Vkorc1 (vitamin K epoxide reductase complex, subunit 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Vkorc1 (vitamin K epoxide reductase complex, subunit 1) Rattus norvegicus
Analyze
Symbol: Vkorc1
Name: vitamin K epoxide reductase complex, subunit 1
RGD ID: 1303107
Description: Enables vitamin-K-epoxide reductase (warfarin-insensitive) activity. Contributes to vitamin-K-epoxide reductase (warfarin-sensitive) activity. Involved in regulation of blood coagulation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum lumen and endoplasmic reticulum membrane. Used to study warfarin sensitivity. Human ortholog(s) of this gene implicated in combined deficiency of vitamin K-dependent clotting factors 2 and warfarin resistance. Orthologous to human VKORC1 (vitamin K epoxide reductase complex subunit 1); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; INTERACTS WITH (+)-schisandrin B; 1,4-dithiothreitol; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: phylloquinone epoxide reductase; vitamin K epoxide reductase complex subunit 1; vitamin K1 2,3-epoxide reductase subunit 1; vitamin K1 epoxide reductase (warfarin-sensitive); Warfarin resistance
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,932,969 - 191,935,490 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.21182,502,491 - 182,505,012 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,500,844 - 182,505,008 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1190,853,032 - 190,855,553 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,039,126 - 198,041,647 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,709,541 - 190,712,063 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,338,785 - 199,341,306 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,337,138 - 199,341,302 (-)Ensemblrn6Rnor6.0
Rnor_5.01206,361,380 - 206,363,901 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41187,176,745 - 187,179,266 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1180,153,292 - 180,155,813 (-)NCBICelera
RGSC_v3.11187,326,627 - 187,329,147 (-)NCBI
Cytogenetic Map1q37NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-epoxyphylloquinone  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxycoumarin  (ISO)
7-Hydroxywarfarin  (ISO)
acenocoumarol  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
Brodifacoum  (ISO)
Bromadiolone  (EXP,ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
Chlorophacinone  (EXP)
chloropicrin  (ISO)
choline  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
Coumachlor  (ISO)
coumarin  (ISO)
coumarins  (ISO)
Coumatetralyl  (EXP,ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
dehydroacetic acid  (EXP)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dicoumarol  (ISO)
Difenacoum  (EXP,ISO)
Difethialone  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
etoposide  (ISO)
fipronil  (EXP)
fluindione  (ISO)
folic acid  (ISO)
GW 4064  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-1,4-dithiothreitol  (EXP)
L-methionine  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
N-ethylmaleimide  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
paracetamol  (ISO)
phenindione  (ISO)
phenprocoumon  (ISO)
phylloquinone  (ISO)
pyrimidifen  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (EXP,ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vitamin K  (EXP)
vitamin K epoxide  (EXP,ISO)
warfarin  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Characterization and purification of the vitamin K1 2,3 epoxide reductases system from rat liver. Begent LA, etal., J Pharm Pharmacol. 2001 Apr;53(4):481-6.
2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, etal., Genome Res 1996 Sep;6(9):791-806.
3. Structural Modeling Insights into Human VKORC1 Phenotypes. Czogalla KJ, etal., Nutrients. 2015 Aug 14;7(8):6837-51. doi: 10.3390/nu7085313.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. A cardiovascular phenotype in warfarin-resistant Vkorc1 mutant rats. Kohn MH, etal., Artery Res. 2008 Nov;2(4):138-147.
6. Depression of liver microsomal vitamin K epoxide reductase activity associated with antibiotic-induced coagulopathy. Matsubara T, etal., Biochem Pharmacol. 1989 Aug 15;38(16):2693-701.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. Rost S, etal., Nature 2004 Feb 5;427(6974):537-41.
15. Effect of N-ethylmaleimide on beef and rat liver vitamin K1 epoxide reductase. Silverman RB and Nandi DL, J Enzyme Inhib. 1990;3(4):289-94.
16. Structural and functional insights into enzymes of the vitamin K cycle. Tie JK and Stafford DW, J Thromb Haemost. 2016 Feb;14(2):236-47. doi: 10.1111/jth.13217. Epub 2016 Jan 29.
