RGD Reference Report - Effect of concurrent administration of aspirin, indomethacin or hydrocortisone with gold sodium thiomalate against adjuvant-induced arthritis in the rat. - Rat Genome Database

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Effect of concurrent administration of aspirin, indomethacin or hydrocortisone with gold sodium thiomalate against adjuvant-induced arthritis in the rat.

Authors: Sofia, D R  Knobloch, L C  Douglas, J F 
Citation: Sofia DR, etal., Agents Actions. 1976 Nov;6(6):728-34. doi: 10.1007/BF02026096.
RGD ID: 42724460
Pubmed: PMID:827200   (View Abstract at PubMed)
DOI: DOI:10.1007/BF02026096   (Journal Full-text)

The activity of gold sodium thiomalate (GST) given i.m. to adjuvant-induced polyarthritic rats was studied alone or in combination with active doses of aspirin, indomethacin and hydrocortisone. In addition to paw volume and body weight changes, erythrocyte sedimentation rate, serum albumin/globulin and gold levels as well as plasma activities of beta-glucuronidase, acid phosphatase, lysozyme and lactic acid dehydrogenase were measured. In prophylactic studies the beneficial activity of GST was unaffected by aspirin, suggesting a positive drug interaction, but additive with indomethacin or hydrocortisone for the 1st but not 2nd lesion of the disease. These results were closely correlated with increased serum gold levels. Similar clinical findings were observed in therapeutic studies except that a positive drug interaction occurred between GST and hydrocortisone. Unlike in the prophylactic experiments, serum gold levels were unaffected by any of the agents tested in the therapeutic studies.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GUSBHumanExperimental Arthritis treatmentISOGusb (Rattus norvegicus) RGD 
GusbRatExperimental Arthritis treatmentIEP  RGD 
GusbMouseExperimental Arthritis treatmentISOGusb (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gusb  (glucuronidase, beta)

Genes (Mus musculus)
Gusb  (glucuronidase, beta)

Genes (Homo sapiens)
GUSB  (glucuronidase beta)


Additional Information