C20h6orf136 (similar to human chromosome 6 open reading frame 136) - Rat Genome Database

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Gene: C20h6orf136 (similar to human chromosome 6 open reading frame 136) Rattus norvegicus
Analyze
Symbol: C20h6orf136 (Ensembl: RGD1302996)
Name: similar to human chromosome 6 open reading frame 136 (Ensembl:RIKEN cDNA 2310061I04 gene)
RGD ID: 1302996
Description: Orthologous to human C6orf136 (chromosome 6 open reading frame 136); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC294231; hypothetical protein MGC15854; hypothetical protein MGC:15854; MGC108866; MGC15854; RGD1302996; uncharacterized protein C6orf136 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8202,862,567 - 2,866,756 (+)NCBIGRCr8
mRatBN7.2202,857,840 - 2,861,952 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx202,909,600 - 2,913,708 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0202,914,570 - 2,918,678 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0202,940,739 - 2,944,849 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,364,787 - 3,368,923 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,364,814 - 3,368,923 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0205,462,189 - 5,466,448 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,005,613 - 3,009,722 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1203,005,824 - 3,009,939 (+)NCBI
Celera20283,823 - 287,969 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
megacolon  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15060004   PMID:15489334   PMID:18614015  


Genomics

Comparative Map Data
C20h6orf136
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8202,862,567 - 2,866,756 (+)NCBIGRCr8
mRatBN7.2202,857,840 - 2,861,952 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx202,909,600 - 2,913,708 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0202,914,570 - 2,918,678 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0202,940,739 - 2,944,849 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0203,364,787 - 3,368,923 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl203,364,814 - 3,368,923 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0205,462,189 - 5,466,448 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,005,613 - 3,009,722 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1203,005,824 - 3,009,939 (+)NCBI
Celera20283,823 - 287,969 (+)NCBICelera
Cytogenetic Map20p12NCBI
C6orf136
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38630,647,133 - 30,653,207 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl630,647,039 - 30,653,210 (+)EnsemblGRCh38hg38GRCh38
GRCh37630,614,910 - 30,620,984 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36630,722,780 - 30,728,963 (+)NCBINCBI36Build 36hg18NCBI36
Build 34630,723,186 - 30,728,857NCBI
Celera632,212,933 - 32,219,096 (+)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef630,414,983 - 30,420,920 (+)NCBIHuRef
CHM1_1630,616,924 - 30,623,095 (+)NCBICHM1_1
T2T-CHM13v2.0630,511,313 - 30,517,381 (+)NCBIT2T-CHM13v2.0
2310061I04Rik
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391736,203,569 - 36,208,270 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1736,203,569 - 36,208,323 (-)EnsemblGRCm39 Ensembl
GRCm381735,892,677 - 35,897,378 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,892,677 - 35,897,431 (-)EnsemblGRCm38mm10GRCm38
MGSCv371736,029,622 - 36,034,323 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361735,500,730 - 35,505,444 (-)NCBIMGSCv36mm8
Celera1739,401,928 - 39,406,638 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.75NCBI
CUNH6orf136
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955583653,994 - 657,385 (+)NCBIChiLan1.0ChiLan1.0
C5H6orf136
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2545,207,246 - 45,213,196 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1641,170,646 - 41,176,404 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0630,391,980 - 30,397,749 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1631,261,960 - 31,267,646 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl631,262,032 - 31,267,457 (+)Ensemblpanpan1.1panPan2
C12H6orf136
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.112456,534 - 460,512 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl12456,657 - 460,510 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha12594,174 - 598,157 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.012599,757 - 603,738 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl12599,882 - 603,736 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.112457,426 - 461,411 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.012526,890 - 530,863 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.012595,503 - 599,468 (+)NCBIUU_Cfam_GSD_1.0
CUNH6orf136
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494633,955,018 - 33,958,977 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936837320,270 - 324,236 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936837320,138 - 324,236 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C7H6orf136
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,185,599 - 23,190,299 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1723,185,588 - 23,190,299 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2726,907,653 - 26,912,226 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CUNH6orf136
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11741,801,354 - 41,807,255 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604430,344,171 - 30,349,908 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CUNH6orf136
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475425,050,910 - 25,057,947 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475425,054,765 - 25,058,103 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in C20h6orf136
19 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:30
Interacting mature miRNAs:31
Transcripts:ENSRNOT00000001077
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724519Bp144Blood pressure QTL 1440.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2013624629Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat

Markers in Region
RH131668  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2202,861,662 - 2,861,856 (+)MAPPERmRatBN7.2
Rnor_6.0203,368,634 - 3,368,827NCBIRnor6.0
Rnor_5.0205,466,157 - 5,466,350UniSTSRnor5.0
RGSC_v3.4203,009,433 - 3,009,626UniSTSRGSC3.4
Celera20287,680 - 287,873UniSTS
RH 3.4 Map2052.1UniSTS
Cytogenetic Map20p12UniSTS
AI548047  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2202,857,364 - 2,857,528 (+)MAPPERmRatBN7.2
Rnor_6.0203,364,336 - 3,364,499NCBIRnor6.0
Rnor_5.0205,461,859 - 5,462,022UniSTSRnor5.0
RGSC_v3.4203,005,135 - 3,005,298UniSTSRGSC3.4
Celera20283,345 - 283,508UniSTS
RH 3.4 Map2052.1UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 18 18 2 18 3 66 27 33 1
Low 8 39 23 17 23 8 8 8 8 8 10 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001077   ⟹   ENSRNOP00000001077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,364,814 - 3,368,923 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000082425
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,367,077 - 3,367,749 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,367,110 - 3,368,919 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000085761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,365,421 - 3,366,242 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091149   ⟹   ENSRNOP00000071762
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl203,367,208 - 3,368,923 (+)Ensembl
RefSeq Acc Id: NM_213610   ⟹   NP_998775
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8202,862,647 - 2,866,756 (+)NCBI
mRatBN7.2202,857,843 - 2,861,952 (+)NCBI
Rnor_6.0203,364,814 - 3,368,923 (+)NCBI
Rnor_5.0205,462,189 - 5,466,448 (+)NCBI
RGSC_v3.4203,005,613 - 3,009,722 (+)RGD
Celera20283,823 - 287,969 (+)RGD
Sequence:
RefSeq Acc Id: XM_006255918   ⟹   XP_006255980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8202,862,644 - 2,866,756 (+)NCBI
mRatBN7.2202,857,840 - 2,861,952 (+)NCBI
Rnor_6.0203,364,787 - 3,368,923 (+)NCBI
Rnor_5.0205,462,189 - 5,466,448 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039098477   ⟹   XP_038954405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8202,862,567 - 2,866,756 (+)NCBI
mRatBN7.2202,857,854 - 2,861,952 (+)NCBI
RefSeq Acc Id: XM_039098479   ⟹   XP_038954407
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8202,862,567 - 2,866,756 (+)NCBI
mRatBN7.2202,857,842 - 2,861,952 (+)NCBI
RefSeq Acc Id: XM_063278996   ⟹   XP_063135066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8202,862,819 - 2,866,756 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_998775   ⟸   NM_213610
- UniProtKB: A6KT78 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255980   ⟸   XM_006255918
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000071762   ⟸   ENSRNOT00000091149
RefSeq Acc Id: ENSRNOP00000001077   ⟸   ENSRNOT00000001077
RefSeq Acc Id: XP_038954407   ⟸   XM_039098479
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038954405   ⟸   XM_039098477
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063135066   ⟸   XM_063278996
- Peptide Label: isoform X4
- UniProtKB: Q6MG12 (UniProtKB/Swiss-Prot),   A6KT79 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6MG12-F1-model_v2 AlphaFold Q6MG12 1-172 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701296
Promoter ID:EPDNEW_R11820
Type:initiation region
Name:RGD1302996_1
Description:hypothetical protein MGC:15854
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0203,364,795 - 3,364,855EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1302996 AgrOrtholog
BioCyc Gene G2FUF-4784 BioCyc
Ensembl Genes ENSRNOG00000000812 Ensembl
IMAGE_CLONE IMAGE:7373688 IMAGE-MGC_LOAD
InterPro DUF2358 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:294231 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108866 IMAGE-MGC_LOAD
NCBI Gene 294231 ENTREZGENE
PANTHER PTHR31094 UniProtKB/Swiss-Prot
  RIKEN CDNA 2310061I04 GENE UniProtKB/Swiss-Prot
  RIKEN CDNA 2310061I04 GENE UniProtKB/TrEMBL
  RIKEN CDNA 2310061I04 GENE UniProtKB/TrEMBL
Pfam DUF2358 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen C20h6orf136 PhenoGen
RatGTEx ENSRNOG00000000812 RatGTEx
UniProt A6KT78 ENTREZGENE, UniProtKB/TrEMBL
  A6KT79 ENTREZGENE, UniProtKB/TrEMBL
  CF136_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 C20h6orf136  similar to human chromosome 6 open reading frame 136  RGD1302996  hypothetical protein MGC:15854  Symbol and Name Changed 1299863 APPROVED
2005-11-17 RGD1302996  hypothetical protein MGC:15854  MGC15854  hypothetical protein MGC15854  Symbol and Name updated 1299863 APPROVED
2005-09-30 MGC15854        Symbol and Name status set to provisional 70820 PROVISIONAL