Tmem35a (transmembrane protein 35A)

Gene: Tmem35a (transmembrane protein 35A) Rattus norvegicus

Analyze

Symbol:

Tmem35a

Name:

transmembrane protein 35A

RGD ID:

1303093

Description:

Enables acetylcholine receptor regulator activity. Involved in chaperone-mediated protein complex assembly and positive regulation of protein localization to cell surface. Predicted to be located in cytoplasmic vesicle; endoplasmic reticulum membrane; and peroxisomal membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human TMEM35A (transmembrane protein 35A); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-sulfonyldiphenol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

novel acetylcholine receptor chaperone; RSEP4; spinal cord expression protein 4; Tmem35; TMEM35 gene-derived unknown factor 1; transmembrane protein 35

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TMEM35A (transmembrane protein 35A)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Tmem35a (transmembrane protein 35A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tmem35a (transmembrane protein 35A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TMEM35A (transmembrane protein 35A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TMEM35A (transmembrane protein 35A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tmem35a (transmembrane protein 35A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TMEM35A (transmembrane protein 35A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TMEM35A (transmembrane protein 35A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tmem35a (transmembrane protein 35A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	TMEM35A (transmembrane protein 35A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Tmem35a (transmembrane protein 35A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tmem35 (transmembrane protein 35)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG13920	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	tmem35a	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	101,796,623 - 101,807,471 (+)	NCBI		GRCr8
mRatBN7.2	X	97,503,350 - 97,514,198 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	97,503,350 - 97,514,197 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	99,177,470 - 99,188,336 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	102,687,284 - 102,698,138 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	100,190,685 - 100,201,539 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	105,134,498 - 105,145,346 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	105,134,498 - 105,145,345 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	105,015,270 - 105,038,197 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	121,773,572 - 121,784,479 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	121,847,004 - 121,857,911 (+)	NCBI
Celera	X	98,544,846 - 98,555,696 (+)	NCBI		Celera
Cytogenetic Map	X	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

developmental and epileptic encephalopathy 9 (ISO)

isolated growth hormone deficiency type III (ISO)

ROLANDIC EPILEPSY, INTELLECTUAL DISABILITY, AND SPEECH DYSPRAXIA, X-LINKED (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

antirheumatic drug (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP)

bisphenol F (EXP)

Butylbenzyl phthalate (EXP)

carbon nanotube (ISO)

clobetasol (ISO)

dibutyl phthalate (EXP)

diethyl phthalate (EXP)

diisobutyl phthalate (EXP)

diisononyl phthalate (EXP)

dorsomorphin (ISO)

endosulfan (EXP)

furan (EXP)

ivermectin (ISO)

levonorgestrel (ISO)

methylmercury chloride (ISO)

ochratoxin A (EXP)

oxaliplatin (EXP)

ozone (ISO)

p-chloromercuribenzoic acid (ISO)

perfluorooctanoic acid (EXP)

phenylmercury acetate (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

Soman (EXP)

sunitinib (ISO)

testosterone undecanoate (ISO)

topotecan (EXP)

trichostatin A (ISO)

triptonide (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chaperone-mediated protein complex assembly (IBA,IMP,ISO)

positive regulation of protein localization to cell surface (IBA,IMP,ISO)

Cellular Component

cytoplasmic vesicle (IEA)

endoplasmic reticulum (IBA,ISO)

endoplasmic reticulum membrane (IEA)

peroxisomal membrane (IEA)

Molecular Function

acetylcholine receptor regulator activity (IBA,IMP,ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Brain α7 Nicotinic Acetylcholine Receptor Assembly Requires NACHO.	Gu S, etal., Neuron. 2016 Mar 2;89(5):948-55. doi: 10.1016/j.neuron.2016.01.018. Epub 2016 Feb 11.
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:20685870

