RGD Reference Report - miR-215 functions as an oncogene in high-grade glioma by regulating retinoblastoma 1. - Rat Genome Database

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miR-215 functions as an oncogene in high-grade glioma by regulating retinoblastoma 1.

Authors: Meng, Xiaofeng  Shi, Baozhong 
Citation: Meng X and Shi B, Biotechnol Lett. 2017 Sep;39(9):1351-1358. doi: 10.1007/s10529-017-2373-7. Epub 2017 Jun 1.
RGD ID: 13782061
Pubmed: PMID:28573541   (View Abstract at PubMed)
DOI: DOI:10.1007/s10529-017-2373-7   (Journal Full-text)


OBJECTIVES: To investigate the roles of miR-215 in high-grade glioma and to clarify the regulation of retinoblastoma 1 (RB1) by miR-215.
RESULTS: miR-215 is frequently up-regulated in high-grade glioma tissues. Increased miR-215 expression is significantly associated with World Health Organization grade (P < 0.01) tumor size (P < 0.05) and poor prognosis (P < 0.01). Over-expression of miR-215 promoted cell proliferation and knockdown of miR-215 inhibited cell proliferation in vitro. RB1 was identified as a direct and functional target of miR-215. RB1 is generally down-regulated in glioma tissues and its expression inversely correlated with miR-215, which is up-regulated in high-grade glioma tissues, and its expression was negatively correlated with miR-215.
CONCLUSIONS: The new miR-215/RB1 axis provides new insights into the molecular mechanism and treatment for glioma.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MIR215Humanhigh grade glioma disease_progressionIEP  RGD 

Objects Annotated

Genes (Homo sapiens)
MIR215  (microRNA 215)


Additional Information