RGD Reference Report - Critical nodes in signalling pathways: insights into insulin action.

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Critical nodes in signalling pathways: insights into insulin action.
Authors:	Taniguchi, CM Emanuelli, B Kahn, CR
Citation:	Taniguchi CM, etal., Nat Rev Mol Cell Biol. 2006 Feb;7(2):85-96.
RGD ID:	5129849
Pubmed:	PMID:16493415 (View Abstract at PubMed)
DOI:	DOI:10.1038/nrm1837 (Journal Full-text)
Physiologically important cell-signalling networks are complex, and contain several points of regulation, signal divergence and crosstalk with other signalling cascades. Here, we use the concept of 'critical nodes' to define the important junctions in these pathways and illustrate their unique role using insulin signalling as a model system.

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.