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Strain Registration

Strain: WIC-Tg(Wap-GH1)2Mni

Symbol: WIC-Tg(Wap-GH1)2Mni
Strain: WIC-Tg(Wap-GH1)2
Substrain: Mni
RGD ID: 2306073
Citation ID: RRID:RGD_2306073
Ontology ID: RS:0002258
Also Known As: WistarImamichi-Tg(Wap-GH1)2Mni; WAP/hGH-transgenic rat (low line); NBRP Rat No: 0491; WI-Tg(Wap-GH1)2Mni
Type: transgenic
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: Ikeda developed transgenic rats carrying the human growth hormone (GH1) driven by murine Wap promoter, originated from Wistar-Imamichi (Ikeda, 1994). Two lines of this transgenic strain were established named Line 1: characterized by relatively high level of serum Gh1 (high line, NBRPNo.0490), and Line 2: relatively low level of serum Gh1 (low line, NBRPNo.0491).
Coat Color: Albino
Last Known Status: Cryopreserved Sperm (as of 2017-04-21)
Research Usage Diabetes Obesity; Metabolism





Disease Annotations     Click to see Annotation Detail View
obesity  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. The novel roles of liver for compensation of insulin resistance in human growth hormone transgenic rats. Cho Y, etal., Endocrinology. 2006 Nov;147(11):5374-84. Epub 2006 Aug 17.
2. Different female reproductive phenotypes determined by human growth hormone (hGH) levels in hGH-transgenic rats. Ikeda A, etal., Biol Reprod. 1997 Apr;56(4):847-51.
3. Changes in endogenous growth hormone secretion and onset of puberty in transgenic rats expressing human growth hormone gene. Ikeda A, etal., Endocr J. 1994 Oct;41(5):523-9.
4. Obesity and insulin resistance in human growth hormone transgenic rats. Ikeda A, etal., Endocrinology. 1998 Jul;139(7):3057-63. doi: 10.1210/endo.139.7.6103.
5. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-04-21 WIC-Tg(Wap-GH1)2Mni    WI-Tg(Wap-GH1)2Mni    Symbol updated 68687 APPROVED
2017-04-21 WIC-Tg(Wap-GH1)2Mni    WI-Tg(Wap-GH1)2Mni    Symbol updated 68687 APPROVED
2012-05-29 WIC-Tg(Wap-GH1)2Mni    WIC-Tg(Wap-GH1)2Mni    Name updated 68913 APPROVED
2012-05-29 WIC-Tg(Wap-GH1)2Mni    WIC-Tg(Wap-GH1)2Mni    Name updated 68913 APPROVED