RGD Reference Report - [Circulating Serum MicroRNA as Diagnostic Biomarkers for Multiple Myeloma]. - Rat Genome Database

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[Circulating Serum MicroRNA as Diagnostic Biomarkers for Multiple Myeloma].

Authors: Xu, Yan-Ni  Xiao, Cui-Rong  Huang, Ying-Dan  Lu, Quan-Yi 
Citation: Xu YN, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017 Apr;25(2):471-475. doi: 10.7534/j.issn.1009-2137.2017.02.029.
RGD ID: 24922226
Pubmed: PMID:28446295   (View Abstract at PubMed)
DOI: DOI:10.7534/j.issn.1009-2137.2017.02.029   (Journal Full-text)


OBJECTIVE: To investigate the diagnostic value of circulating serum miRNA for multiple myeloma.
METHODS: Forty blood samples from patients with multiple myeloma were collected from July 2013 to June 2014 in Department of Hematology, Zhongshan Hospital Affiliated to Xiamen University. The real-time quantitative PCR was performed to detect the serum expression levels of miRNAs (miR-29a, miR-155, miR-16 and miR-92a) circulating in the different stages of patients with multiple myeloma and evaluate the diagnostic value for patients with multiple myeloma.
RESULTS: The serum level of miR-29a significantly increased in newly diagnosed patients as compared to healthy donor (P<0.01), serum miR-155 levels were significantly lower as compared with healthy donor(P<0.001); The ratio of miR-29a and miR-155 was an effective biomarker for distinguishing multiple myeloma from healthy donor, their sensitivity and specificity were 80.8% and 83.3% respectively for myeloma diagnosis. the change of miR-29a expression was consistent with the changes of bone marrow plasma cells and M protein levels.
CONCLUSION: These circulating serum microRNA, such as miR-29a, miR-155 and miR-16, may serve as potential diagnostic biomarkers for multiple myeloma, and the ratio of miR-29a/miR-155 may serve as a most useful biomarker for myeloma diagnosis.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MIR155Humanmultiple myeloma  IEP miRNA:decreased expression:serumRGD 
Mir155Mousemultiple myeloma  ISOMIR155 (Homo sapiens)miRNA:decreased expression:serumRGD 
Mir155Ratmultiple myeloma  ISOMIR155 (Homo sapiens)miRNA:decreased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Mir155  (microRNA 155)

Genes (Mus musculus)
Mir155  (microRNA 155)

Genes (Homo sapiens)
MIR155  (microRNA 155)


Additional Information