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Strain Registration

Strain: Hsd:SD

Symbol: Hsd:SD
Strain: SD
Substrain: Hsd
Full Name: Sprague Dawley
RGD ID: 737903
Citation ID: RRID:RGD_737903
Ontology ID: RS:0000698
Also Known As: SD/Hsd; Sprague Dawley outbred rat; Hsd:Sprague Dawley SD; RS:0001453; SPRD/Hsd; RGD:68140
Type: outbred
Available Source: Envigo
Description: Originated by the Sprague-Dawley Company in 1925 through a series of crosses begun with a single-hooded male and six albino females of unknown origin. Current Harlan Laboratories' colonies are direct descendants of this original colony.
Last Known Status: Unknown





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
left ventricular diastolic blood pressure
left ventricular systolic blood pressure
mean arterial blood pressure
body weight
body temperature
heart weight
left ventricular developed pressure
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
blood neutrophil count
blood lymphocyte count
blood monocyte count
blood eosinophil count
blood basophil count
hematocrit
mean corpuscular volume
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
blood urea nitrogen level
plasma total protein level
plasma albumin level
serum creatinine level
plasma anion gap
heart wet weight
kidney weight
liver weight
lung weight
lung dry weight to body weight ratio
heart right ventricle weight to left ventricle weight ratio
plasma renin activity level
minute ventilation
brain weight
brain weight to body weight ratio
liver weight as percentage of body weight
adrenal gland weight
spleen weight
spleen weight to body weight ratio
both testes wet weight
arterial blood flow rate
blood fibrinogen level
tidal volume
partial pressure of blood carbon dioxide (Pco2)
percent change in ventilation
respiration rate
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
absolute change in partial pressure of blood carbon dioxide
absolute change in partial pressure of blood oxygen
absolute change in blood pH
pancreas weight
serum triglyceride level
serum total cholesterol level
total white blood cell count
serum total bilirubin level
blood pH
partial pressure of blood oxygen
both ovaries weight
serum bicarbonate level
serum chloride level
serum potassium level
serum sodium level
serum calcium level
percent change in respiration rate
percent change in tidal volume
absolute change in mean arterial blood pressure
absolute change in heart rate
plasma creatinine level
serum phosphate level
serum glucose level
plasma free fatty acids level
serum albumin level
serum alanine aminotransferase activity level
serum alkaline phosphatase activity level
serum aspartate aminotransferase activity level
plasma adiponectin level
serum urea nitrogen level
thymus weight
thymus weight to body weight ratio
pituitary gland weight
epididymides weight
plasma high density lipoprotein cholesterol level
serum total protein level
time to onset of heart contraction
time to peak heart contraction
heart contraction pressure
heart left ventricle infarction weight to total heart left ventricle weight ratio
absolute change in body temperature
calculated pulmonary vascular resistance normalized to body weight
FAPGG metabolism-surface area product
methylene blue metabolism-surface area product without auto-oxidation
methylene blue metabolism-surface area product after auto-oxidation
methylene blue to FAPGG metabolism-surface area product ratio
dose of methacholine at which pulmonary conductance is half its pretreatment value
fractional change in blood vessel diameter per unit change in intravascular pressure
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
maximum contractile force per wet weight of aorta
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
hypoxia-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
percent change in heart rate
percent change in arterial blood flow rate
percent change in left ventricular developed pressure
percent change in left ventricular systolic blood pressure
urine total protein excretion rate
urine albumin excretion rate
urine sodium excretion rate
creatinine clearance
heart effluent lactate dehydrogenase activity level normalized to heart weight
plasma leptin level
prostate gland weight
artery neointimal hyperplastic lesion area
artery neointimal hyperplastic lesion area to total wall area ratio
liver cholesterol level
liver triglyceride level
auditory brainstem response threshold
plasma creatine kinase activity level
thyroid gland weight
serum globulin level
blood albumin level to blood globulin level ratio
blood high density lipoprotein particle diameter
blood low density lipoprotein particle diameter
blood very low density lipoprotein particle diameter
both ovaries weight to body weight ratio
plasma plasminogen activator inhibitor 1 level
photopic B wave amplitude of ERG waveform
scotopic B wave amplitude of ERG waveform
scotopic A wave amplitude of ERG waveform
plasma chylomicron and VLDL cholesterol level
plasma IDL and LDL cholesterol

References

References - curated
# Reference Title Reference Citation
1. Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats. Blasi ER, etal., Kidney Int. 2003 May;63(5):1791-800.
2. Antioxidant defense responses to sleep loss and sleep recovery. Everson CA, etal., Am J Physiol Regul Integr Comp Physiol 2005 Feb;288(2):R374-83. Epub 2004 Oct 7.
3. Single Nucleotide Polymorphisms associated with rat expressed sequences. Guryev V, etal., Genome Res. 2004 Jul;14(7):1438-43.
4. Comparison of the hepatic and thyroid gland effects of sodium phenobarbital in wild type and constitutive androstane receptor (CAR) knockout rats and pregnenolone-16α-carbonitrile in wild type and pregnane X receptor (PXR) knockout rats. Haines C, etal., Toxicology. 2018 May 1;400-401:20-27. doi: 10.1016/j.tox.2018.03.002. Epub 2018 Mar 13.
5. Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice. Harrill JA, etal., Toxicol Appl Pharmacol. 2013 Oct 15;272(2):503-18. doi: 10.1016/j.taap.2013.06.024. Epub 2013 Jul 13.
6. Strains registered by Harlan Laboratories, Inc. Personal communication with Harlan Laboratories
7. RGD Strain RSO annotation pipeline RGD Automated Pipelines
8. Skeletal muscle fiber atrophy: altered thin filament density changes slow fiber force and shortening velocity. Riley DA, etal., Am J Physiol Cell Physiol 2005 Feb;288(2):C360-5. Epub 2004 Oct 6.
9. Protective effect of thymoquinone against cisplatin-induced ototoxicity. Sagit M, etal., Eur Arch Otorhinolaryngol. 2013 Aug;270(8):2231-7. doi: 10.1007/s00405-012-2254-6. Epub 2012 Nov 17.
10. The rat oncogenome: comparative genetics and genomics of rat models of mammary carcinogenesis. Shull JD Breast Dis. 2007;28:69-86.
11. Genetic variation in coding regions between and within commonly used inbred rat strains. Smits BM, etal., Genome Res. 2004 Jul;14(7):1285-90.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics 5 days of sleep deprivation resulted in a decrease in glutathione and catalase activity in the liver. 1357920
strain_life_disease Aldosterone/salt induced albuminuria and expression of proinflammatory genes was reduced by eplerenone 6903837
strain_phys_biochem This strain was used for genotyping candidate single nucleotide polymorphisms; SNPs obtained from this study can be found in NCBI dbSNP under accession numbers ss12535137 - ss12568440, ss12588074 - ss12588105 or Cuppen Group 737879
strain_phys_biochem Sleep-deprived animals showed a negative energy balance with diminished antioxidant capacity and increased food intake. 1357920
strain_phys_biochem During transition from quadrupedal position to hindlimb suspension unloading (HSU) position the soleus muscle shorten by 23%; these fibres show 25% reduction in thin filaments 1357921

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-10-14 Hsd:SD  Sprague Dawley  SD/Hsd    Symbol and/or name change 68913 APPROVED