| 1305471 | Atf6 | activating transcription factor 6 | ENCODES a protein that exhibits ubiquitin protein ligase binding; DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN eye development (ortholog); positive regulation of apoptotic process (ortholog); po sitive regulation of ATF6-mediated unfolded protein response (ortholog); PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; Alzheimer's disease pathway; Endoplasmic Reticulum-associated degradation pathway; ASSOCIATED WITH borna disease; Temporomandibular Joint Osteoarthritis; achromatopsia (ortholog); FOUND IN nucleus; endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); INTERACTS WITH (+)-schisandrin B; (S)-nicotine; 1,2-dimethylhydrazine | 13 | 85460312 | 85639959 | Rat | 589 | symbol , old_gene_name , PhenoGen , description | gene, protein-coding, PROVISIONAL [RefSeq] |
| 1303317 | Atf6b | activating transcription factor 6 beta | ENCODES a protein that exhibits DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN negative regulation of ATF6 'font-weight:700;'>ATF6-mediated unfolded protein response (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); response to endoplasmic reticulum stress (ortholog); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; FOUND IN endoplasmic reticulum membrane (ortholog); nucleolus (ortholog); nucleoplasm (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-phenylbutyric acid; bisphenol A | 20 | 4095534 | 4103534 | Rat | 116 | symbol , PhenoGen , description | gene, protein-coding, VALIDATED [RefSeq] |
| 1307252 | Manf | mesencephalic astrocyte-derived neurotrophic factor | ENCODES a protein that exhibits sulfatide binding (ortholog); INVOLVED IN ATF6-mediated unfolded protein response (ortholog); regulation of response to endoplasmic reticulum stress (ortholog); vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure (ortholog); ASSOCIATED WITH Reperfusion Injury; breast cancer (ortholog); Diabetes, Deafness, Developmental Delay, and Short Stature Syndrome (ortholog); FOUND IN extracellular space; perinuclear region of cytoplasm; endoplasmic reticulum (ortholog); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine | 8 | 116427053 | 116430259 | Rat | 187 | description | gene, protein-coding, VALIDATED [RefSeq] |
| 68954 | Wfs1 | wolframin ER transmembrane glycoprotein | ENCODES a protein that exhibits calcium-dependent protein binding; calmodulin binding; DNA-binding transcription factor binding; INVOLVED IN negative regulation of ATF6-mediated unfolded protein response; negative regulation of transcription by RNA polymerase II ; olfactory behavior; PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; ASSOCIATED WITH abnormal brainstem morphology; decreased insulin secretion; decreased pancreatic beta cell mass; ASSOCIATED WITH cataract; diabetes mellitus; Experimental Seizures; FOUND IN synaptic vesicle membrane; endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; aconitine | 14 | 78035205 | 78059718 | Rat | 287 | description | gene, protein-coding, PROVISIONAL [RefSeq] |