Genomics

Comparative Map Data

Tmem35a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	101,796,623 - 101,807,471 (+)	NCBI		GRCr8
mRatBN7.2	X	97,503,350 - 97,514,198 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	97,503,350 - 97,514,197 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	99,177,470 - 99,188,336 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	102,687,284 - 102,698,138 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	100,190,685 - 100,201,539 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	105,134,498 - 105,145,346 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	105,134,498 - 105,145,345 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	105,015,270 - 105,038,197 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	121,773,572 - 121,784,479 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	121,847,004 - 121,857,911 (+)	NCBI
Celera	X	98,544,846 - 98,555,696 (+)	NCBI		Celera
Cytogenetic Map	X	q32	NCBI

TMEM35A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	101,078,879 - 101,096,367 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	101,078,879 - 101,096,367 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	100,333,868 - 100,351,356 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	100,220,519 - 100,238,009 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	100,140,007 - 100,157,498	NCBI
Celera	X	100,852,601 - 100,870,122 (+)	NCBI		Celera
Cytogenetic Map	X	q22.1	NCBI
HuRef	X	90,152,739 - 90,154,514 (+)	NCBI		HuRef
CHM1_1	X	100,226,956 - 100,244,443 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	99,522,299 - 99,539,787 (+)	NCBI		T2T-CHM13v2.0

Tmem35a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	133,195,974 - 133,206,718 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	133,195,974 - 133,206,718 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	134,295,225 - 134,305,969 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	134,295,225 - 134,305,969 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	130,829,764 - 130,840,508 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	129,641,575 - 129,652,319 (+)	NCBI		MGSCv36	mm8
Celera	X	117,173,994 - 117,184,692 (+)	NCBI		Celera
Cytogenetic Map	X	E3	NCBI
cM Map	X	56.06	NCBI

Tmem35a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955503	7,224,814 - 7,235,527 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955503	7,224,847 - 7,234,210 (+)	NCBI	ChiLan1.0	ChiLan1.0

TMEM35A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	100,677,259 - 100,694,839 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	100,680,919 - 100,698,844 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	90,280,549 - 90,298,080 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	100,415,789 - 100,432,897 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	100,415,789 - 100,432,897 (+)	Ensembl	panpan1.1		panPan2

TMEM35A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	75,020,157 - 75,033,714 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	75,020,238 - 75,032,525 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	X	76,434,049 - 76,447,584 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	76,434,105 - 76,447,582 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	74,002,267 - 74,015,798 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	75,662,576 - 75,676,109 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	75,425,102 - 75,438,638 (+)	NCBI		UU_Cfam_GSD_1.0

Tmem35a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	63,308,092 - 63,324,898 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936813	150,081 - 167,945 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936813	150,204 - 167,931 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMEM35A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	82,761,589 - 82,774,951 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	82,761,552 - 82,774,952 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	90,744,038 - 90,757,434 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TMEM35A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	89,421,634 - 89,432,905 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	89,421,693 - 89,432,899 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666065	14,339,200 - 14,355,449 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tmem35a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624902	1,500,874 - 1,513,127 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624902	1,501,186 - 1,513,036 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tmem35a
28 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	302
Count of miRNA genes:	187
Interacting mature miRNAs:	233
Transcripts:	ENSRNOT00000002058
Prediction methods:	Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61430	Cia18	Collagen induced arthritis QTL 18	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	14843113	120568734	Rat
1598837	Memor13	Memory QTL 13	3.2		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	41052407	146860749	Rat
738035	Stresp1	Stress response QTL 1	4.96	0.000011	stress-related behavior trait (VT:0010451)	defensive burying - coping	X	41304447	112935181	Rat
61431	Cia19	Collagen induced arthritis QTL 19	4.4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	65612192	120568734	Rat
724551	Glom1	Glomerulus QTL 1	2.8	0.0004	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	X	75294106	120294106	Rat
1598872	Memor14	Memory QTL 14	4.5		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	93956491	138956491	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium									70	6	4
Low	3	33	15	7		7	5	5	4	29	29	10	5
Below cutoff		10	41	33	16	33	3	6			7	1	3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001001799	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC094684	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY540309	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473969	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000002058 ⟹ ENSRNOP00000002058

