Gene: Rfwd2 (ring finger and WD repeat domain 2) Rattus norvegicus
Analyze
Symbol: Rfwd2
Name: ring finger and WD repeat domain 2
Description: ENCODES a protein that exhibits ubiquitin protein ligase activity (ortholog); INVOLVED IN positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); proteasome-mediated ubiquitin-dependent protein catabolic process (ortholog); response to ionizing radiation (ortholog); PARTICIPATES IN p53 signaling pathway; ubiquitin/proteasome degradation pathway; ASSOCIATED WITH abnormal circadian regulation of systemic arterial blood pressure; salt-sensitive hypertension; ASSOCIATED WITH Autistic Disorder (ortholog); autistic disorder (ortholog); FOUND IN Golgi membrane; Cul4A-RING E3 ubiquitin ligase complex (ortholog); INTERACTS WITH bisphenol A; (-)-epigallocatechin 3-gallate (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Cop1; E3 ubiquitin-protein ligase RFWD2; LOC100360800; LOC360860; MGC109175; RGD1304773; ring finger and WD repeat domain 2, E3 ubiquitin protein ligase; similar to constitutive photomorphogenic protein 1
Orthologs:
Homo sapiens (human) : RFWD2 (ring finger and WD repeat domain 2)  HGNC  AGR
Mus musculus (house mouse) : Rfwd2 (ring finger and WD repeat domain 2)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Rfwd2 (ring finger and WD repeat domain 2)
Pan paniscus (bonobo/pygmy chimpanzee) : RFWD2 (ring finger and WD repeat domain 2)
Canis lupus familiaris (dog) : RFWD2 (ring finger and WD repeat domain 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rfwd2 (ring finger and WD repeat domain 2)
more info ...
Allele / Splice: Rfwd2em1Mcwi  
Genetic Models: SS-Rfwd2em1Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01376,942,883 - 77,076,015 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01381,853,391 - 81,986,197 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41374,552,876 - 74,590,608 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11374,979,314 - 74,981,857 (-)NCBI
Celera1371,277,941 - 71,371,841 (+)NCBICelera
Cytogenetic Map13q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
 
More on Rfwd2
AGR Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1304773
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2017-10-03
Status: ACTIVE