RGD Reference Report - Selective expression of transthyretin in subtypes of lung cancer. - Rat Genome Database

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Selective expression of transthyretin in subtypes of lung cancer.

Authors: Hao, Shuai  Sun, Suozhu  Xiao, Xueyuan  He, Dacheng  Liu, Liyun 
Citation: Hao S, etal., J Mol Histol. 2016 Jun;47(3):239-47. doi: 10.1007/s10735-016-9666-3. Epub 2016 Mar 4.
RGD ID: 151665207
Pubmed: PMID:26943652   (View Abstract at PubMed)
DOI: DOI:10.1007/s10735-016-9666-3   (Journal Full-text)

Transthyretin (TTR) is expressed primarily in liver, choroid plexus of brain and pancreatic islet A and B cells. It is also synthesized in some endocrine tumors. In the present study, the protein expression of TTR in lung cancer tissues and cell lines was investigated by western blot. The mRNA expression of TTR in 24 pairs of frozen lung cancer tissues was examined by RT-PCR. The specific expression and cellular distribution of TTR were also evaluated in 104 paraffin-embedded lung cancer samples and 3 normal lung tissues by immunohistochemistry. Similarly, the subcellular localization and expression of TTR were further analyzed in lung cancer cell lines. With the exception of mucinous adenocarcinoma, the expression of TTR protein was observed in all tested subtypes of lung carcinoma. Adenocarcinoma displayed the highest positive expression rate of TTR, accounting for 84.4 %, and the positive expression rate of TTR was up to 85.7 % at stages III and IV. The secretory bubbles with strong TTR staining were observed in luminal cells of lung cancer. Furthermore, the localization of TTR in the cytoplasm of lung cancer cells and the secretion of TTR into extracellular milieu were also confirmed. Taken together, TTR is selectively synthesized in lung cancer cells and can be secreted extracellularly.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TTRHumanadenosquamous lung carcinoma  HEP protein:increased expression:lung (human)RGD 
TTRHumanlung adenocarcinoma  HEP mRNA and protein:increased expression:lung (human)RGD 
TTRHumanlung large cell carcinoma  HEP protein:increased expression:lung (human)RGD 
TTRHumanlung small cell carcinoma  HEP protein:increased expression:lung (human)RGD 

Objects Annotated

Genes (Homo sapiens)
TTR  (transthyretin)


Additional Information