17. The inhibitory effect of calumenin on the vitamin K-dependent gamma-carboxylation system. Characterization of the system in normal and warfarin-resistant rats. Wajih N, etal., J Biol Chem. 2004 Jun 11;279(24):25276-83. Epub 2004 Apr 9.
18. Engineering of a recombinant vitamin K-dependent gamma-carboxylation system with enhanced gamma-carboxyglutamic acid forming capacity: evidence for a functional CXXC redox center in the system. Wajih N, etal., J Biol Chem. 2005 Mar 18;280(11):10540-7. Epub 2005 Jan 7.
19. Species comparison of vitamin K1 2,3-epoxide reductase activity in vitro: kinetics and warfarin inhibition. Wilson CR, etal., Toxicology. 2003 Aug 1;189(3):191-8.
Additional References at PubMed
PMID:12477932   PMID:15879509   PMID:16270630   PMID:19200363   PMID:19492146   PMID:20978134   PMID:21127708   PMID:23018795   PMID:23918929   PMID:23928358   PMID:24611351   PMID:27846632  
PMID:29155484   PMID:30214074   PMID:31484376   PMID:32687688   PMID:33771253   PMID:35296766   PMID:35430058   PMID:35970209   PMID:36309944   PMID:37151288  


Genomics

Comparative Map Data
Vkorc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81191,932,969 - 191,935,490 (-)NCBIGRCr8GRCr8GRCr8
mRatBN7.21182,502,491 - 182,505,012 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,500,844 - 182,505,008 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1190,853,032 - 190,855,553 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,039,126 - 198,041,647 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,709,541 - 190,712,063 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,338,785 - 199,341,306 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,337,138 - 199,341,302 (-)Ensemblrn6Rnor6.0
Rnor_5.01206,361,380 - 206,363,901 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41187,176,745 - 187,179,266 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1180,153,292 - 180,155,813 (-)NCBICelera
RGSC_v3.11187,326,627 - 187,329,147 (-)NCBI
Cytogenetic Map1q37NCBI
VKORC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381631,090,854 - 31,094,797 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1631,090,842 - 31,095,980 (-)Ensemblhg38GRCh38
GRCh371631,102,175 - 31,106,118 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361631,009,676 - 31,013,777 (-)NCBIBuild 36Build 36hg18NCBI36
Celera1629,191,224 - 29,195,328 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1628,663,874 - 28,667,978 (-)NCBIHuRef
CHM1_11632,419,476 - 32,423,596 (-)NCBICHM1_1
T2T-CHM13v2.01631,478,282 - 31,482,234 (-)NCBIT2T-CHM13v2.0
Vkorc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,492,235 - 127,494,833 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,485,399 - 127,494,626 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm39 Ensembl7127,492,235 - 127,494,789 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm387127,893,063 - 127,895,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7127,886,227 - 127,895,454 (-)Ensemblmm10GRCm38
GRCm38.p6 Ensembl7127,893,063 - 127,895,617 (-)Ensemblmm10GRCm38
MGSCv377135,036,577 - 135,039,131 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367127,684,211 - 127,686,765 (-)NCBIMGSCv36mm8
Celera7127,728,262 - 127,730,816 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map769.81NCBI
Vkorc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554937,928,843 - 7,931,185 (-)Ensembl
ChiLan1.0NW_0049554937,928,516 - 7,931,265 (-)NCBIChiLan1.0ChiLan1.0
VKORC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21834,298,329 - 34,303,550 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11639,099,732 - 39,104,570 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01623,871,756 - 23,876,599 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11631,459,556 - 31,464,617 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1631,459,560 - 31,464,897 (-)EnsemblpanPan2panpan1.1
