Rpl17 (ribosomal protein L17) - Rat Genome Database

Name: Rpl17
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Rpl17 (ribosomal protein L17) Rattus norvegicus

Analyze

Symbol:

Rpl17

Name:

ribosomal protein L17

RGD ID:

1303019

Description:

Enables large ribosomal subunit rRNA binding activity. Involved in cellular response to amino acid starvation and positive regulation of G1/S transition of mitotic cell cycle. Located in A band. Part of cytosolic large ribosomal subunit. Orthologous to human RPL17 (ribosomal protein L17); PARTICIPATES IN ribosome biogenesis pathway; translation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

60S ribosomal protein L17; amino acid starvation-induced; ASI; L23; large ribosomal subunit protein uL22; MGC112577; rpL23

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RPL17 (ribosomal protein L17)	HGNC	HomoloGene, Inparanoid, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Rpl17 (ribosomal protein L17)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RPL17 (ribosomal protein L17)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LOC106559613 (60S ribosomal protein L17-like)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rpl17 (ribosomal protein L17)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RPL17 (ribosomal protein L17)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RPL17 (ribosomal protein L17)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rpl17 (ribosomal protein L17)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	KLHL1 (kelch like family member 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	RPL17 (ribosomal protein L17)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Mus musculus (house mouse):	Rpl17 (ribosomal protein L17)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Danio rerio (zebrafish):	rpl17 (ribosomal protein L17)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rpl-17	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	RPL17A	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	RPL17B	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	RpL17	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rpl17	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|SonicParanoid)

Related Pseudogenes:

LOC121627837 Rpl17-ps1 Rpl17-ps11 Rpl17-ps16 Rpl17-ps17

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	70,856,275 - 70,859,388 (+)	NCBI		GRCr8
mRatBN7.2	18	68,581,141 - 68,584,253 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	68,581,098 - 68,584,253 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	70,693,899 - 70,697,012 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	71,362,454 - 71,365,566 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	69,219,915 - 69,223,028 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	70,969,733 - 70,972,839 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	70,970,596 - 70,975,494 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	70,108,978 - 70,112,084 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	71,863,062 - 71,866,168 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	71,936,262 - 71,939,366 (+)	NCBI
Celera	18	66,756,106 - 66,759,212 (+)	NCBI		Celera
Cytogenetic Map	18	q12.2	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

intellectual disability (ISO)

Myocardial Ischemia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (ISO)

(-)-demecolcine (ISO)

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-nitrofluorene (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one (EXP)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

6-propyl-2-thiouracil (EXP)

acrolein (ISO)

aflatoxin B1 (EXP)

alpha-pinene (ISO)

amiodarone (EXP)

ammonium chloride (EXP)

antimycin A (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

azoxystrobin (ISO)

benzbromarone (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

caffeine (ISO)

carbon nanotube (ISO)

chloropicrin (ISO)

chromium(6+) (ISO)

clofibrate (EXP)

copper(II) sulfate (ISO)

deguelin (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

dibenzo[a,l]pyrene (ISO)

diethylstilbestrol (EXP)

diquat (ISO)

disodium selenite (ISO)

diuron (ISO)

doxorubicin (ISO)

enzyme inhibitor (ISO)

ethanol (ISO)

fenpyroximate (ISO)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

fulvestrant (ISO)

gentamycin (EXP)

hydralazine (ISO)

indole-3-methanol (EXP)

indometacin (ISO)

ivermectin (ISO)

L-ethionine (EXP)

lead diacetate (EXP)

methapyrilene (EXP)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

miconazole (ISO)

N-nitrosodiethylamine (ISO)

N-nitrosodimethylamine (EXP)

nefazodone (EXP)

nimesulide (EXP)

omeprazole (EXP)

ozone (ISO)

paraquat (EXP)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

picoxystrobin (ISO)

piperonyl butoxide (EXP)

pirinixic acid (EXP)

pyrimidifen (ISO)

rotenone (ISO)

