ENCODES a protein that exhibits 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity (ortholog); 3',5'-cyclic-AMP phosphodiesterase activity (ortholog); 3',5'-cyclic-GMP phosphodiesterase activity (ortholog); INVOLVED IN negative regulation of apoptotic process; negative regulation of c
AMP/PKA signal transduction; oocyte maturation; PARTICIPATES IN protein kinase A (PKA) signaling pathway; insulin signaling pathway; purine metabolic pathway; ASSOCIATED WITH Experimental Diabetes Mellitus; Left Ventricular Hypertrophy; obesity; FOUND IN cytosol (ortholog); membrane (ortholog); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine
The rat mutant allele was generated by pronuclear microinjection of Sprague-Dawley rat zygotes with a mixture of Cas9/Cas9 system to target the region in the rat Pde3a gene homologous to the human T445N mutation. The rat model exhibits a 9-bp deletion within the
The rat mutant allele was generated by pronuclear microinjection of Sprague-Dawley rat zygotes with a mixture of Cas9/Cas9 system to target the region in the rat Pde3a gene homologous to the human T445N mutation. The rat model exhibits a 20-bp deletion within th
The rat mutant allele was generated by pronuclear microinjection of Sprague-Dawley rat zygotes with a mixture of Cas9/Cas9 system to target the catalytic domain in the rat Pde3a gene. The model has a carriesa CGT to TGT missense mutation and results in R862C sub