Advanced Search (OLGA)

Gene: Spint1 (serine peptidase inhibitor, Kunitz type 1) Rattus norvegicus

Analyze

Symbol:

Spint1

Name:

serine peptidase inhibitor, Kunitz type 1

RGD ID:

1303138

Description:

Enables serine-type endopeptidase inhibitor activity. Involved in cellular response to BMP stimulus; negative regulation of neural precursor cell proliferation; and positive regulation of glial cell differentiation. Predicted to be located in cytoplasm; extracellular region; and membrane. Predicted to be active in plasma membrane. Biomarker of liver cirrhosis. Orthologous to human SPINT1 (serine peptidase inhibitor, Kunitz type 1); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

HAI-1; hepatocyte growth factor activator inhibitor 1; hepatocyte growth factor activator inhibitor-1; kunitz-type protease inhibitor 1; serine protease inhibitor, Kunitz type 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	126,685,017 - 126,697,957 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	126,685,422 - 126,697,956 (+)	Ensembl				GRCr8
mRatBN7.2	3	106,231,082 - 106,244,121 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	106,231,444 - 106,244,119 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	109,904,232 - 109,916,890 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	118,499,779 - 118,512,434 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	116,160,160 - 116,172,815 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	111,049,132 - 111,061,991 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	111,049,118 - 111,062,011 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	117,599,717 - 117,612,635 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	105,757,666 - 105,770,345 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	105,144,668 - 105,157,338 (+)	NCBI		Celera
RGSC_v3.1	3	105,654,093 - 105,666,772 (+)	NCBI
Cytogenetic Map	3	q35	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

biliary atresia (ISO)

breast cancer (ISO)

cholestasis (ISO)

Colorectal Neoplasms (ISO)

ichthyosis (ISO)

liver cirrhosis (IEP)

ovarian cancer (ISO)

primary biliary cholangitis (ISO)

prostate carcinoma (ISO)

stomach carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,4'-trichlorobiphenyl (ISO)

3-Nitrobenzanthrone (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

actinomycin D (ISO)

aflatoxin B1 (EXP)

aldrin (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (ISO)

Aroclor 1254 (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butan-1-ol (ISO)

cadmium dichloride (ISO)

camptothecin (ISO)

choline (ISO)

cisplatin (ISO)

DDE (ISO)

diarsenic trioxide (ISO)

dibenz[a,h]anthracene (ISO)

diethyl phthalate (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

drometrizole (ISO)

elemental selenium (ISO)

folic acid (ISO)

gentamycin (EXP)

hydralazine (ISO)

inulin (ISO)

L-methionine (ISO)

N-ethyl-N-nitrosourea (ISO)

N-nitrosodiethylamine (EXP)

N-nitrosodimethylamine (EXP)

Nutlin-3 (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (ISO)

PCB138 (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

SB 431542 (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

Soman (EXP)

sulforaphane (ISO)

sunitinib (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

topotecan (EXP)

tributylstannane (ISO)

trichostatin A (ISO)

triclosan (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

tris(2-butoxyethyl) phosphate (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

branching involved in labyrinthine layer morphogenesis (ISO)

cellular response to BMP stimulus (IEP)

embryonic placenta development (ISO)

epidermis development (IBA)

epithelium development (IBA)

extracellular matrix organization (IBA,ISO)

negative regulation of neural precursor cell proliferation (IMP)

neural tube closure (ISO)

placenta blood vessel development (ISO)

positive regulation of glial cell differentiation (IMP)

Cellular Component

cytoplasm (IEA)

cytosol (IEA,ISO)

extracellular region (IEA)

membrane (IEA)

plasma membrane (IBA,IEA,ISO)

Molecular Function

peptidase inhibitor activity (IEA)

protein binding (ISO)

