RGD Reference Report - MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients. - Rat Genome Database

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MUC5AC expression is increased in bronchial submucosal glands of stable COPD patients.

Authors: Caramori, G  Casolari, P  Di Gregorio, C  Saetta, M  Baraldo, S  Boschetto, P  Ito, K  Fabbri, LM  Barnes, PJ  Adcock, IM  Cavallesco, G  Chung, KF  Papi, A 
Citation: Caramori G, etal., Histopathology. 2009 Sep;55(3):321-31.
RGD ID: 5131190
Pubmed: PMID:19723147   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1365-2559.2009.03377.x   (Journal Full-text)

AIMS: Mucus expectoration is a common feature of chronic obstructive pulmonary disease (COPD). MUC5AC and MUC5B, the major mucins, are released predominantly from submucosal glands in the central airways. The aim was to investigate gland size and MUC5AC and MUC5B expression in bronchial rings from smokers with COPD compared with control groups. METHODS AND RESULTS: Bronchial rings from 10 non-smoking subjects, 20 smokers with normal lung function and 20 smokers with COPD were studied. Periodic acid-Schiff (PAS) and Alcian blue histochemistry and MUC5AC and MUC5B immunohistochemistry followed by quantification of the immunoreactive area was performed. The area occupied by MUC5AC+ cells in bronchial submucosal glands was increased in COPD [20% (5.5-31.7%) gland area] compared with smokers with normal lung function [9.5% (2.5-17.5%); P < 0.05] and non-smoking subjects [2% (0.4-6.2%); P < 0.05]. The area occupied by MUC5AC+ cells in the bronchial surface epithelium was also increased in smokers (with/without COPD) [73.5% (25-92%) epithelial area] compared with non-smoking subjects [15% (2.7-32%); P < 0.01]. Gland size, PAS, Alcian blue staining and MUC5B expression were not significantly different among groups. MUC5AC expression correlated with the degree of airflow obstruction. MUC5AC and MUC5B expression correlated with pack-years. CONCLUSIONS: COPD is associated with increased MUC5AC expression in submucosal glands, indicating that MUC5AC may be involved in the pathophysiology of the disease.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MUC5ACHumanchronic obstructive pulmonary disease  IEP protein:increased expression:bronchiRGD 
Muc5acRatchronic obstructive pulmonary disease  ISOMUC5AC (Homo sapiens)protein:increased expression:bronchiRGD 
Muc5acMousechronic obstructive pulmonary disease  ISOMUC5AC (Homo sapiens)protein:increased expression:bronchiRGD 

Objects Annotated

Genes (Rattus norvegicus)
Muc5ac  (mucin 5AC, oligomeric mucus/gel-forming)

Genes (Mus musculus)
Muc5ac  (mucin 5, subtypes A and C, tracheobronchial/gastric)

Genes (Homo sapiens)
MUC5AC  (mucin 5AC, oligomeric mucus/gel-forming)


Additional Information