Rnase6 (ribonuclease A family member k6) - Rat Genome Database

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Gene: Rnase6 (ribonuclease A family member k6) Rattus norvegicus
Analyze
Symbol: Rnase6
Name: ribonuclease A family member k6
RGD ID: 1303020
Description: Predicted to enable RNA nuclease activity. Predicted to be involved in defense response to other organism. Predicted to be located in cytoplasmic vesicle. Predicted to be active in extracellular space. Orthologous to human RNASE6 (ribonuclease A family member k6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC103694852; LOC305842; ribonuclease K6; ribonuclease K6-like; ribonuclease, RNase A family, 6; ribonuclease, RNase A family, k6; RNase 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,827,896 - 26,830,807 (+)NCBIGRCr8
mRatBN7.21524,354,305 - 24,357,289 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,354,303 - 24,357,328 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1527,127,289 - 27,127,750 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,086,431 - 28,086,892 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,335,850 - 26,336,311 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,080,307 - 28,084,269 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,081,004 - 28,081,465 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01531,888,498 - 31,906,605 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,117,646 - 27,118,107 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11527,133,345 - 27,133,807 (+)NCBI
Celera1524,673,730 - 24,674,191 (+)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:9826755   PMID:23376485   PMID:25075772  


Genomics

Comparative Map Data
Rnase6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81526,827,896 - 26,830,807 (+)NCBIGRCr8
mRatBN7.21524,354,305 - 24,357,289 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1524,354,303 - 24,357,328 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1527,127,289 - 27,127,750 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,086,431 - 28,086,892 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,335,850 - 26,336,311 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,080,307 - 28,084,269 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,081,004 - 28,081,465 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01531,888,498 - 31,906,605 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,117,646 - 27,118,107 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11527,133,345 - 27,133,807 (+)NCBI
Celera1524,673,730 - 24,674,191 (+)NCBICelera
Cytogenetic Map15p14NCBI
RNASE6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381420,781,070 - 20,782,467 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1420,781,268 - 20,782,467 (+)EnsemblGRCh38hg38GRCh38
GRCh371421,249,427 - 21,250,626 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361420,319,050 - 20,320,466 (+)NCBINCBI36Build 36hg18NCBI36
Build 341420,319,049 - 20,320,464NCBI
Celera141,110,074 - 1,111,490 (+)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef141,370,222 - 1,371,638 (+)NCBIHuRef
CHM1_11421,251,198 - 21,252,614 (+)NCBICHM1_1
T2T-CHM13v2.01414,978,092 - 14,979,588 (+)NCBIT2T-CHM13v2.0
Rnase6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391451,361,365 - 51,369,644 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1451,361,365 - 51,369,644 (+)EnsemblGRCm39 Ensembl
GRCm381451,123,908 - 51,132,187 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1451,123,908 - 51,132,187 (+)EnsemblGRCm38mm10GRCm38
MGSCv371451,748,743 - 51,750,797 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361450,051,041 - 50,052,975 (+)NCBIMGSCv36mm8
Celera1447,424,272 - 47,426,326 (+)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1426.39NCBI
Rnase6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555501,687,068 - 1,688,160 (-)NCBIChiLan1.0ChiLan1.0
RNASE6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21522,278,035 - 22,279,920 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11421,494,353 - 21,496,407 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0141,642,819 - 1,644,582 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11419,699,881 - 19,701,303 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1419,700,536 - 19,700,988 (+)Ensemblpanpan1.1panPan2
LOC106559796
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11518,024,375 - 18,025,871 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1518,509,979 - 18,511,491 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01518,285,311 - 18,286,754 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11517,966,610 - 17,968,121 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01518,022,678 - 18,024,183 (+)NCBIUNSW_CanFamBas_1.0
Rnase6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864032,168,616 - 32,169,962 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493688078,081 - 79,021 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493688078,532 - 79,342 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RNASE6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl778,220,131 - 78,221,665 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1778,220,131 - 78,221,665 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RNASE6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12921,285,708 - 21,287,452 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2921,286,685 - 21,287,134 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605925,143,712 - 25,145,458 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rnase6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248254,468,213 - 4,469,566 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248254,468,213 - 4,469,557 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rnase6
23 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:305
Count of miRNA genes:181
Interacting mature miRNAs:207
Transcripts:ENSRNOT00000033739
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

