RGD Reference Report - Protein interacting with C kinase 1 (PICK1) and GluR2 are associated with presynaptic plasma membrane and vesicles in hippocampal excitatory synapses. - Rat Genome Database

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Protein interacting with C kinase 1 (PICK1) and GluR2 are associated with presynaptic plasma membrane and vesicles in hippocampal excitatory synapses.

Authors: Haglerød, C  Kapic, A  Boulland, J-L  Hussain, S  Holen, T  Skare, O  Laake, P  Ottersen, O P  Haug, F-M S  Davanger, S 
Citation: Haglerød C, etal., Neuroscience. 2009 Jan 12;158(1):242-52. doi: 10.1016/j.neuroscience.2008.11.029. Epub 2008 Nov 27.
RGD ID: 155230751
Pubmed: PMID:19071197   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neuroscience.2008.11.029   (Journal Full-text)

AMPA receptors have been identified in different populations of presynaptic terminals and found to be involved in the modulation of neurotransmitter release. The mechanisms that govern the expression of presynaptic AMPA receptors are not known. One possibility is that pre- and postsynaptic AMPA receptors are regulated according to the same principles. To address this hypothesis we investigated whether protein interacting with C kinase 1 (PICK1), known to interact with AMPA receptors postsynaptically, also is expressed presynaptically, together with AMPA receptors. Subfractionation and high-resolution immunogold analyses of the rat hippocampus revealed that GluR2 and PICK1 are enriched postsynaptically, but also in presynaptic membrane compartments, including the active zone and vesicular membranes. PICK1 and GluR2 are associated with the same vesicles, which are immunopositive also for synaptophysin and vesicle-associated membrane protein 2. Based on what is known about the function of PICK1 postsynaptically, the present data suggest that PICK1 is involved in the regulation of presynaptic AMPA receptor trafficking and in determining the size of the AMPA receptor pool that modulates presynaptic glutamate release.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Pick1Ratglutamatergic synapse is_active_inIDA PMID:19071197SynGO 
Pick1Ratpostsynaptic specialization is_active_inIDA PMID:19071197SynGO 
Pick1Ratsynaptic vesicle is_active_inIDA PMID:19071197SynGO 

Objects Annotated

Genes (Rattus norvegicus)
Pick1  (protein interacting with PRKCA 1)


Additional Information