ENCODES a protein that exhibits GTPase activator activity (ortholog); guanyl-nucleotide exchange factor activity (ortholog); kinase binding (ortholog); INVOLVED IN Ras protein signal transduction (ortholog); PARTICIPATES IN B cell receptor signaling pathway; mitogen activated protein kinase signalin
g pathway; ASSOCIATED WITH head and neck squamous cell carcinoma (ortholog); hypertension (ortholog); systemic lupus erythematosus (ortholog); FOUND IN cytoplasm (ortholog); guanyl-nucleotide exchange factor complex (ortholog); perinuclear region of cytoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil
RAS guanyl releasing protein 3 (calcium and DAG-regulated); zinc finger nuclease induced mutant 1, Medical College of Wisconsin
This allele was made by zinc finger nuclease mutagenesis. The resulting mutation is an 5-bp frameshift deletion in exon 12 (del 1501-1503, ins. Ttaggtgg).