Top1mt (DNA topoisomerase I mitochondrial) - Rat Genome Database

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Gene: Top1mt (DNA topoisomerase I mitochondrial) Rattus norvegicus
Analyze
Symbol: Top1mt
Name: DNA topoisomerase I mitochondrial
RGD ID: 1303177
Description: Predicted to enable DNA topoisomerase type I (single strand cut, ATP-independent) activity. Predicted to be involved in DNA replication and DNA topological change. Predicted to be located in chromosome; mitochondrion; and nucleoplasm. Predicted to be active in mitochondrial nucleoid. Orthologous to human TOP1MT (DNA topoisomerase I mitochondrial); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DNA topoisomerase 1, mitochondrial; DNA topoisomerase I, mitochondrial; mitochondrial topoisomerase I; topoisomerase (DNA) I, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87109,223,269 - 109,248,855 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7109,139,527 - 109,246,799 (-)EnsemblGRCr8
mRatBN7.27107,338,092 - 107,368,125 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7107,342,527 - 107,366,049 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7109,077,854 - 109,100,706 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07111,301,524 - 111,324,376 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07111,247,445 - 111,270,297 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07116,688,801 - 116,714,421 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7116,688,701 - 116,712,387 (-)Ensemblrn6Rnor6.0
Rnor_5.07116,582,993 - 116,608,875 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47113,596,083 - 113,619,109 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7103,705,366 - 103,728,376 (-)NCBICelera
RGSC_v3.17113,630,312 - 113,653,339 (-)NCBI
Cytogenetic Map7q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
chromosome  (IEA)
mitochondrial nucleoid  (IBA,IEA,ISO)
mitochondrion  (IEA,ISO)
nucleus  (IEA)
plasma membrane  (IBA,IEA)
side of membrane  (IEA)
synapse  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Thirteen-exon-motif signature for vertebrate nuclear and mitochondrial type IB topoisomerases. Zhang H, etal., Nucleic Acids Res 2004 Apr 19;32(7):2087-92. Print 2004.
Additional References at PubMed
PMID:18063578   PMID:18614015  


Genomics

Comparative Map Data
Top1mt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87109,223,269 - 109,248,855 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7109,139,527 - 109,246,799 (-)EnsemblGRCr8
mRatBN7.27107,338,092 - 107,368,125 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7107,342,527 - 107,366,049 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7109,077,854 - 109,100,706 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07111,301,524 - 111,324,376 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07111,247,445 - 111,270,297 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07116,688,801 - 116,714,421 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7116,688,701 - 116,712,387 (-)Ensemblrn6Rnor6.0
Rnor_5.07116,582,993 - 116,608,875 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.47113,596,083 - 113,619,109 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera7103,705,366 - 103,728,376 (-)NCBICelera
RGSC_v3.17113,630,312 - 113,653,339 (-)NCBI
Cytogenetic Map7q34NCBI
TOP1MT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388143,309,324 - 143,359,977 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8143,304,384 - 143,359,979 (-)Ensemblhg38GRCh38
GRCh378144,391,494 - 144,442,147 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368144,462,901 - 144,488,425 (-)NCBIBuild 36Build 36hg18NCBI36
Build 348144,462,904 - 144,488,425NCBI
Celera8140,700,651 - 140,727,260 (-)NCBICelera
Cytogenetic Map8q24.3NCBI
HuRef8139,629,915 - 139,695,642 (-)NCBIHuRef
CHM1_18144,431,738 - 144,482,220 (-)NCBICHM1_1
T2T-CHM13v2.08144,456,634 - 144,507,610 (-)NCBIT2T-CHM13v2.0
Top1mt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391575,528,878 - 75,551,184 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1575,528,884 - 75,550,649 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381575,657,033 - 75,678,800 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1575,657,035 - 75,678,800 (-)Ensemblmm10GRCm38
MGSCv371575,487,463 - 75,509,220 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361575,484,288 - 75,506,045 (-)NCBIMGSCv36mm8
Celera1577,157,202 - 77,179,081 (-)NCBICelera
Cytogenetic Map15D3NCBI
cM Map1534.69NCBI
Top1mt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554542,021,563 - 2,046,190 (-)Ensembl
ChiLan1.0NW_0049554542,020,884 - 2,045,939 (-)NCBIChiLan1.0ChiLan1.0
TOP1MT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27160,779,424 - 160,836,852 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18136,303,888 - 136,354,388 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08140,056,468 - 140,106,510 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18143,077,224 - 143,125,987 (-)NCBIPanPan1.1PanPan1.1panPan2
TOP1MT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl41,148,890 - 1,188,130 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.141,134,179 - 1,188,149 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.241,068,174 - 1,125,241 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TOP1MT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18137,523,739 - 137,574,672 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl8137,523,955 - 137,552,407 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236670188,188 - 24,004 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Top1mt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473513,417,185 - 13,441,097 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Top1mt
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11247,976,719 - 247,999,015 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Top1mt
198 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:109
Count of miRNA genes:88
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000009965
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)792388565119280177Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)782111245123048330Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)771621154114982716Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)773618702118618702Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)793302009131686183Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)746307490127866166Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)785043242130043242Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)785497398130497398Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)783626689128626689Rat
1331723Bw25Body weight QTL 253.348body mass (VT:0001259)body weight (CMO:0000012)796700404111672180Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)782111382132099989Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
631201Panci1Pancreas inflammation QTL 100.001pancreas integrity trait (VT:0010560)percentage of study population displaying chronic pancreatitis at a point in time (CMO:0001214)773557047118557047Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)782111245123048330Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)740540077123682549Rat
2313102Bmd79Bone mineral density QTL 792.30.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)796700404118618702Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)749682832115766396Rat
10450862Kidm55Kidney mass QTL 554.9kidney mass (VT:0002707)kidney weight (CMO:0000081)772725037117725037Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
10450856Livw4Liver weight QTL 43.8liver mass (VT:0003402)liver weight (CMO:0000092)772725037117725037Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)777807807122807807Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)749682832115766396Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)778682549123682549Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)749682832115766396Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)771621154119349044Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat

Markers in Region
AI175848  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27107,342,580 - 107,342,706 (+)MAPPERmRatBN7.2
Rnor_6.07116,688,855 - 116,688,980NCBIRnor6.0
Rnor_5.07116,583,047 - 116,583,172UniSTSRnor5.0
RGSC_v3.47113,596,129 - 113,596,254UniSTSRGSC3.4
Celera7103,705,412 - 103,705,537UniSTS
RH 3.4 Map7780.6UniSTS
Cytogenetic Map7q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000009965   ⟹   ENSRNOP00000009965
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7109,140,361 - 109,246,303 (-)Ensembl
mRatBN7.2 Ensembl7107,342,527 - 107,365,573 (-)Ensembl
Rnor_6.0 Ensembl7116,688,803 - 116,711,837 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000056554   ⟹   ENSRNOP00000053394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7109,139,527 - 109,141,979 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076014   ⟹   ENSRNOP00000068013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7109,139,527 - 109,142,116 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000088064   ⟹   ENSRNOP00000070025
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7109,218,523 - 109,246,799 (-)Ensembl
mRatBN7.2 Ensembl7107,342,527 - 107,366,049 (-)Ensembl
Rnor_6.0 Ensembl7116,688,701 - 116,712,387 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106595   ⟹   ENSRNOP00000090208
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7109,217,786 - 109,246,303 (-)Ensembl
mRatBN7.2 Ensembl7107,342,527 - 107,363,526 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000155631   ⟹   ENSRNOP00000105400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7109,217,769 - 109,246,303 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000166649   ⟹   ENSRNOP00000100549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7109,221,823 - 109,246,303 (-)Ensembl
RefSeq Acc Id: NM_001002798   ⟹   NP_001002798
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,223,275 - 109,246,303 (-)NCBI
mRatBN7.27107,342,535 - 107,365,565 (-)NCBI
Rnor_6.07116,688,809 - 116,711,837 (-)NCBI
Rnor_5.07116,582,993 - 116,608,875 (-)NCBI
RGSC_v3.47113,596,083 - 113,619,109 (-)RGD
Celera7103,705,366 - 103,728,376 (-)RGD
Sequence:
RefSeq Acc Id: XM_006241784   ⟹   XP_006241846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,223,269 - 109,248,166 (-)NCBI
mRatBN7.27107,338,092 - 107,366,084 (-)NCBI
Rnor_6.07116,688,803 - 116,712,159 (-)NCBI
Rnor_5.07116,582,993 - 116,608,875 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594763   ⟹   XP_017450252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,223,269 - 109,248,854 (-)NCBI
mRatBN7.27107,338,092 - 107,368,124 (-)NCBI
Rnor_6.07116,688,801 - 116,714,421 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078807   ⟹   XP_038934735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,223,269 - 109,248,855 (-)NCBI
mRatBN7.27107,338,092 - 107,368,125 (-)NCBI
RefSeq Acc Id: XM_063263272   ⟹   XP_063119342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87109,223,269 - 109,246,649 (-)NCBI
RefSeq Acc Id: NP_001002798   ⟸   NM_001002798
- UniProtKB: Q6IM78 (UniProtKB/Swiss-Prot),   A6HS14 (UniProtKB/TrEMBL),   A0A8I6ADZ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241846   ⟸   XM_006241784
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JWV0 (UniProtKB/TrEMBL),   A0A8I6ADZ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450252   ⟸   XM_017594763
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ADZ0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009965   ⟸   ENSRNOT00000009965
Ensembl Acc Id: ENSRNOP00000070025   ⟸   ENSRNOT00000088064
RefSeq Acc Id: XP_038934735   ⟸   XM_039078807
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ADZ0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000090208   ⟸   ENSRNOT00000106595
RefSeq Acc Id: XP_063119342   ⟸   XM_063263272
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ADZ0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000100549   ⟸   ENSRNOT00000166649
Ensembl Acc Id: ENSRNOP00000068013   ⟸   ENSRNOT00000076014
Ensembl Acc Id: ENSRNOP00000105400   ⟸   ENSRNOT00000155631
Ensembl Acc Id: ENSRNOP00000053394   ⟸   ENSRNOT00000056554
Protein Domains
DNA topoisomerase I eukaryotic-type   Topo IB-type catalytic   UPAR/Ly6

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6IM78-F1-model_v2 AlphaFold Q6IM78 1-593 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695388
Promoter ID:EPDNEW_R5913
Type:initiation region
Name:Top1mt_1
Description:DNA topoisomerase I mitochondrial
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07116,711,839 - 116,711,899EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303177 AgrOrtholog
BioCyc Gene G2FUF-32987 BioCyc
Ensembl Genes ENSRNOG00000007500 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000009965.5 UniProtKB/Swiss-Prot
  ENSRNOT00000088064 ENTREZGENE
  ENSRNOT00000155631 ENTREZGENE
Gene3D-CATH 1.10.10.41 UniProtKB/Swiss-Prot
  1.10.132.10 UniProtKB/Swiss-Prot
  2.170.11.10 UniProtKB/Swiss-Prot
  Topoisomerase I, Chain A, domain 3 UniProtKB/Swiss-Prot
InterPro DNA_brk_join_enz UniProtKB/Swiss-Prot
  DNA_topo_DNA_db_N_dom1 UniProtKB/Swiss-Prot
  DNA_topo_DNA_db_N_dom2 UniProtKB/Swiss-Prot
  TopoI UniProtKB/Swiss-Prot
  TopoI_C_dom UniProtKB/Swiss-Prot
  TopoI_cat_a-hlx-sub_euk UniProtKB/Swiss-Prot
  TopoI_cat_a/b-sub_euk UniProtKB/Swiss-Prot
  TopoI_cat_euk UniProtKB/Swiss-Prot
  TopoI_DNA-bd_euk UniProtKB/Swiss-Prot
  TopoI_DNA-bd_euk_N_sf UniProtKB/Swiss-Prot
  TopoI_euk UniProtKB/Swiss-Prot
  Topoisomer_I_DNA-bd UniProtKB/Swiss-Prot
  Topoisomerase_IB UniProtKB/Swiss-Prot
KEGG Report rno:300029 UniProtKB/Swiss-Prot
NCBI Gene 300029 ENTREZGENE
PANTHER DNA TOPOISOMERASE I UniProtKB/Swiss-Prot
  DNA TOPOISOMERASE I, MITOCHONDRIAL UniProtKB/Swiss-Prot
Pfam Topo_C_assoc UniProtKB/Swiss-Prot
  Topoisom_I UniProtKB/Swiss-Prot
  Topoisom_I_N UniProtKB/Swiss-Prot
PhenoGen Top1mt PhenoGen
PRINTS EUTPISMRASEI UniProtKB/Swiss-Prot
PROSITE TOPO_IB_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007500 RatGTEx
SMART TOPEUc UniProtKB/Swiss-Prot
Superfamily-SCOP Eukaryotic DNA topoisomerase I, dispensable insert domain UniProtKB/Swiss-Prot
  SSF56349 UniProtKB/Swiss-Prot
  SSF56741 UniProtKB/Swiss-Prot
UniProt A0A0G2JWV0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ADZ0 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LBK5_RAT UniProtKB/TrEMBL
  A0ABK0LUE4_RAT UniProtKB/TrEMBL
  A6HS14 ENTREZGENE, UniProtKB/TrEMBL
  F1LNW6_RAT UniProtKB/TrEMBL
  Q6IM78 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-16 Top1mt  DNA topoisomerase I mitochondrial  Top1mt  topoisomerase (DNA) I, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-06 Top1mt  topoisomerase (DNA) I, mitochondrial  Top1mt  DNA topoisomerase 1, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Top1mt  DNA topoisomerase 1, mitochondrial  Top1mt  DNA topoisomerase I, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Top1mt  DNA topoisomerase I, mitochondrial      Symbol and Name status set to approved 1299863 APPROVED
2005-09-30 Top1mt        Symbol and Name status set to provisional 70820 PROVISIONAL