serine-type endopeptidase inhibitor activity (IBA,IEA,IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Persistent elevation of hepatocyte growth factor activator inhibitors in cholangiopathies affects liver fibrosis and differentiation.	Huang HP, etal., Hepatology. 2012 Jan;55(1):161-72. doi: 10.1002/hep.24657. Epub 2011 Nov 16.
3.	Expressions of molecules associated with hepatocyte growth factor activation after hepatectomy in liver cirrhosis.	Kaido T, etal., Hepatogastroenterology. 2004 Mar-Apr;51(56):547-51.
4.	Tissue expression, protease specificity, and Kunitz domain functions of hepatocyte growth factor activator inhibitor-1B (HAI-1B), a new splice variant of HAI-1.	Kirchhofer D, etal., J Biol Chem 2003 Sep 19;278(38):36341-9. Epub 2003 Jun 18.
5.	Hepatocyte growth factor activator inhibitor-1 is induced by bone morphogenetic proteins and regulates proliferation and cell fate of neural progenitor cells.	Koivuniemi R, etal., PLoS One. 2013;8(2):e56117. doi: 10.1371/journal.pone.0056117. Epub 2013 Feb 7.
6.	Roles of functional and structural domains of hepatocyte growth factor activator inhibitor type 1 in the inhibition of matriptase.	Kojima K, etal., J Biol Chem. 2008 Feb 1;283(5):2478-87. Epub 2007 Nov 29.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Defect of hepatocyte growth factor activator inhibitor type 1/serine protease inhibitor, Kunitz type 1 (Hai-1/Spint1) leads to ichthyosis-like condition and abnormal hair development in mice.	Nagaike K, etal., Am J Pathol. 2008 Nov;173(5):1464-75. doi: 10.2353/ajpath.2008.071142. Epub 2008 Oct 2.
9.	Expression of the serine protease matriptase and its inhibitor HAI-1 in epithelial ovarian cancer: correlation with clinical outcome and tumor clinicopathological parameters.	Oberst MD, etal., Clin Cancer Res. 2002 Apr;8(4):1101-7.
10.	The hepatocyte growth factor regulatory factors in human breast cancer.	Parr C, etal., Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):202-11.
11.	GOA pipeline	RGD automated data pipeline
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	A novel biomarker for staging human prostate adenocarcinoma: overexpression of matriptase with concomitant loss of its inhibitor, hepatocyte growth factor activator inhibitor-1.	Saleem M, etal., Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):217-27.
14.	The ratio of Matriptase/HAI-1 mRNA is higher in colorectal cancer adenomas and carcinomas than corresponding tissue from control individuals.	Vogel LK, etal., BMC Cancer. 2006 Jul 4;6:176.
15.	White matter astrocytes produce hepatocyte growth factor activator inhibitor in human brain tissues.	Yamada T, etal., Exp Neurol. 1998 Sep;153(1):60-4.
16.	Expression of serine protease SNC19/matriptase and its inhibitor hepatocyte growth factor activator inhibitor type 1 in normal and malignant tissues of gastrointestinal tract.	Zeng L, etal., World J Gastroenterol. 2005 Oct 21;11(39):6202-7.

Additional References at PubMed

PMID:12477932	PMID:15669920	PMID:15964823	PMID:16502470	PMID:17174946	PMID:19592578	PMID:20682770	PMID:23376485	PMID:23533145	PMID:25758223

Genomics

Comparative Map Data

Spint1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	126,685,017 - 126,697,957 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	126,685,422 - 126,697,956 (+)	Ensembl				GRCr8
mRatBN7.2	3	106,231,082 - 106,244,121 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	106,231,444 - 106,244,119 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	109,904,232 - 109,916,890 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	118,499,779 - 118,512,434 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	116,160,160 - 116,172,815 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	111,049,132 - 111,061,991 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	111,049,118 - 111,062,011 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	117,599,717 - 117,612,635 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	105,757,666 - 105,770,345 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	105,144,668 - 105,157,338 (+)	NCBI		Celera
RGSC_v3.1	3	105,654,093 - 105,666,772 (+)	NCBI
Cytogenetic Map	3	q35	NCBI

SPINT1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	40,844,048 - 40,858,207 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	40,843,513 - 40,858,383 (+)	Ensembl			hg38	GRCh38
GRCh37	15	41,136,246 - 41,150,405 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	38,923,538 - 38,937,145 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	15	17,904,155 - 17,917,761 (+)	NCBI		Celera
Cytogenetic Map	15	q15.1	NCBI
HuRef	15	17,956,043 - 17,998,087 (+)	NCBI		HuRef
CHM1_1	15	41,254,190 - 41,267,796 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	38,650,076 - 38,664,232 (+)	NCBI		T2T-CHM13v2.0

Spint1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	119,067,841 - 119,079,995 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	119,067,843 - 119,080,008 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	119,237,360 - 119,249,535 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	119,237,362 - 119,249,527 (+)	Ensembl			mm10	GRCm38
MGSCv37	2	119,063,096 - 119,075,250 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	118,928,918 - 118,940,633 (+)	NCBI		MGSCv36	mm8
Celera	2	120,387,921 - 120,400,196 (+)	NCBI		Celera
Cytogenetic Map	2	E5	NCBI
cM Map	2	59.97	NCBI

Spint1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	7,715,536 - 7,729,158 (+)	Ensembl
ChiLan1.0	NW_004955416	7,715,536 - 7,728,759 (+)	NCBI	ChiLan1.0	ChiLan1.0

SPINT1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	30,086,766 - 30,100,403 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	34,238,095 - 34,251,732 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	19,786,621 - 19,800,297 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	38,036,638 - 38,050,303 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	38,036,638 - 38,050,303 (+)	Ensembl			panPan2	panpan1.1

SPINT1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	7,976,094 - 7,989,019 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	7,975,235 - 7,988,339 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	8,030,789 - 8,043,874 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	8,104,320 - 8,117,280 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	8,104,237 - 8,117,684 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	8,026,984 - 8,039,921 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	8,134,558 - 8,147,504 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	8,264,088 - 8,277,146 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Spint1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	86,390,799 - 86,403,274 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	4,238,845 - 4,251,350 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	4,238,883 - 4,251,291 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SPINT1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	130,458,909 - 130,473,783 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	1	130,458,909 - 130,473,791 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	145,616,937 - 145,631,763 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SPINT1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	42,136,749 - 42,150,125 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	42,134,536 - 42,150,118 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666048	98,833,369 - 98,846,726 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Spint1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624804	8,093,346 - 8,106,193 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624804	8,092,700 - 8,105,478 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Spint1
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	5	97,418,986 - 97,431,418 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Spint1
69 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	98
Count of miRNA genes:	81
Interacting mature miRNAs:	95
Transcripts:	ENSRNOT00000017223
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	96509147	141509147	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	73592512	136118980	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	73592512	136118980	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	51581665	184004958	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	67641776	167835660	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	58601291	153936591	Rat
1582216	Bw65	Body weight QTL 65	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	122654702	136118980	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	49872657	138829559	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	73592512	136118980	Rat
1582219	Bw63	Body weight QTL 63	3.8	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	3	116582412	136118980	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	85062224	136118980	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	85062224	136118980	Rat
7387306	Bw124	Body weight QTL 124	3.2	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	3	104545086	149545086	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	81425008	141509147	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	70845569	136091483	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	longest distance run on treadmill (CMO:0001406)	3	93829559	138829559	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	112250810	157250810	Rat
2302273	Gluco35	Glucose level QTL 35	5.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	101255536	134750886	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	79649560	177741895	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	96509147	141509147	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	117537367	162537367	Rat
2303620	Vencon4	Ventilatory control QTL 4	3.9		respiration trait (VT:0001943)	tidal volume (CMO:0000222)	3	125116475	170116475	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	67641995	130815812	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	110225882	155225882	Rat
5686842	Rf59	Renal function QTL 59			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	3	122395989	167395989	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	90755164	141509147	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	1	141509147	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	98651826	167012663	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	125814931	139636791	Rat
1331758	Bp207	Blood pressure QTL 207	2.848		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	110634702	155634702	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	5675975	141509147	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	67641995	130815812	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	116188400	161188400	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	164	91	90	59	92	59	6	355	191	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001004265	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001433377	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001433378	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006234763	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006234764	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB154834	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC132987	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC097253	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000017223 ⟹ ENSRNOP00000017223

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	126,685,422 - 126,697,956 (+)	Ensembl
mRatBN7.2 Ensembl	3	106,231,444 - 106,244,119 (+)	Ensembl
Rnor_6.0 Ensembl	3	111,049,315 - 111,061,990 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000088870 ⟹ ENSRNOP00000069737

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	3	111,049,118 - 111,062,011 (+)	Ensembl

RefSeq Acc Id:

NM_001004265 ⟹ NP_001004265

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	126,685,281 - 126,697,957 (+)	NCBI
mRatBN7.2	3	106,231,444 - 106,244,120 (+)	NCBI
Rnor_6.0	3	111,049,315 - 111,061,991 (+)	NCBI
Rnor_5.0	3	117,599,717 - 117,612,635 (+)	NCBI
RGSC_v3.4	3	105,757,666 - 105,770,345 (+)	RGD
Celera	3	105,144,668 - 105,157,338 (+)	RGD

Sequence:

show sequence

GAGCTCCCGAGCGGTGCTCTGCCCGACGTCGGGTTCGAGTGTGCGTGGACGGATAGGCCCGCGT
GCGCCTGCTCGTTCCCAGTGCCCCGCGCCACTACCCGAGCTGATCAGGTGCGTCTCTTGTGTCT
CCTCCCCTCTCAGGTCACAAGCACCCTCGGAACCCAGAGGCCCGCACTGTGAAGGTGACTCCCG
CCTTGGGGAGGAGGGCGACGGCCCCTGGGAGCACGATGGCGGCCCGCCGCCTGGCGCAGGCCAG
CATCTCTACGGTCTGCGTATGGCTCCTTTGCGCGCTTGGTCTCCAGGGCACTGAGACCGAGCTG
CCGTCCGCACCCCCTGAGTTTTCCGGGGGAGCCGCCTGCTTGAACCGCTTTACCAGCGGGGTGC
CGGCTTTTGTGTTGGACACCGAAGCTTCAGTCAGCAACGGGGCCACCTTCCTGGGTTCCCCGAC
GGTGCACCGCGGCTGGGACTGCGTGCGTGCCTGCTGCACCACCCAAAACTGTAACCTGGCGCTG
GTGGAGCTGCAGCCGGACGGAGGCGAGGACGCCATCTCTGCCTGCTTCCTCATGAACTGCCTGT
ATGAGCAGAACTTCGTGTGCAAATTCGCTCCGAAGGACGGCTTCATCAACTATCTTACCCAAGA
TCTTTACAACTCCTACCGCGAGCTGCGAACTCGAGGCTTTGGAGGTTCCCGGATCCCTCGAATC
TGGATGGGCATAGACTTGAAGGTGCAGCTGCAGAAGCCCCTGGTACTGAGAGATGCAGACAACA
CAGACTGGCATCTACTGCAAGGTGACCAAGATGTCAGTGTTAAGAGAAACCATCCAGAAGAAGT
TGAGCTGTGGGGACTTAAGGAGGGAACCTACCTGTTCCAACTGACAAGAACCGACTCAGACCAG
CTAGAGGAAACAGTCAACCTGACTATCACCGTGCTAACTGCCGAGCAGACGGAAGATTATTGCC
TCGCATCCTACAAGGTGGGCCGCTGCCGGGGCTCCTTCCCACGCTGGTACTATGACCCCAAGGA
ACAGATCTGCAAAAGTTTCACTTTTGGAGGTTGCCTAGGCAACAAGAACAACTACCTTCGTGAG
GAAGAGTGCATGCTAGCCTGCAAGGATGTGAAAGGAATCTCACCTAAAAGGCATCATCCAGTGT
GCACCGGCAGCTGCCATAGCACGCAGTTCCAGTGCAGCAATGGCTGCTGTATCGACGGCTTCCT
GGAGTGTGATGACACGCCTGACTGCCCTGATGGCTCCGATGAGGCCACTTGTGAAAAATATAGC
AGCGGCTTTGATGAACTTCAGAGTATCCACTTCCTCAGTGACAAAGGGTACTGTGCAGAGCTGC
CAGACACTGGATTTTGCAAGGAGAACATCCCACGCTGGTATTACAACCCATTCAGTGAACGCTG
TGCCCGCTTCACCTATGGTGGTTGCTACGGGAACAAGAACAACTTTGAGAAGGAACAGCAGTGT
CTTGAGTCCTGTCGTGGCATCTCCAAGAAGGATGTGTTCGGTCTTCGGAGGGAAAGCTCCGTTC
CCAGTGCAGGCTCTGTGGAGGTAGCTATTGCTGTATTGCTGGCCGTCTGCATCATAGTGGTCTT
GACCATCCTGGGCTACTGTTTCTTCAAGAACCAAAAAAAGAACTTCCACAGCCCCCTGCACCAA
CCACCTCCCACACCAGCCAGCTCCACTGTTTCCACCACTGAGGACACAGAGCACCTGGTCTATA
ATCACACAACCCAGCCTCTCTGAGCCTGGGACTCTTGCCAGTCTCACCAGGTTCTGTCTTAAGA
CAGAAGCCAGACCTGGGAAAACTTGGGGACCAGAATCTTTCTACCTCTTCCTGGGCATACTTAC
TCTGTCTCAGGAGACAGATCTCTGGGCCTCTCAGAGGACTCTCAGCTGCACTCAGGCCAGTTCT
GGAGAAGGCCCAGGAGTCTGGGAGAAGCAACAGCCTTGAGCCAGGAATACTATACATAGAAGGA
CCTGCTTATCCAGGAGCCAGAGGAAGTTTGTGTTTTTCATCTTGTTCAAAGCTGCCTGCCCCCA
TCCAATGACGCTAGGGCCGTGAGTGGAGTCGGAGGCCAGAAGCCACACACTGCCTTCCACGATG
TCCTCCACTCTGCACAGGCCTGCACTGAAGGACATGGCTTTGTAGTTTATGCTGTAAATAATTG
CTTTTGGGGCCCCAGGGTCATAGCTCAGTGGTAGCGTGTGTATGGTCACCCTCAGTGCTCTACA
CGGCACCACAAATTACATTAAATTAAAGAATAAAATGTTGTGTTTGTCCAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006234763 ⟹ XP_006234825

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	126,685,063 - 126,697,942 (+)	NCBI
mRatBN7.2	3	106,231,084 - 106,244,121 (+)	NCBI
Rnor_6.0	3	111,049,132 - 111,061,991 (+)	NCBI
Rnor_5.0	3	117,599,717 - 117,612,635 (+)	NCBI

Sequence:

show sequence

AGAAACTAGGGAGCGGGGAAGAGGCAGCCAATCGTCCGCGCACCCAGAGCCGAGCGGAAGCCGG
GCGGGATCTTCGGCGGGCCCACCCCGTTCACCTGCGCAGGTCACAAGCACCCTCGGAACCCAGA
GGCCCGCACTGTGAAGGTGACTCCCGCCTTGGGGAGGAGGGCGACGGCCCCTGGGAGCACGATG
GCGGCCCGCCGCCTGGCGCAGGCCAGCATCTCTACGGTCTGCGTATGGCTCCTTTGCGCGCTTG
GTCTCCAGGGCACTGAGACCGAGCTGCCGTCCGCACCCCCTGAGTTTTCCGGGGGAGCCGCCTG
CTTGAACCGCTTTACCAGCGGGGTGCCGGCTTTTGTGTTGGACACCGAAGCTTCAGTCAGCAAC
GGGGCCACCTTCCTGGGTTCCCCGACGGTGCACCGCGGCTGGGACTGCGTGCGTGCCTGCTGCA
CCACCCAAAACTGTAACCTGGCGCTGGTGGAGCTGCAGCCGGACGGAGGCGAGGACGCCATCTC
TGCCTGCTTCCTCATGAACTGCCTGTATGAGCAGAACTTCGTGTGCAAATTCGCTCCGAAGGAC
GGCTTCATCAACTATCTTACCCAAGATCTTTACAACTCCTACCGCGAGCTGCGAACTCGAGGCT
TTGGAGGTTCCCGGATCCCTCGAATCTGGATGGGCATAGACTTGAAGGTGCAGCTGCAGAAGCC
CCTGGTACTGAGAGATGCAGACAACACAGACTGGCATCTACTGCAAGGTGACCAAGATGTCAGT
GTTAAGAGAAACCATCCAGAAGAAGTTGAGCTGTGGGGACTTAAGGAGGGAACCTACCTGTTCC
AACTGACAAGAACCGACTCAGACCAGCTAGAGGAAACAGTCAACCTGACTATCACCGTGCTAAC
TGCCGAGCAGACGGAAGATTATTGCCTCGCATCCTACAAGGTGGGCCGCTGCCGGGGCTCCTTC
CCACGCTGGTACTATGACCCCAAGGAACAGATCTGCAAAAGTTTCACTTTTGGAGGTTGCCTAG
GCAACAAGAACAACTACCTTCGTGAGGAAGAGTGCATGCTAGCCTGCAAGGATGTGAAAGGAAT
CTCACCTAAAAGGCATCATCCAGTGTGCACCGGCAGCTGCCATAGCACGCAGTTCCAGTGCAGC
AATGGCTGCTGTATCGACGGCTTCCTGGAGTGTGATGACACGCCTGACTGCCCTGATGGCTCCG
ATGAGGCCACTTGTGAAAAATATAGCAGCGGCTTTGATGAACTTCAGAGTATCCACTTCCTCAG
TGACAAAGGGTACTGTGCAGAGCTGCCAGACACTGGATTTTGCAAGGAGAACATCCCACGCTGG
TATTACAACCCATTCAGTGAACGCTGTGCCCGCTTCACCTATGGTGGTTGCTACGGGAACAAGA
ACAACTTTGAGAAGGAACAGCAGTGTCTTGAGTCCTGTCGTGGCATCTCCAAGAAGGATGTGTT
CGGTCTTCGGAGGGAAAGCTCCGTTCCCAGTGCAGGCTCTGTGGAGGTAGCTATTGCTGTATTG
CTGGCCGTCTGCATCATAGTGGTCTTGACCATCCTGGGCTACTGTTTCTTCAAGAACCAAAAAA
AGAACTTCCACAGCCCCCTGCACCAACCACCTCCCACACCAGCCAGCTCCACTGTTTCCACCAC
TGAGGACACAGAGCACCTGGTCTATAATCACACAACCCAGCCTCTCTGAGCCTGGGACTCTTGC
CAGTCTCACCAGGTTCTGTCTTAAGACAGAAGCCAGACCTGGGAAAACTTGGGGACCAGAATCT
TTCTACCTCTTCCTGGGCATACTTACTCTGTCTCAGGAGACAGATCTCTGGGCCTCTCAGAGGA
CTCTCAGCTGCACTCAGGCCAGTTCTGGAGAAGGCCCAGGAGTCTGGGAGAAGCAACAGCCTTG
AGCCAGGAATACTATACATAGAAGGACCTGCTTATCCAGGAGCCAGAGGAAGTTTGTGTTTTTC
ATCTTGTTCAAAGCTGCCTGCCCCCATCCAATGACGCTAGGGCCGTGAGTGGAGTCGGAGGCCA
GAAGCCACACACTGCCTTCCACGATGTCCTCCACTCTGCACAGGCCTGCACTGAAGGACATGGC
TTTGTAGTTTATGCTGTAAATAATTGCTTTTGGGGCCCCAGGGTCATAGCTCAGTGGTAGCGTG
TGTATGGTCACCCTCAGTGCTCTACACGGCACCACAAATTACATTAAATTAAAGAATAAAATGT
TGTGTTTGTCCA

hide sequence

RefSeq Acc Id:

XM_006234764 ⟹ XP_006234826

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	126,685,017 - 126,697,942 (+)	NCBI
mRatBN7.2	3	106,231,082 - 106,244,121 (+)	NCBI
Rnor_6.0	3	111,049,230 - 111,061,991 (+)	NCBI
Rnor_5.0	3	117,599,717 - 117,612,635 (+)	NCBI

Sequence:

show sequence

CGCAGGTAGCCTGGGCGGACGGTAGGCGGAGGCCCAGCGGGGTCCGAGCGTGTTTGGCGGACAT
CCGCTCTGTGTTGGGGTCACAAGCACCCTCGGAACCCAGAGGCCCGCACTGTGAAGGTGACTCC
CGCCTTGGGGAGGAGGGCGACGGCCCCTGGGAGCACGATGGCGGCCCGCCGCCTGGCGCAGGCC
AGCATCTCTACGGTCTGCGTATGGCTCCTTTGCGCGCTTGGTCTCCAGGGCACTGAGACCGAGC
TGCCGTCCGCACCCCCTGAGTTTTCCGGGGGAGCCGCCTGCTTGAACCGCTTTACCAGCGGGGT
GCCGGCTTTTGTGTTGGACACCGAAGCTTCAGTCAGCAACGGGGCCACCTTCCTGGGTTCCCCG
ACGGTGCACCGCGGCTGGGACTGCGTGCGTGCCTGCTGCACCACCCAAAACTGTAACCTGGCGC
TGGTGGAGCTGCAGCCGGACGGAGGCGAGGACGCCATCTCTGCCTGCTTCCTCATGAACTGCCT
GTATGAGCAGAACTTCGTGTGCAAATTCGCTCCGAAGGACGGCTTCATCAACTATCTTACCCAA
GATCTTTACAACTCCTACCGCGAGCTGCGAACTCGAGGCTTTGGAGGTTCCCGGATCCCTCGAA
TCTGGATGGGCATAGACTTGAAGGTGCAGCTGCAGAAGCCCCTGGTACTGAGAGATGCAGACAA
CACAGACTGGCATCTACTGCAAGGTGACCAAGATGTCAGTGTTAAGAGAAACCATCCAGAAGAA
GTTGAGCTGTGGGGACTTAAGGAGGGAACCTACCTGTTCCAACTGACAAGAACCGACTCAGACC
AGCTAGAGGAAACAGTCAACCTGACTATCACCGTGCTAACTGCCGAGCAGACGGAAGATTATTG
CCTCGCATCCTACAAGGTGGGCCGCTGCCGGGGCTCCTTCCCACGCTGGTACTATGACCCCAAG
GAACAGATCTGCAAAAGTTTCACTTTTGGAGGTTGCCTAGGCAACAAGAACAACTACCTTCGTG
AGGAAGAGTGCATGCTAGCCTGCAAGGATGTGAAAGGAATCTCACCTAAAAGGCATCATCCAGT
GTGCACCGGCAGCTGCCATAGCACGCAGTTCCAGTGCAGCAATGGCTGCTGTATCGACGGCTTC
CTGGAGTGTGATGACACGCCTGACTGCCCTGATGGCTCCGATGAGGCCACTTGTGAAAAATATA
GCAGCGGCTTTGATGAACTTCAGAGTATCCACTTCCTCAGTGACAAAGGGTACTGTGCAGAGCT
GCCAGACACTGGATTTTGCAAGGAGAACATCCCACGCTGGTATTACAACCCATTCAGTGAACGC
TGTGCCCGCTTCACCTATGGTGGTTGCTACGGGAACAAGAACAACTTTGAGAAGGAACAGCAGT
GTCTTGAGTCCTGTCGTGGCATCTCCAAGAAGGATGTGTTCGGTCTTCGGAGGGAAAGCTCCGT
TCCCAGTGCAGGCTCTGTGGAGGTAGCTATTGCTGTATTGCTGGCCGTCTGCATCATAGTGGTC
TTGACCATCCTGGGCTACTGTTTCTTCAAGAACCAAAAAAAGAACTTCCACAGCCCCCTGCACC
AACCACCTCCCACACCAGCCAGCTCCACTGTTTCCACCACTGAGGACACAGAGCACCTGGTCTA
TAATCACACAACCCAGCCTCTCTGAGCCTGGGACTCTTGCCAGTCTCACCAGGTTCTGTCTTAA
GACAGAAGCCAGACCTGGGAAAACTTGGGGACCAGAATCTTTCTACCTCTTCCTGGGCATACTT
ACTCTGTCTCAGGAGACAGATCTCTGGGCCTCTCAGAGGACTCTCAGCTGCACTCAGGCCAGTT
CTGGAGAAGGCCCAGGAGTCTGGGAGAAGCAACAGCCTTGAGCCAGGAATACTATACATAGAAG
GACCTGCTTATCCAGGAGCCAGAGGAAGTTTGTGTTTTTCATCTTGTTCAAAGCTGCCTGCCCC
CATCCAATGACGCTAGGGCCGTGAGTGGAGTCGGAGGCCAGAAGCCACACACTGCCTTCCACGA
TGTCCTCCACTCTGCACAGGCCTGCACTGAAGGACATGGCTTTGTAGTTTATGCTGTAAATAAT
TGCTTTTGGGGCCCCAGGGTCATAGCTCAGTGGTAGCGTGTGTATGGTCACCCTCAGTGCTCTA
CACGGCACCACAAATTACATTAAATTAAAGAATAAAATGTTGTGTTTGTCCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001004265	(Get FASTA)	NCBI Sequence Viewer
	NP_001420306	(Get FASTA)	NCBI Sequence Viewer
	NP_001420307	(Get FASTA)	NCBI Sequence Viewer
	XP_006234825	(Get FASTA)	NCBI Sequence Viewer
	XP_006234826	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH97253	(Get FASTA)	NCBI Sequence Viewer
	BAD23971	(Get FASTA)	NCBI Sequence Viewer
	EDL79898	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000017223
	ENSRNOP00000017223.3

RefSeq Acc Id:	NP_001004265 ⟸ NM_001004265
- Peptide Label:	precursor
- UniProtKB:	Q4V8Q2 (UniProtKB/TrEMBL), F7ERY9 (UniProtKB/TrEMBL), Q6I750 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAARRLAQASISTVCVWLLCALGLQGTETELPSAPPEFSGGAACLNRFTSGVPAFVLDTEASVS NGATFLGSPTVHRGWDCVRACCTTQNCNLALVELQPDGGEDAISACFLMNCLYEQNFVCKFAPK DGFINYLTQDLYNSYRELRTRGFGGSRIPRIWMGIDLKVQLQKPLVLRDADNTDWHLLQGDQDV SVKRNHPEEVELWGLKEGTYLFQLTRTDSDQLEETVNLTITVLTAEQTEDYCLASYKVGRCRGS FPRWYYDPKEQICKSFTFGGCLGNKNNYLREEECMLACKDVKGISPKRHHPVCTGSCHSTQFQC SNGCCIDGFLECDDTPDCPDGSDEATCEKYSSGFDELQSIHFLSDKGYCAELPDTGFCKENIPR WYYNPFSERCARFTYGGCYGNKNNFEKEQQCLESCRGISKKDVFGLRRESSVPSAGSVEVAIAV LLAVCIIVVLTILGYCFFKNQKKNFHSPLHQPPPTPASSTVSTTEDTEHLVYNHTTQPL hide sequence

RefSeq Acc Id:

XP_006234825 ⟸ XM_006234763

- Peptide Label:

isoform X1

- Sequence:

show sequence

MAARRLAQASISTVCVWLLCALGLQGTETELPSAPPEFSGGAACLNRFTSGVPAFVLDTEASVS
NGATFLGSPTVHRGWDCVRACCTTQNCNLALVELQPDGGEDAISACFLMNCLYEQNFVCKFAPK
DGFINYLTQDLYNSYRELRTRGFGGSRIPRIWMGIDLKVQLQKPLVLRDADNTDWHLLQGDQDV
SVKRNHPEEVELWGLKEGTYLFQLTRTDSDQLEETVNLTITVLTAEQTEDYCLASYKVGRCRGS
FPRWYYDPKEQICKSFTFGGCLGNKNNYLREEECMLACKDVKGISPKRHHPVCTGSCHSTQFQC
SNGCCIDGFLECDDTPDCPDGSDEATCEKYSSGFDELQSIHFLSDKGYCAELPDTGFCKENIPR
WYYNPFSERCARFTYGGCYGNKNNFEKEQQCLESCRGISKKDVFGLRRESSVPSAGSVEVAIAV
LLAVCIIVVLTILGYCFFKNQKKNFHSPLHQPPPTPASSTVSTTEDTEHLVYNHTTQPL

hide sequence

RefSeq Acc Id:

XP_006234826 ⟸ XM_006234764

- Peptide Label:

isoform X1

- Sequence:

show sequence

MAARRLAQASISTVCVWLLCALGLQGTETELPSAPPEFSGGAACLNRFTSGVPAFVLDTEASVS
NGATFLGSPTVHRGWDCVRACCTTQNCNLALVELQPDGGEDAISACFLMNCLYEQNFVCKFAPK
DGFINYLTQDLYNSYRELRTRGFGGSRIPRIWMGIDLKVQLQKPLVLRDADNTDWHLLQGDQDV
SVKRNHPEEVELWGLKEGTYLFQLTRTDSDQLEETVNLTITVLTAEQTEDYCLASYKVGRCRGS
FPRWYYDPKEQICKSFTFGGCLGNKNNYLREEECMLACKDVKGISPKRHHPVCTGSCHSTQFQC
SNGCCIDGFLECDDTPDCPDGSDEATCEKYSSGFDELQSIHFLSDKGYCAELPDTGFCKENIPR
WYYNPFSERCARFTYGGCYGNKNNFEKEQQCLESCRGISKKDVFGLRRESSVPSAGSVEVAIAV
LLAVCIIVVLTILGYCFFKNQKKNFHSPLHQPPPTPASSTVSTTEDTEHLVYNHTTQPL

hide sequence

Ensembl Acc Id:

ENSRNOP00000017223 ⟸ ENSRNOT00000017223

Ensembl Acc Id:

ENSRNOP00000069737 ⟸ ENSRNOT00000088870

Protein Domains

BPTI/Kunitz inhibitor MANSC

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4V8Q2-F1-model_v2	AlphaFold	Q4V8Q2	1-507	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303138	AgrOrtholog
BioCyc Gene	G2FUF-48211	BioCyc
Ensembl Genes	ENSRNOG00000012811	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000017223	ENTREZGENE
	ENSRNOT00000017223.6	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
	4.10.400.10	UniProtKB/TrEMBL
	4.10.410.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7459422	IMAGE-MGC_LOAD
InterPro	Ig-like_fold	UniProtKB/TrEMBL
	Kunitz_BPTI_sf	UniProtKB/TrEMBL
	LDL_receptor-like_sf	UniProtKB/TrEMBL
	LDLR_class-A_CS	UniProtKB/TrEMBL
	LDLR_classA_rpt	UniProtKB/TrEMBL
	MANSC	UniProtKB/TrEMBL
	MANSC_N	UniProtKB/TrEMBL
	Prot_inh_Kunz-m	UniProtKB/TrEMBL
	Prtase_inh_Kunz-CS	UniProtKB/TrEMBL
KEGG Report	rno:311331	UniProtKB/TrEMBL
MGC_CLONE	MGC:114209	IMAGE-MGC_LOAD
NCBI Gene	311331	ENTREZGENE
PANTHER	KUNITZ-TYPE PROTEASE INHIBITOR 1	UniProtKB/TrEMBL
	PTHR46750	UniProtKB/TrEMBL
Pfam	K319L-like_PKD	UniProtKB/TrEMBL
	Kunitz_BPTI	UniProtKB/TrEMBL
	Ldl_recept_a	UniProtKB/TrEMBL
	MANEC	UniProtKB/TrEMBL
PhenoGen	Spint1	PhenoGen
PRINTS	BASICPTASE	UniProtKB/TrEMBL
PROSITE	BPTI_KUNITZ_1	UniProtKB/TrEMBL
	BPTI_KUNITZ_2	UniProtKB/TrEMBL
	LDLRA_1	UniProtKB/TrEMBL
	LDLRA_2	UniProtKB/TrEMBL
	MANSC	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000012811	RatGTEx
SMART	LDLa	UniProtKB/TrEMBL
	MANEC	UniProtKB/TrEMBL
	SM00131	UniProtKB/TrEMBL
Superfamily-SCOP	LDL_rcpt_classA_cys-rich	UniProtKB/TrEMBL
	Prot_inh_Kunz-m	UniProtKB/TrEMBL
UniProt	F7ERY9	ENTREZGENE, UniProtKB/TrEMBL
	Q4V8Q2	ENTREZGENE, UniProtKB/TrEMBL
	Q6I750	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-18	Spint1	serine peptidase inhibitor, Kunitz type 1	Spint1	serine protease inhibitor, Kunitz type 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Spint1	serine peptidase inhibitor, Kunitz type 1		hepatocyte growth factor activator inhibitor 1	Name updated	1299863	APPROVED
2005-02-14	Spint1	hepatocyte growth factor activator inhibitor 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message