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	97,503,350 - 97,514,197 (+)	Ensembl
Rnor_6.0 Ensembl	X	105,134,498 - 105,145,345 (+)	Ensembl

RefSeq Acc Id:

NM_001001799 ⟹ NP_001001799

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	101,796,623 - 101,807,471 (+)	NCBI
mRatBN7.2	X	97,503,350 - 97,514,198 (+)	NCBI
Rnor_6.0	X	105,134,498 - 105,145,346 (+)	NCBI
Rnor_5.0	X	105,015,270 - 105,038,197 (+)	NCBI
RGSC_v3.4	X	121,773,572 - 121,784,479 (+)	RGD
Celera	X	98,544,846 - 98,555,696 (+)	RGD

Sequence:

show sequence

TTGGGAGTTCCCGTCTCAGTTCAGGGCTTCTTTTAACTTCTGCACGATCCTTTACACAGGGAGG
TGCACGCGTAGGGCATTAGGACCCAGCGATTGTTGTAGTGAGAGTGGTTGAATCTCGATCTCTC
AATTTTTCTCTCCAGCTCCCTCCTCTCCCTTTGTCATTCTCTCTGCTGCCTCCGCGGCGTGCCT
CTAGCTCTCCCTGTGCTAACTGCCCGCGCCTTGACAGCCGGGCTGCGCAAAGCAGAGGGATTAG
TTGGGACCTGCCTTGGTGACCCCATGGCATCCCCACGAACCATAACTATTGTGGCCCTCTCTGT
GGCCCTGGGACTCTTCTTTGTTTTCATGGGGACTATCAAGTTGACCCCCAGGCTCAGCAAGGAT
GCCTACAGTGAGATGAAACGTGCTTACAAGAGCTATGTTCGAGCCCTTCCTCTGCTGAAGAAAA
TGGGCATTAATTCCATTCTCCTTCGGAAAAGCATTGGTGCGCTTGAAGTAGCCTGTGGCATTGT
CATGACCCTGGTACCCGGTCGTCCCAAAGATGTGGCCAACTTCTTCCTGCTCTTGCTGGTGTTG
GCTGTGCTTTTCTTCCACCAGCTGGTTGGCGATCCTCTCAAACGTTATGCCCATGCTCTGGTGT
TTGGAATCCTGCTCACCTGCCGCCTGCTGATTGCCCGCAAGCCTGAAGACCGGTCTTCTGAGAA
GAAGGCTTTGCCTGAGAGTGCAGAAGAGCAACCGTCCTTATATGAGAAGGCCCCACAGGGCAAA
GTGAAGGTGTCATAAAAATTGGAAGAGCAAAGAATGGACCTTCTAGGCAGTTGCTTCTTTGACA
CCCAAGATGACATTAGTGTGTATGTGTGTGTGTGTTTTCCTTTGATTTATTTATCTTGGGAGTA
AAGAGAAAAATACAATCTGTAAGTTACTTGGCTTGTGTACATCTATACCCTAAAATGACCTCCC
CACATTGACATCCGTGTGCCACCTTTAATCACTCTGGAGCAACATTCATCTTGCTGCATGTATA
TGTGTATGAATATAATTGAGGTGTATTTGTGAGATGGACTCCAGCAAGCATGTGACTGAGATTA
TGTGTGGGGGAACGTATATAACTGCCATGTGTGTGGGTATACACACACATATAGAGGAGGTTCA
GATCTTGAACTAATCCTGCACAAGTATCCTTCCCTCTATAAATTAATTCCAGCAAAGACAGAAT
AAAAGAACCATCCCGTAAAGAGAGTTGTTTCTGGTGGAAAACAAATAACCTAGTTTGATTCTTC
AAGCAATGCAGTAGGAGGGGTCTCCTTGCCTTTGTCCGAGCCCAAGCAACTGAGCTCTTTAGTG
GTTTCACATTCGATTCGTGACCTTTTACTAGACACCTTCAACTTTTGTTGTAAGCACAAAGCTG
CCCCACTTTACCATTATCAGCAGCCAACCAGGATCTGAAGCTTCCCCATCGTTTCCATTGAGGG
ACCAGAGATTGGTCCTGGTACAAGTTTCAATCTCCAGCCCTAGTGGTTTTCTGAAAGCTGTAAT
TGGATGGAGAAGCTATAGCCACTGTTTATCTGTAGGAAGAGTTCTCTACTGCTATTGATTCCCC
ACTGAACTTTGCTAAAGTTAACAAAGACCAAAACACCCCCTAGAAATGTCTATTTTACACCTCT
TCAGCATTCCAGAGGGTGGAGTTTAGCTGGGGGAGGACATTTGACATGGGTTAGTCAGATTGAC
CAGTATGGAAATTTGCTTTTGTAGTTAGTTACACACTGCTGTTTCTCTTGGTTAAATGTGCTTT
GATGGTTTTAATATTGTGCCAGGGATGGGAAACGGGGTGGGGTTGTGTGTGGGGAGAGTACTTC
CTGTATTTTCTTCAGTGCCATTGTTCTTGGTAATTGATACTTGTCTTCTTTCGCTCATTCTTTC
CAAATAAAGAGTTTTGAAATTTGGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001001799	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAT08467	(Get FASTA)	NCBI Sequence Viewer
	EDM07032	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000002058
	ENSRNOP00000002058.3
	ENSRNOP00055019834
	ENSRNOP00060030072
	ENSRNOP00065006946
GenBank Protein	Q6JAM9	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001001799 ⟸ NM_001001799
- UniProtKB:	Q6JAM9 (UniProtKB/Swiss-Prot), A6IVE8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MASPRTITIVALSVALGLFFVFMGTIKLTPRLSKDAYSEMKRAYKSYVRALPLLKKMGINSILL RKSIGALEVACGIVMTLVPGRPKDVANFFLLLLVLAVLFFHQLVGDPLKRYAHALVFGILLTCR LLIARKPEDRSSEKKALPESAEEQPSLYEKAPQGKVKVS hide sequence

