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Gene: Nop53 (NOP53 ribosome biogenesis factor) Rattus norvegicus

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Symbol:

Nop53

Name:

NOP53 ribosome biogenesis factor

RGD ID:

1303085

Description:

Predicted to enable 5S rRNA binding activity; identical protein binding activity; and p53 binding activity. Predicted to be involved in several processes, including protein localization to nucleus; regulation of intracellular signal transduction; and regulation of primary metabolic process. Predicted to be located in cytosol; nuclear lumen; and rDNA heterochromatin. Predicted to be active in nucleolus. Orthologous to human NOP53 (NOP53 ribosome biogenesis factor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; aristolochic acid A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

glioma tumor suppressor candidate region gene 2; glioma tumor suppressor candidate region gene 2 protein; Gltscr2; LOC292624; preS1 binding protein; ribosome biogenesis protein NOP53

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NOP53 (NOP53 ribosome biogenesis factor)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Nop53 (NOP53 ribosome biogenesis factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Nop53 (NOP53 ribosome biogenesis factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NOP53 (NOP53 ribosome biogenesis factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NOP53 (NOP53 ribosome biogenesis factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Nop53 (NOP53 ribosome biogenesis factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NOP53 (NOP53 ribosome biogenesis factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NOP53 (NOP53 ribosome biogenesis factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Nop53 (NOP53 ribosome biogenesis factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Nop53 (NOP53 ribosome biogenesis factor)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	NOP53 (NOP53 ribosome biogenesis factor)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Nop53 (NOP53 ribosome biogenesis factor)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG1785	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG1785	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	NOP53	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	NOP53	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	Y39B6A.33	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	nop53	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	nop53	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	85,757,271 - 85,765,089 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	85,756,586 - 85,765,089 (-)	Ensembl				GRCr8
mRatBN7.2	1	76,629,084 - 76,636,902 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	76,629,069 - 76,636,902 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	82,004,061 - 82,011,895 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	90,568,120 - 90,575,954 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	83,759,201 - 83,767,035 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	77,836,522 - 77,843,991 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	77,836,196 - 77,844,189 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	79,101,202 - 79,108,671 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	76,281,104 - 76,288,571 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	71,119,638 - 71,127,111 (-)	NCBI		Celera
RGSC_v3.1	1	76,359,212 - 76,366,682 (-)	NCBI
Cytogenetic Map	1	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

polycystic ovary syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

aristolochic acid A (EXP,ISO)

arsenous acid (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

buspirone (EXP)

Butylbenzyl phthalate (EXP)

caffeine (ISO)

calcium silicate (ISO)

carbon nanotube (ISO)

chloropicrin (ISO)

cisplatin (ISO)

clozapine (ISO)

cobalt dichloride (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

doxorubicin (ISO)

enzyme inhibitor (ISO)

ethanol (ISO)

fipronil (EXP)

glafenine (EXP)

GSK-J4 (ISO)

haloperidol (ISO)

ivermectin (ISO)

lead(0) (ISO)

okadaic acid (ISO)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenethyl isothiocyanate (EXP)

potassium chromate (ISO)

propiconazole (ISO)

resveratrol (ISO)

rotenone (EXP)

sodium arsenite (ISO)

temozolomide (ISO)

tetrachloroethene (ISO)

thimerosal (ISO)

thiram (ISO)

titanium dioxide (ISO)

tunicamycin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to hypoxia (IEA,ISO)

DNA damage response (IEA,ISO)

DNA repair (IEA,ISO)

mitotic G2 DNA damage checkpoint signaling (IEA,ISO)

negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (IEA,ISO)

negative regulation of proteasomal ubiquitin-dependent protein catabolic process (IEA,ISO)

negative regulation of protein-containing complex assembly (IEA,ISO)

negative regulation of signal transduction by p53 class mediator (IEA,ISO)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

negative regulation of transcription of nucleolar large rRNA by RNA polymerase I (IEA,ISO)

positive regulation of proteasomal ubiquitin-dependent protein catabolic process (IEA,ISO)

positive regulation of protein K63-linked deubiquitination (IEA,ISO)

protein localization to nucleolus (IEA,ISO)

protein localization to nucleoplasm (IEA,ISO)

protein stabilization (IEA,ISO)

regulation of aerobic respiration (IEA,ISO)

regulation of apoptotic process (IEA,ISO)

regulation of cell cycle (IEA,ISO)

regulation of protein phosphorylation (ISO)

regulation of RIG-I signaling pathway (IEA,ISO)

regulation of signal transduction by p53 class mediator (IEA,ISO)

ribosomal large subunit assembly (IBA,IEA,ISO)

ribosome biogenesis (IEA)

rRNA processing (IBA)