SB 431542 (ISO)

sodium arsenite (EXP,ISO)

sodium fluoride (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

tungsten (ISO)

valproic acid (ISO)

vincristine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to amino acid starvation (IEP)

cytoplasmic translation (IBA)

positive regulation of G1/S transition of mitotic cell cycle (IMP)

response to amino acid starvation (IEP)

Cellular Component

A band (IDA)

cytoplasm (ISO)

cytosolic large ribosomal subunit (IBA,IDA,ISO)

cytosolic ribosome (ISO)

synapse (ISO)

Molecular Function

large ribosomal subunit rRNA binding (IDA)

protein binding (ISO)

structural constituent of ribosome (IBA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

ribosome biogenesis pathway (ISO)

translation pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Structures of the human and Drosophila 80S ribosome.	Anger AM, etal., Nature. 2013 May 2;497(7447):80-5. doi: 10.1038/nature12104.
2.	Carbodiimide-induced protein--RNA crosslinking in mammalian ribosomal subunits.	Buisson M and Reboud AM, FEBS Lett. 1982 Nov 8;148(2):247-50.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Liver-specific induction of ribosomal protein gene expression by amino acid starvation in rats.	Hitomi Y, etal., Biosci Biotechnol Biochem. 1993 Jul;57(7):1216-7.
6.	Immunological localization of ribosomes in striated rat muscle. Evidence for myofibrillar association and ontological changes in the subsarcolemmal:myofibrillar distribution.	Horne Z and Hesketh J, Biochem J. 1990 May 15;268(1):231-6.
7.	Nuclear retention of the induced mRNA following amino acid-dependent transcriptional regulation of mammalian ribosomal proteins L17 and S25.	Laine RO, etal., J Biol Chem 1994 Apr 1;269(13):9693-7.
8.	Identification of an amino acid-regulated mRNA from rat liver as the mammalian equivalent of bacterial ribosomal protein L22.	Laine RO, etal., J Biol Chem. 1991 Sep 15;266(26):16969-72.
9.	GOA pipeline	RGD automated data pipeline
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Comprehensive gene review and curation	RGD comprehensive gene curation
12.	Molecular cloning of an amino acid-regulated mRNA (amino acid starvation-induced) in rat hepatoma cells.	Shay NF, etal., J Biol Chem 1990 Oct 15;265(29):17844-8.
13.	Ribosomal protein L17, RpL17, is an inhibitor of vascular smooth muscle growth and carotid intima formation.	Smolock EM, etal., Circulation. 2012 Nov 13;126(20):2418-27. doi: 10.1161/CIRCULATIONAHA.112.125971. Epub 2012 Oct 12.

Additional References at PubMed

PMID:2069571	PMID:12477932	PMID:12962325	PMID:16452087	PMID:16854843	PMID:21630459	PMID:22658674	PMID:22681889	PMID:30053369

Genomics

Comparative Map Data

Rpl17
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	18	70,856,275 - 70,859,388 (+)	NCBI		GRCr8
mRatBN7.2	18	68,581,141 - 68,584,253 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	68,581,098 - 68,584,253 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	18	70,693,899 - 70,697,012 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	18	71,362,454 - 71,365,566 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	18	69,219,915 - 69,223,028 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	18	70,969,733 - 70,972,839 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	70,970,596 - 70,975,494 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	70,108,978 - 70,112,084 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	71,863,062 - 71,866,168 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	71,936,262 - 71,939,366 (+)	NCBI
Celera	18	66,756,106 - 66,759,212 (+)	NCBI		Celera
Cytogenetic Map	18	q12.2	NCBI