VKORC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1617,140,565 - 17,142,621 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl617,140,633 - 17,142,547 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha618,715,931 - 18,717,978 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0617,271,459 - 17,273,505 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl617,271,517 - 17,273,431 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1617,071,856 - 17,073,902 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0616,990,716 - 16,992,762 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0617,303,101 - 17,305,147 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Vkorc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,361,540 - 125,363,993 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650113,459,022 - 13,462,174 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493650113,459,400 - 13,461,864 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VKORC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,386,245 - 17,389,905 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1317,386,230 - 17,389,162 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,483,272 - 17,485,908 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VKORC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1527,778,553 - 27,782,639 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl527,776,416 - 27,782,640 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660681,685,255 - 1,689,345 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vkorc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478214,141,545 - 14,144,177 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478214,141,545 - 14,144,181 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Vkorc1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1274,010,533 - 74,012,963 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Vkorc1
11 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:164
Count of miRNA genes:119
Interacting mature miRNAs:130
Transcripts:ENSRNOT00000073596
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1191177449205813246Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
2312558Glom17Glomerulus QTL 173.90.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1175967553200707874Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
2325725Eae31Experimental allergic encephalomyelitis QTL 31nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1188241285197807511Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1183564652205813246Rat

Markers in Region
RH128112  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,502,683 - 182,502,877 (+)MAPPERmRatBN7.2
Rnor_6.01199,338,978 - 199,339,171NCBIRnor6.0
Rnor_5.01206,361,573 - 206,361,766UniSTSRnor5.0
RGSC_v3.41187,176,938 - 187,177,131UniSTSRGSC3.4
Celera1180,153,485 - 180,153,678UniSTS
Cytogenetic Map1q36UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 89 59 6 353 189 11 144 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_203335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC111812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW253787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY423047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC166413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB314647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC218168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MH430820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MH430821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MH430822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MH430823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MH430824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MH430825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MH430826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MW148998 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000073596   ⟹   ENSRNOP00000063977
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,500,844 - 182,505,008 (-)Ensembl
Rnor_6.0 Ensembl1199,337,138 - 199,341,302 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101446   ⟹   ENSRNOP00000087618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1182,500,844 - 182,504,595 (-)Ensembl
RefSeq Acc Id: NM_203335   ⟹   NP_976080
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81191,932,969 - 191,935,490 (-)NCBI
mRatBN7.21182,502,491 - 182,505,012 (-)NCBI
Rnor_6.01199,338,785 - 199,341,306 (-)NCBI
Rnor_5.01206,361,380 - 206,363,901 (-)NCBI
RGSC_v3.41187,176,745 - 187,179,266 (-)RGD
Celera1180,153,292 - 180,155,813 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_976080 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI66413 (Get FASTA)   NCBI Sequence Viewer  
  AAR82917 (Get FASTA)   NCBI Sequence Viewer  
  BAX00317 (Get FASTA)   NCBI Sequence Viewer  