hemolymphoid system
High
Medium
Low
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000033739   ⟹   ENSRNOP00000031392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1524,354,303 - 24,357,328 (+)Ensembl
Rnor_6.0 Ensembl1528,081,004 - 28,081,465 (-)Ensembl
RefSeq Acc Id: NM_206815   ⟹   NP_996538
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81526,829,645 - 26,830,106 (+)NCBI
mRatBN7.21524,356,131 - 24,356,592 (+)NCBI
Rnor_6.01528,081,004 - 28,081,465 (-)NCBI
Rnor_5.01531,888,498 - 31,906,605 (+)NCBI
RGSC_v3.41527,117,646 - 27,118,107 (+)RGD
Celera1524,673,730 - 24,674,191 (+)RGD
Sequence:
RefSeq Acc Id: XM_008773787   ⟹   XP_008772009
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81526,827,976 - 26,830,807 (+)NCBI
mRatBN7.21524,354,305 - 24,357,289 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008773788   ⟹   XP_008772010
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81526,827,896 - 26,830,807 (+)NCBI
mRatBN7.21524,354,313 - 24,357,289 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_996538 (Get FASTA)   NCBI Sequence Viewer  
  XP_008772009 (Get FASTA)   NCBI Sequence Viewer  
  XP_008772010 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAS48639 (Get FASTA)   NCBI Sequence Viewer  
  EDL88442 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000031392
  ENSRNOP00000031392.1
Reference Protein Sequences
RefSeq Acc Id: NP_996538   ⟸   NM_206815
- Peptide Label: precursor
- UniProtKB: Q6QDX6 (UniProtKB/TrEMBL),   F7ETH7 (UniProtKB/TrEMBL),   W0UTF7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000031392   ⟸   ENSRNOT00000033739
RefSeq Acc Id: XP_008772009   ⟸   XM_008773787
- Peptide Label: isoform X1
- UniProtKB: W0UTF7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008772010   ⟸   XM_008773788
- Peptide Label: isoform X2
- UniProtKB: Q6QDX6 (UniProtKB/TrEMBL),   F7ETH7 (UniProtKB/TrEMBL),   W0UTF7 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
Ribonuclease A-domain

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6QDX6-F1-model_v2 AlphaFold Q6QDX6 1-153 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303020 AgrOrtholog
BioCyc Gene G2FUF-14026 BioCyc
Ensembl Genes ENSRNOG00000025597 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033739.4 UniProtKB/TrEMBL
Gene3D-CATH 3.10.130.10 UniProtKB/TrEMBL
InterPro RNaseA UniProtKB/TrEMBL
  RNaseA-like_dom_sf UniProtKB/TrEMBL
  RNaseA_AS UniProtKB/TrEMBL
  RNaseA_domain UniProtKB/TrEMBL
KEGG Report rno:305842 UniProtKB/TrEMBL
NCBI Gene 305842 ENTREZGENE
PANTHER RIBONUCLEASE K6 UniProtKB/TrEMBL
  RNaseA UniProtKB/TrEMBL
Pfam RnaseA UniProtKB/TrEMBL
PharmGKB RNASE6 RGD
PhenoGen Rnase6 PhenoGen
PRINTS RIBONUCLEASE UniProtKB/TrEMBL
PROSITE RNASE_PANCREATIC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025597 RatGTEx
SMART RNAse_Pc UniProtKB/TrEMBL
Superfamily-SCOP RNaseA UniProtKB/TrEMBL
UniProt F7ETH7 ENTREZGENE, UniProtKB/TrEMBL
  Q6QDX6 ENTREZGENE, UniProtKB/TrEMBL
  W0UTF7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Rnase6  ribonuclease A family member k6  LOC103694852  ribonuclease K6-like  Data merged from RGD:9070017 737654 PROVISIONAL
2018-04-04 Rnase6  ribonuclease A family member k6  Rnase6  ribonuclease, RNase A family, 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103694852  ribonuclease K6-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-19 Rnase6  ribonuclease, RNase A family, 6  Rnase6  ribonuclease, RNase A family, k6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Rnase6  ribonuclease, RNase A family, k6  Rnase6  ribonuclease, RNase A family, 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-28   ribonuclease, RNase A family, 6  Rnase6  ribonuclease, RNase A family, k6  status set to approved 1299863 APPROVED
2005-01-11 Rnase6  ribonuclease, RNase A family, k6  LOC305842  RNase 6  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 PROVISIONAL