RGD Reference Report - Cloning of a novel putative G-protein-coupled receptor (NLR) which is expressed in neuronal and lymphatic tissue. - Rat Genome Database

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Cloning of a novel putative G-protein-coupled receptor (NLR) which is expressed in neuronal and lymphatic tissue.

Authors: Kouba, M  Vanetti, M  Wang, X  Schafer, M  Hollt, V 
Citation: Kouba M, etal., FEBS Lett 1993 Apr 26;321(2-3):173-8.
RGD ID: 61543
Pubmed: PMID:8386678   (View Abstract at PubMed)

A novel G-protein-coupled receptor was isolated from mouse and rat neuronal and lymphatic tissues. The amino acid sequence of the rat receptor (rNLR) shows an overall homology of 80% to a recently cloned receptor from Burkitt's lymphoma cells (BLR1) which is exclusively expressed in lymphatic tissues [(1992) Eur. J. Immunol. 22, 2795]. Much less homology between rNLR and BLR1 was observed at the N-terminus (about 40%), whereas rNLR and the mouse homologue mNLR show 92% amino acid identity. Northern blot analysis of NLR revealed a predominant 5.5 kb mRNA species in various brain regions and neuronal cell lines, whereas in the spleen a 3 kb transcript is predominant. This distribution suggests a role of NLR in the nervous and immune systems.



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Gene Cxcr5 C-X-C motif chemokine receptor 5 Rattus norvegicus

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