RGD Reference Report - Up-regulation of interleukin-13 receptor alpha1 on human keratinocytes in the skin of psoriasis and atopic dermatitis. - Rat Genome Database

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Up-regulation of interleukin-13 receptor alpha1 on human keratinocytes in the skin of psoriasis and atopic dermatitis.

Authors: Wongpiyabovorn, J  Suto, H  Ushio, H  Izuhara, K  Mitsuishi, K  Ikeda, S  Nakao, A  Okumura, K  Ogawa, H 
Citation: Wongpiyabovorn J, etal., J Dermatol Sci. 2003 Oct;33(1):31-40.
RGD ID: 8549525
Pubmed: PMID:14527737   (View Abstract at PubMed)

BACKGROUND: Interleukin (IL)-13 is a pleiotropic cytokine, which shares many biological functions with IL-4. The receptor subunits of IL-13 consist of IL-4Ralpha, IL-13Ralpha1 and IL-13Ralpha2. The regulatory mechanisms of the IL-13Ralpha expression in the keratinocytes of certain skin disease have not been known. OBJECTIVE: To clear the roles of IL-13 and the regulatory mechanisms of its receptor in atopic dermatitis (AD) and psoriasis. METHOD: The expression of IL-13Ralpha1 in the skin of AD and psoriasis was investigated by immunohistochemistry. The regulation of IL-13Ralpha mRNA in the skin and human primary keratinocyte (HPK) was investigated by quantitative PCR. The secretion of IL-6 and RANTES from HPK was measured by ELISA. RESULTS: The expression of IL-13Ralpha1 was more prominent on the suprabasal keratinocytes in the skin of AD and striking increase of staining was observed on all layers of keratinocyte in the skin of psoriasis. The mRNA of IL-13Ralpha1, but not of IL-13Ralpha2 was overexpressed in both skin of AD and psoriasis. In vitro experiment using HPK demonstrated that IFN-gamma, IL-13 but not IL-4 could up-regulate the mRNA expression of IL-13Ralpha1. In contrast, IL-13Ralpha2 mRNA expression was up-regulated by IFN-gamma plus IL-4. Furthermore, the stimulation of HPK with IFN-gamma plus IL-13 and/or IL-4 resulted in significant enhancement of IL-6 and RANTES secretion. CONCLUSION: These findings indicate that IL-4 and IL-13 have different regulatory effects on the expression of IL-13Ralpha1 and alpha2, and the overexpression of IL-13Ralpha1 may play some roles in the pathogenesis of chronic stage of AD or psoriasis.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL13RA1Humanatopic dermatitis  IEP mRNA:increased expression:skinRGD 
Il13ra1Ratatopic dermatitis  ISOIL13RA1 (Homo sapiens)mRNA:increased expression:skinRGD 
Il13ra1Mouseatopic dermatitis  ISOIL13RA1 (Homo sapiens)mRNA:increased expression:skinRGD 
IL13RA1Humanpsoriasis  IEP mRNA:increased expression:skinRGD 
Il13ra1Ratpsoriasis  ISOIL13RA1 (Homo sapiens)mRNA:increased expression:skinRGD 
Il13ra1Mousepsoriasis  ISOIL13RA1 (Homo sapiens)mRNA:increased expression:skinRGD 

Objects Annotated

Genes (Rattus norvegicus)
Il13ra1  (interleukin 13 receptor subunit alpha 1)

Genes (Mus musculus)
Il13ra1  (interleukin 13 receptor, alpha 1)

Genes (Homo sapiens)
IL13RA1  (interleukin 13 receptor subunit alpha 1)


Additional Information