| 621466 | Il2rg | interleukin 2 receptor subunit gamma | ENCODES a protein that exhibits coreceptor activity (ortholog); interleukin-15 receptor activity (ortholog); interleukin-2 binding (ortholog); INVOLVED IN cell surface receptor signaling pathway via JAK-STAT (ortholog); cellular homeostasis (ortholog); interleukin-15-mediated signaling pathway (orth olog); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-2 signaling pathway; interleukin-4 signaling pathway; ASSOCIATED WITH decreased bone marrow cell number; decreased CD4-positive, alpha-beta T cell number; decreased CD8-positive, alpha-beta T cell number; ASSOCIATED WITH combined T cell and B cell immunodeficiency; Immune Deficiency Disease; X-linked severe combined immunodeficiency; FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); plasma membrane (ortholog); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane | X | 70435340 | 70439052 | Rat | 156 | symbol , PhenoGen | gene, protein-coding, PROVISIONAL [RefSeq] |
| 13628731 | Il2rgem1Ang | interleukin 2 receptor subunit gamma;TALEN induced mutant1, Ang | ASSOCIATED WITH decreased bone marrow cell number; decreased CD4-positive, alpha-beta T cell number; decreased CD8-positive, alpha-beta T cell number; ASSOCIATED WITH Immune Deficiency Disease | | | | Rat | 10 | symbol , description | gene, allele |
| 12798560 | Il2rgem1Kyo | interleukin 2 receptor subunit gamma; ZFN induced mutant 1, Kyo | ASSOCIATED WITH combined T cell and B cell immunodeficiency; X-linked severe combined immunodeficiency | | | | Rat | 2 | symbol , description , old_gene_symbol | gene, allele |
| 12798561 | Il2rgem2Kyo | interleukin 2 receptor subunit gamma; ZFN induced mutant 2, Kyo | ASSOCIATED WITH combined T cell and B cell immunodeficiency; X-linked severe combined immunodeficiency | | | | Rat | 2 | symbol , description , old_gene_symbol | gene, allele |
| 13464340 | Il2rgem3Kyo | interleukin 2 receptor subunit gamma; ZFN induced mutant 3, Kyo | This mutant allele was generated by a zinc finger nuclease induced 332-bp deletion in Il2rg gene of F344/TM embryo. | | | | Rat | | symbol , description , old_gene_symbol | gene, allele |
| 13464339 | Il2rgem4Kyo | interleukin 2 receptor subunit gamma; ZFN induced mutant 4, Kyo | The mutant allele has a zinc finger nuclease-induced 162-bp deletion mutation in the Il2rg gene of the the TM/Kyo embryo. | | | | Rat | | symbol , description , old_gene_symbol | gene, allele |
| 12910099 | Il2rgem5Kyo | interleukin 2 receptor subunit gamma; ZFN induced mutant 5, Kyo | This ZFN induced mutant allele contains a 653-bp deletion in the Il2rg gene. | | | | Rat | | symbol , description , old_gene_symbol | gene, allele |
| 12910097 | Il2rgem6Kyo | interleukin 2 receptor subunit gamma; ZFN induced mutant 6, Kyo | These ZFN mutant rats were produced by injecting zinc finger nuclease targeting rat Il2rg into F344/Stm. A 332-bp deletion mutation was created. | | | | Rat | | symbol , description , old_gene_symbol | gene, allele |
| 13628732 | Il2rgem7Kyo | interleukin 2 receptor subunit gamma; TALEN induced mutant 7, Kyo | This mutant allele has a 7 bp deletion in the 2nd exon of the rat Il2rg gene created by TALEN. | | | | Rat | | symbol , description | gene, allele |
| 12798562 | Il2rgem1Hina | interleukin 2 receptor subunit gamma; endonuclease-induced mutant 1, Hina | This mutation was generated by electroporation method: introduction of Il2rg gene-targeting vector (PKG promoter-HSV TK, loxp Tk2 promoter-Neor loxp) into ES cells of Wistar rat(Crlj:Wistar). | | | | Rat | | symbol , description , old_gene_symbol | gene, allele |
| 12790633 | Il2rgem1Mcwi | interleukin 2 receptor, gamma; TALEN induced mutant 1, Medical College of Wisconsin | This allele was made by TALEN mutagensis. The resulting mutation is a 19-bp deletion in exon 2. | | | | Rat | | symbol , old_gene_symbol | gene, allele |
| 10002792 | Il2rgem2Mcwi | interleukin 2 receptor, gamma; TALEN induced mutant 2, Medical College of Wisconsin | This allele was made by TALEN mutagensis. The resulting mutation is a 1-bp frameshift deletion in exon 2 causing a predicted non-functional protein. | | | | Rat | | symbol , old_gene_symbol | gene, allele |
| 12790660 | Il2rgem3Mcwi | interleukin 2 receptor, gamma; TALEN induced mutant 3, Medical College of Wisconsin | This allele was made by TALEN mutagensis. The resulting mutation is a 2-bp deletion in exon 2. | | | | Rat | | symbol , old_gene_symbol | gene, allele |
| 13464264 | Il2rgem1Iexas | interleukin 2 receptor subunit gamma; CRISPR/Cas9 induced mutant 1, Iexas | This mutation was established by targeting il2rg gene in F344/Jcl using CRISPR/Cas9 system. gRNA seq to Il2rg: CCAACCTCACTATGCACTATAGG (PAM: first CCA); gRNA; Cas 9 mRNA transcribed from T7-NLS hCas9-pA (RDB13130) was used f or the system. Gene transfer was performed by electroporation. This resulting mutation was 5-bp deletion in Il2rg gene on X chromosome. | | | | Rat | | symbol , description , old_gene_symbol | gene, allele |
| 629096379 | Rag1em6Mcwi | recombination activating 1; CRISPR/Cas9 induced mutant 1, Mcwi | The allele was produced by injection of CRISPR/Cas9 targeting the genomic sequence GGTGAGATCCTTTGAAAAGG in Rag1 into double homozygous embryos with knockout of Fah and Il2rg produced following multiple generations of intercrossing strains SD-Il2rg ight:700;'>Il2rgem2Mcwi (RGDID:10002794) and SD-Fahem3Mcw (RGDID: 10002791). The resulting CRISPR-induced mutation in Rag1 deletes 25-bp (rn7: chr3:87,923,384-87,923,408) and inserts 17 bp (ACCCTAAACAGCTGTGC) for a net 8-bp deletion. | | | | Rat | | description | gene, allele |