RGD Reference Report - Characterization of the gene encoding the major rat liver asialoglycoprotein receptor. - Rat Genome Database

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Characterization of the gene encoding the major rat liver asialoglycoprotein receptor.

Authors: Leung, JO  Holland, EC  Drickamer, K 
Citation: Leung JO, etal., J Biol Chem 1985 Oct 15;260(23):12523-7.
RGD ID: 631721
Pubmed: PMID:2995379   (View Abstract at PubMed)

A cloned cDNA encoding the major rat liver asialoglycoprotein receptor has been used to analyze the gene for this protein. Genomic Southern blot analysis reveals that the gene is contained on a single EcoRI restriction fragment and is unique. A clone containing the gene (isolated from a rat liver genomic library) has been characterized by sequence analysis. The mRNA for the receptor is encoded by nine exons separated by eight introns. The first exon is confined to the 5'-untranslated region of the mRNA, the second exon encodes most of the cytoplasmic NH2-terminal domain of the receptor polypeptide, the third exon corresponds to the hydrophobic transmembrane portion of the polypeptide, and the remaining exons encode the extracellular parts of the receptor. Some, but not all, of the divisions between exons correspond to boundaries between functional domains of the polypeptide.



Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Asgr1Ratasialoglycoprotein receptor activity  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Asgr1  (asialoglycoprotein receptor 1)


Additional Information