ENCODES a protein that exhibits ubiquitin protein ligase activity (ortholog); INVOLVED IN negative regulation of fatty acid biosynthetic process (ortholog); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); proteasome-mediated ubiquitin-dependent protein ca
tabolic process (ortholog); PARTICIPATES IN p53 signaling pathway; ubiquitin/proteasome degradation pathway; ASSOCIATED WITH abnormal circadian regulation of systemic arterial blood pressure; salt-sensitive hypertension; ASSOCIATED WITH autistic disorder (ortholog); FOUND IN Golgi membrane; Cul4A-RING E3 ubiquitin ligase complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A