Cellular Component

cytosol (IEA,ISO)

fibrillar center (IEA,ISO)

nucleolus (IBA,IEA,ISO)

nucleoplasm (IEA,ISO)

rDNA heterochromatin (IEA,ISO)

Molecular Function

5S rRNA binding (IBA,IEA,ISO)

identical protein binding (IEA,ISO)

p53 binding (IEA,ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Regulation of PTEN phosphorylation and stability by a tumor suppressor candidate protein.	Okahara F, etal., J Biol Chem 2004 Oct 29;279(44):45300-3. Epub 2004 Sep 07.
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:16971513	PMID:20042497	PMID:21167305	PMID:21741933	PMID:21804542	PMID:22522597	PMID:22658674	PMID:22681889	PMID:24120868	PMID:24556985	PMID:24735870
PMID:24923447	PMID:25818168	PMID:25956029	PMID:27323397	PMID:27729611	PMID:27824081	PMID:27829214

Genomics

Comparative Map Data

Nop53
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	85,757,271 - 85,765,089 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	85,756,586 - 85,765,089 (-)	Ensembl				GRCr8
mRatBN7.2	1	76,629,084 - 76,636,902 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	76,629,069 - 76,636,902 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	82,004,061 - 82,011,895 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	90,568,120 - 90,575,954 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	83,759,201 - 83,767,035 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	77,836,522 - 77,843,991 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	77,836,196 - 77,844,189 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	79,101,202 - 79,108,671 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	76,281,104 - 76,288,571 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	71,119,638 - 71,127,111 (-)	NCBI		Celera
RGSC_v3.1	1	76,359,212 - 76,366,682 (-)	NCBI
Cytogenetic Map	1	q21	NCBI

NOP53
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	47,745,546 - 47,757,058 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	47,745,520 - 47,757,058 (+)	Ensembl			hg38	GRCh38
GRCh37	19	48,248,803 - 48,260,315 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	52,940,620 - 52,952,127 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	19	52,940,619 - 52,952,126	NCBI
Celera	19	45,054,495 - 45,066,024 (+)	NCBI		Celera
Cytogenetic Map	19	q13.33	NCBI
HuRef	19	44,675,424 - 44,686,829 (+)	NCBI		HuRef
CHM1_1	19	48,251,102 - 48,262,632 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	50,576,356 - 50,587,868 (+)	NCBI		T2T-CHM13v2.0

Nop53
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	15,671,760 - 15,680,033 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	15,670,108 - 15,679,999 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	7	15,937,835 - 15,946,108 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	15,936,183 - 15,946,074 (-)	Ensembl			mm10	GRCm38
MGSCv37	7	16,523,184 - 16,531,457 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	7	15,096,357 - 15,104,578 (-)	NCBI		MGSCv36	mm8
Celera	7	13,136,540 - 13,144,813 (-)	NCBI		Celera
Cytogenetic Map	7	A2	NCBI
cM Map	7	8.64	NCBI

Nop53
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955574	1,506,022 - 1,517,130 (+)	Ensembl
ChiLan1.0	NW_004955574	1,505,997 - 1,514,680 (+)	NCBI	ChiLan1.0	ChiLan1.0

NOP53
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	53,897,649 - 53,911,514 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	55,768,753 - 55,780,320 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	44,739,739 - 44,751,303 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	53,393,238 - 53,404,708 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2

