RGD Reference Report - GSTT1 and GSTM1 null genotypes may facilitate hepatitis C virus infection becoming chronic. - Rat Genome Database

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GSTT1 and GSTM1 null genotypes may facilitate hepatitis C virus infection becoming chronic.

Authors: Martínez, Carmen  García-Martín, Elena  Ladero, José M  Herráez, Oscar  Ortega, Luis  Taxonera, Carlos  Suárez, Avelina  Díaz-Rubio, Manuel  Agúndez, José A G 
Citation: Martínez C, etal., J Infect Dis. 2007 May 1;195(9):1320-3. doi: 10.1086/513569. Epub 2007 Mar 15.
RGD ID: 14700966
Pubmed: PMID:17397002   (View Abstract at PubMed)
DOI: DOI:10.1086/513569   (Journal Full-text)

Oxidative stress contributes to hepatitis C virus (HCV)-induced liver damage. The activity of antioxidant glutathione S-transferases (GSTs) T1 and M1 is polymorphic. The GSTT1 and GSTM1 genotypes were identified in 139 HCV-infected patients and in 329 healthy individuals. Among patients, there was an excess of GSTT1 (odds ratio [OR], 2.76 [95% confidence interval [CI], 1.77-4.30]; P<.001) and GSTM1 (OR, 1.54 [95% CI, 1.02-2.35]; P=.032) null genotypes and of double-null haplotypes (OR, 3.65 [95% CI, 1.98-6.75]; P<.001). The GSTT1 null genotype, particularly if associated with the GSTM1 null genotype, may facilitate HCV infection becoming chronic.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GSTM1HumanChronic Hepatitis C  IAGP  RGD 
GSTT1HumanChronic Hepatitis C  IAGP  RGD 
Gstm1RatChronic Hepatitis C  ISOGSTM1 (Homo sapiens) RGD 
Gstm1MouseChronic Hepatitis C  ISOGSTM1 (Homo sapiens) RGD 
Gstt1RatChronic Hepatitis C  ISOGSTT1 (Homo sapiens) RGD 
Gstt1MouseChronic Hepatitis C  ISOGSTT1 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gstm1  (glutathione S-transferase mu 1)
Gstt1  (glutathione S-transferase theta 1)

Genes (Mus musculus)
Gstm1  (glutathione S-transferase, mu 1)
Gstt1  (glutathione S-transferase, theta 1)

Genes (Homo sapiens)
GSTM1  (glutathione S-transferase mu 1)
GSTT1  (glutathione S-transferase theta 1)


Additional Information