TMEM35A (transmembrane protein 35A)

Gene: TMEM35A (transmembrane protein 35A) Chlorocebus sabaeus

Analyze

Symbol:

TMEM35A

Name:

transmembrane protein 35A

RGD ID:

18599499

Description:

ENCODES a protein that exhibits acetylcholine receptor regulator activity (inferred); INVOLVED IN chaperone-mediated protein complex assembly (inferred); positive regulation of protein localization to cell surface (inferred); ASSOCIATED WITH autistic disorder (ortholog); developmental and epileptic encephalopathy 9 (ortholog); isolated growth hormone deficiency type III (ortholog); FOUND IN endoplasmic reticulum (inferred); endoplasmic reticulum membrane (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

transmembrane protein 35

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChlSab1.1 - Green Monkey 1.1 Assembly

Position:

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	89,421,634 - 89,432,905 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	89,421,693 - 89,432,899 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666065	14,339,200 - 14,355,449 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

developmental and epileptic encephalopathy 9 (ISO)

isolated growth hormone deficiency type III (ISO)

ROLANDIC EPILEPSY, INTELLECTUAL DISABILITY, AND SPEECH DYSPRAXIA, X-LINKED (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chaperone-mediated protein complex assembly (IEA)

positive regulation of protein localization to cell surface (IEA)

Cellular Component

endoplasmic reticulum (IEA)

endoplasmic reticulum membrane (IEA)

membrane (IEA)

Molecular Function

acetylcholine receptor regulator activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

TMEM35A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	89,421,634 - 89,432,905 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	89,421,693 - 89,432,899 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666065	14,339,200 - 14,355,449 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

TMEM35A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	101,078,879 - 101,096,367 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	101,078,879 - 101,096,367 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	100,333,868 - 100,351,356 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	100,220,519 - 100,238,009 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	100,140,007 - 100,157,498	NCBI
Celera	X	100,852,601 - 100,870,122 (+)	NCBI		Celera
Cytogenetic Map	X	q22.1	NCBI
HuRef	X	90,152,739 - 90,154,514 (+)	NCBI		HuRef
CHM1_1	X	100,226,956 - 100,244,443 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	99,522,299 - 99,539,787 (+)	NCBI		T2T-CHM13v2.0

Tmem35a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	133,195,974 - 133,206,718 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	133,195,974 - 133,206,718 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	134,295,225 - 134,305,969 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	134,295,225 - 134,305,969 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	130,829,764 - 130,840,508 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	129,641,575 - 129,652,319 (+)	NCBI		MGSCv36	mm8
Celera	X	117,173,994 - 117,184,692 (+)	NCBI		Celera
Cytogenetic Map	X	E3	NCBI
cM Map	X	56.06	NCBI

Tmem35a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	101,796,623 - 101,807,471 (+)	NCBI		GRCr8
mRatBN7.2	X	97,503,350 - 97,514,198 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	97,503,350 - 97,514,197 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	99,177,470 - 99,188,336 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	102,687,284 - 102,698,138 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	100,190,685 - 100,201,539 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	105,134,498 - 105,145,346 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	105,134,498 - 105,145,345 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	105,015,270 - 105,038,197 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	121,773,572 - 121,784,479 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	121,847,004 - 121,857,911 (+)	NCBI
Celera	X	98,544,846 - 98,555,696 (+)	NCBI		Celera
Cytogenetic Map	X	q32	NCBI

Tmem35a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955503	7,224,814 - 7,235,527 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955503	7,224,847 - 7,234,210 (+)	NCBI	ChiLan1.0	ChiLan1.0

TMEM35A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	100,677,259 - 100,694,839 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	100,680,919 - 100,698,844 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	90,280,549 - 90,298,080 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	100,415,789 - 100,432,897 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	100,415,789 - 100,432,897 (+)	Ensembl	panpan1.1		panPan2

TMEM35A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	75,020,157 - 75,033,714 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	75,020,238 - 75,032,525 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	X	76,434,049 - 76,447,584 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	76,434,105 - 76,447,582 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	74,002,267 - 74,015,798 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	75,662,576 - 75,676,109 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	75,425,102 - 75,438,638 (+)	NCBI		UU_Cfam_GSD_1.0

Tmem35a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	63,308,092 - 63,324,898 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936813	150,081 - 167,945 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936813	150,204 - 167,931 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TMEM35A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	82,761,589 - 82,774,951 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	82,761,552 - 82,774,952 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	90,744,038 - 90,757,434 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

Tmem35a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624902	1,500,874 - 1,513,127 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624902	1,501,186 - 1,513,036 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	hemolymphoid system	nervous system
High
Medium	16		54
Low	20	13	6
Below cutoff		7

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_007992271	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACDXN010000033	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCSAT00000008317 ⟹ ENSCSAP00000006465

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1 Ensembl	X	89,421,693 - 89,432,899 (+)	Ensembl

RefSeq Acc Id:

XM_007992271 ⟹ XP_007990462

Type:

CODING

Position:

Green Monkey Assembly	Chr	Position (strand)	Source
ChlSab1.1	X	89,421,634 - 89,432,905 (+)	NCBI
Vero_WHO_p1.0	NW_023666065	14,339,200 - 14,355,449 (+)	NCBI