  BAX00318 (Get FASTA)   NCBI Sequence Viewer  
  BAX00319 (Get FASTA)   NCBI Sequence Viewer  
  BAX00320 (Get FASTA)   NCBI Sequence Viewer  
  BAX00321 (Get FASTA)   NCBI Sequence Viewer  
  BAX00322 (Get FASTA)   NCBI Sequence Viewer  
  BAX00323 (Get FASTA)   NCBI Sequence Viewer  
  BAX00324 (Get FASTA)   NCBI Sequence Viewer  
  BAX00325 (Get FASTA)   NCBI Sequence Viewer  
  BAX00326 (Get FASTA)   NCBI Sequence Viewer  
  BAX00327 (Get FASTA)   NCBI Sequence Viewer  
  BAX00328 (Get FASTA)   NCBI Sequence Viewer  
  BAX00329 (Get FASTA)   NCBI Sequence Viewer  
  BAX00330 (Get FASTA)   NCBI Sequence Viewer  
  BAX00331 (Get FASTA)   NCBI Sequence Viewer  
  BAX00332 (Get FASTA)   NCBI Sequence Viewer  
  BAX00333 (Get FASTA)   NCBI Sequence Viewer  
  EDM17218 (Get FASTA)   NCBI Sequence Viewer  
  EDM17219 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000063977.1
GenBank Protein Q6TEK4 (Get FASTA)   NCBI Sequence Viewer  
  QBB72906 (Get FASTA)   NCBI Sequence Viewer  
  QBB72907 (Get FASTA)   NCBI Sequence Viewer  
  QBB72908 (Get FASTA)   NCBI Sequence Viewer  
  QBB72909 (Get FASTA)   NCBI Sequence Viewer  
  QBB72910 (Get FASTA)   NCBI Sequence Viewer  
  QBB72911 (Get FASTA)   NCBI Sequence Viewer  
  QBB72912 (Get FASTA)   NCBI Sequence Viewer  
  UQJ72509 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_976080   ⟸   NM_203335
- UniProtKB: Q6TEK4 (UniProtKB/Swiss-Prot),   B2GUU6 (UniProtKB/TrEMBL),   A6I9W1 (UniProtKB/TrEMBL),   A0A1S7IVH8 (UniProtKB/TrEMBL),   A0A1S7IVH9 (UniProtKB/TrEMBL),   A0A1S7IVI8 (UniProtKB/TrEMBL),   A0A1S7IVJ5 (UniProtKB/TrEMBL),   A0A1S7IVG2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063977   ⟸   ENSRNOT00000073596
Ensembl Acc Id: ENSRNOP00000087618   ⟸   ENSRNOT00000101446
Protein Domains
Vitamin K epoxide reductase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6TEK4-F1-model_v2 AlphaFold Q6TEK4 1-161 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690444
Promoter ID:EPDNEW_R969
Type:initiation region
Name:Vkorc1_1
Description:vitamin K epoxide reductase complex, subunit 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01199,341,313 - 199,341,373EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303107 AgrOrtholog
BioCyc Gene G2FUF-57331 BioCyc
BioCyc Pathway PWY-7999 [vitamin K-epoxide cycle] BioCyc
BioCyc Pathway Image PWY-7999 BioCyc
Ensembl Genes ENSRNOG00000050828 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000073596.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1440.130 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:9100951 IMAGE-MGC_LOAD
InterPro VKOR UniProtKB/Swiss-Prot
  VKOR_sf UniProtKB/Swiss-Prot
  VKORC1/VKORC1L1 UniProtKB/Swiss-Prot
KEGG Report rno:309004 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187297 IMAGE-MGC_LOAD
NCBI Gene 309004 ENTREZGENE
PANTHER PTHR14519 UniProtKB/Swiss-Prot
  VITAMIN K EPOXIDE REDUCTASE COMPLEX SUBUNIT 1 UniProtKB/Swiss-Prot
Pfam VKOR UniProtKB/Swiss-Prot
PharmGKB VKORC1 RGD
PhenoGen Vkorc1 PhenoGen
RatGTEx ENSRNOG00000050828 RatGTEx
SMART VKc UniProtKB/Swiss-Prot
UniProt A0A1S7IVG2 ENTREZGENE, UniProtKB/TrEMBL
  A0A1S7IVG9_RAT UniProtKB/TrEMBL
  A0A1S7IVH4_RAT UniProtKB/TrEMBL
  A0A1S7IVH6_RAT UniProtKB/TrEMBL
  A0A1S7IVH8 ENTREZGENE, UniProtKB/TrEMBL
  A0A1S7IVH9 ENTREZGENE, UniProtKB/TrEMBL
  A0A1S7IVI4_RAT UniProtKB/TrEMBL
  A0A1S7IVI8 ENTREZGENE, UniProtKB/TrEMBL
  A0A1S7IVJ5 ENTREZGENE, UniProtKB/TrEMBL
  A0A411HQX2_RAT UniProtKB/TrEMBL
  A0A411HQZ0_RAT UniProtKB/TrEMBL
  A0A411HR06_RAT UniProtKB/TrEMBL
  A0A411HR20_RAT UniProtKB/TrEMBL
  A0A411HR25_RAT UniProtKB/TrEMBL
  A6I9W1 ENTREZGENE
  A6I9W2_RAT UniProtKB/TrEMBL
  B2GUU6 ENTREZGENE, UniProtKB/TrEMBL
  Q6TEK4 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Vkorc1  vitamin K epoxide reductase complex, subunit 1      Symbol and Name status set to approved 1299863 APPROVED
2005-02-14 Vkorc1  vitamin K epoxide reductase complex, subunit 1  Rw  Warfarin resistance  Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Rw  Warfarin resistance      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutations of the human homolog are detected in individuals with combined deficiency of Vitamin K-dependent clotting factors type 2 (VKCFD2) and warfarin resistance (WR) 1303972
gene_mutations_overexpression Tyr139Cys mutation is associated with warfarin resistance in the Rw strain 1303972