RPL17
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	49,488,481 - 49,492,465 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	18	49,488,453 - 49,492,508 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	18	47,014,851 - 47,018,835 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	45,268,852 - 45,272,904 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	18	45,268,855 - 45,272,849	NCBI
Celera	18	43,870,209 - 43,874,262 (-)	NCBI		Celera
Cytogenetic Map	18	q21.1	NCBI
HuRef	18	43,868,521 - 43,872,605 (-)	NCBI		HuRef
CHM1_1	18	47,010,161 - 47,014,245 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	18	49,686,222 - 49,690,206 (-)	NCBI		T2T-CHM13v2.0

Rpl17
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	75,132,049 - 75,136,455 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	75,131,629 - 75,136,452 (+)	Ensembl		GRCm39 Ensembl
GRCm38	18	74,998,978 - 75,003,381 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	74,998,558 - 75,003,381 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	75,160,131 - 75,163,035 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	75,125,887 - 75,128,745 (+)	NCBI		MGSCv36	mm8
Celera	18	76,224,173 - 76,227,059 (+)	NCBI		Celera
Cytogenetic Map	18	E3	NCBI
cM Map	18	50.96	NCBI

RPL17
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	17	67,016,409 - 67,021,957 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	18	52,708,881 - 52,714,560 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	18	42,870,133 - 42,874,162 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	18	46,219,527 - 46,223,586 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	46,219,530 - 46,223,503 (-)	Ensembl	panpan1.1		panPan2

LOC106559613
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	12,340,847 - 12,341,465 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	12,330,621 - 12,331,238 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	13	12,625,937 - 12,626,538 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	13	12,377,599 - 12,378,201 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	13	12,477,158 - 12,477,759 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	13	12,575,254 - 12,575,855 (+)	NCBI		UU_Cfam_GSD_1.0

Rpl17
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	38,218,242 - 38,222,227 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936497	13,457,328 - 13,460,606 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RPL17
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	99,043,219 - 99,048,410 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	99,044,511 - 99,048,406 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	108,447,524 - 108,451,400 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RPL17
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	31,473,050 - 31,477,287 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666050	5,693,487 - 5,697,782 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rpl17
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624778	13,003,900 - 13,007,903 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624778	13,003,936 - 13,007,903 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Rpl17
28 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	23
Count of miRNA genes:	20
Interacting mature miRNAs:	23
Transcripts:	ENSRNOT00000025217
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578661	Bss20	Bone structure and strength QTL 20	3.7		femur morphology trait (VT:0000559)	femoral neck cross-sectional area (CMO:0001697)	18	11791518	83218561	Rat
1578667	Bss21	Bone structure and strength QTL 21	3.5		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	18	11791518	83218561	Rat
1600373	Mamtr6	Mammary tumor resistance QTL 6			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	18	19278901	83218561	Rat
1331741	Bp232	Blood pressure QTL 232	3.59112		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	21372893	83213037	Rat
1331733	Bp233	Blood pressure QTL 233	3.97196		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	24796977	79788953	Rat
2325839	Bp348	Blood pressure QTL 348		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	25570985	70570985	Rat
2293704	Bss35	Bone structure and strength QTL 35	4.59	0.0002	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	18	28964853	73964853	Rat
2300157	Bmd66	Bone mineral density QTL 66	13.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	18	28964853	73964853	Rat
2300177	Bmd65	Bone mineral density QTL 65	19.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	18	28964853	73964853	Rat
9589816	Gluco68	Glucose level QTL 68	7.25	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	29792965	74792965	Rat
8694378	Bw157	Body weight QTL 157	3.59	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	29792965	74792965	Rat
9590318	Scort22	Serum corticosterone level QTL 22	7.64	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	18	29792965	74792965	Rat
1331754	Bp230	Blood pressure QTL 230	4.61609		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	29792965	74792965	Rat
738005	Anxrr11	Anxiety related response QTL 11	3.4		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	18	30039813	75039813	Rat
61429	Cia17	Collagen induced arthritis QTL 17	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	18	31359408	70263868	Rat
2303120	Mamtr8	Mammary tumor resistance QTL 8		0.001	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	18	31359408	83218561	Rat
631274	Sprol1	Serum protein level QTL 1	5.3		blood total protein amount (VT:0005567)	serum total protein level (CMO:0000661)	18	31393320	77209694	Rat
631518	Bw11	Body weight QTL 11	2.8		body mass (VT:0001259)	body weight (CMO:0000012)	18	35870723	80870723	Rat
61367	Iddm4	Insulin dependent diabetes mellitus QTL 4	2.33	0.0074	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	18	38192455	83192455	Rat
1598826	Anxrr20	Anxiety related response QTL 20	3.04		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	18	41432971	83828827	Rat
6893683	Bw110	Body weight QTL 110	2.7	0.002	body mass (VT:0001259)	body weight (CMO:0000012)	18	43345022	83828827	Rat
8694366	Abfw8	Abdominal fat weight QTL 8	6.38	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	18	46640675	83828827	Rat
8694432	Bw165	Body weight QTL 165	3.81	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	18	46640675	83828827	Rat
9589041	Epfw12	Epididymal fat weight QTL 12	17.08	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	18	46640675	83828827	Rat
2303571	Bw92	Body weight QTL 92	3		body mass (VT:0001259)	body weight (CMO:0000012)	18	48520044	83828827	Rat
2303584	Gluco55	Glucose level QTL 55	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	18	48520044	83828827	Rat
738008	Hcar14	Hepatocarcinoma resistance QTL 14	4.3		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion number (CMO:0001462)	18	51464733	83218561	Rat
1359020	Ppulsi2	Prepulse inhibition QTL 2	2.71		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	18	52292875	73997283	Rat
631509	Sald2	Serum aldosterone level QTL 2	2.9		blood aldosterone amount (VT:0005346)	serum aldosterone level (CMO:0000487)	18	52539763	69140759	Rat
12880368	Bw187	Body weight QTL 187		0.045	body mass (VT:0001259)	body weight (CMO:0000012)	18	52539763	76104388	Rat
12904067	Cm122	Cardiac mass QTL 122		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	18	52539763	76104388	Rat
12904069	Cm123	Cardiac mass QTL 123		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	52539763	76104388	Rat
12904070	Cm124	Cardiac mass QTL 124		0.01	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	52539763	76104388	Rat
12904071	Am18	Aortic mass QTL 18		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	52539763	76104388	Rat
12904073	Kidm71	Kidney mass QTL 71		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	52539763	76104388	Rat
2301417	Bp319	Blood pressure QTL 319		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	52539763	76104388	Rat
1298072	Cia26	Collagen induced arthritis QTL 26	3.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	18	54709769	83828827	Rat
724542	Kidm2	Kidney mass QTL 2	2.6		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	18	59172115	83828827	Rat
2312600	Bp341	Blood pressure QTL 341		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	59330409	70263868	Rat
2301969	Bp324	Blood pressure QTL 324	4.05		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	59712417	76477814	Rat
70185	BpQTLcluster15	Blood pressure QTL cluster 15	4.61		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	59712417	76477814	Rat
70185	BpQTLcluster15	Blood pressure QTL cluster 15	4.61		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	59712417	76477814	Rat
70185	BpQTLcluster15	Blood pressure QTL cluster 15	4.61		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	18	59712417	76477814	Rat
70185	BpQTLcluster15	Blood pressure QTL cluster 15	4.61		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	18	59712417	76477814	Rat
1331770	Bp234	Blood pressure QTL 234	3.807		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	59796478	71893566	Rat
6903353	Bp353	Blood pressure QTL 353	2.8		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	59796478	83828827	Rat
6903356	Bp354	Blood pressure QTL 354	4.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	18	59796478	83828827	Rat
61384	Bp48	Blood pressure QTL 48	19.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	60622311	77209844	Rat
631675	Iddm15	Insulin dependent diabetes mellitus QTL 15			urine glucose amount (VT:0001758)	percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)	18	60622311	77209844	Rat

