RGD Reference Report - Epigenetic Role of Histone 3 Lysine Methyltransferase and Demethylase in Regulating Apoptosis Predicting the Recurrence of Atypical Meningioma. - Rat Genome Database

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Epigenetic Role of Histone 3 Lysine Methyltransferase and Demethylase in Regulating Apoptosis Predicting the Recurrence of Atypical Meningioma.

Authors: Lee, Sang Hyuk  Lee, Eun Hee  Lee, Sung-Hun  Lee, Young Min  Kim, Hyung Dong  Kim, Young Zoon 
Citation: Lee SH, etal., J Korean Med Sci. 2015 Aug;30(8):1157-66. doi: 10.3346/jkms.2015.30.8.1157. Epub 2015 Jul 15.
RGD ID: 155582218
Pubmed: PMID:26240495   (View Abstract at PubMed)
PMCID: PMC4520948   (View Article at PubMed Central)
DOI: DOI:10.3346/jkms.2015.30.8.1157   (Journal Full-text)

Alteration of apoptosis is related with progression and recurrence of atypical meningiomas (AMs). However, no comprehensive study has been conducted regarding histone modification regulating apoptosis in AMs. This study aimed to determine the prognostic values of certain apoptosis-associated factors, and examine the role of histone modification on apoptosis in AMs. The medical records of 67 patients with AMs, as diagnosed during recent 13 yr, were reviewed retrospectively. Immunohistochemical staining was performed on archived paraffin-embedded tissues for pro-apoptotic factors (CASP3, IGFBP, TRAIL-R1, BAX, and XAF1), anti-apoptotic factors (survivin, ERK, RAF1, MDM2, and BCL2), and the histone modifying enzymes (MLL2, RIZ, EZH1, NSD2, KDM5c, JMJD2a, UTX, and JMJD5). Twenty-six (38.8%) patients recurred during the follow-up period (mean duration 47.7 months). In terms of time-to-recurrence (TTR), overexpression of CASP3, TRAIL-R1, and BAX had a longer TTR than low expression, and overexpression of survivin, MDM2, and BCL2 had a shorter TTR than low expression (P<0.05). Additionally, overexpression of MLL2, UTX, and JMJ5 had shorter TTRs than low expression, and overexpression of KDM5c had a longer TTR than low expression. However, in the multi-variate analysis of predicting factors for recurrence, low expression of CASP3 (P<0.001), and BAX (P<0.001), and overexpression of survivin (P=0.007), and MDM2 (P=0.037) were associated with recurrence independently, but any enzymes modifying histone were not associated with recurrence. Conclusively, this study suggests certain apoptosis-associated factors should be associated with recurrence of AMs, which may be regulated epigenetically by histone modifying enzymes.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
KMT2DHumanmeningioma disease_progressionIEP  RGD 
Kmt2dMousemeningioma disease_progressionISOKMT2D (Homo sapiens) RGD 
Kmt2dRatmeningioma disease_progressionISOKMT2D (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Kmt2d  (lysine methyltransferase 2D)

Genes (Mus musculus)
Kmt2d  (lysine (K)-specific methyltransferase 2D)

Genes (Homo sapiens)
KMT2D  (lysine methyltransferase 2D)


Additional Information