NOP53
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	108,307,039 - 108,315,732 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	108,307,042 - 108,316,495 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	107,789,230 - 107,797,912 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	108,833,077 - 108,841,767 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	108,829,885 - 108,842,457 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	108,501,211 - 108,509,476 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	108,145,336 - 108,154,020 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	109,013,492 - 109,022,181 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Nop53
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	19,716,350 - 19,725,739 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936664	1,334,510 - 1,342,321 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936664	1,334,487 - 1,343,867 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NOP53
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	53,443,385 - 53,452,017 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	53,443,453 - 53,451,707 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	48,973,573 - 48,982,147 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NOP53
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	41,058,199 - 41,070,220 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	41,057,906 - 41,071,202 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666073	20,811,521 - 20,823,571 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nop53
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624832	6,145,749 - 6,154,411 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624832	6,144,260 - 6,154,172 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Nop53
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	2	173,007,697 - 173,015,678 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Nop53
37 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	115
Count of miRNA genes:	99
Interacting mature miRNAs:	105
Transcripts:	ENSRNOT00000017555
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331732	Srn4	Serum renin concentration QTL 4	4.467		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	1	43457837	87558729	Rat
1578649	Bmd8	Bone mineral density QTL 8	4.9		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	51940904	101229020	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	51941022	208479811	Rat
1358359	Sradr1	Stress Responsive Adrenal Weight QTL 1	4.74		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	1	39728272	132889942	Rat
4889929	Bss87	Bone structure and strength QTL 87	6.7		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	1	46302615	91302615	Rat
1331792	Rf29	Renal function QTL 29	4.589		urine potassium amount (VT:0010539)	urine potassium level (CMO:0000128)	1	43457837	87558729	Rat
2313062	Bmd73	Bone mineral density QTL 73	3.9	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	46302615	91302615	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	51940904	168768703	Rat
8552900	Pigfal1	Plasma insulin-like growth factor 1 level QTL 1	7.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	43509952	88509952	Rat
1354643	Foco2	Food consumption QTL 2	7.17	0.0001	eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	1	42122968	87122968	Rat
2313065	Bss67	Bone structure and strength QTL 67	3.1	0.0001	tibia area (VT:1000281)	tibia total energy absorbed before break (CMO:0001736)	1	46302615	91302615	Rat
7421628	Bp361	Blood pressure QTL 361		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	83019780	128019780	Rat
631495	Bp96	Blood pressure QTL 96	4.52		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	66404680	111404680	Rat
2313069	Bss68	Bone structure and strength QTL 68	2.9	0.0001	tibia size trait (VT:0100001)	tibia total energy absorbed before break (CMO:0001736)	1	46302615	91302615	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34184556	172281316	Rat
2313075	Bss66	Bone structure and strength QTL 66	3.4	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	46302615	91302615	Rat
631512	Scl6	Serum cholesterol level QTL 6	9.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	1	81269860	99645535	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	66009857	160501508	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	34565911	208798288	Rat
1331778	Rf28	Renal function QTL 28	4.66		urine potassium amount (VT:0010539)	urine potassium excretion rate (CMO:0000761)	1	43457837	87558729	Rat
2313077	Bss69	Bone structure and strength QTL 69	3.5	0.0001	tibia strength trait (VT:1000284)	bone polar moment of inertia (CMO:0001558)	1	46302615	91302615	Rat
1302788	Scl19	Serum cholesterol QTL 19	4.6	0.001	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	66400974	132889942	Rat
1549903	Bp267	Blood pressure QTL 267			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	84107164	115183752	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	51511344	153680016	Rat
1331785	Rf27	Renal function QTL 27	4.643		urine sodium amount (VT:0006274)	urine sodium level (CMO:0000129)	1	30708375	87558729	Rat
61342	Bp27	Blood pressure QTL 27	3.4	0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	65405637	96805205	Rat
4889962	Bss94	Bone structure and strength QTL 94	3.8		tibia area (VT:1000281)	tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)	1	51909206	91302615	Rat
6903308	Scl36	Serum cholesterol QTL 36	2	0.0125	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	58769992	103769992	Rat
2300164	Bmd44	Bone mineral density QTL 44	5.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	1	66077886	111077886	Rat
2313092	Bmd72	Bone mineral density QTL 72	2.5	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	1	46302615	91302615	Rat
2313097	Bss70	Bone structure and strength QTL 70	3.5	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	1	46302615	91302615	Rat
9589820	Insglur3	Insulin/glucose ratio QTL 3	10.75	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	1	43509952	88509952	Rat
152025249	Scl82	Serum cholesterol level QTL 82	4.77		blood cholesterol amount (VT:0000180)		1	52891222	109116986	Rat
1354599	Bw29	Body weight QTL 29	3.46	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	1	42122968	87122968	Rat
4889919	Bss86	Bone structure and strength QTL 86	4.1		tibia area (VT:1000281)	tibia midshaft total cross-sectional area (CMO:0001715)	1	46302615	91302615	Rat
8552948	Pigfal11	Plasma insulin-like growth factor 1 level QTL 11	4.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	1	43509952	88509952	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_207591	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY535002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC086359	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212888	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213201	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214363	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ215499	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218937	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219058	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ222789	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ235109	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000017555 ⟹ ENSRNOP00000017556

