ENCODES a protein that exhibits pyruvate dehydrogenase (acetyl-transferring) activity; INVOLVED IN pyruvate decarboxylation to acetyl-CoA; PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; Leigh disease pathway; ASSOCIATED WITH pyruvate decarboxylase deficiency; Disease Progressio
n (ortholog); epilepsy (ortholog); FOUND IN mitochondrial matrix; pyruvate dehydrogenase complex; mitochondrion (ortholog); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran