RGD Reference Report - Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion. - Rat Genome Database

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Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion.

Authors: Castelo-Branco, G  Sousa, KM  Bryja, V  Pinto, L  Wagner, J  Arenas, E 
Citation: Castelo-Branco G, etal., Mol Cell Neurosci. 2006 Feb;31(2):251-62. Epub 2005 Oct 21.
RGD ID: 2317901
Pubmed: PMID:16243537   (View Abstract at PubMed)
DOI: DOI:10.1016/j.mcn.2005.09.014   (Journal Full-text)

Glial cells have been classically described as supporting cells for neurons. Recently, additional roles during neural development have begun to emerge. Here, we report that ventral midbrain glia, including astrocytes and radial glia, are the source of signals required by neural precursors to acquire a dopaminergic phenotype. We found that ventral midbrain glia, but not cortical glia, secrete high levels of the glycolipoprotein Wnt-5a, express region-specific transcription factors such as Pax-2, En-1 and Otx-2 and increase the differentiation of cortical or ventral midbrain Nurr1 precursors into tyrosine hydroxylase-positive neurons. Moreover, blocking experiments using a Wnt-5a blocking antibody indicated that the effects of ventral midbrain glia on Nurr1-positive neural precursors are partially mediated by Wnt-5a. Thus, our results identify Wnt-5a as an important component of the dopaminergic inductive activity of the ventral midbrain glia.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Wnt5aRatextracellular space  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Wnt5a  (Wnt family member 5A)


Additional Information