Advanced Search (OLGA)

Gene: Pla2g15 (phospholipase A2, group XV) Rattus norvegicus

Analyze

Symbol:

Pla2g15

Name:

phospholipase A2, group XV

RGD ID:

1302982

Description:

Enables O-acyltransferase activity and calcium-independent phospholipase A2 activity. Involved in ceramide metabolic process and phosphatidylcholine metabolic process. Predicted to be located in extracellular region; membrane; and nucleoplasm. Predicted to be active in extracellular space and lysosome. Orthologous to human PLA2G15 (phospholipase A2 group XV); PARTICIPATES IN glycerophospholipid metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

1-O-acylceramide synthase; 1-O-acylceramidesynthase; ACS; group XV phospholipase A2; LCAT-like lysophospholipase; LLPL; LOC361401; LPLA2; Lypla3; lysophospholipase 3; lysosomal phospholipase A and acyltransferase; lysosomal phospholipase A2; MGC114208; phospholipase A2 group XV

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PLA2G15 (phospholipase A2 group XV)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Pla2g15 (phospholipase A2, group XV)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pla2g15 (phospholipase A2 group XV)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PLA2G15 (phospholipase A2 group XV)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PLA2G15 (phospholipase A2 group XV)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pla2g15 (phospholipase A2 group XV)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PLA2G15 (phospholipase A2 group XV)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PLA2G15 (phospholipase A2 group XV)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pla2g15 (phospholipase A2 group XV)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Pla2g15 (phospholipase A2 group XV)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	BNIP3L (BCL2 interacting protein 3 like)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	PLA2G15 (phospholipase A2 group XV)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pla2g15 (phospholipase A2, group XV)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pla2g15 (phospholipase A2, group XV)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG18858	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	LRO1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector)
Saccharomyces cerevisiae (baker's yeast):	LRO1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	M05B5.4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG31683	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pla2g15	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pla2g15	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	50,960,568 - 50,977,948 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	50,960,598 - 50,977,946 (+)	Ensembl				GRCr8
mRatBN7.2	19	34,050,685 - 34,068,070 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	34,050,694 - 34,068,063 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	40,866,356 - 40,883,643 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	41,519,663 - 41,536,951 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	43,818,810 - 43,836,097 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	38,129,666 - 38,146,958 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	38,129,584 - 38,146,956 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	48,996,419 - 49,013,716 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	35,997,758 - 36,015,531 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	33,478,138 - 33,495,415 (+)	NCBI		Celera
RGSC_v3.1	19	36,002,666 - 36,019,035 (+)	NCBI
Cytogenetic Map	19	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

arteriosclerosis (ISO)

COVID-19 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

amiodarone (ISO)

benzo[a]pyrene (ISO)

beta-hexachlorocyclohexane (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (ISO)

C60 fullerene (EXP)

cadmium atom (EXP)

cadmium dichloride (EXP)

capsaicin (EXP)

carbon nanotube (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

Dibutyl phosphate (ISO)

doxorubicin (ISO)

endosulfan (EXP)

ethyl methanesulfonate (ISO)

fenthion (ISO)

fentin chloride (EXP)

finasteride (EXP)

flutamide (EXP)

GW 7647 (EXP)

lead(0) (ISO)

lipopolysaccharide (ISO)

methimazole (EXP)

methyl methanesulfonate (ISO)

monosodium L-glutamate (ISO)

okadaic acid (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

pirinixic acid (ISO)

rotenone (EXP,ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (EXP,ISO)

sodium arsenate (ISO)

sodium benzoate (ISO)

sulfadimethoxine (EXP)

tamoxifen (ISO)

testosterone (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

ceramide metabolic process (IBA,IDA,IEA,ISO)

diacylglycerol biosynthetic process (IEA,ISO,ISS)

fatty acid metabolic process (IEA)

glycerophospholipid metabolic process (IEA,ISO,ISS)

lipid metabolic process (IEA)

phosphatidylcholine catabolic process (IEA,ISO,ISS)

phosphatidylcholine metabolic process (IBA,IEA,IMP,ISO,ISS)

phosphatidylethanolamine catabolic process (IEA,ISO,ISS)

phosphatidylglycerol metabolic process (IEA,ISO,ISS)

phosphatidylserine metabolic process (IEA,ISO,ISS)

