Itgb6 (integrin subunit beta 6) - Rat Genome Database

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Gene: Itgb6 (integrin subunit beta 6) Rattus norvegicus
Analyze
Symbol: Itgb6
Name: integrin subunit beta 6
RGD ID: 1303119
Description: Predicted to enable integrin binding activity and molecular function activator activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; integrin-mediated signaling pathway; and transforming growth factor beta production. Predicted to act upstream of or within several processes, including enamel mineralization; lung development; and mononuclear cell differentiation. Predicted to be located in external side of plasma membrane. Predicted to be part of integrin alphav-beta6 complex. Predicted to be active in cell surface and focal adhesion. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1H. Orthologous to human ITGB6 (integrin subunit beta 6); PARTICIPATES IN integrin mediated signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; cell-extracellular matrix signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: integrin beta 6; integrin beta-6; integrin, beta 6; MGC94023
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8365,454,964 - 65,579,179 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl365,456,713 - 65,530,333 (-)EnsemblGRCr8
mRatBN7.2345,046,295 - 45,170,532 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl345,048,044 - 45,121,671 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx348,404,699 - 48,477,782 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0356,988,255 - 57,061,340 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0354,757,778 - 54,831,418 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0346,652,624 - 46,775,362 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl346,652,623 - 46,726,958 (-)Ensemblrn6Rnor6.0
Rnor_5.0351,760,871 - 51,883,770 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4342,286,140 - 42,360,793 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera344,745,206 - 44,817,710 (-)NCBICelera
RGSC_v3.1342,182,533 - 42,257,165 (-)NCBI
Cytogenetic Map3q21NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dimethoxyphenol  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
aflatoxin B1  (EXP,ISO)
alpha-Zearalanol  (EXP)
amitriptyline  (EXP)
aristolochic acid A  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bortezomib  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
Cuprizon  (EXP)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
DDE  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
dimethylarsinic acid  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
folic acid  (ISO)
furan  (EXP)
furfural  (ISO)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP)
L-methionine  (ISO)
manganese(II) chloride  (EXP,ISO)
mercury dibromide  (ISO)
methimazole  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
pravastatin  (ISO)
progesterone  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
streptozocin  (ISO)
sucrose  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetrathiomolybdate(2-)  (EXP)
Theaflavin 3,3'-digallate  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (IBA,IEA,ISO)
external side of plasma membrane  (IEA,ISO)
focal adhesion  (IBA,IEA,ISO,ISS)
integrin alphav-beta6 complex  (IBA,IEA,ISO,ISS)
plasma membrane  (IEA)
receptor complex  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Integrins: bidirectional, allosteric signaling machines. Hynes RO Cell 2002 Sep 20;110(6):673-87.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. Morris DG, etal., Nature 2003 Mar 13;422(6928):169-73.
5. Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression. Patsenker E, etal., Gastroenterology. 2008 Aug;135(2):660-70. Epub 2008 Apr 16.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies. Popov Y, etal., J Hepatol. 2008 Mar;48(3):453-64. Epub 2008 Jan 14.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
Additional References at PubMed
PMID:8601592   PMID:9553049   PMID:15489334   PMID:15963261   PMID:17158881   PMID:22278742   PMID:22885106   PMID:23376485   PMID:23382219   PMID:23422496   PMID:24681597   PMID:26279426  
PMID:36307995  


Genomics

Comparative Map Data
Itgb6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8365,454,964 - 65,579,179 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl365,456,713 - 65,530,333 (-)EnsemblGRCr8
mRatBN7.2345,046,295 - 45,170,532 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl345,048,044 - 45,121,671 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx348,404,699 - 48,477,782 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0356,988,255 - 57,061,340 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0354,757,778 - 54,831,418 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0346,652,624 - 46,775,362 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl346,652,623 - 46,726,958 (-)Ensemblrn6Rnor6.0
Rnor_5.0351,760,871 - 51,883,770 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4342,286,140 - 42,360,793 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera344,745,206 - 44,817,710 (-)NCBICelera
RGSC_v3.1342,182,533 - 42,257,165 (-)NCBI
Cytogenetic Map3q21NCBI
ITGB6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382160,099,671 - 160,200,272 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2160,099,664 - 160,271,888 (-)Ensemblhg38GRCh38
GRCh372160,956,182 - 161,056,783 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362160,666,479 - 160,764,836 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342160,783,739 - 160,882,097NCBI