RefSeq Acc Id:

ENSRNOP00000002058 ⟸ ENSRNOT00000002058

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6JAM9-F1-model_v2	AlphaFold	Q6JAM9	1-167	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303093	AgrOrtholog
BioCyc Gene	G2FUF-1690	BioCyc
Ensembl Genes	ENSRNOG00000001506	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOG00055014136	UniProtKB/Swiss-Prot
	ENSRNOG00060021106	UniProtKB/Swiss-Prot
	ENSRNOG00065006288	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000002058	ENTREZGENE
	ENSRNOT00000002058.5	UniProtKB/Swiss-Prot
	ENSRNOT00055024284	UniProtKB/Swiss-Prot
	ENSRNOT00060036540	UniProtKB/Swiss-Prot
	ENSRNOT00065009638	UniProtKB/Swiss-Prot
InterPro	TM35A/B	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:308134	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	308134	ENTREZGENE
PANTHER	NOVEL ACETYLCHOLINE RECEPTOR CHAPERONE	UniProtKB/TrEMBL
	PTHR13163	UniProtKB/Swiss-Prot
	PTHR13163:SF0	UniProtKB/Swiss-Prot
	SPINAL CORD EXPRESSION PROTEIN 4	UniProtKB/TrEMBL
PhenoGen	Tmem35a	PhenoGen
RatGTEx	ENSRNOG00000001506	RatGTEx
	ENSRNOG00055014136	RatGTEx
	ENSRNOG00060021106	RatGTEx
	ENSRNOG00065006288	RatGTEx
UniProt	A6IVE8	ENTREZGENE, UniProtKB/TrEMBL
	Q6JAM9	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-05-18	Tmem35a	transmembrane protein 35A	Tmem35	transmembrane protein 35	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Tmem35	transmembrane protein 35	RSEP4	spinal cord expression protein 4	Symbol and Name updated	1299863	APPROVED
2005-09-30	RSEP4				Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar