RGD Reference Report - Identification of potential diagnostic markers of prostate cancer and prostatic intraepithelial neoplasia using cDNA microarray. - Rat Genome Database

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Identification of potential diagnostic markers of prostate cancer and prostatic intraepithelial neoplasia using cDNA microarray.

Authors: Bull, JH  Ellison, G  Patel, A  Muir, G  Walker, M  Underwood, M  Khan, F  Paskins, L 
Citation: Bull JH, etal., Br J Cancer. 2001 Jun 1;84(11):1512-9.
RGD ID: 2302990
Pubmed: PMID:11384102   (View Abstract at PubMed)
PMCID: PMC2363654   (View Article at PubMed Central)
DOI: DOI:10.1054/bjoc.2001.1816   (Journal Full-text)

The identification of novel genes or groups of genes expressed in prostate cancer may allow earlier diagnosis or more accurate staging of the disease. We describe the assembly and use of a 1877-member microarray representing cDNA clones from a range of prostate cancer stages and grades, precursor lesions and normal tissue. Using labelled cDNA from tumour samples obtained from TURP or radical prostatectomy, analysis of expression patterns identified many up-regulated transcripts. Cell lines were found to over-express fewer genes than diseased tissue samples. 17 known genes were found to over-express more than 4-fold in 4 or more cancers out of 15 cancers. Only 2 genes were over-expressed in 6 out of 15 cancers or more, whilst no genes were consistently found to be over-expressed in all cancer samples. Novel prostate cancer associations for several well characterized genes or full length cDNAs were identified, including PLRP1, JM27, human UbcM2, dynein light intermediate chain 2 and human homologue of rat sec61. Novel associations with high-grade PIN include: breast carcinoma fatty acid synthase and cDNA DKFZp434B0335. We shortlist and discuss the most significant over-expressed genes in prostate cancer and PIN, and highlight expression differences between malignant and benign samples.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PNLIPRP1Humanprostate cancer  IEP  RGD 
Pnliprp1Ratprostate cancer  ISOPNLIPRP1 (Homo sapiens) RGD 
Pnliprp1Mouseprostate cancer  ISOPNLIPRP1 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pnliprp1  (pancreatic lipase-related protein 1)

Genes (Mus musculus)
Pnliprp1  (pancreatic lipase related protein 1)

Genes (Homo sapiens)
PNLIPRP1  (pancreatic lipase related protein 1)


Additional Information