Celera2154,569,718 - 154,668,069 (-)NCBICelera
Cytogenetic Map2q24.2NCBI
HuRef2152,841,567 - 152,939,796 (-)NCBIHuRef
CHM1_12160,964,913 - 161,062,919 (-)NCBICHM1_1
T2T-CHM13v2.02160,557,539 - 160,657,754 (-)NCBIT2T-CHM13v2.0
Itgb6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39260,428,636 - 60,553,005 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl260,428,636 - 60,552,987 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38260,598,292 - 60,722,603 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl260,598,292 - 60,722,643 (-)Ensemblmm10GRCm38
MGSCv37260,436,349 - 60,560,660 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36260,399,131 - 60,474,500 (-)NCBIMGSCv36mm8
Celera262,295,485 - 62,419,857 (-)NCBICelera
Cytogenetic Map2C1.1- C1.2NCBI
cM Map234.81NCBI
Itgb6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544913,448,084 - 13,520,879 (+)Ensembl
ChiLan1.0NW_00495544913,387,013 - 13,520,879 (+)NCBIChiLan1.0ChiLan1.0
ITGB6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21362,791,601 - 62,961,884 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B62,806,572 - 62,909,714 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B47,386,913 - 47,496,491 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B164,757,913 - 164,867,426 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B164,764,251 - 164,867,426 (-)EnsemblpanPan2panpan1.1
ITGB6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1365,833,206 - 5,962,699 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl365,834,638 - 5,962,633 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha365,972,263 - 6,101,021 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0365,957,679 - 6,086,682 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl365,957,684 - 6,086,586 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1365,974,904 - 6,103,502 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0366,018,081 - 6,146,821 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0366,127,531 - 6,256,234 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Itgb6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303122,961,499 - 123,089,078 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646918,581,840 - 18,650,123 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493646918,581,855 - 18,650,109 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGB6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1567,041,522 - 67,175,234 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11567,041,516 - 67,175,409 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21574,181,822 - 74,276,814 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITGB6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11045,506,355 - 45,650,979 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1045,504,987 - 45,595,543 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666040153,971,887 - 154,066,448 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itgb6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247325,403,956 - 5,499,855 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247325,348,589 - 5,499,826 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Itgb6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1538,244,518 - 38,319,850 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Itgb6
950 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:46
Count of miRNA genes:34
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000011030
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)32862533967641995Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
10450816Scl75Serum cholesterol level QTL 754.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)35860129171157804Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)33779691982796919Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)34790417270710963Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33870893167641995Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33870893167641995Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33870893167641995Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)33870893167641995Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33870893167641995Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)34790417270710963Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33870893167641995Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893167641995Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)33610140381101403Rat
10450852Stl33Serum triglyceride level QTL 333.40.05blood LDL triglyceride amount (VT:0010699)blood lipoprotein triglyceride level (CMO:0002685)35860129171157804Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
4889975Bmd81Bone mineral density QTL 814.3tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)35911940270710963Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
634317Bw117Body weight QTL 1173.58abdominal fat pad mass (VT:1000711)abdominal fat pad weight to body weight ratio (CMO:0000095)35986366373704481Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)35986366387321459Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)34790417270710963Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)35986366387321459Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)34790417270710963Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33642511681425116Rat
10450813Scl74Serum cholesterol level QTL 745.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)35860129171157804Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)35986366383358329Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
2325840Bp345Blood pressure QTL 3450.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)33870893183708931Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)33736373482363734Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)34790417270710963Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 65 137 90 90 59 31 59 6 292 128 11 109 81 89 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000011030   ⟹   ENSRNOP00000011030
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl365,456,713 - 65,530,333 (-)Ensembl
mRatBN7.2 Ensembl345,048,044 - 45,121,671 (-)Ensembl
Rnor_6.0 Ensembl346,654,373 - 46,726,946 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086576   ⟹   ENSRNOP00000074271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl346,652,623 - 46,726,958 (-)Ensembl
RefSeq Acc Id: NM_001004263   ⟹   NP_001004263
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8365,456,690 - 65,530,333 (-)NCBI
mRatBN7.2345,048,021 - 45,121,671 (-)NCBI
Rnor_6.0346,654,350 - 46,726,946 (-)NCBI
Rnor_5.0351,760,871 - 51,883,770 (-)NCBI
RGSC_v3.4342,286,140 - 42,360,793 (-)RGD
Celera344,745,206 - 44,817,710 (-)RGD
Sequence:
RefSeq Acc Id: XM_006234232   ⟹   XP_006234294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8365,454,964 - 65,579,179 (-)NCBI
mRatBN7.2345,046,295 - 45,170,532 (-)NCBI
Rnor_6.0346,652,624 - 46,775,362 (-)NCBI
Rnor_5.0351,760,871 - 51,883,770 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234233   ⟹   XP_006234295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8365,454,964 - 65,530,404 (-)NCBI
mRatBN7.2345,046,295 - 45,121,737 (-)NCBI
Rnor_6.0346,652,624 - 46,727,265 (-)NCBI
Rnor_5.0351,760,871 - 51,883,770 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001004263   ⟸   NM_001004263
- Peptide Label: precursor
- UniProtKB: Q6AYF4 (UniProtKB/Swiss-Prot),   A6HLT3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234294   ⟸   XM_006234232
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006234295   ⟸   XM_006234233
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000074271   ⟸   ENSRNOT00000086576
Ensembl Acc Id: ENSRNOP00000011030   ⟸   ENSRNOT00000011030
Protein Domains
I-EGF   Integrin beta subunit cytoplasmic   Integrin beta subunit tail   Integrin beta subunit VWA   PSI   VWFA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AYF4-F1-model_v2 AlphaFold Q6AYF4 1-787 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692103
Promoter ID:EPDNEW_R2617
Type:initiation region
Name:Itgb6_1
Description:integrin beta 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0346,727,009 - 46,727,069EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303119 AgrOrtholog
BioCyc Gene G2FUF-49617 BioCyc
Ensembl Genes ENSRNOG00000008346 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000011030 ENTREZGENE
  ENSRNOT00000011030.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.410 UniProtKB/Swiss-Prot
  4.10.1240.30 UniProtKB/Swiss-Prot
  Cytochrome c1, transmembrane anchor, C-terminal UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
  ligand-binding face of the semaphorins, domain 2 UniProtKB/Swiss-Prot
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7121642 IMAGE-MGC_LOAD
InterPro EGF_extracell UniProtKB/Swiss-Prot
  I-EGF_1 UniProtKB/Swiss-Prot
  Integrin_beta_N UniProtKB/Swiss-Prot
  Integrin_bsu UniProtKB/Swiss-Prot
  Integrin_bsu_cyt_dom UniProtKB/Swiss-Prot
  Integrin_bsu_tail UniProtKB/Swiss-Prot
  Integrin_bsu_tail_dom_sf UniProtKB/Swiss-Prot
  Integrin_bsu_VWA UniProtKB/Swiss-Prot
  Integrin_dom_sf UniProtKB/Swiss-Prot
  PSI UniProtKB/Swiss-Prot
  vWFA_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:311061 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94023 IMAGE-MGC_LOAD
NCBI Gene 311061 ENTREZGENE
PANTHER PTHR10082 UniProtKB/Swiss-Prot
  PTHR10082:SF11 UniProtKB/Swiss-Prot
Pfam EGF_2 UniProtKB/Swiss-Prot
  EGF_integrin UniProtKB/Swiss-Prot
  I-EGF_1 UniProtKB/Swiss-Prot
  Integrin_b_cyt UniProtKB/Swiss-Prot
  Integrin_B_tail UniProtKB/Swiss-Prot
  Integrin_beta UniProtKB/Swiss-Prot
  PSI_integrin UniProtKB/Swiss-Prot
PhenoGen Itgb6 PhenoGen
PIRSF Integrin_B UniProtKB/Swiss-Prot
PRINTS INTEGRINB UniProtKB/Swiss-Prot
PROSITE EGF_1 UniProtKB/Swiss-Prot
  EGF_2 UniProtKB/Swiss-Prot
  I_EGF_2 UniProtKB/Swiss-Prot
  INTEGRIN_BETA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008346 RatGTEx
SMART INB UniProtKB/Swiss-Prot
  Integrin_b_cyt UniProtKB/Swiss-Prot
  Integrin_B_tail UniProtKB/Swiss-Prot
  PSI UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot
  Plexin repeat UniProtKB/Swiss-Prot
  SSF53300 UniProtKB/Swiss-Prot
  SSF69179 UniProtKB/Swiss-Prot
  SSF69687 UniProtKB/Swiss-Prot
UniProt A6HLT3 ENTREZGENE, UniProtKB/TrEMBL
  ITB6_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-05-29 Itgb6  integrin subunit beta 6  Itgb6  integrin beta 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-05-16 Itgb6  integrin beta 6  Itgb6  integrin subunit beta 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-12-23 Itgb6  integrin subunit beta 6  Itgb6  integrin, beta 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Itgb6  integrin, beta 6      Symbol and Name status set to approved 1299863 APPROVED
2005-02-14 Itgb6  integrin, beta 6      Symbol and Name status set to provisional 70820 PROVISIONAL