Markers in Region

BI286279

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	68,582,277 - 68,582,491 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	70,970,864 - 70,971,077	NCBI	Rnor6.0
Rnor_5.0	18	70,110,109 - 70,110,322	UniSTS	Rnor5.0
RGSC_v3.4	18	71,864,193 - 71,864,406	UniSTS	RGSC3.4
Celera	18	66,757,237 - 66,757,450	UniSTS
RH 3.4 Map	18	685.7	UniSTS
Cytogenetic Map	18	q12.3	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High	2	12	14	14	3	14			28	18	28	2
Medium	1	31	43	27	16	27	8	11	46	17	13	9	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_201415	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039096639	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277167	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063277168	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC135265	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098644	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474095	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211037	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ211890	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ221050	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ221111	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ221236	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ221445	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ221630	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ222545	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ222824	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223312	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223528	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223728	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224659	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ228520	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ228658	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ229921	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M60478	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X60212	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000025217 ⟹ ENSRNOP00000025217

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	68,581,098 - 68,584,253 (+)	Ensembl
Rnor_6.0 Ensembl	18	70,970,596 - 70,972,821 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000039203 ⟹ ENSRNOP00000034364

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	18	70,970,596 - 70,975,494 (+)	Ensembl

RefSeq Acc Id:

NM_201415 ⟹ NP_958818

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	70,856,276 - 70,859,388 (+)	NCBI
mRatBN7.2	18	68,581,141 - 68,584,253 (+)	NCBI
Rnor_6.0	18	70,969,733 - 70,972,839 (+)	NCBI
Rnor_5.0	18	70,108,978 - 70,112,084 (+)	NCBI
RGSC_v3.4	18	71,863,062 - 71,866,168 (+)	RGD
Celera	18	66,756,106 - 66,759,212 (+)	RGD

Sequence:

show sequence

CTGTTAGCGGCCAGAGGTGACCTGTGAAGATGGTTCGCTACTCCCTTGACCCAGAAAACCCCAC
GAAATCATGCAAGTCAAGAGGCTCAAACCTTCGTGTTCACTTTAAGAACACCCGGGAAACTGCC
CAGGCCATCAAGGGTATGCATATCCGCAAAGCCACCAAGTATCTGAAGGATGTCACTTTAAAGA
AGCAGTGTGTGCCATTCCGGCGGTATAACGGTGGAGTTGGTAGGTGCGCCCAGGCCAAACAGTG
GGGCTGGACACAGGGACGGTGGCCAAAAAAGAGTGCTGAATTTTTGCTGCACATGCTTAAAAAT
GCAGAGAGTAATGCTGAACTTAAGGGTTTGGATGTAGACTCTCTGGTCATTGAACACATCCAGG
TGAACAAGGCTCCTAAGATGCGCAGACGGACCTACAGAGCTCACGGCCGGATTAACCCATACAT
GAGCTCCCCCTGCCACATCGAAATGATCCTCACTGAGAAGGAACAGATTGTTCCAAAGCCAGAA
GAGGAGGTTGCACAGAAGAAAAAGATATCCCAGAAGAAATTGAAGAAACAAAAGCTCATGGCAC
GGGAATAAATTCAGCATAAATAAATGCGGATAAAGTAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039096639 ⟹ XP_038952567

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	70,856,290 - 70,859,388 (+)	NCBI
mRatBN7.2	18	68,581,372 - 68,584,253 (+)	NCBI

RefSeq Acc Id:

XM_063277167 ⟹ XP_063133237

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	70,856,312 - 70,859,388 (+)	NCBI

RefSeq Acc Id:

