RGD Reference Report - Glucose-mediated repression of menin promotes pancreatic beta-cell proliferation. - Rat Genome Database

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Glucose-mediated repression of menin promotes pancreatic beta-cell proliferation.

Authors: Zhang, H  Li, W  Wang, Q  Wang, X  Li, F  Zhang, C  Wu, L  Long, H  Liu, Y  Li, X  Luo, M  Li, G  Ning, G 
Citation: Zhang H, etal., Endocrinology. 2012 Feb;153(2):602-11. doi: 10.1210/en.2011-1460. Epub 2011 Dec 13.
RGD ID: 9589127
Pubmed: PMID:22166975   (View Abstract at PubMed)
DOI: DOI:10.1210/en.2011-1460   (Journal Full-text)

Menin, encoded by the Men1 gene, is responsible for beta-cell tumor formation in patients with multiple endocrine neoplasia type 1. Recently, menin has been proven to negatively regulate beta-cell proliferation during pregnancy. However, it is unclear whether menin is involved in pancreatic beta-cell proliferation in response to other physiological replication stimuli, such as glucose. In this study, we found that the menin level was significantly reduced in high glucose-treated INS1 cells and primary rat islets, both with increased proliferation. A similar observation was found in islets isolated from rats subjected to 72-h continuous glucose infusion. The glucose-induced proliferation was inhibited by menin overexpression. Further molecular studies showed that glucose-induced menin suppression was blocked by PI3K/Akt pathway inhibitors. A major PI3K/Akt substrate, Foxo1, was shown to enhance menin transcription levels by binding the promoter region of the Men1 gene. Therefore, we conclude that glucose inhibits menin expression via the PI3K/Akt/Foxo1 pathway and hence promotes pancreatic beta-cell proliferation. Our study suggests that menin might serve as an important intracellular target of glucose to mediate the mitogenic effect that glucose exerts in pancreatic beta-cells.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Men1Ratcellular response to glucose stimulus  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Men1  (menin 1)


Additional Information