Sequence:

show sequence

CGATCTCTCAATTTTTCTCTCGAGCTCCCTCCTCTCCCTTTGTCATTCTAGCTGCCTGCTGCCT
CCGCAGCGTCCCCCCAGCTCTCCCTGTGCTAAGTGCCTGCGCCTTGGACAGAGCGGTGCGCAAA
TCAGAAGGATTAGTTGGGACCTGCCTTGGCGACCACATGGCATCCCCCAGAACCGTAACTATTG
TGGCCCTCTCAGTGGCCCTGGGACTCTTCTTTGTTTTCATGGGGACTATCAAGTTGACCCCCAG
GCTCAGCAAGGATGCCTACAGTGAGATGAAACGTGCTTATAAGAGCTATGTTCGAGCCCTCCCT
CTGCTGAAGAAAATGGGGATCAATTCCATTCTCCTCCGAAAAAGCATTGGTGCCCTTGAGGTGG
CCTGTGGCATCGTCATGACCCTTGTGCCCGGGCGTCCCAAAGATGTGGCCAACTTCTTCCTACT
CTTGCTGGTGTTGGCTGTGCTCTTCTTCCACCAGCTGGTCGGTGATCCTCTCAAACGCTACGCC
CATGCTCTGGTGTTTGGAATCCTGCTCACCTGCCGCCTGCTGATTGCCCGCAAGCCTGAAGACC
GGTCTTCTGAGAAGAAGCCTTTGCCAGGGAATGCTGAGGAGCAACCCTCCTTATATGAGAAGGC
CCCTCAGGGCAAAGTGAAGGTGTCATAGGAAAGTGGAAGTACAAAGAGTGGACCTTCCAGGCAG
TTGTGTCCATGACACCAGGAAGATGTCAGTGTGTGTTTTTCATTTGATTTATTTATCTTGGGGA
AAGGGAAAAATGTAATCTGCAAGTTAATGACCCTATTGGCTTGTGTACATCTATATGCTAAAAT
GACTTCCCCACATTGACATTTGTGCACCACCTTTAATCACTCTGGGGCAACTCTCACATCTTGC
TGCATGTACATGTATATGGCTACTATTGAAGTGTAATTGTGAGATGGACTCCAACAAGCATTGT
GTGTGGGAAAATGTATTTAACTACTGTGCGTGTGTGTGTGTGTGTGTGTGTGTGCGCGCGCCCA
TGCATACACACACGAGCAGAGAAATCTCTGATCTTGAACTAATCCTGCACAGGCATCCTTCCCT
TTATAGATTGATTCCAGCAAAGGCAGAATAAAACAAATTTCCTATAAAGAGAATTCTGATATAA
AACAAGTCATGTAGTCCCATGGCCGGGAATCTCTCCACAGATGCTGAAAACTTAAACTTACTAC
TTTAGGAAAAAAAAAAAATTCAATTTCGGACACTGAGTTATATATGAAATTAATTAGGCTCTAT
TCCAACAGTTGTTTAAATTTTAAATAGTCCATATTGAGTTTAATTAAAACAAGGGATGCATGCA
GTCAAATTGATAATTTAATTCTTCAAGGGATAATATAGGAAGTTTCACCTTGCCTTTGTCCGAG
CCCCACCTATTAAACCCCTTTACTTACAGTTTGAAACTGAAGCAGTAAACTTGTTTCCAGATAT
CTTTTTCAGATTGTCTTAAGCCCAAAGTTGCCTCACTTCCACTATTCTCAGCAGCCAACCACGA
TTTGGCAGCTGCTCCACTGTTAGGGTTGAGGGAACAGGGATCAGTCCTATTAGAAGTCTGTGAG
TCTCAAACTCTACCTGTTCTCTGCAATCATCCAAAATTTGAAAAGGAAGTTATATCCAGTGTTT
CATTGCCAAACAGATTCACTACTCTTACTGATTCTTCACTGAGCTTTGCTAGTATAAGCAGAGT
TCCAAGTCCCCCCTAGGGGTTGTCTCTACACTTCTTTATCATTCCAGTGGGTGGAGTTTAGCTG
AGGGAAGGACATTTCATAAGGGTTAGTTGGACTGAGCAGTATGGGCATTTGCTTTTTTCATTAC
GTACTGTTGTTTTTCCTTGTTAGATGTGCTTTGGTGGTTTTAATATTGTGCCAGGGATGGGGAA
ATGGGTGGGGGGTGTGTGTGTGGGAAGAGTACTTATTATTGTGTTTTCTTCAGTGTAATTGTTC
TTGGTAATTGATACCTCTCTGTTTTATTTCTCTCATTCTTTCAAAATAAAACTTTTTGAAATTT
GGAGGAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_007990462	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCSAP00000006465
	ENSCSAP00000006465.1

RefSeq Acc Id:	XP_007990462 ⟸ XM_007992271
- UniProtKB:	A0A0D9RCX6 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCSAP00000006465 ⟸ ENSCSAT00000008317

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCSAG00000010229	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCSAT00000008317.1	UniProtKB/TrEMBL
InterPro	TM35A/B	UniProtKB/TrEMBL
KEGG Report	csab:103232352	UniProtKB/TrEMBL
NCBI Gene	TMEM35A	ENTREZGENE
PANTHER	PTHR13163	UniProtKB/TrEMBL
	PTHR13163:SF0	UniProtKB/TrEMBL
UniProt	A0A0D9RCX6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar