Spink14 (serine peptidase inhibitor, Kazal type 14) - Rat Genome Database

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Gene: Spink14 (serine peptidase inhibitor, Kazal type 14) Rattus norvegicus
Analyze
Symbol: Spink14
Name: serine peptidase inhibitor, Kazal type 14
RGD ID: 1303288
Description: Predicted to enable hydrolase activity and serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular region. Orthologous to human SPINK14 (serine peptidase inhibitor Kazal type 14 (putative)); INTERACTS WITH 6-propyl-2-thiouracil; amitrole; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Kazal type serine protease inhibitor 5-like 2; putative serine protease inhibitor Kazal-type 5-like 2; serine protease inhibitor Kazal-type 14; Spink5l2
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81836,589,158 - 36,593,309 (+)NCBIGRCr8
mRatBN7.21836,339,223 - 36,341,261 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1836,339,223 - 36,342,144 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1836,443,247 - 36,445,285 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01837,161,597 - 37,163,635 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01836,538,498 - 36,540,536 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01229,349,133 - 229,351,168 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1835,196,537 - 35,199,458 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl236,011,045 - 36,013,966 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1229,349,133 - 229,351,171 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01236,506,634 - 236,508,669 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41837,638,618 - 37,641,539 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11837,673,883 - 37,676,805 (+)NCBI
Cytogenetic Map18q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A genomic analysis of rat proteases and protease inhibitors. Puente XS and Lopez-Otin C, Genome Res 2004 Apr;14(4):609-22.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Spink14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81836,589,158 - 36,593,309 (+)NCBIGRCr8
mRatBN7.21836,339,223 - 36,341,261 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1836,339,223 - 36,342,144 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1836,443,247 - 36,445,285 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01837,161,597 - 37,163,635 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01836,538,498 - 36,540,536 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01229,349,133 - 229,351,168 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1835,196,537 - 35,199,458 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl236,011,045 - 36,013,966 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1229,349,133 - 229,351,171 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01236,506,634 - 236,508,669 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41837,638,618 - 37,641,539 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11837,673,883 - 37,676,805 (+)NCBI
Cytogenetic Map18q11NCBI
SPINK14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385148,168,546 - 148,175,619 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5148,168,546 - 148,175,619 (+)EnsemblGRCh38hg38GRCh38
GRCh375147,548,109 - 147,555,182 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365147,529,489 - 147,535,154 (+)NCBINCBI36Build 36hg18NCBI36
Celera5143,630,039 - 143,634,356 (+)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5142,696,417 - 142,702,136 (+)NCBIHuRef
CHM1_15146,981,715 - 146,987,380 (+)NCBICHM1_1
T2T-CHM13v2.05148,704,264 - 148,709,980 (+)NCBIT2T-CHM13v2.0
Spink14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391844,160,936 - 44,165,275 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1844,160,936 - 44,165,484 (+)EnsemblGRCm39 Ensembl
GRCm381844,027,869 - 44,032,208 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1844,027,869 - 44,032,417 (+)EnsemblGRCm38mm10GRCm38
MGSCv371844,187,523 - 44,191,862 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361844,153,792 - 44,157,748 (+)NCBIMGSCv36mm8
Celera1845,404,003 - 45,408,310 (+)NCBICelera
Cytogenetic Map18B3NCBI
cM Map1823.74NCBI
SPINK14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24143,402,557 - 143,408,579 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15141,542,107 - 141,548,129 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05143,598,502 - 143,604,524 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15149,606,819 - 149,612,784 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5149,606,819 - 149,612,784 (+)Ensemblpanpan1.1panPan2
SPINK14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1242,388,792 - 42,393,375 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl242,388,311 - 42,393,197 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha239,431,445 - 39,439,229 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0242,845,240 - 42,853,022 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl242,849,693 - 42,853,029 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1239,915,223 - 39,923,002 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0240,725,232 - 40,733,013 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0241,548,458 - 41,556,244 (+)NCBIUU_Cfam_GSD_1.0
Spink14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213145,061,304 - 145,064,879 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365046,635,277 - 6,638,296 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365046,635,277 - 6,638,852 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPINK14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2149,415,857 - 149,424,227 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12149,414,615 - 149,423,473 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22156,181,121 - 156,189,865 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPINK14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603427,059,376 - 27,066,698 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spink14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247747,596,610 - 7,600,661 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Spink14
12 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:22
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000048335, ENSRNOT00000073750
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1641923Colcr8Colorectal carcinoma resistance QTL 83.10.0014intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)182206624252293055Rat
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
12904673Cm127Cardiac mass QTL 1270.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)182654808246969551Rat
12904675Am19Aortic mass QTL 190.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)182654808246969551Rat
12904677Kidm72Kidney mass QTL 720.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)182654808246969551Rat
12904668Bw188Body weight QTL 1880.03body mass (VT:0001259)body weight (CMO:0000012)182654808246969551Rat
12904669Cm125Cardiac mass QTL 1250.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)182654808246969551Rat
12904670Cm126Cardiac mass QTL 1260.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)182654808246969551Rat
2301413Bp318Blood pressure QTL 3180.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182654808246969551Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
61383Bp47Blood pressure QTL 4717.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)183127168160377755Rat
1331742Bp228Blood pressure QTL 2283.88752arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331774Bp226Blood pressure QTL 2264.41065arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331776Bp225Blood pressure QTL 2252.829arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)183135940859796643Rat
1331798Bp224Blood pressure QTL 2243.53873arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940859796643Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940861698465Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
6903347Bp350Blood pressure QTL 3504.4arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135953059796478Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat


Expression


Sequence


RefSeq Acc Id: ENSRNOT00000048335   ⟹   ENSRNOP00000041361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1836,339,223 - 36,342,144 (+)Ensembl
Rnor_6.0 Ensembl1835,196,537 - 35,199,458 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000073750   ⟹   ENSRNOP00000066837
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl236,011,045 - 36,013,966 (+)Ensembl
RefSeq Acc Id: NR_172952
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81836,590,117 - 36,592,155 (+)NCBI
mRatBN7.21836,339,223 - 36,341,261 (+)NCBI
RefSeq Acc Id: XR_010059592
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81836,589,158 - 36,593,309 (+)NCBI
Protein Sequences
GenBank Protein CAE51399 (Get FASTA)   NCBI Sequence Viewer  
  EDL84759 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000041361.2
  ENSRNOP00055024843
  ENSRNOP00060015398
  ENSRNOP00065025289
GenBank Protein Q6IE46 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: ENSRNOP00000041361   ⟸   ENSRNOT00000048335
RefSeq Acc Id: ENSRNOP00000066837   ⟸   ENSRNOT00000073750
Protein Domains
Kazal-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IE46-F1-model_v2 AlphaFold Q6IE46 1-98 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303288 AgrOrtholog
BioCyc Gene G2FUF-7670 BioCyc
Ensembl Genes ENSRNOG00000028902 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000045824 Ensembl
  ENSRNOG00000046686 Ensembl
  ENSRNOG00055018205 UniProtKB/Swiss-Prot
  ENSRNOG00060011571 UniProtKB/Swiss-Prot
  ENSRNOG00065018900 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000048335 ENTREZGENE
  ENSRNOT00000048335.3 UniProtKB/Swiss-Prot
  ENSRNOT00055030856 UniProtKB/Swiss-Prot
  ENSRNOT00060019582 UniProtKB/Swiss-Prot
  ENSRNOT00065031726 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.60.30 UniProtKB/Swiss-Prot
InterPro Kazal_dom UniProtKB/Swiss-Prot
  Kazal_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:408231 UniProtKB/Swiss-Prot
NCBI Gene 408231 ENTREZGENE
PANTHER SERINE PROTEASE INHIBITOR KAZAL-TYPE 14 UniProtKB/Swiss-Prot
  SERINE PROTEASE INHIBITOR KAZAL-TYPE 7 SPINK7 UniProtKB/Swiss-Prot
Pfam Kazal_1 UniProtKB/Swiss-Prot
PhenoGen Spink14 PhenoGen
PROSITE KAZAL_1 UniProtKB/Swiss-Prot
  KAZAL_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000028902 RatGTEx
  ENSRNOG00000045824 RatGTEx
  ENSRNOG00000046686 RatGTEx
  ENSRNOG00055018205 RatGTEx
  ENSRNOG00060011571 RatGTEx
  ENSRNOG00065018900 RatGTEx
SMART KAZAL UniProtKB/Swiss-Prot
Superfamily-SCOP SSF100895 UniProtKB/Swiss-Prot
UniProt ISK14_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Spink14  serine peptidase inhibitor, Kazal type 14  Spink5l2  Kazal type serine protease inhibitor 5-like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-14 Spink5l2  Kazal type serine protease inhibitor 5-like 2      Symbol and Name status set to provisional 70820 PROVISIONAL