Cellular Component

extracellular region (IEA)

extracellular space (IBA,IEA,ISO,ISS)

lysosome (IBA,IEA,ISO,ISS)

membrane (IEA)

Molecular Function

A2-type glycerophospholipase activity (IEA,ISO)

acylglycerol O-acyltransferase activity (IEA,ISO,ISS)

acyltransferase activity (IEA)

glycerophospholipid phospholipase A1 activity (IEA,ISO,ISS)

hydrolase activity (IEA)

metal ion binding (IEA)

O-acyltransferase activity (IBA,IDA,IEA,ISO)

obsolete calcium-independent phospholipase A2 activity (ISO)

phosphatidylcholine lysophospholipase A1 activity (IEA)

protein binding (ISO)

transferase activity (IEA)

zinc ion binding (IEA,ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

glycerophospholipid metabolic pathway (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Lysosomal phospholipase A2 is selectively expressed in alveolar macrophages.	Abe A, etal., J Biol Chem 2004 Oct 8;279(41):42605-11. Epub 2004 Aug 04.
2.	Lysosomal-type PLA2 and turnover of alveolar DPPC.	Fisher AB and Dodia C, Am J Physiol Lung Cell Mol Physiol. 2001 Apr;280(4):L748-54.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Loss of lysophospholipase 3 increases atherosclerosis in apolipoprotein E-deficient mice.	Taniyama Y, etal., Biochem Biophys Res Commun. 2005 Apr 29;330(1):104-10.

Additional References at PubMed

PMID:11790796	PMID:12477932	PMID:16837646	PMID:16880524	PMID:17626977	PMID:18614015	PMID:20410020	PMID:23376485	PMID:23533145	PMID:24006456	PMID:29514215

Genomics

Comparative Map Data

Pla2g15
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	50,960,568 - 50,977,948 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	50,960,598 - 50,977,946 (+)	Ensembl				GRCr8
mRatBN7.2	19	34,050,685 - 34,068,070 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	34,050,694 - 34,068,063 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	40,866,356 - 40,883,643 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	41,519,663 - 41,536,951 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	43,818,810 - 43,836,097 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	38,129,666 - 38,146,958 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	38,129,584 - 38,146,956 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	48,996,419 - 49,013,716 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	35,997,758 - 36,015,531 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	33,478,138 - 33,495,415 (+)	NCBI		Celera
RGSC_v3.1	19	36,002,666 - 36,019,035 (+)	NCBI
Cytogenetic Map	19	q12	NCBI

PLA2G15
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	68,245,373 - 68,261,058 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	68,245,304 - 68,261,063 (+)	Ensembl			hg38	GRCh38
GRCh37	16	68,279,276 - 68,294,961 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	66,836,748 - 66,852,462 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	16	66,836,776 - 66,852,460	NCBI
Celera	16	52,787,740 - 52,803,454 (+)	NCBI		Celera
Cytogenetic Map	16	q22.1	NCBI
HuRef	16	54,152,349 - 54,167,959 (+)	NCBI		HuRef
CHM1_1	16	69,687,284 - 69,702,994 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	74,041,120 - 74,056,809 (+)	NCBI		T2T-CHM13v2.0

Pla2g15
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	106,876,986 - 106,891,350 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	106,877,031 - 106,891,347 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	106,150,354 - 106,164,718 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	106,150,399 - 106,164,715 (+)	Ensembl			mm10	GRCm38
MGSCv37	8	108,674,299 - 108,688,615 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	109,039,528 - 109,053,844 (+)	NCBI		MGSCv36	mm8
Celera	8	110,378,173 - 110,392,489 (+)	NCBI		Celera
Cytogenetic Map	8	D3	NCBI
cM Map	8	53.1	NCBI

Pla2g15
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955484	8,386,274 - 8,412,952 (-)	Ensembl
ChiLan1.0	NW_004955484	8,386,274 - 8,412,952 (-)	NCBI	ChiLan1.0	ChiLan1.0

PLA2G15
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	77,782,345 - 77,806,080 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	83,693,645 - 83,717,372 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	48,612,240 - 48,635,721 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	68,006,108 - 68,030,808 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	68,006,105 - 68,030,812 (+)	Ensembl			panPan2	panpan1.1

PLA2G15
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	81,269,914 - 81,280,700 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	81,269,920 - 81,280,700 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	81,260,068 - 81,270,848 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	81,704,925 - 81,715,711 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	81,704,925 - 81,715,773 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	81,531,643 - 81,542,423 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	81,214,083 - 81,224,865 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	81,855,603 - 81,866,386 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Pla2g15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	41,004,137 - 41,017,549 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936475	18,571,516 - 18,585,009 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936475	18,571,599 - 18,584,977 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PLA2G15
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	28,820,668 - 28,832,767 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	28,820,620 - 28,832,768 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

PLA2G15
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	59,160,396 - 59,184,472 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	59,160,100 - 59,177,709 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666047	21,895,979 - 21,921,026 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pla2g15
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	18,048,246 - 18,063,291 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624746	18,048,370 - 18,063,297 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Pla2g15
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	17	25,887,964 - 25,905,615 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Pla2g15
68 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	210
Count of miRNA genes:	137
Interacting mature miRNAs:	178
Transcripts:	ENSRNOT00000026996
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8552935	Pigfal10	Plasma insulin-like growth factor 1 level QTL 10	5.7		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	19	7997750	52997750	Rat
61447	Tcas1	Tongue tumor susceptibility QTL 1	6.08		tongue integrity trait (VT:0010553)	squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)	19	19220689	64220689	Rat
9590298	Uminl5	Urine mineral level QTL 5	3.59	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	19	7997750	52997750	Rat
724546	Kidm3	Kidney mass QTL 3	3.1		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	19	46226778	74246245	Rat
631840	Niddm38	Non-insulin dependent diabetes mellitus QTL 38	3.86		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	19	10329076	74246245	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	32365311	74246245	Rat
724518	Uae19	Urinary albumin excretion QTL 19	5.5		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	24093973	69093973	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	36289	74246245	Rat
2303628	Vencon9	Ventilatory control QTL 9		0.005	respiration trait (VT:0001943)	minute ventilation (CMO:0000132)	19	23188586	68188586	Rat
61423	Cia14	Collagen induced arthritis QTL 14	3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	19	10833618	74246245	Rat
2313395	Anxrr26	Anxiety related response QTL 26			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	19	44385134	74246245	Rat
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	32539615	74246245	Rat
1558656	Prcs1	Prostate cancer susceptibility QTL 1	5		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	19	31287532	51431640	Rat
1331788	Rf45	Renal function QTL 45	2.818		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	19	31777888	74246245	Rat
9590250	Scort11	Serum corticosterone level QTL 11	23.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	19	7997750	52997750	Rat
9590090	Insglur8	Insulin/glucose ratio QTL 8	10.81	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	19	7997750	52997750	Rat
1554318	Bmd5	Bone mineral density QTL 5	12.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	19	23188586	68188586	Rat
1354607	Gmadr1	Adrenal mass QTL 1	5.83		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	19	40727092	54856850	Rat
2317848	Alcrsp21	Alcohol response QTL 21	1.899999976158142	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	19	20109306	65109306	Rat
1354600	Salc2	Saline consumption QTL 2	9.91	0.001	drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	19	40727092	54856850	Rat
1549835	Tcas7	Tongue tumor susceptibility QTL 7		0.001	tongue integrity trait (VT:0010553)	squamous cell carcinoma of the head and neck tumor number (CMO:0001876)	19	41722546	74246245	Rat
7247442	Uae39	Urinary albumin excretion QTL 39			urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	19	2194317	74246245	Rat
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2194317	74246245	Rat
1354633	Bw28	Body weight QTL 28	6.04		body mass (VT:0001259)	body weight (CMO:0000012)	19	40727092	54856850	Rat

Markers in Region

RH130126

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	34,067,789 - 34,067,987 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	38,146,678 - 38,146,875	NCBI	Rnor6.0
Rnor_5.0	19	49,013,436 - 49,013,633	UniSTS	Rnor5.0
RGSC_v3.4	19	36,015,251 - 36,015,448	UniSTS	RGSC3.4
Celera	19	33,495,135 - 33,495,332	UniSTS
RH 3.4 Map	19	317.8	UniSTS
Cytogenetic Map	19	q12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	163	91	90	59	92	59	6	356	192	11	142	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001004277	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097856	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC128800	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY490816	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098894	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000026996 ⟹ ENSRNOP00000026996

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	50,960,598 - 50,977,946 (+)	Ensembl
mRatBN7.2 Ensembl	19	34,050,694 - 34,068,063 (+)	Ensembl
Rnor_6.0 Ensembl	19	38,129,584 - 38,146,956 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000139025 ⟹ ENSRNOP00000102313

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	50,963,382 - 50,977,945 (+)	Ensembl

RefSeq Acc Id:

NM_001004277 ⟹ NP_001004277

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	50,960,656 - 50,977,948 (+)	NCBI
mRatBN7.2	19	34,050,773 - 34,068,070 (+)	NCBI
Rnor_6.0	19	38,129,666 - 38,146,958 (+)	NCBI
Rnor_5.0	19	48,996,419 - 49,013,716 (+)	NCBI
RGSC_v3.4	19	35,997,758 - 36,015,531 (+)	RGD
Celera	19	33,478,138 - 33,495,415 (+)	RGD

Sequence:

show sequence

CTTGGACCTGCGGCCACAGTCTCATGCCATGGATCGCCATCTCTGCATTTGTCGCGAGATCCAG
CTCCGGAGTGGCCTCCTGTTCCCTTTTCTTCTACTAATGATGCTGGCAGACCTAGCGCTCCCGG
CCCAACGTCACCCCCCGGTGGTGCTGGTGCCTGGTGATTTGGGTAACCAGTTGGAAGCAAAGCT
GGATAAGCCAAAGGTTGTACACTACCTGTGCTCCAAGAGGACGGACAGTTACTTCACACTCTGG
CTGAATCTTGAACTGCTCCTGCCAGTTATCATTGACTGCTGGATTGACAATATCAGGCTGGTTT
ACAACAGAACATCTCGGACTACCCAGTTTCCTGATGGTGTAGATGTGCGTGTTCCTGGCTTTGG
GGAAACATTTTCTCTGGAATTCCTAGACCCAAGCAAAAGGAACGTGGGTTCCTATTTCTACACT
ATGGTGGAGAGTCTTGTGGGCTGGGGCTACACACGGGGGGAAGATGTCCGTGGTGCTCCCTATG
ATTGGCGCAGAGCCCCAAATGAAAACGGGCCTTACTTCTTGGCCCTCCAAGAGATGATCGAGGA
GATGTACCAGATGTATGGGGGCCCCGTGGTGCTGGTCGCCCACAGCATGGGCAACATGTACATG
CTCTACTTTCTGCAGCGGCAACCACAGGCCTGGAAGGACAAGTATATCCAAGCCTTCGTCTCAC
TGGGTGCGCCCTGGGGGGGCGTGGCCAAGACCCTGCGTGTCCTGGCCTCAGGAGACAACAACCG
TATCCCTGTCATTGGGCCACTGAAGATCCGGGAACAGCAGCGATCTGCAGTCTCCACCAGCTGG
CTACTGCCGTACAACCACACGTGGTCACATGAAAAGGTGTTTGTGTACACACCCACAGCTAACT
ACACACTCCGGGACTATCACCGGTTCTTCCAAGACATCGGCTTTGAAGACGGCTGGTTCATGAG
GCAGGACACACAAGGGCTGGTGGAAGCCCTGGTACCGCCTGGTGTAGAGCTGCACTGCCTGTAC
GGGACCGGTGTTCCCACACCAAACTCTTTCTACTACGAGAACTTTCCTGATCGTGACCCAAAAA
TCTGCTTTGGGGATGGTGACGGCACAGTGAACTTGGAGAGTGTCCTGCAGTGCCAAGCCTGGCA
GAGCCGCCAAGAGCACAAAGTGTCATTGCAGGAGCTGCCAGGGAGCGAACACATTGAGATGCTG
GCCAATGCCACTACCTTGGCTTATCTGAAACGTGTGCTTCTAGAAGAACCTTGATTTCCTGTGC
CAGGCAAGGCTGCTGCATGGCTGGACCACGGAGCTTCTCTTGGCCTCTCTGACTCTTTCATGGT
CTGCAAACCTGGCAAAGTTTGTGACCGTCATCCAAGGTCCTAAGTCTTAGGAGGCATCTGCCTC
AGGGGAAATGCTATTTCTCAACCTTCTTATGTAGAATGGCAATGAAGAAGGAAGAAGAAGTGAG
TGTGGACTCAGAGGACATTTGATGGAAAGAATGCTGCTACTGATGCTGAATTGTGACCTCACGC
TGGCTCTGGAGGCTGGATTGTTTGTCCCTAACTTGGGCCATGCAATCCTCTTATCTTCTCTGGT
CTTTCTACTCTAGCTCACTGGGCCCTAGCCTTCCTGTGAGTGAGGGATGTTAGTTACTGAGCTG
ACGTCCTGTCATAGAAGGTTCCACAGAGATCCTCGGGTGACCTTCCCCCATACTGGCCTCAGGT
TGCCTACTGCACTGGCCGTAGGTGGCTAGAGCTGCTGGCTTCCCTGTGACCTCACTGGTAGGCA
TTCTGAGTGTGGGGTCTTCTGGAGGCAGTCAGGTAAACCCCCTGCAGGCAGGGCAGTTGGTCGT
GTCTCCCTGATTCCTTCGGGTTGGGTTATTTACAGTCCGTTCCTACCTCTCATTTAGTGGCATC
CTAGCTCTGGACTGGACAGCAGAGGACCTCTCAATTCTGGGGGCCATGTCCTAGGATTCCTGAT
CTCCCTGCCCGTGATGCAGGTTCCAGTACTGAAGCTGGTTCTGTTGGTTCTGGGACTGTAGTTT
AAGAGGGGCGGGGCCTAATGTCATGCCTTCTCTTAAGGTCCTAGGAAGAAAACGAGCTCAAGGG
AATAACCATGCTTGCTTAGAGCTTCCCATGAGCCACCTTCTTGAGAATTCCACCACCATGGTGC
GCCCTGCTCTGGGGCCTTTCTACCATCTACTTGGGCTGTCACAGGGTTGAGAGGTGGTAGAGTC
CCTGCCCAACACTTGCTACCAGCTGAATGGGTTTTGGTTTGCGGGGAAACAGTCCAGAGATTTG
AAAGGGCCCCCAAGAGAGCTAGGAACTTAGAGTCCCAGCTAGGGGCTTTTGTTTGTTTGTCCCA
GGGATGCCACATAGTCTCTGTGACAGCAGGGATGGGGAATCTCGGCCTGCCTTAGGGACAGTGG
ACCTGACTATAAGCTTGGATCAGCTTTTAGGTCAGGGTCTCAAAACCACTTGGAGGCTGGACCA
CACTGCCTTCCCATACCGTTTCTGGCGCTGGACTTACCTTGTTAAGCACATTCCTATCATCTGT
CCCTCACCTGAGTGGTGGGACCCCCACTCTGGGTCCTGAGCAAGCTGTACCTCGATTTTGGCAA
TAAAAGTATTCTGGATGCTGTAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039097856 ⟹ XP_038953784

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	50,960,568 - 50,977,948 (+)	NCBI
mRatBN7.2	19	34,050,685 - 34,068,070 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001004277	(Get FASTA)	NCBI Sequence Viewer
	XP_038953784	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98894	(Get FASTA)	NCBI Sequence Viewer
	AAS66767	(Get FASTA)	NCBI Sequence Viewer
	EDL92440	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000026996
	ENSRNOP00000026996.4
GenBank Protein	Q675A5	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_001004277 ⟸ NM_001004277
- Peptide Label:	precursor
- UniProtKB:	Q675A5 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MDRHLCICREIQLRSGLLFPFLLLMMLADLALPAQRHPPVVLVPGDLGNQLEAKLDKPKVVHYL CSKRTDSYFTLWLNLELLLPVIIDCWIDNIRLVYNRTSRTTQFPDGVDVRVPGFGETFSLEFLD PSKRNVGSYFYTMVESLVGWGYTRGEDVRGAPYDWRRAPNENGPYFLALQEMIEEMYQMYGGPV VLVAHSMGNMYMLYFLQRQPQAWKDKYIQAFVSLGAPWGGVAKTLRVLASGDNNRIPVIGPLKI REQQRSAVSTSWLLPYNHTWSHEKVFVYTPTANYTLRDYHRFFQDIGFEDGWFMRQDTQGLVEA LVPPGVELHCLYGTGVPTPNSFYYENFPDRDPKICFGDGDGTVNLESVLQCQAWQSRQEHKVSL QELPGSEHIEMLANATTLAYLKRVLLEEP hide sequence

Ensembl Acc Id:

ENSRNOP00000026996 ⟸ ENSRNOT00000026996

RefSeq Acc Id:	XP_038953784 ⟸ XM_039097856
- Peptide Label:	isoform X1
- UniProtKB:	A6IYW2 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000102313 ⟸ ENSRNOT00000139025

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q675A5-F1-model_v2	AlphaFold	Q675A5	1-413	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701105

Promoter ID:

EPDNEW_R11628

Type:

multiple initiation site

Name:

Pla2g15_1

Description:

phospholipase A2, group XV

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	19	38,129,644 - 38,129,704	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1302982	AgrOrtholog
BioCyc Gene	G2FUF-5786	BioCyc
Ensembl Genes	ENSRNOG00000019859	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000026996	ENTREZGENE
	ENSRNOT00000026996.6	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.50.1820	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7099635	IMAGE-MGC_LOAD
InterPro	AB_hydrolase	UniProtKB/Swiss-Prot
	LACT/PDAT_acylTrfase	UniProtKB/Swiss-Prot
KEGG Report	rno:361401	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:114208	IMAGE-MGC_LOAD
NCBI Gene	361401	ENTREZGENE
PANTHER	LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED	UniProtKB/Swiss-Prot
Pfam	LCAT	UniProtKB/Swiss-Prot
PhenoGen	Pla2g15	PhenoGen
RatGTEx	ENSRNOG00000019859	RatGTEx
Superfamily-SCOP	SSF53474	UniProtKB/Swiss-Prot
UniProt	A0ABK0LDG3_RAT	UniProtKB/TrEMBL
	A6IYW2	ENTREZGENE, UniProtKB/TrEMBL
	PAG15_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-10-23	Pla2g15	phospholipase A2, group XV	Lypla3	lysophospholipase 3	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Lypla3	lysophospholipase 3	LOC361401	lysosomal phospholipase A2	Symbol and Name updated	1299863	APPROVED
2005-02-14	LOC361401	lysosomal phospholipase A2			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed exclusively in alveolar macrophages	1304489

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Send us a Message

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)