

doxifluridine (ISO)

Enterolactone (ISO)

folic acid (ISO)

fulvestrant (ISO)

furan (EXP)

genistein (ISO)

glycidyl methacrylate (ISO)

glyphosate (ISO)

hydrogen peroxide (ISO)

isotretinoin (ISO)

ivermectin (ISO)

menadione (ISO)

methimazole (EXP)

nitrofen (EXP)

O-methyleugenol (ISO)

octadecanoic acid (ISO)

okadaic acid (ISO)

ozone (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

pirinixic acid (ISO)

quercetin (ISO)

resveratrol (ISO)

serpentine asbestos (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sotorasib (ISO)

sulfur dioxide (ISO)

tamoxifen (ISO)

tanespimycin (ISO)

testosterone (EXP,ISO)

titanium dioxide (ISO)

trametinib (ISO)

trichloroethene (EXP)

tris(2-butoxyethyl) phosphate (ISO)

triticonazole (EXP)

zinc atom (ISO)

zinc(0) (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

cell chemotaxis (ISO)

digestive tract morphogenesis (IEA,ISO)

endoplasmic reticulum unfolded protein response (ISO)

inflammatory response (ISO)

lung goblet cell differentiation (ISO)

mucus secretion (IEA,ISO)

positive regulation of cell-substrate adhesion (IEA,ISO)

positive regulation of developmental growth (IEA,ISO)

positive regulation of epidermal growth factor receptor signaling pathway (IEA,ISO)

positive regulation of gene expression (IEA,ISO)

positive regulation of IRE1-mediated unfolded protein response (IEA,ISO)

positive regulation of PERK-mediated unfolded protein response (IEA,ISO)

positive regulation of protein localization to plasma membrane (IEA,ISO)

protein folding in endoplasmic reticulum (ISO)

response to endoplasmic reticulum stress (ISO)

Cellular Component

endoplasmic reticulum (IBA,IEA,ISO)

extracellular region (IEA,ISO)

extracellular space (IEA,ISO)

Molecular Function

dystroglycan binding (IBA,IEA,ISO)

epidermal growth factor receptor binding (IEA,ISO)

identical protein binding (IEA,ISO)

protein binding (ISO)

protein homodimerization activity (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Significance of the metastasis-inducing protein AGR2 for outcome in hormonally treated breast cancer patients.	Innes HE, etal., Br J Cancer. 2006 Apr 10;94(7):1057-65.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Comprehensive gene review and curation	RGD comprehensive gene curation
6.	Prognostic significance of AGR2 in pancreatic ductal adenocarcinoma.	Riener MO, etal., Histol Histopathol. 2009 Sep;24(9):1121-8.
7.	Analysis of the pancreatic tumor progression by a quantitative proteomic approach and immunhistochemical validation.	Sitek B, etal., J Proteome Res. 2009 Apr;8(4):1647-56.

Additional References at PubMed

PMID:12592373	PMID:18614015	PMID:19359471	PMID:22184114	PMID:22675208	PMID:23220234	PMID:23274113	PMID:24251762	PMID:25666625	PMID:26169982

Genomics

Comparative Map Data

Agr2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	58,435,908 - 58,456,678 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	6	58,435,908 - 58,456,677 (+)	Ensembl				GRCr8
mRatBN7.2	6	52,708,602 - 52,729,378 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	52,708,602 - 52,729,371 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	6	52,999,619 - 53,020,416 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	53,314,493 - 53,335,286 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	52,779,800 - 52,800,569 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	55,465,782 - 55,487,087 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	55,465,782 - 55,487,714 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	6	65,081,213 - 65,102,524 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	6	54,695,633 - 54,716,858 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	6	51,855,174 - 51,875,917 (+)	NCBI		Celera
RGSC_v3.1	6	54,709,609 - 54,719,927 (+)	NCBI
Cytogenetic Map	6	q16	NCBI

AGR2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	16,791,811 - 16,804,999 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	16,791,387 - 16,833,433 (-)	Ensembl			hg38	GRCh38
GRCh37	7	16,831,435 - 16,844,623 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	16,797,960 - 16,811,133 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	7	16,604,675 - 16,617,848	NCBI
Celera	7	16,812,569 - 16,825,043 (-)	NCBI		Celera
Cytogenetic Map	7	p21.1	NCBI
HuRef	7	16,719,359 - 16,731,797 (-)	NCBI		HuRef
CHM1_1	7	16,833,176 - 16,845,615 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	16,921,380 - 16,934,682 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	16,885,921 - 16,898,395 (-)	NCBI

Agr2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	36,042,924 - 36,054,080 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	36,042,906 - 36,054,086 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	12	35,992,925 - 36,004,081 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	35,992,907 - 36,004,087 (+)	Ensembl			mm10	GRCm38
MGSCv37	12	36,719,512 - 36,730,668 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	12	36,503,191 - 36,514,347 (+)	NCBI		MGSCv36	mm8
Celera	12	37,446,354 - 37,457,458 (+)	NCBI		Celera
Cytogenetic Map	12	A3	NCBI
cM Map	12	16.18	NCBI

Agr2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955410	19,984,768 - 19,995,733 (-)	Ensembl
ChiLan1.0	NW_004955410	19,984,768 - 19,995,446 (-)	NCBI	ChiLan1.0	ChiLan1.0

AGR2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	21,624,614 - 21,637,773 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	69,949,337 - 69,962,590 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	17,446,275 - 17,489,802 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	16,773,281 - 16,785,721 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	16,773,281 - 16,785,879 (-)	Ensembl			panPan2	panpan1.1

AGR2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	31,303,784 - 31,316,752 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	31,305,567 - 31,316,686 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	30,825,073 - 30,838,046 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	31,224,288 - 31,237,241 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	31,226,071 - 31,237,170 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	31,326,448 - 31,339,401 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	31,038,306 - 31,051,283 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	31,351,630 - 31,364,787 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Agr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	75,641,522 - 75,654,857 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936546	3,315,543 - 3,328,369 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936546	3,316,622 - 3,328,317 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

AGR2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	86,041,369 - 86,053,857 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	86,042,070 - 86,053,893 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	94,843,416 - 94,855,248 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

AGR2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	41,311,250 - 41,324,806 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	41,312,415 - 41,326,663 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666042	63,184,604 - 63,199,875 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Agr2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624739	13,428,130 - 13,442,070 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624739	13,428,049 - 13,440,949 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Agr2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	7	49,253,415 - 49,263,683 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Agr2
149 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	33
Count of miRNA genes:	29
Interacting mature miRNAs:	33
Transcripts:	ENSRNOT00000006682
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9590290	Uminl2	Urine mineral level QTL 2	3.96	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	6	44510974	89510974	Rat
634318	Bw118	Body weight QTL 118	3.55		abdominal fat pad mass (VT:1000711)	abdominal fat pad weight (CMO:0000088)	6	39028659	63457441	Rat
4889933	Bss88	Bone structure and strength QTL 88	3.8		tibia size trait (VT:0100001)	tibia total bone volume (CMO:0001724)	6	53684921	98684921	Rat
10401812	Kidm54	Kidney mass QTL 54			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	20097635	65097635	Rat
634307	Bp141	Blood pressure QTL 141	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	40957564	85957564	Rat
1331743	Uae28	Urinary albumin excretion QTL 28	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	45153786	90153786	Rat
8552910	Pigfal5	Plasma insulin-like growth factor 1 level QTL 5	4.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	22653889	67653889	Rat
10401800	Kidm49	Kidney mass QTL 49			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	20097635	65097635	Rat
5684992	Bmd83	Bone mineral density QTL 82	4.8		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	6	53684921	98684921	Rat
1331779	Rf38	Renal function QTL 38	2.876		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	6	31185002	76185002	Rat
737827	Hcar11	Hepatocarcinoma resistance QTL 11	4.4		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	6	46050607	116278722	Rat
724513	Uae14	Urinary albumin excretion QTL 14	6.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	6	46047353	91047353	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	26618314	86868070	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	20859430	113082285	Rat
9590140	Scort4	Serum corticosterone level QTL 4	14.49	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	44510974	89510974	Rat
2301964	Bp323	Blood pressure QTL 323	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	86868070	Rat
9590306	Scort18	Serum corticosterone level QTL 18	2.88	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	6	44510974	89510974	Rat
1578665	Bss16	Bone structure and strength QTL 16	4.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	6	33328841	78328841	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	26618314	86868070	Rat
1641898	Colcr4	Colorectal carcinoma resistance QTL4	3.71	0.0007	intestine integrity trait (VT:0010554)	well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)	6	30937632	75937632	Rat
1578668	Bmd14	Bone mineral density QTL 14	3.8		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	33328841	78328841	Rat
6893340	Cm77	Cardiac mass QTL 77	0.26	0.57	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	39028659	86867923	Rat
5684963	Bss99	Bone structure and strength QTL 99	3.1		tibia area (VT:1000281)	tibia area measurement (CMO:0001382)	6	53684921	98684921	Rat
70199	Coreg1	Compensatory renal growth QTL 1	11.8		kidney mass (VT:0002707)	compensatory renal growth score (CMO:0001894)	6	14599473	63457687	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	16089372	61967788	Rat
1354664	Slep2	Serum leptin concentration QTL 2	4.49		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	6	22288257	67288257	Rat
1300143	Rf14	Renal function QTL 14	2.92		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	40163183	85163183	Rat

Markers in Region

D6Got62

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	52,718,280 - 52,718,455 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	55,475,496 - 55,475,670	NCBI	Rnor6.0
Rnor_5.0	6	65,090,927 - 65,091,101	UniSTS	Rnor5.0
RGSC_v3.4	6	54,705,768 - 54,705,942	UniSTS	RGSC3.4
RGSC_v3.4	6	54,705,767 - 54,705,942	RGD	RGSC3.4
Celera	6	51,864,827 - 51,865,001	UniSTS
RGSC_v3.1	6	54,708,894 - 54,709,068	RGD
RH 3.4 Map	6	349.6	UniSTS
RH 3.4 Map	6	349.6	RGD
RH 2.0 Map	6	548.2	RGD
Cytogenetic Map	6	q16	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	10	65	61	39	45	14	54	14	6	216	134	4	47	44	88	31	1	1

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106725	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001434243	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006240041	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000006682 ⟹ ENSRNOP00000006682

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	6	58,435,908 - 58,456,677 (+)	Ensembl
mRatBN7.2 Ensembl	6	52,708,602 - 52,729,371 (+)	Ensembl
Rnor_6.0 Ensembl	6	55,465,782 - 55,487,086 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000091213 ⟹ ENSRNOP00000068828

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	6	55,479,283 - 55,487,714 (+)	Ensembl

RefSeq Acc Id:

NM_001106725 ⟹ NP_001100195

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	58,435,908 - 58,456,677 (+)	NCBI
mRatBN7.2	6	52,708,602 - 52,729,371 (+)	NCBI
Rnor_6.0	6	55,465,782 - 55,487,086 (+)	NCBI
Rnor_5.0	6	65,081,213 - 65,102,524 (+)	NCBI
RGSC_v3.4	6	54,695,633 - 54,716,858 (+)	RGD
Celera	6	51,855,174 - 51,875,917 (+)	RGD

Sequence:

show sequence

CTTTAAGGTACAAGAGTTCTCTCCAGAGTTCCAGGGCCAGTGGCATCACAGATGACTAGCCTGG
AAGGGTCCTTCCACATTCCTTTGTAACAAGGCACTCTTCCTACTGAATGTACGGGCATCCTCAC
CAAACACAACTCTGAATAAGGTCTAGCTGAGGTGCTGAGACTGGAAAGACAGCAGCTGTTGGAA
GCAGCATCTTACTTCTCTTCCTTTTGCGATTTGCCATGGAGAAATTTTCAGTCTCGGCAATCCT
GCTTCTTGTGGCCATCTCTGGTACTCTGGCCAAAGACACCACAGTCAAATCTGGATCCAAAAAG
GACCCAAAGGACTCTCGACCCAAACTACCCCAGACCCTGTCCAGAGGTTGGGGAGATCAGCTCA
TCTGGACTCAGACTTACGAAGAAGCCTTATACAAATCCAAGACAAGCAACAGACCCTTGATGGT
CATTCATCACTTGGACGAATGCCCGCACAGTCAAGCTTTAAAGAAAGTGTTTGCTGAAAATAAG
GAGATCCAGAAATTGGCAGAGCAGTTTGTTCTCCTCAACTTGATCTATGAAACAACTGACAAGC
ACCTTTCTCCTGATGGCCAGTACGTCCCCAGAATTGTGTTTGTGGACCCTTCCCTGACGGTGAG
GGCAGACATCACCGGAAGATACTCAAACCGTCTCTACGCTTACGAACCTTCTGACACAGCTCTG
CTGCACGACAACATGAAGAAAGCTCTCAAGTTGCTGAAGACAGAGTTGTAGAGTCAACTGTACA
GTGCCTCAGGAGCCGGGAAGGCAGAAGCACTGTGGACCTGCCGATGACATTACAGTTTAATGTT
ACAACAAATGTATTTTTTAAACACCCACGTGTGGGGAAACAATATTATTATCTACTACAGACAC
ATGATTTTCTAGAAAATAAAGTCTTGTGAGAACTCC

hide sequence

RefSeq Acc Id:

XM_006240041 ⟹ XP_006240103

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	58,446,052 - 58,456,678 (+)	NCBI
mRatBN7.2	6	52,718,809 - 52,729,378 (+)	NCBI
Rnor_6.0	6	55,472,328 - 55,487,087 (+)	NCBI
Rnor_5.0	6	65,081,213 - 65,102,524 (+)	NCBI

Sequence:

show sequence

ATCTTATGTGTATTAGTGTTTTTCTTGTGTGTGCCTGTGTCCCACATGTGTATCTGGCACCCAT
GAAGGTAAGAAGAGGAAGGCATTGGATCTCCTGGAACTGGAATTACAGGTGGTTGTGAGCCACC
GTGTGCAGCAAATGCTGTTAATGTCTGAGCCCTGTGTCTGGCCCTGACTTTACTTCTTTACAAC
CTTTTATGTATCCTATAAAATATGTATTGCTAGCCCACATCACAAACCGTAAGGCCAAAGCCCA
GAGATTTAGTTATGACCTTGGTTAATAAGGTGTGCAATGCCATACAACTAGGTTTGAACTCAAG
TCAGTCTGAACTGTAACTTTCCTTTTAACCACCGCATACTTCCTATTGAAGGGAAAGTCTAAAC
ACTAGGACAATACGAACAAATGTTAGTATTATTACACATTAATAATATAACAAGAGGTCTCACT
TGGATAGTGAGACATCTTTCCAACCTATTATGTCTGAGCTACTCAGACTCTCTCCAGCCAGACT
CAGCCAATAAATACCCCATGAGTACATTATGCAAATTCTTCATCACTTTTTCAAAAGCATCTTG
ACTTTTAACATTAATTTGAGCACTAATTTGCACCACTGGACAGCTTTCCCTCCTCTAAAAAGAA
ATTCCCGAAGTCTGTACCACTTTCCTGTCTTTTCTTGCATGCTAGTTCCATATGGATGGTTAAT
TTTTAGTCTTAATATTCTATTTCTTCGATCAGACTAATAGAAACATAAAGCAGGGGCAACATGT
TAAACTTCCGTTTGCTCTCCCCAGGACATGTTGGATCACCCTGAATTTCAGGTATCTATGCTGC
TCCTGTCTAACTCCATAGTGTACCATAACACCTCCACCTTTGTATTTTAATGCATGGCATAATA
TTTGCTGAGTAGCCTTGTTGACTATTTGATGAAGGGGGGAAAATAGGCTGAGGTTATGGGTCTG
TGGATCGAGCACTTGTCACACAAAGGCAGCAACCTGAGTCTTGATCTGTAGAGTCTACATTAAA
GCTGGATGTTGTCCACGGGTGTCTATAGTCCCAGGAGGGAGGTAGAGACAAGAGAATCTCAGAA
ACCTCACAGGCTCGTCTTACTCAGCAGTGAAGAAGACAGACCCTATCTCAAATAAAGTAGAAGC
CAAGGACTAGCAGCCATGGTTATTCTATGATCTCTCCACAGGCCTTGATGTACACATACAATAA
ATAATAAATAAAAACATCCTAGACTTTCAATAAACTAGTTATTATAGGAAATAAACTACTTAAA
AATATGGTTGTTCAAACCATCAGCGCAGACATTTCTAACATAAGCATCCTCATTACGATAACTC
TAAGGATCACTGGTACCATGCTTGGTTCTGTTGATCCAATGGTTGTTTGGAATTATCAAGTCCT
ACCCATAGAAACTCCCATTCAGATATTATCAAAACCATATACCTAGAATAGCATACCTTTACCT
TTGGAAGAGAGCAAGTTTCCTCCAACGAGTTTAAAGATACACAAGAGATATTTTATTTCGTGTA
AACTTTCCTTTTTGGCAGACAAACAGAAAACCACTTACCTCATTTTTTATACAAATGTCTAGAA
TCCCCACATATACCCAATTGCCTAATTACTAAATATTTTAAAATTGGAACTCAAGTTTTCTCTT
CAAAAGAATTCAGTCTGTAGTTTGCTCACAAAGCCATATACAAAAAAGTCTGGTCCAAGGAGTT
GTCAATGGGAACGAGCCAGTGGAATGAAAGGTCCAGAAAGAAACTTTTTAAATGAATTAACTTT
ATCATACCTAAAAATATTTTAAGTGTATATCTTTCTTTCATCAGAGGCTTGGATTCTGTGGGCT
AGTGACGCTTGAATGATTCCATTTGCTTAGGACTCTAAAATGTCTATGAAGAGCATTTCTTATA
GATGTTTGACCAAGCACAATGATTTGAGCTAAAGCCTTAACTAGAATTGCTCTCACATTGGCTG
TTACTGTTTAGCCCTTAGTTCTATTCAAACCATTATTTTACAGATTGAAGCCACCAAACAACAA
ACAAACAAACAATAGAACAACCAATGGCTTTCTAAAGGCCCTACAATTAGTTGAGGGCAGAGCT
AGGAGCAAAGCCAGAGCTCTTCTACTCCATTAATTGGACACTGGAAAATGTGTGGGATCGAGGG
TCAAGATTTCAGTCAGCAGCATCTTGTGTCTACTCACTGGATGATGACATCAGAGATGTCACTG
AACACCCTGAAATGTTAGTTTCCATACCTGTAATGGGGTCACAAGCAACGGTTCTGAGCGACAT
ACTGGTTAGCTTAGAGTGAACTAAGGAAGGGGAAGAGACTTGGTATGAACATAGGATCCCTGCC
TCCACAGGAACAGTACAGCCCAGCAGGCTGAAGCATCAAAGATTTACCTTCTCTCAATTCTGGA
GGCTCCATCCAGAGCATCCATGTGTCAGCAGGGTTAGGTTCTTCTGCCCTTGGCATGTAGAAGA
CGTCATCATGTGCCTGTACCTGACCTCCCCTCTGTACCCGTCTCTGACCTAATTTTCTTTCCAA
CGAGAATAGCAGCCATATTAGATTAGAACCCAGCCTAATGACCTATTTCACTTACTCTCAATTA
CTTAGTCACTTACTTCAATTACTTTCACTTTATTTACTTACTGTGGTGCTTAGGATCAAATTCA
GAGTCTTGCACATACTTAGCAAAATGTCCCACCTGAAGAATTGCACCGTCAGACCTAAGCTTAA
GACCCTCTCTCTGTATACAGTCATCCTCTAAGGTCCTGGGGAATCACAACACGTGGATTATTTT
GAGGCACATCTCAACCATATCTCTTGATAATTGAAAACATCTCTGATTTGCTATAACTCATTAC
AATGATATAACAGCTATCTCGGAGTATTCTTGTATCTAATCTCATGTTGGTAAGGATCTGGTTA
TGGTACTGCAAGGAGGAAGTAATTATTACAACATCCTGCACACGCTGGGGTAACCTTGGCATCC
TTGGTACATGAGTCCTGAAGTGAAGCAAATGTCTACAGAGTCTTAGAGATGGGTGGGTGAGGGT
AGTTTTCTATGCTGCTAAGGTGGTGTGTTCTATGCTGTGTGGTTCATGCTGTGTGGTGTGTTTT
ATGCTGTGCGGTGGTTCTTTGTGATCTCCTGATGTTGTGATGCACACACATGTGCACACACACA
CACACACACACACACACACACACACACACTTACACACACTTGTACATCAGGGCAATTCTTAGCT
CACAACATTAGCCTATTCTTCCTTTCTTCAGTAACTTCCCCAAGTTTGAAGAGTCCGTGGGTGA
TGATTTGTGGGTTTTTATACCTGTAATTAGAGCACATTTTAAAAGGAAGAAGAAGGATAATGTG
GAAAATAGCATGTGTGGTGATCAAGCCTGGCCAGCTGCATTACTGTAAGAAGGGTTGGAATGAT
GAATCATCTTTTATTCTAAAAGCTAAATAAATGCAATCTGCCCAAGAGGGAGGAAATTAATATC
TATAAACCACAACTTCCATCCAATCACATACAGACAAATCAGCCTTCAGACCAATCAAATGTCT
TCATTTAAAGCTTACCTGGATTTGGCACACTGCCCAGCTTTTCCAAAACTACTCACAATAATAC
CTTCGAAAACAGTGAAAATGCTGGTACTCAAATAAAATCAACAGCCTTCTCAATGACTTTTATT
TTTAAGAGAAAAAAAAAGAAAACAAGGAACTTTTTAACGGAGAAAAGACAATTGCTTGGGAGAA
GGGAAGTTTGCTTCTGAGTTAGCTGCCTGTGGAAACAGGATTAGTGGGTGGGATTGGGGTGTGC
TCTGCCCATAAATACAGGCTCAGGGCTGTGCTGGCACACTCAGAAGCTTGGACGGCAACCCTTG
CGGCTCACACAAAGCAGGAGGGAGGAGAGCTCAGATTTGCCATGGAGAAATTTTCAGTCTCGGC
AATCCTGCTTCTTGTGGCCATCTCTGGTACTCTGGCCAAAGACACCACAGTCAAATCTGGATCC
AAAAAGGACCCAAAGGACTCTCGACCCAAACTACCCCAGACCCTGTCCAGAGGTTGGGGAGATC
AGCTCATCTGGACTCAGACTTACGAAGAAGCCTTATACAAATCCAAGACAAGCAACAGACCCTT
GATGGTCATTCATCACTTGGACGAATGCCCGCACAGTCAAGCTTTAAAGAAAGTGTTTGCTGAA
AATAAGGAGATCCAGAAATTGGCAGAGCAGTTTGTTCTCCTCAACTTGATCTATGAAACAACTG
ACAAGCACCTTTCTCCTGATGGCCAGTACGTCCCCAGAATTGTGTTTGTGGACCCTTCCCTGAC
GGTGAGGGCAGACATCACCGGAAGATACTCAAACCGTCTCTACGCTTACGAACCTTCTGACACA
GCTCTGCTGCACGACAACATGAAGAAAGCTCTCAAGTTGCTGAAGACAGAGTTGTAGAGTCAAC
TGTACAGTGCCTCAGGAGCCGGGAAGGCAGAAGCACTGTGGACCTGCCGATGACATTACAGTTT
AATGTTACAACAAATGTATTTTTTAAACACCCACGTGTGGGGAAACAATATTATTATCTACTAC
AGACACATGATTTTCTAGAAAATAAAGTCTTGTGAGAACTCCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001100195	(Get FASTA)	NCBI Sequence Viewer
	NP_001421172	(Get FASTA)	NCBI Sequence Viewer
	XP_006240103	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM03309	(Get FASTA)	NCBI Sequence Viewer
	EDM03310	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000006682
	ENSRNOP00000006682.5

RefSeq Acc Id:	NP_001100195 ⟸ NM_001106725
- Peptide Label:	precursor
- UniProtKB:	D3ZIA7 (UniProtKB/TrEMBL), A6HBA4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEKFSVSAILLLVAISGTLAKDTTVKSGSKKDPKDSRPKLPQTLSRGWGDQLIWTQTYEEALYK SKTSNRPLMVIHHLDECPHSQALKKVFAENKEIQKLAEQFVLLNLIYETTDKHLSPDGQYVPRI VFVDPSLTVRADITGRYSNRLYAYEPSDTALLHDNMKKALKLLKTEL hide sequence

RefSeq Acc Id:	XP_006240103 ⟸ XM_006240041
- Peptide Label:	isoform X1
- Sequence:	show sequence MEKFSVSAILLLVAISGTLAKDTTVKSGSKKDPKDSRPKLPQTLSRGWGDQLIWTQTYEEALYK SKTSNRPLMVIHHLDECPHSQALKKVFAENKEIQKLAEQFVLLNLIYETTDKHLSPDGQYVPRI VFVDPSLTVRADITGRYSNRLYAYEPSDTALLHDNMKKALKLLKTEL hide sequence

Ensembl Acc Id:

ENSRNOP00000006682 ⟸ ENSRNOT00000006682

Ensembl Acc Id:

ENSRNOP00000068828 ⟸ ENSRNOT00000091213

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZIA7-F1-model_v2	AlphaFold	D3ZIA7	1-175	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694566

Promoter ID:

EPDNEW_R5083

Type:

single initiation site

Name:

Agr2_1

Description:

anterior gradient 2, protein disulphide isomerase family member

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	55,479,307 - 55,479,367	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1304606	AgrOrtholog
BioCyc Gene	G2FUF-37804	BioCyc
Ensembl Genes	ENSRNOG00000005023	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000006682	ENTREZGENE
	ENSRNOT00000006682.8	UniProtKB/TrEMBL
Gene3D-CATH	Glutaredoxin	UniProtKB/TrEMBL
InterPro	AGR/TXD	UniProtKB/TrEMBL
	Thioredoxin-like_sf	UniProtKB/TrEMBL
KEGG Report	rno:298961	UniProtKB/TrEMBL
NCBI Gene	298961	ENTREZGENE
PANTHER	ANTERIOR GRADIENT PROTEIN 2 HOMOLOG	UniProtKB/TrEMBL
	ANTERIOR GRADIENT PROTEIN-RELATED	UniProtKB/TrEMBL
Pfam	Thioredoxin_7	UniProtKB/TrEMBL
PhenoGen	Agr2	PhenoGen
RatGTEx	ENSRNOG00000005023	RatGTEx
Superfamily-SCOP	Thiordxn-like_fd	UniProtKB/TrEMBL
UniProt	A6HBA4	ENTREZGENE, UniProtKB/TrEMBL
	D3ZIA7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-07-09	Agr2	anterior gradient 2, protein disulphide isomerase family member	Agr2	anterior gradient 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-07	Agr2	anterior gradient 2	Agr2	anterior gradient 2 homolog (Xenopus laevis)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-12-06	Agr2	anterior gradient 2 homolog (Xenopus laevis)	Agr2	anterior gradient homolog 2 (Xenopus laevis)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-26	Agr2	anterior gradient homolog 2 (Xenopus laevis)	Agr2	anterior gradient 2 (Xenopus laevis)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Agr2	anterior gradient 2 (Xenopus laevis)	Agr2_predicted	anterior gradient 2 (Xenopus laevis) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Agr2_predicted	anterior gradient 2 (Xenopus laevis) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM