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Gene: Ttc12 (tetratricopeptide repeat domain 12) Rattus norvegicus

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Symbol:

Ttc12

Name:

tetratricopeptide repeat domain 12

RGD ID:

1303264

Description:

Predicted to be involved in axonemal dynein complex assembly and sperm axoneme assembly. Predicted to be located in cytosol; nuclear membrane; and plasma membrane. Predicted to be active in centrosome and cytoplasm. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; alcohol dependence; drug dependence (multiple); nicotine dependence; and primary ciliary dyskinesia 45. Orthologous to human TTC12 (tetratricopeptide repeat domain 12); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

MGC94947; tetratricopeptide repeat protein 12

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TTC12 (tetratricopeptide repeat domain 12)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ttc12 (tetratricopeptide repeat domain 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ttc12 (tetratricopeptide repeat domain 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TTC12 (tetratricopeptide repeat domain 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TTC12 (tetratricopeptide repeat domain 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ttc12 (tetratricopeptide repeat domain 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TTC12 (tetratricopeptide repeat domain 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TTC12 (tetratricopeptide repeat domain 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ttc12 (tetratricopeptide repeat domain 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Ttc12 (tetratricopeptide repeat domain 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	OVOL3 (ovo like zinc finger 3)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Ttc12 (tetratricopeptide repeat domain 12)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TTC12 (tetratricopeptide repeat domain 12)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ttc12 (tetratricopeptide repeat domain 12)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG34274	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	CG34297	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG6980	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	CG6980	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG31294	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	CG31294	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	ttc12	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ttc12	Alliance	DIOPT (OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	58,696,381 - 58,743,857 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	58,696,385 - 58,742,717 (-)	Ensembl				GRCr8
mRatBN7.2	8	49,799,916 - 49,847,940 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	49,799,920 - 49,847,087 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	55,304,063 - 55,349,980 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	53,582,939 - 53,628,859 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	51,447,199 - 51,493,116 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	53,770,685 - 53,818,873 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	53,770,681 - 53,816,447 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	52,390,855 - 52,437,800 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	52,734,792 - 52,799,135 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	49,351,775 - 49,397,613 (-)	NCBI		Celera
RGSC_v3.1	8	52,753,849 - 52,818,189 (-)	NCBI
Cytogenetic Map	8	q23	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute lymphoblastic leukemia (ISO)

alcohol dependence (ISO)

Asthenozoospermia (ISO)

drug dependence (ISO)

genetic disease (ISO)

heroin dependence (ISO)

nicotine dependence (ISO)

primary ciliary dyskinesia 45 (ISO)

Teratozoospermia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (EXP)

alpha-Zearalanol (EXP)

amitrole (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

carbon nanotube (ISO)

chlormequat chloride (EXP)

choline (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

Cuprizon (EXP)

decabromodiphenyl ether (EXP)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

dicrotophos (ISO)

doxorubicin (ISO)

endosulfan (EXP)

ethanol (ISO)

folic acid (ISO)

fulvestrant (ISO)

furan (EXP)

GSK-J4 (ISO)

iron dichloride (ISO)

L-methionine (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

methimazole (EXP)

methylmercury chloride (ISO)

nickel atom (ISO)

okadaic acid (ISO)

perfluorooctanoic acid (EXP)

potassium dichromate (ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

thioacetamide (EXP)

thiram (ISO)

triphenyl phosphate (ISO)

Triptolide (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

axonemal dynein complex assembly (IBA,IEA,ISO)

cell projection organization (IEA)

sperm axoneme assembly (IBA,IEA,ISO)

Cellular Component

centrosome (IBA,IEA,ISO)

cytoplasm (IBA,IEA,ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	NCAM1-TTC12-ANKK1-DRD2 variants and smoking motives as intermediate phenotypes for nicotine dependence.	Bidwell LC, etal., Psychopharmacology (Berl). 2015 Apr;232(7):1177-86. doi: 10.1007/s00213-014-3748-2. Epub 2014 Oct 3.
2.	TTC12-ANKK1-DRD2 and CHRNA5-CHRNA3-CHRNB4 influence different pathways leading to smoking behavior from adolescence to mid-adulthood.	Ducci F, etal., Biol Psychiatry. 2011 Apr 1;69(7):650-60. doi: 10.1016/j.biopsych.2010.09.055. Epub 2010 Dec 17.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations.	Gelernter J, etal., Hum Mol Genet. 2006 Dec 15;15(24):3498-507. doi: 10.1093/hmg/ddl426. Epub 2006 Nov 3.
5.	A neurobiological pathway to smoking in adolescence: TTC12-ANKK1-DRD2 variants and reward response.	Macare C, etal., Eur Neuropsychopharmacol. 2018 Oct;28(10):1103-1114. doi: 10.1016/j.euroneuro.2018.07.101. Epub 2018 Aug 11.
6.	ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure.	Nelson EC, etal., JAMA Psychiatry. 2013 Mar;70(3):325-33. doi: 10.1001/jamapsychiatry.2013.282.
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
11.	Hypermethylation of TTC12 gene in acute lymphoblastic leukemia.	Wattanawaraporn R, etal., Leukemia. 2007 Nov;21(11):2370-3. doi: 10.1038/sj.leu.2404876. Epub 2007 Jul 26.
12.	Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence.	Yang BZ, etal., Alcohol Clin Exp Res. 2008 Dec;32(12):2117-27. doi: 10.1111/j.1530-0277.2008.00800.x. Epub 2008 Sep 30.
13.	Association of haplotypic variants in DRD2, ANKK1, TTC12 and NCAM1 to alcohol dependence in independent case control and family samples.	Yang BZ, etal., Hum Mol Genet. 2007 Dec 1;16(23):2844-53. doi: 10.1093/hmg/ddm240. Epub 2007 Aug 30.

Additional References at PubMed

PMID:23300604

Genomics

Comparative Map Data

Ttc12
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	58,696,381 - 58,743,857 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	8	58,696,385 - 58,742,717 (-)	Ensembl				GRCr8
mRatBN7.2	8	49,799,916 - 49,847,940 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	49,799,920 - 49,847,087 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	8	55,304,063 - 55,349,980 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	53,582,939 - 53,628,859 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	51,447,199 - 51,493,116 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	53,770,685 - 53,818,873 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	53,770,681 - 53,816,447 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	8	52,390,855 - 52,437,800 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	8	52,734,792 - 52,799,135 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	8	49,351,775 - 49,397,613 (-)	NCBI		Celera
RGSC_v3.1	8	52,753,849 - 52,818,189 (-)	NCBI
Cytogenetic Map	8	q23	NCBI

TTC12
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	113,314,583 - 113,373,297 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	113,314,579 - 113,383,544 (+)	Ensembl			hg38	GRCh38
GRCh37	11	113,185,305 - 113,244,019 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	112,690,461 - 112,742,324 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	11	112,690,538 - 112,749,226	NCBI
Celera	11	110,338,185 - 110,390,045 (+)	NCBI		Celera
Cytogenetic Map	11	q23.2	NCBI
HuRef	11	109,112,836 - 109,164,715 (+)	NCBI		HuRef
CHM1_1	11	113,068,217 - 113,120,081 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	113,325,023 - 113,383,787 (+)	NCBI		T2T-CHM13v2.0

Ttc12
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	49,348,261 - 49,397,572 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	49,348,263 - 49,397,525 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	9	49,436,961 - 49,486,275 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	49,436,963 - 49,486,225 (-)	Ensembl			mm10	GRCm38
MGSCv37	9	49,245,066 - 49,294,330 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	9	49,189,191 - 49,238,455 (-)	NCBI		MGSCv36	mm8
Celera	9	46,737,486 - 46,784,579 (-)	NCBI		Celera
Cytogenetic Map	9	A5.3	NCBI
cM Map	9	26.83	NCBI

Ttc12
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955412	14,945,116 - 15,011,708 (+)	Ensembl
ChiLan1.0	NW_004955412	14,945,237 - 15,011,560 (+)	NCBI	ChiLan1.0	ChiLan1.0

TTC12
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	114,058,945 - 114,110,778 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	115,153,311 - 115,205,166 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	108,194,610 - 108,253,161 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	112,037,530 - 112,089,324 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	112,037,620 - 112,106,537 (+)	Ensembl			panPan2	panpan1.1

TTC12
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	19,829,873 - 19,874,934 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	19,829,874 - 19,873,145 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	19,751,625 - 19,796,713 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	19,850,774 - 19,895,839 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	19,850,775 - 19,894,042 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	19,913,255 - 19,958,310 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	19,814,463 - 19,859,535 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	19,862,293 - 19,907,355 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Ttc12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	95,463,892 - 95,524,922 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936612	1,194,662 - 1,241,624 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936612	1,194,899 - 1,241,624 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TTC12
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	40,988,920 - 41,046,900 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	9	40,988,881 - 41,032,928 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	45,823,490 - 45,867,582 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TTC12
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	104,675,076 - 104,742,326 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	104,675,768 - 104,731,843 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666043	21,273,060 - 21,331,890 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ttc12
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624784	8,655,408 - 8,752,397 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624784	8,655,543 - 8,751,307 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Ttc12
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	8	43,923,675 - 43,970,945 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Ttc12
370 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	32
Count of miRNA genes:	28
Interacting mature miRNAs:	31
Transcripts:	ENSRNOT00000011454
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2313057	Bss76	Bone structure and strength QTL 76	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	8	39106258	91341052	Rat
1298065	Scl16	Serum cholesterol level QTL 16	3.8		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39752803	84752803	Rat
1549908	Neudeg1	Neurodegradation QTL 1	5.5	0	nervous system integrity trait (VT:0010566)	logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)	8	58337123	103337123	Rat
2317030	Wbc5	White blood cell count QTL 5	3.21	0.005	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	8	16994642	61994642	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	49849908	118871671	Rat
2313067	Bss77	Bone structure and strength QTL 77	3.1	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	8	39106258	91341052	Rat
1578769	Uae31	Urinary albumin excretion QTL 31	3.3	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	39106363	103375781	Rat
2301416	Bp315	Blood pressure QTL 315		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	15952279	60952279	Rat
1298079	Activ2	Activity QTL 2	9.5	0.000001	voluntary movement trait (VT:0003491)	rearing measurement (CMO:0001515)	8	50763951	95763951	Rat
11556286	Cm81	Cardiac mass QTL 81		0.01	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	39106258	84106258	Rat
70161	Bp62	Blood pressure QTL 62	2.9	0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	51589699	99045312	Rat
1578765	Klgr1	Kidney lesion grade QTL 1	3.3	0.0001	kidney morphology trait (VT:0002135)	organ lesion measurement (CMO:0000677)	8	39106363	103375781	Rat
5684993	Bmd84	Bone mineral density QTL 84	4.1		tibia mineral mass (VT:1000283)	bone mineral content (CMO:0001554)	8	51589699	58991895	Rat
2317051	Aia18	Adjuvant induced arthritis QTL 18	2.42		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	8	16994642	61994642	Rat
61464	Niddm11	Non-insulin dependent diabetes mellitus QTL 11	3.1	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	8	44477926	89477926	Rat
1578755	Pur5	Proteinuria QTL 5	3.3	0.0001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	8	39106258	103375958	Rat
2313088	Bss75	Bone structure and strength QTL 75	3.1	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	8	39106258	91341052	Rat
1358896	Bp262	Blood pressure QTL 262	2.89		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	35464071	107982864	Rat
2302278	Gluco36	Glucose level QTL 36	4.2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	8	37760859	58991895	Rat
731182	Uae24	Urinary albumin excretion QTL 24	6.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	47541419	92541419	Rat
631648	Stl5	Serum triglyceride level QTL 5	4	0.0003	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	35464071	71842899	Rat
724514	Uae15	Urinary albumin excretion QTL 15	2.9		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	8	37760859	61459705	Rat
61353	Bp35	Blood pressure QTL 35		0.001	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	8	39106258	84106258	Rat
1331837	Bw23	Body weight QTL 23	4.19	0.00007	body mass (VT:0001259)	body weight (CMO:0000012)	8	55428416	107963099	Rat
631842	Inf1	Infertility severity QTL 1	4.1	0.001	seminal gland mass (VT:0010524)	seminal vesicle wet weight (CMO:0001603)	8	31543661	76543661	Rat
737824	Hcar10	Hepatocarcinoma resistance QTL 10	2.9		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	8	49610204	68373388	Rat
1359033	Bp273	Blood pressure QTL 273			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	39106258	84106258	Rat
1331769	Rf39	Renal function QTL 39	3.871		urine output (VT:0003620)	timed urine volume (CMO:0000260)	8	50763951	107970527	Rat
61358	Bp39	Blood pressure QTL 39	2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	44447837	89447837	Rat
1358906	Bp253	Blood pressure QTL 253	4	0.0004	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	49610204	94610204	Rat
1358907	Cm40	Cardiac mass QTL 40	1.89		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	8	35464071	107982864	Rat
1598824	Memor4	Memory QTL 4	2.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	8	17993862	62252873	Rat
1331744	Bp217	Blood pressure QTL 217	3.398		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	39106258	67378345	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	55428333	127966348	Rat
2313046	Bss78	Bone structure and strength QTL 78	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	8	39106258	91341052	Rat
2316950	Scl66	Serum cholesterol level QTL 66	4.1		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	8	39106363	114525825	Rat
1582254	Kidm31	Kidney mass QTL 31	3		kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	8	49245178	94245178	Rat
724540	Uae8	Urinary albumin excretion QTL 8	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	8	39106258	103375958	Rat
1358892	Kidm26	Kidney mass QTL 26	3.69		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	8	35464071	107982864	Rat
631216	Stl9	Serum triglyceride level QTL 9	4.71	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	8	50763951	67219641	Rat
1582243	Bw66	Body weight QTL 66	3.4	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	8	49245178	94245178	Rat
61373	Mcs4	Mammary carcinoma susceptibility QTL 4	1.1		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	8	44475043	89475043	Rat

Markers in Region

BE114671

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	49,826,221 - 49,826,376 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	53,796,990 - 53,797,144	NCBI	Rnor6.0
Rnor_5.0	8	52,416,928 - 52,417,082	UniSTS	Rnor5.0
RGSC_v3.4	8	52,779,670 - 52,779,824	UniSTS	RGSC3.4
Celera	8	49,378,154 - 49,378,308	UniSTS
RH 3.4 Map	8	536.1	UniSTS
Cytogenetic Map	8	q23	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	44	59	6	308	144	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001004246	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006243004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006243005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC079409	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473975	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000011454 ⟹ ENSRNOP00000011454

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	58,696,385 - 58,742,144 (-)	Ensembl
mRatBN7.2 Ensembl	8	49,799,920 - 49,845,685 (-)	Ensembl
Rnor_6.0 Ensembl	8	53,770,681 - 53,816,447 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000102297 ⟹ ENSRNOP00000097363

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	8	58,696,385 - 58,742,717 (-)	Ensembl
mRatBN7.2 Ensembl	8	49,799,920 - 49,847,087 (-)	Ensembl

RefSeq Acc Id:

NM_001004246 ⟹ NP_001004246

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	58,696,381 - 58,742,144 (-)	NCBI
mRatBN7.2	8	49,799,916 - 49,845,685 (-)	NCBI
Rnor_6.0	8	53,770,685 - 53,816,453 (-)	NCBI
Rnor_5.0	8	52,390,855 - 52,437,800 (-)	NCBI
RGSC_v3.4	8	52,734,792 - 52,799,135 (-)	RGD
Celera	8	49,351,775 - 49,397,613 (-)	RGD

Sequence:

show sequence

AGAGATTTGTGTCTGCAATGGCTGATGATCAAGAGAGAGACTTGCAGAGATTTCTGGAAAATGT
GGATGAAATAACCAATTTAATCCAAGAGATGAATTCCGATGATCCCTTCATACAGCAGAAAGCT
GTCCTGGACACGGAAAAGAAACTCCTGCTGATGGAGAGAGAGCAAGAGGAGGACGGGTGCAGGA
CCACTCTGAACAAGACCATGATCAGTCCTCCACAAGCTCCTGAGAATGCAAATGAAATGAACCC
AGATGCCTTCTTGGCATCTGTGGAGAAGGACGCCAAGGAACGAGCCAAGAGAAGACGAGAAAAC
AGAGTCCTAGCAGATGCCCTAAAGGAGAAGGGGAATGAGGCCTTTGTCAAGGGCGACTATGAAA
CAGCCATTTTCTTCTACAGTGAGGGGTTAGGGAAGCTCAAGGACATGAAGGTGCTGTACACCAA
CCGAGCCCAGGCTTATATAAAACTTGGGGATTATCAGAAGGCTCTCGTGGATTGTGACTGGGCT
CTCAAGTGTGATGAAAATTGCACAAAGGCCTATTTCCACATGGGGAAGGCCCACTTGGCTCTGA
AGAACTACAGCAAGTCTAAAGAGTGTTATCAGAAGATCGGAGAGATAAACCCCAAGCTGAAGGC
ACAGGTGAAAGAACACCTAAATCAAGTAACTCTTCGAGAAAAAGCAGATCTCCAAGAGAAGAAA
GCCCGGGAATCTCTAGATTCAGGAAAGAACACAGCCATGACAACCAGAAATCTCCTGGAGACCC
TATCCAAGCCCGGCCAGACACCCTTGTTCTATGCAGGAGGCATTGAGATTCTGACAGAAATGAT
GACTGACTGCACAGAGCGAACACTGTTCAGAACATATGGTGGATTCAGCATCATCAATGACCAT
GAGGTCATTAAAAGGTGCCTCTTCTTAGCAGGGAAAGATGCAGTTGAGGAGATTGTCTGCGTAT
CTGTTCTAAAGCTCTGGCAAGAAGTGTGCATTGACAACGAGGAGAACCAGCGCCTGCTTTTGTC
CCACCCTGATATGGCCAAGCTGCTGCCTTCCTTCATGGACTCCAGAATCCTGGTGATTCAACAG
CAGAGCCTGGCCCTACTGCTGCAGCTCACCCAGACGGATAATGGCCGGAACCAAGTGATCAAGC
ACCTTGACATGACCCGACTGTGTGAAGCATTGCTGTCGTTTCTTGACTTCTCAGATAAGAAGGC
CAATACGGCCATCGGACTTTTCACAGATTTGGCTCTAGAAGAAAGATTCCAAGTGTGGTTCCAT
GCCAACCTTCCAGATGTCCTCCCTGCTCTCACGGGTGCTCTGAAACGAGAGCCCAAGTTAACCA
GCCCCTCGGCCCTCTGCCAGTGCATTGCTCTGATGGGAAACATCAGTGCTGAGCCTACTGCCAG
AAGACACATGCTAGCCTATGAAGAGTTTGGGGATGCCTGCTTGGACCTCCTGGTCAAGTGTGAG
GAGGACATGGACCTGTACAGAGAGGTCACCTATACTCTCTTAGGACTCATCATGAACTTGTGTC
TTGAGGTCCCCTTCCTCTCCGAGTCGTGGGCAATGAAGATAAGCCGGAAGTGCCTGTCTCTACT
GAACAGCCAGGATGGAGGAATCTTAACAAGAGCGGCGGGTGTTCTGAGCCGGACCCTTTCCTCC
TCTCAGACCATTGTGGAGGAGGCCCTGACAGCAGGAGTGGTCAAGAAAATGATTAAATTCCTGA
AGACGGGAGGCCCGACTGCATCACGTTATGCCATGAAGACACTGGCTGTCTGCACAAACAGCTA
CCACGCAGCTCGAGAAGAAGTAATGAGACTTGATAAAAAGTTCAATGTTTTGATGACACTGCTT
GCCTCAGAGGATGAAGTTGTGGTGGGCAATGCAGCCCTCTGCCTTGGCAACTGTATGGAAGTGC
CCAGTGCAGCCTCTTCCTTGCTGAAGACAGACATCATGAGGGTGCTGTTGAAGCTGGCAGGCGG
CGACTCACAGGAGACGGCTGTCCAGCTGAATGCAGGCATCGCTCTGGGGAAGCTGTGCACTGCT
GAGCCCAGGTTCGCTGTCCAACTGCAAGAGCTTCATGGGATACAAATACTCAACTCTACAATGA
AACACTTGAATGATTCTTGAAAGACACAGTGAGCACACACAACTCTGGGTCAAAGGGGTCACTG
CTCTACTAATAAATTCTTTTTAAATGTTTAGCTCCAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006243004 ⟹ XP_006243066

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	58,696,381 - 58,743,857 (-)	NCBI
mRatBN7.2	8	49,799,916 - 49,846,731 (-)	NCBI
Rnor_6.0	8	53,770,685 - 53,816,917 (-)	NCBI
Rnor_5.0	8	52,390,855 - 52,437,800 (-)	NCBI

Sequence:

show sequence

GTGTGGCCATGGACATGATGAAAATTTTCTTCCTCCCTACTTATATCCTGTGCTTTACCTGGTC
CAAGCTTCTGACTAGGCACACCTGTCATGGCCAAGGTTGGGAAGAACTACACTCCTCCTCCAGC
CCTGAGATTTGTGTCTGCAATGGCTGATGATCAAGAGAGAGACTTGCAGAGATTTCTGGAAAAT
GTGGATGAAATAACCAATTTAATCCAAGAGATGAATTCCGATGATCCCTTCATACAGCAGAAAG
CTGTCCTGGACACGGAAAAGAAACTCCTGCTGATGGAGAGAGAGCAAGAGGAGGACGGGTGCAG
GACCACTCTGAACAAGACCATGATCAGTCCTCCACAAGCTCCTGAGAATGCAAATGAAATGAAC
CCAGATGCCTTCTTGGCATCTGTGGAGAAGGACGCCAAGGAACGAGCCAAGAGAAGACGAGAAA
ACAGAGTCCTAGCAGATGCCCTAAAGGAGAAGGGGAATGAGGCCTTTGTCAAGGGCGACTATGA
AACAGCCATTTTCTTCTACAGTGAGGGGTTAGGGAAGCTCAAGGACATGAAGGTGCTGTACACC
AACCGAGCCCAGGCTTATATAAAACTTGGGGATTATCAGAAGGCTCTCGTGGATTGTGACTGGG
CTCTCAAGTGTGATGAAAATTGCACAAAGGCCTATTTCCACATGGGGAAGGCCCACTTGGCTCT
GAAGAACTACAGCAAGTCTAAAGAGTGTTATCAGAAGATCGGAGAGATAAACCCCAAGCTGAAG
GCACAGGTGAAAGAACACCTAAATCAAGTAACTCTTCGAGAAAAAGCAGATCTCCAAGAGAAGA
AAGCCCGGGAATCTCTAGATTCAGGAAAGAACACAGCCATGACAACCAGAAATCTCCTGGAGAC
CCTATCCAAGCCCGGCCAGACACCCTTGTTCTATGCAGGAGGCATTGAGATTCTGACAGAAATG
ATGACTGACTGCACAGAGCGAACACTGTTCAGAACATATGGTGGATTCAGCATCATCAATGACC
ATGAGGTCATTAAAAGGTGCCTCTTCTTAGCAGGGAAAGATGCAGTTGAGGAGATTGTCTGCGT
ATCTGTTCTAAAGCTCTGGCAAGAAGTGTGCATTGACAACGAGGAGAACCAGCGCCTGCTTTTG
TCCCACCCTGATATGGCCAAGCTGCTGCCTTCCTTCATGGACTCCAGAATCCTGGTGATTCAAC
AGCAGAGCCTGGCCCTACTGCTGCAGCTCACCCAGACGGATAATGGCCGGAACCAAGTGATCAA
GCACCTTGACATGACCCGACTGTGTGAAGCATTGCTGTCGTTTCTTGACTTCTCAGATAAGAAG
GCCAATACGGCCATCGGACTTTTCACAGATTTGGCTCTAGAAGAAAGATTCCAAGTGTGGTTCC
ATGCCAACCTTCCAGATGTCCTCCCTGCTCTCACGGGTGCTCTGAAACGAGAGCCCAAGTTAAC
CAGCCCCTCGGCCCTCTGCCAGTGCATTGCTCTGATGGGAAACATCAGTGCTGAGCCTACTGCC
AGAAGACACATGCTAGCCTATGAAGAGTTTGGGGATGCCTGCTTGGACCTCCTGGTCAAGTGTG
AGGAGGACATGGACCTGTACAGAGAGGTCACCTATACTCTCTTAGGACTCATCATGAACTTGTG
TCTTGAGGTCCCCTTCCTCTCCGAGTCGTGGGCAATGAAGATAAGCCGGAAGTGCCTGTCTCTA
CTGAACAGCCAGGATGGAGGAATCTTAACAAGAGCGGCGGGTGTTCTGAGCCGGACCCTTTCCT
CCTCTCAGACCATTGTGGAGGAGGCCCTGACAGCAGGAGTGGTCAAGAAAATGATTAAATTCCT
GAAGACGGGAGGCCCGACTGCATCACGTTATGCCATGAAGACACTGGCTGTCTGCACAAACAGC
TACCACGCAGCTCGAGAAGAAGTAATGAGACTTGATAAAAAGTTCAATGTTTTGATGACACTGC
TTGCCTCAGAGGATGAAGTTGTGGTGGGCAATGCAGCCCTCTGCCTTGGCAACTGTATGGAAGT
GCCCAGTGCAGCCTCTTCCTTGCTGAAGACAGACATCATGAGGGTGCTGTTGAAGCTGGCAGGC
GGCGACTCACAGGAGACGGCTGTCCAGCTGAATGCAGGCATCGCTCTGGGGAAGCTGTGCACTG
CTGAGCCCAGGTTCGCTGTCCAACTGCAAGAGCTTCATGGGATACAAATACTCAACTCTACAAT
GAAACACTTGAATGATTCTTGAAAGACACAGTGAGCACACACAACTCTGGGTCAAAGGGGTCAC
TGCTCTACTAATAAATTCTTTTTAAATGTTTAGCTCCAAAA

hide sequence

RefSeq Acc Id:

XM_006243005 ⟹ XP_006243067

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	58,696,381 - 58,743,689 (-)	NCBI
mRatBN7.2	8	49,799,916 - 49,847,222 (-)	NCBI
Rnor_6.0	8	53,770,685 - 53,817,940 (-)	NCBI
Rnor_5.0	8	52,390,855 - 52,437,800 (-)	NCBI

Sequence:

show sequence

CCCACCCAGGCCCCGCCTCTTCCCAGCAAAAGCCAGTCACAGCCTGTCCTCAGCTTCCACTTCC
GTCAGATCCTGAGTACTAAAGAGATTTGTGTCTGCAATGGCTGATGATCAAGAGAGAGACTTGC
AGAGATTTCTGGAAAATGTGGATGAAATAACCAATTTAATCCAAGAGATGAATTCCGATGATCC
CTTCATACAGCAGAAAGCTGTCCTGGACACGGAAAAGAAACTCCTGCTGATGGAGAGAGAGCAA
GAGGAGGACGGGTGCAGGACCACTCTGAACAAGACCATGATCAGTCCTCCACAAGCTCCTGAGA
ATGCAAATGAAATGAACCCAGATGCCTTCTTGGCATCTGTGGAGAAGGACGCCAAGGAACGAGC
CAAGAGAAGACGAGAAAACAGAGTCCTAGCAGATGCCCTAAAGGAGAAGGGGAATGAGGCCTTT
GTCAAGGGCGACTATGAAACAGCCATTTTCTTCTACAGTGAGGGGTTAGGGAAGCTCAAGGACA
TGAAGGTGCTGTACACCAACCGAGCCCAGGCTTATATAAAACTTGGGGATTATCAGAAGGCTCT
CGTGGATTGTGACTGGGCTCTCAAGTGTGATGAAAATTGCACAAAGGCCTATTTCCACATGGGG
AAGGCCCACTTGGCTCTGAAGAACTACAGCAAGTCTAAAGAGTGTTATCAGAAGATCGGAGAGA
TAAACCCCAAGCTGAAGGCACAGGTGAAAGAACACCTAAATCAAGTAACTCTTCGAGAAAAAGC
AGATCTCCAAGAGAAGAAAGCCCGGGAATCTCTAGATTCAGGAAAGAACACAGCCATGACAACC
AGAAATCTCCTGGAGACCCTATCCAAGCCCGGCCAGACACCCTTGTTCTATGCAGGAGGCATTG
AGATTCTGACAGAAATGATGACTGACTGCACAGAGCGAACACTGTTCAGAACATATGGTGGATT
CAGCATCATCAATGACCATGAGGTCATTAAAAGGTGCCTCTTCTTAGCAGGGAAAGATGCAGTT
GAGGAGATTGTCTGCGTATCTGTTCTAAAGCTCTGGCAAGAAGTGTGCATTGACAACGAGGAGA
ACCAGCGCCTGCTTTTGTCCCACCCTGATATGGCCAAGCTGCTGCCTTCCTTCATGGACTCCAG
AATCCTGGTGATTCAACAGCAGAGCCTGGCCCTACTGCTGCAGCTCACCCAGACGGATAATGGC
CGGAACCAAGTGATCAAGCACCTTGACATGACCCGACTGTGTGAAGCATTGCTGTCGTTTCTTG
ACTTCTCAGATAAGAAGGCCAATACGGCCATCGGACTTTTCACAGATTTGGCTCTAGAAGAAAG
ATTCCAAGTGTGGTTCCATGCCAACCTTCCAGATGTCCTCCCTGCTCTCACGGGTGCTCTGAAA
CGAGAGCCCAAGTTAACCAGCCCCTCGGCCCTCTGCCAGTGCATTGCTCTGATGGGAAACATCA
GTGCTGAGCCTACTGCCAGAAGACACATGCTAGCCTATGAAGAGTTTGGGGATGCCTGCTTGGA
CCTCCTGGTCAAGTGTGAGGAGGACATGGACCTGTACAGAGAGGTCACCTATACTCTCTTAGGA
CTCATCATGAACTTGTGTCTTGAGGTCCCCTTCCTCTCCGAGTCGTGGGCAATGAAGATAAGCC
GGAAGTGCCTGTCTCTACTGAACAGCCAGGATGGAGGAATCTTAACAAGAGCGGCGGGTGTTCT
GAGCCGGACCCTTTCCTCCTCTCAGACCATTGTGGAGGAGGCCCTGACAGCAGGAGTGGTCAAG
AAAATGATTAAATTCCTGAAGACGGGAGGCCCGACTGCATCACGTTATGCCATGAAGACACTGG
CTGTCTGCACAAACAGCTACCACGCAGCTCGAGAAGAAGTAATGAGACTTGATAAAAAGTTCAA
TGTTTTGATGACACTGCTTGCCTCAGAGGATGAAGTTGTGGTGGGCAATGCAGCCCTCTGCCTT
GGCAACTGTATGGAAGTGCCCAGTGCAGCCTCTTCCTTGCTGAAGACAGACATCATGAGGGTGC
TGTTGAAGCTGGCAGGCGGCGACTCACAGGAGACGGCTGTCCAGCTGAATGCAGGCATCGCTCT
GGGGAAGCTGTGCACTGCTGAGCCCAGGTTCGCTGTCCAACTGCAAGAGCTTCATGGGATACAA
ATACTCAACTCTACAATGAAACACTTGAATGATTCTTGAAAGACACAGTGAGCACACACAACTC
TGGGTCAAAGGGGTCACTGCTCTACTAATAAATTCTTTTTAAATGTTTAGCTCCAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001004246	(Get FASTA)	NCBI Sequence Viewer
	XP_006243066	(Get FASTA)	NCBI Sequence Viewer
	XP_006243067	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79409	(Get FASTA)	NCBI Sequence Viewer
	EDL95443	(Get FASTA)	NCBI Sequence Viewer
	EDL95444	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000011454
	ENSRNOP00000011454.6
	ENSRNOP00000097363
	ENSRNOP00000097363.1

RefSeq Acc Id:

NP_001004246 ⟸ NM_001004246

- UniProtKB:

Q68FR0 (UniProtKB/TrEMBL), F7FHS8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MADDQERDLQRFLENVDEITNLIQEMNSDDPFIQQKAVLDTEKKLLLMEREQEEDGCRTTLNKT
MISPPQAPENANEMNPDAFLASVEKDAKERAKRRRENRVLADALKEKGNEAFVKGDYETAIFFY
SEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHLALKNYSKS
KECYQKIGEINPKLKAQVKEHLNQVTLREKADLQEKKARESLDSGKNTAMTTRNLLETLSKPGQ
TPLFYAGGIEILTEMMTDCTERTLFRTYGGFSIINDHEVIKRCLFLAGKDAVEEIVCVSVLKLW
QEVCIDNEENQRLLLSHPDMAKLLPSFMDSRILVIQQQSLALLLQLTQTDNGRNQVIKHLDMTR
LCEALLSFLDFSDKKANTAIGLFTDLALEERFQVWFHANLPDVLPALTGALKREPKLTSPSALC
QCIALMGNISAEPTARRHMLAYEEFGDACLDLLVKCEEDMDLYREVTYTLLGLIMNLCLEVPFL
SESWAMKISRKCLSLLNSQDGGILTRAAGVLSRTLSSSQTIVEEALTAGVVKKMIKFLKTGGPT
ASRYAMKTLAVCTNSYHAAREEVMRLDKKFNVLMTLLASEDEVVVGNAALCLGNCMEVPSAASS
LLKTDIMRVLLKLAGGDSQETAVQLNAGIALGKLCTAEPRFAVQLQELHGIQILNSTMKHLNDS

hide sequence

RefSeq Acc Id:	XP_006243067 ⟸ XM_006243005
- Peptide Label:	isoform X2
- UniProtKB:	Q68FR0 (UniProtKB/TrEMBL), F7FHS8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MADDQERDLQRFLENVDEITNLIQEMNSDDPFIQQKAVLDTEKKLLLMEREQEEDGCRTTLNKT MISPPQAPENANEMNPDAFLASVEKDAKERAKRRRENRVLADALKEKGNEAFVKGDYETAIFFY SEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHLALKNYSKS KECYQKIGEINPKLKAQVKEHLNQVTLREKADLQEKKARESLDSGKNTAMTTRNLLETLSKPGQ TPLFYAGGIEILTEMMTDCTERTLFRTYGGFSIINDHEVIKRCLFLAGKDAVEEIVCVSVLKLW QEVCIDNEENQRLLLSHPDMAKLLPSFMDSRILVIQQQSLALLLQLTQTDNGRNQVIKHLDMTR LCEALLSFLDFSDKKANTAIGLFTDLALEERFQVWFHANLPDVLPALTGALKREPKLTSPSALC QCIALMGNISAEPTARRHMLAYEEFGDACLDLLVKCEEDMDLYREVTYTLLGLIMNLCLEVPFL SESWAMKISRKCLSLLNSQDGGILTRAAGVLSRTLSSSQTIVEEALTAGVVKKMIKFLKTGGPT ASRYAMKTLAVCTNSYHAAREEVMRLDKKFNVLMTLLASEDEVVVGNAALCLGNCMEVPSAASS LLKTDIMRVLLKLAGGDSQETAVQLNAGIALGKLCTAEPRFAVQLQELHGIQILNSTMKHLNDS hide sequence

RefSeq Acc Id:	XP_006243066 ⟸ XM_006243004
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6GMH4 (UniProtKB/TrEMBL), F7FHS8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAKVGKNYTPPPALRFVSAMADDQERDLQRFLENVDEITNLIQEMNSDDPFIQQKAVLDTEKKL LLMEREQEEDGCRTTLNKTMISPPQAPENANEMNPDAFLASVEKDAKERAKRRRENRVLADALK EKGNEAFVKGDYETAIFFYSEGLGKLKDMKVLYTNRAQAYIKLGDYQKALVDCDWALKCDENCT KAYFHMGKAHLALKNYSKSKECYQKIGEINPKLKAQVKEHLNQVTLREKADLQEKKARESLDSG KNTAMTTRNLLETLSKPGQTPLFYAGGIEILTEMMTDCTERTLFRTYGGFSIINDHEVIKRCLF LAGKDAVEEIVCVSVLKLWQEVCIDNEENQRLLLSHPDMAKLLPSFMDSRILVIQQQSLALLLQ LTQTDNGRNQVIKHLDMTRLCEALLSFLDFSDKKANTAIGLFTDLALEERFQVWFHANLPDVLP ALTGALKREPKLTSPSALCQCIALMGNISAEPTARRHMLAYEEFGDACLDLLVKCEEDMDLYRE VTYTLLGLIMNLCLEVPFLSESWAMKISRKCLSLLNSQDGGILTRAAGVLSRTLSSSQTIVEEA LTAGVVKKMIKFLKTGGPTASRYAMKTLAVCTNSYHAAREEVMRLDKKFNVLMTLLASEDEVVV GNAALCLGNCMEVPSAASSLLKTDIMRVLLKLAGGDSQETAVQLNAGIALGKLCTAEPRFAVQL QELHGIQILNSTMKHLNDS hide sequence

Ensembl Acc Id:

ENSRNOP00000011454 ⟸ ENSRNOT00000011454

Ensembl Acc Id:

ENSRNOP00000097363 ⟸ ENSRNOT00000102297

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q68FR0-F1-model_v2	AlphaFold	Q68FR0	1-704	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303264	AgrOrtholog
BioCyc Gene	G2FUF-30582	BioCyc
Ensembl Genes	ENSRNOG00000008595	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000011454	ENTREZGENE
	ENSRNOT00000011454.7	UniProtKB/TrEMBL
	ENSRNOT00000102297	ENTREZGENE
	ENSRNOT00000102297.2	UniProtKB/TrEMBL
Gene3D-CATH	1.25.10.10	UniProtKB/TrEMBL
	1.25.40.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7113087	IMAGE-MGC_LOAD
InterPro	ARM-like	UniProtKB/TrEMBL
	ARM-type_fold	UniProtKB/TrEMBL
	TPR-like_helical	UniProtKB/TrEMBL
	TPR_2	UniProtKB/TrEMBL
	TPR_repeat	UniProtKB/TrEMBL
	TTC12	UniProtKB/TrEMBL
KEGG Report	rno:300696	UniProtKB/TrEMBL
MGC_CLONE	MGC:94947	IMAGE-MGC_LOAD
NCBI Gene	300696	ENTREZGENE
PANTHER	PTHR46540	UniProtKB/TrEMBL
	TETRATRICOPEPTIDE REPEAT PROTEIN 12	UniProtKB/TrEMBL
Pfam	TPR_1	UniProtKB/TrEMBL
	TPR_2	UniProtKB/TrEMBL
	TPR_8	UniProtKB/TrEMBL
PhenoGen	Ttc12	PhenoGen
PROSITE	TPR	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000008595	RatGTEx
SMART	TPR	UniProtKB/TrEMBL
Superfamily-SCOP	ARM-type_fold	UniProtKB/TrEMBL
	SSF48452	UniProtKB/TrEMBL
UniProt	A0A8I6GMH4	ENTREZGENE, UniProtKB/TrEMBL
	A6J4C0_RAT	UniProtKB/TrEMBL
	A6J4C1_RAT	UniProtKB/TrEMBL
	F7FHS8	ENTREZGENE, UniProtKB/TrEMBL
	Q68FR0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Ttc12	tetratricopeptide repeat domain 12			Symbol and Name status set to approved	1299863	APPROVED
2005-09-30	Ttc12				Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM