RGD Reference Report - White matter astrocytes produce hepatocyte growth factor activator inhibitor in human brain tissues. - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

White matter astrocytes produce hepatocyte growth factor activator inhibitor in human brain tissues.

Authors: Yamada, T  Tsujioka, Y  Taguchi, J  Takahashi, M  Tsuboi, Y  Shimomura, T 
Citation: Yamada T, etal., Exp Neurol. 1998 Sep;153(1):60-4.
RGD ID: 1581317
Pubmed: PMID:9743567   (View Abstract at PubMed)
DOI: DOI:10.1006/exnr.1998.6874   (Journal Full-text)

Hepatocyte growth factor (HGF) is a potent mitogen for mature hepatocytes and also has multifunctional effects on some other cells in various organs. A HGF activator (HGFA) has been identified as a key enzyme that regulates the activity of HGF in vivo. Our previous studies have shown that brain astrocytes produce both proteins. Recently, HGFA inhibitor-1 (HAI-1), a novel Kunitz-type serine protease inhibitor, has been isolated. We examined HAI-1 immunolabeling in the brains of neurologically normal persons and patients with Alzheimer's disease (AD) and cerebral infarction. Furthermore, we identified the expression of the mRNA for HAI-1 by in situ hybridization histochemistry. The HAI-1 antibody stained astrocytes in the white matter of all brain tissues and was present in plasma. In AD, the intensity of HAI-1 immunolabeling was less than in the other cases. Expression of the mRNA for HAI-1 was also seen in astrocytes. The intensity of the signal for HAI-1 mRNA was similar in AD and normal control brains. These results suggest that, in human brain, secreted pro-HGF from astrocytes may be activated by HGFA and inhibited by HAI-1 on or near the astrocytic cell surface and that rapid HAI-1 consumption may occur in the white matter in AD.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Alzheimer's disease  IEP 1581317protein:decreased expression:parietal cortex (human)RGD 
Alzheimer's disease  ISOSPINT1 (Homo sapiens)1581317; 1581317protein:decreased expression:parietal cortex (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Spint1  (serine peptidase inhibitor, Kunitz type 1)

Genes (Mus musculus)
Spint1  (serine protease inhibitor, Kunitz type 1)

Genes (Homo sapiens)
SPINT1  (serine peptidase inhibitor, Kunitz type 1)


Additional Information