Lag3 (lymphocyte activating 3) - Rat Genome Database

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Gene: Lag3 (lymphocyte activating 3) Rattus norvegicus
Analyze
Symbol: Lag3
Name: lymphocyte activating 3
RGD ID: 1302990
Description: Predicted to enable MHC class II protein binding activity and transmembrane signaling receptor activity. Predicted to be involved in several processes, including innate immune response; negative regulation of regulatory T cell differentiation; and plasmacytoid dendritic cell activation. Predicted to act upstream of or within negative regulation of T cell activation; negative regulation of interleukin-2 production; and positive regulation of natural killer cell mediated cytotoxicity. Predicted to be located in external side of plasma membrane and extracellular region. Predicted to be active in cell surface and plasma membrane. Orthologous to human LAG3 (lymphocyte activating 3); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CD223; LAG-3; LOC297596; lymphocyte activation gene 3 protein; lymphocyte-activation gene 3; MGC108901
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,398,930 - 159,407,001 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4159,398,932 - 159,406,669 (-)EnsemblGRCr8
mRatBN7.24157,712,665 - 157,722,229 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,712,667 - 157,720,404 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4163,940,943 - 163,948,668 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,723,860 - 159,731,590 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,359,232 - 158,367,008 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,425,644 - 157,433,700 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,425,644 - 157,433,467 (-)Ensemblrn6Rnor6.0
Rnor_5.04224,443,422 - 224,451,485 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44161,031,506 - 161,039,255 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4146,449,946 - 146,457,685 (-)NCBICelera
RGSC_v3.14161,276,441 - 161,284,191 (-)NCBI
Cytogenetic Map4q42NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells. Workman CJ and Vignali DA, Eur J Immunol 2003 Apr;33(4):970-9.
Additional References at PubMed
PMID:8602528   PMID:9159144   PMID:12209638   PMID:12421911   PMID:12477932   PMID:15009174   PMID:15485628   PMID:15489334   PMID:17245433   PMID:17785860   PMID:18091527   PMID:19201841  
PMID:30580966  


Genomics

Comparative Map Data
Lag3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84159,398,930 - 159,407,001 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4159,398,932 - 159,406,669 (-)EnsemblGRCr8
mRatBN7.24157,712,665 - 157,722,229 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4157,712,667 - 157,720,404 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4163,940,943 - 163,948,668 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04159,723,860 - 159,731,590 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04158,359,232 - 158,367,008 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04157,425,644 - 157,433,700 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4157,425,644 - 157,433,467 (-)Ensemblrn6Rnor6.0
Rnor_5.04224,443,422 - 224,451,485 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44161,031,506 - 161,039,255 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4146,449,946 - 146,457,685 (-)NCBICelera
RGSC_v3.14161,276,441 - 161,284,191 (-)NCBI
Cytogenetic Map4q42NCBI
LAG3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38126,772,520 - 6,778,455 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl126,772,360 - 6,778,455 (+)Ensemblhg38GRCh38
GRCh37126,881,686 - 6,887,621 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36126,751,931 - 6,757,880 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34126,751,930 - 6,757,880NCBI
Celera128,498,967 - 8,504,918 (+)NCBICelera
Cytogenetic Map12p13.31NCBI
HuRef126,735,007 - 6,740,958 (+)NCBIHuRef
CHM1_1126,880,658 - 6,886,609 (+)NCBICHM1_1
T2T-CHM13v2.0126,782,086 - 6,788,021 (+)NCBIT2T-CHM13v2.0
Lag3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396124,881,322 - 124,888,668 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6124,881,324 - 124,888,668 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm386124,904,359 - 124,912,434 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6124,904,361 - 124,911,705 (-)Ensemblmm10GRCm38
MGSCv376124,854,377 - 124,861,723 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv366124,869,980 - 124,877,324 (-)NCBIMGSCv36mm8
Celera6126,580,475 - 126,587,853 (-)NCBICelera
Cytogenetic Map6F2NCBI
cM Map659.17NCBI
Lag3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554134,378,972 - 4,385,909 (+)Ensembl
ChiLan1.0NW_0049554134,379,529 - 4,385,456 (+)NCBIChiLan1.0ChiLan1.0
LAG3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21012,335,059 - 12,341,070 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11212,331,815 - 12,337,845 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0126,903,770 - 6,909,778 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1126,817,143 - 6,823,112 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl126,817,507 - 6,823,047 (+)EnsemblpanPan2panpan1.1
LAG3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12738,260,673 - 38,266,771 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2738,260,674 - 38,265,819 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha278,349,842 - 8,355,893 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02738,613,389 - 38,619,438 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2738,613,390 - 38,619,087 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12738,487,367 - 38,493,411 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02738,528,603 - 38,534,658 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0277,829,072 - 7,835,123 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Lag3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945102,374,004 - 102,381,088 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367091,041,530 - 1,047,280 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367091,041,519 - 1,048,630 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LAG3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl563,929,625 - 63,935,410 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1563,929,669 - 63,935,054 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2566,364,099 - 66,369,484 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LAG3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1116,809,381 - 6,815,390 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl116,809,584 - 6,815,325 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660631,408,483 - 1,414,491 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lag3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248603,456,347 - 3,461,592 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248603,454,587 - 3,461,649 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Lag3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1622,975,811 - 22,984,277 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Lag3
53 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:43
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000028965
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4146370897184426481Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4134095016179095016Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4149763204169799698Rat
6478757Anxrr44Anxiety related response QTL 440.01087locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4146370897184426481Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4131384565176384565Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4123870974168870974Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4140059299181024663Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4117559384162559384Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4157292416184426481Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4127263297172263297Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4126334185171334185Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4147299608184426481Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
6478782Anxrr52Anxiety related response QTL 520.02091locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4124700988169700988Rat
6478720Alc23Alcohol consumption QTL 230.00509drinking behavior trait (VT:0001422)ethanol drink intake rate to body weight ratio (CMO:0001616)4155834926184426481Rat
6478785Anxrr53Anxiety related response QTL 530.01397locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1581566Eae21Experimental allergic encephalomyelitis QTL 216.2body mass (VT:0001259)maximum body weight loss to initial body weight ratio (CMO:0001400)4137447185182447185Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4137430611182430611Rat
6478728Anxrr36Anxiety related response QTL 360.01061locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4134199006168870974Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4148121375176967367Rat
6478733Anxrr37Anxiety related response QTL 370.00095locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4123870974168870974Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4140059299184426481Rat
6478737Anxrr38Anxiety related response QTL 380.00159locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4155834926184426481Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146370897184426481Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4148834094168870974Rat

Markers in Region
RH131051  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24157,721,378 - 157,721,566 (+)MAPPERmRatBN7.2
Rnor_6.04157,434,366 - 157,434,553NCBIRnor6.0
Rnor_5.04224,452,134 - 224,452,321UniSTSRnor5.0
RGSC_v3.44161,040,228 - 161,040,415UniSTSRGSC3.4
Celera4146,458,658 - 146,458,845UniSTS
RH 3.4 Map41004.3UniSTS
Cytogenetic Map4q42UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 9 67 161 91 90 59 92 59 6 353 191 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000028965   ⟹   ENSRNOP00000036771
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4159,398,932 - 159,406,669 (-)Ensembl
mRatBN7.2 Ensembl4157,712,667 - 157,720,404 (-)Ensembl
Rnor_6.0 Ensembl4157,425,644 - 157,433,467 (-)Ensembl
RefSeq Acc Id: NM_212513   ⟹   NP_997678
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,398,930 - 159,406,669 (-)NCBI
mRatBN7.24157,712,665 - 157,720,404 (-)NCBI
Rnor_6.04157,425,644 - 157,433,393 (-)NCBI
Rnor_5.04224,443,422 - 224,451,485 (-)NCBI
RGSC_v3.44161,031,506 - 161,039,255 (-)RGD
Celera4146,449,946 - 146,457,685 (-)RGD
Sequence:
RefSeq Acc Id: XM_039107451   ⟹   XP_038963379
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,398,930 - 159,406,997 (-)NCBI
mRatBN7.24157,712,665 - 157,722,229 (-)NCBI
RefSeq Acc Id: XM_039107452   ⟹   XP_038963380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84159,399,923 - 159,407,001 (-)NCBI
mRatBN7.24157,713,660 - 157,722,229 (-)NCBI
RefSeq Acc Id: NP_997678   ⟸   NM_212513
- Peptide Label: precursor
- UniProtKB: Q5BK54 (UniProtKB/Swiss-Prot),   A6ILM9 (UniProtKB/TrEMBL),   Q6XJQ1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000036771   ⟸   ENSRNOT00000028965
RefSeq Acc Id: XP_038963379   ⟸   XM_039107451
- Peptide Label: isoform X1
- UniProtKB: Q5BK54 (UniProtKB/Swiss-Prot),   A6ILM9 (UniProtKB/TrEMBL),   Q6XJQ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963380   ⟸   XM_039107452
- Peptide Label: isoform X2
Protein Domains
Ig-like   Ig-like C2-type   Ig-like V-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BK54-F1-model_v2 AlphaFold Q5BK54 1-525 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693396
Promoter ID:EPDNEW_R3920
Type:multiple initiation site
Name:Lag3_1
Description:lymphocyte activating 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04157,433,520 - 157,433,580EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1302990 AgrOrtholog
BioCyc Gene G2FUF-43055 BioCyc
Ensembl Genes ENSRNOG00000021334 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028965 ENTREZGENE
  ENSRNOT00000028965.6 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7380279 IMAGE-MGC_LOAD
InterPro Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_sub2 UniProtKB/Swiss-Prot
  IL-1_rcpt_fam UniProtKB/Swiss-Prot
  Immunoglobulin UniProtKB/Swiss-Prot
KEGG Report rno:297596 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108901 IMAGE-MGC_LOAD
NCBI Gene 297596 ENTREZGENE
PANTHER LYMPHOCYTE ACTIVATION GENE 3 PROTEIN UniProtKB/Swiss-Prot
  PTHR11890 UniProtKB/Swiss-Prot
Pfam Ig_2 UniProtKB/Swiss-Prot
  PF00047 UniProtKB/Swiss-Prot
PhenoGen Lag3 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021334 RatGTEx
SMART IGc2 UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt A6ILM9 ENTREZGENE, UniProtKB/TrEMBL
  LAG3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6XJQ1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Lag3  lymphocyte activating 3  Lag3  lymphocyte-activation gene 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Lag3  lymphocyte-activation gene 3  LOC297596  LAG-3  Symbol and Name updated 1299863 APPROVED
2005-02-14 LOC297596  LAG-3      Symbol and Name status set to provisional 70820 PROVISIONAL