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	85,757,247 - 85,765,089 (-)	Ensembl
mRatBN7.2 Ensembl	1	76,629,084 - 76,636,902 (-)	Ensembl
Rnor_6.0 Ensembl	1	77,836,196 - 77,844,189 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000116606 ⟹ ENSRNOP00000096721

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	85,756,586 - 85,765,089 (-)	Ensembl
mRatBN7.2 Ensembl	1	76,629,069 - 76,636,902 (-)	Ensembl

RefSeq Acc Id:

NM_207591 ⟹ NP_997474

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	85,757,271 - 85,765,089 (-)	NCBI
mRatBN7.2	1	76,629,084 - 76,636,902 (-)	NCBI
Rnor_6.0	1	77,836,522 - 77,843,991 (-)	NCBI
Rnor_5.0	1	79,101,202 - 79,108,671 (-)	NCBI
RGSC_v3.4	1	76,281,104 - 76,288,571 (-)	RGD
Celera	1	71,119,638 - 71,127,111 (-)	NCBI

Sequence:

show sequence

ATGGCTGCGGGTAGTAACAGAGGCGGTGATAAGCGCGGCTCGAAAAGCCAGGCGGACTCTAACT
TTCTGGGGCTGCGGCCCACCTCGGTGGATCCCGCTCTGAGGCGGCGGCGGCGGGGCCCCAGAAA
CAAGAAGCGCGGCTGGAGGAGGCTCGCTGAGGAGCCGCTGGGGCTAGAGGTAGACCAGTTCCTG
GAAGATGTACGGCTACAAGAGCGCACGACCGGTGGCTTGTTGGCAGAGGCCCCAAATGAACAGC
TCTTCTTCGTGGACACTGGACTCAAGAAAAAAGAACCACGCAAGAAGAGGACCTGGGTCCAGAA
GAAGTCAAAGCATCTCCAGAAACCCCTACGGGTTGACCTTGCCCTTGAGAATCATTCTAAGATC
CCTGCTCCCAAAGACATCCTTGCACACCAGGTCCCCAATGCCAAAAAGCTCAGGCGAAAGGAGG
AGCTATGGGAGAAACTGGCAAAGCAGGGAGAGCTGCCCAGGGATGTGCGCAAGGCACAGGCCCG
GCTTCTTAACCCTCCTGCACCAAAGGCCAAACCTGGGCCCCAGGATATCATTGAGCGGCCCTTC
TATGACCTCTGGAACCCAAACAATCCTCTGGATAAGCCTTTGATCGGTCAGGATGCATTTTTTC
TGGAGCAGACCAAGAAGAAAGGTGTGAGGCGGCCACCACGACTCCACATCAAGCCTTCCCAGGT
GCCTGCGGTGGAAGTGATTCCTGCGGGAGCCTCCTACAACCCAACCTTTGAAGATCACCAGGCC
TTGCTTCTAGAGGCCCATGAGGTGGAGCTGCAGCGTGAGAAAGAGGCAGAAAAGCTGGAGCGAC
AGCTGGCCCTGCCCACTGCAGAGCAAGCTGCTACCCAGGAGTCCGTGTTTCGGGAGATGTGTGA
GGGCCTGCTCGAAGAGTCTGAGGATGAGGATGGGCCAGGCTGTGCTGAGCAGCCAGAGGCTGAC
GATGGGGCCACTGAGACCTCACCCACTGGTGCTGCTGGTCCTGAGAAGAGGATGGAGAAGAAGA
CAGAGCAGCAGCGGCGGCGGGAGAAGGCTGCTCGCAAGCTGCGGGTGCAGCAGGCTGCACTGAG
GGCAGCCCGGCTTCAGCACCAAGAACTCTTCAGGCTACGTGGGATCAAGGCCCAGGTGGCCCGG
AGGCTGGCAGAGCTGGCACGCCGGAAGGAGCAGCGGCGCATACGGCGACTGGCAGAGGCTGACA
AACCCCGAAGGCTGGGACGGCTCAAGTACCAGGCCCCTGACATTGATGTGCAGCTCAGCTCTGA
GCTATCTGACTCACTCAGGAAACTGAAGCCAGAAGGTAACATTCTCCGAGACAGGTTCAAAAGC
TTCCAGAAGAGAAATATGATTGAGCCCCGGGAACGAGCCAAGTTCAAGCGCAAATACAAAGTGA
AGCTGGTGGAGAAGCGGGCTTTCCGCGAGATTCAGTTGTAG