XM_063277168 ⟹ XP_063133238

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	18	70,856,275 - 70,859,388 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_958818	(Get FASTA)	NCBI Sequence Viewer
	XP_038952567	(Get FASTA)	NCBI Sequence Viewer
	XP_063133237	(Get FASTA)	NCBI Sequence Viewer
	XP_063133238	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA40765	(Get FASTA)	NCBI Sequence Viewer
	AAH98644	(Get FASTA)	NCBI Sequence Viewer
	CAA42765	(Get FASTA)	NCBI Sequence Viewer
	EDL82871	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000025217
	ENSRNOP00000025217.7
	ENSRNOP00000039774.5
	ENSRNOP00055012607
	ENSRNOP00060012033
	ENSRNOP00065031910
GenBank Protein	P24049	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_958818 ⟸ NM_201415
- UniProtKB:	Q4G093 (UniProtKB/Swiss-Prot), P24049 (UniProtKB/Swiss-Prot), D3Z9G9 (UniProtKB/TrEMBL), A6KRH3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVRYSLDPENPTKSCKSRGSNLRVHFKNTRETAQAIKGMHIRKATKYLKDVTLKKQCVPFRRYN GGVGRCAQAKQWGWTQGRWPKKSAEFLLHMLKNAESNAELKGLDVDSLVIEHIQVNKAPKMRRR TYRAHGRINPYMSSPCHIEMILTEKEQIVPKPEEEVAQKKKISQKKLKKQKLMARE hide sequence

RefSeq Acc Id:

ENSRNOP00000025217 ⟸ ENSRNOT00000025217

RefSeq Acc Id:

ENSRNOP00000034364 ⟸ ENSRNOT00000039203

RefSeq Acc Id:	XP_038952567 ⟸ XM_039096639
- Peptide Label:	isoform X1
- UniProtKB:	P24049 (UniProtKB/Swiss-Prot), Q4G093 (UniProtKB/Swiss-Prot), D3Z9G9 (UniProtKB/TrEMBL), A6KRH3 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063133238 ⟸ XM_063277168
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063133237 ⟸ XM_063277167
- Peptide Label:	isoform X1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P24049-F1-model_v2	AlphaFold	P24049	1-184	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303019	AgrOrtholog
BioCyc Gene	G2FUF-6995	BioCyc
Ensembl Genes	ENSRNOG00000018680	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOG00000029262	UniProtKB/TrEMBL
	ENSRNOG00055009279	UniProtKB/Swiss-Prot
	ENSRNOG00060009163	UniProtKB/Swiss-Prot
	ENSRNOG00065022991	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000025217	ENTREZGENE
	ENSRNOT00000025217.7	UniProtKB/Swiss-Prot
	ENSRNOT00000049695.5	UniProtKB/TrEMBL
	ENSRNOT00055015694	UniProtKB/Swiss-Prot
	ENSRNOT00060015433	UniProtKB/Swiss-Prot
	ENSRNOT00065039280	UniProtKB/Swiss-Prot
Gene3D-CATH	3.90.470.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7129700	IMAGE-MGC_LOAD
InterPro	Ribosomal_L22	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ribosomal_L22/L17_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ribosomal_L22/L17_euk/arc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ribosomal_L22/L17_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:291434	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:112577	IMAGE-MGC_LOAD
NCBI Gene	291434	ENTREZGENE
PANTHER	60S RIBOSOMAL PROTEIN L17	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	60S RIBOSOMAL PROTEIN L17	UniProtKB/TrEMBL
	PTHR11593	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Ribosomal_L22	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Rpl17	PhenoGen
PROSITE	RIBOSOMAL_L22	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000018680	RatGTEx
	ENSRNOG00000029262	RatGTEx
	ENSRNOG00055009279	RatGTEx
	ENSRNOG00060009163	RatGTEx
	ENSRNOG00065022991	RatGTEx
Superfamily-SCOP	SSF54843	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6KRH3	ENTREZGENE, UniProtKB/TrEMBL
	D3Z9G9	ENTREZGENE, UniProtKB/TrEMBL
	P24049	ENTREZGENE
	Q4G093	ENTREZGENE
	RL17_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	Q4G093	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-02-14	Rpl17	ribosomal protein L17			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

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RGD Manual Annotations