hide sequence

Protein Sequences


Protein RefSeqs	NP_997474	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH86359	(Get FASTA)	NCBI Sequence Viewer
	AAS46030	(Get FASTA)	NCBI Sequence Viewer
	EDM08347	(Get FASTA)	NCBI Sequence Viewer
	EDM08348	(Get FASTA)	NCBI Sequence Viewer
	EDM08349	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000017556
	ENSRNOP00000017556.3
	ENSRNOP00000096721.1

RefSeq Acc Id:

NP_997474 ⟸ NM_207591

- UniProtKB:

Q6QLN3 (UniProtKB/TrEMBL), A6J885 (UniProtKB/TrEMBL), A0A8I6AQV7 (UniProtKB/TrEMBL), A6J887 (UniProtKB/TrEMBL), F7ENW2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAGSNRGGDKRGSKSQADSNFLGLRPTSVDPALRRRRRGPRNKKRGWRRLAEEPLGLEVDQFL
EDVRLQERTTGGLLAEAPNEQLFFVDTGLKKKEPRKKRTWVQKKSKHLQKPLRVDLALENHSKI
PAPKDILAHQVPNAKKLRRKEELWEKLAKQGELPRDVRKAQARLLNPPAPKAKPGPQDIIERPF
YDLWNPNNPLDKPLIGQDAFFLEQTKKKGVRRPPRLHIKPSQVPAVEVIPAGASYNPTFEDHQA
LLLEAHEVELQREKEAEKLERQLALPTAEQAATQESVFREMCEGLLEESEDEDGPGCAEQPEAD
DGATETSPTGAAGPEKRMEKKTEQQRRREKAARKLRVQQAALRAARLQHQELFRLRGIKAQVAR
RLAELARRKEQRRIRRLAEADKPRRLGRLKYQAPDIDVQLSSELSDSLRKLKPEGNILRDRFKS
FQKRNMIEPRERAKFKRKYKVKLVEKRAFREIQL

hide sequence

Ensembl Acc Id:

ENSRNOP00000017556 ⟸ ENSRNOT00000017555

Ensembl Acc Id:

ENSRNOP00000096721 ⟸ ENSRNOT00000116606

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6QLN3-F1-model_v2	AlphaFold	Q6QLN3	1-482	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13689722

Promoter ID:

EPDNEW_R246

Type:

multiple initiation site

Name:

Nop53_1

Description:

NOP53 ribosome biogenesis factor

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	77,844,001 - 77,844,061	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303085	AgrOrtholog
BioCyc Gene	G2FUF-60632	BioCyc
Ensembl Genes	ENSRNOG00000013023	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000017555	ENTREZGENE
	ENSRNOT00000017555.7	UniProtKB/TrEMBL
	ENSRNOT00000116606.2	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7304013	IMAGE-MGC_LOAD
InterPro	P60-like	UniProtKB/TrEMBL
KEGG Report	rno:292624	UniProtKB/TrEMBL
MGC_CLONE	MGC:105253	IMAGE-MGC_LOAD
NCBI Gene	292624	ENTREZGENE
PANTHER	P60_like	UniProtKB/TrEMBL
	RIBOSOME BIOGENESIS PROTEIN NOP53	UniProtKB/TrEMBL
Pfam	Nop53	UniProtKB/TrEMBL
PhenoGen	Nop53	PhenoGen
PIRSF	Gltscr2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000013023	RatGTEx
UniProt	A0A8I6AQV7	ENTREZGENE, UniProtKB/TrEMBL
	A0ABZ3NN62_RAT	UniProtKB/TrEMBL
	A6J885	ENTREZGENE
	A6J887	ENTREZGENE, UniProtKB/TrEMBL
	F7ENW2	ENTREZGENE, UniProtKB/TrEMBL
	Q6QLN3	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	A6J885	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-03-27	Nop53	NOP53 ribosome biogenesis factor	Gltscr2	glioma tumor suppressor candidate region gene 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-11-17	Gltscr2	glioma tumor suppressor candidate region gene 2			Symbol updated	1299863	APPROVED
2005-02-14	LOC292624	glioma tumor suppressor candidate region gene 2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD