RGD Reference Report - PDE6 is an effector for the Wnt/Ca2+/cGMP-signalling pathway in development. - Rat Genome Database

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PDE6 is an effector for the Wnt/Ca2+/cGMP-signalling pathway in development.

Authors: Wang, H  Lee, Y  Malbon, CC 
Citation: Wang H, etal., Biochem Soc Trans 2004 Nov;32(Pt 5):792-6.
RGD ID: 1357992
Pubmed: PMID:15494017   (View Abstract at PubMed)
DOI: DOI:10.1042/BST0320792   (Journal Full-text)

Wnt signalling in development operates via members of the Frizzleds, G-protein-coupled receptors that bind specific Wnt ligands and mediate signalling via distinct pathways. The Wnt/Ca(2+)/cGMP pathway mediated by Frizzled-2 was discovered recently. Activation of this pathway leads to increased intracellular concentrations of Ca(2+) and decreased intracellular concentrations of cGMP. The nature of the phosphodiesterase responsible for this Frizzled-2-mediated effect on cGMP levels was identified based on three separate criteria: (i) sensitivity to selective enzyme inhibitors, (ii) behaviour on chromatographic separation, and (ii) isolation by two-dimensional gels in tandem with direct mapping by MS of tryptic digests of the activity. On the basis of results from these three analyses, the cGMP-specific phosphodiesterase, PDE6, is demonstrated to be an effector for the Wnt/Ca(2+)/cGMP signalling pathway of development, which is mediated by Frizzled-2.



Objects referenced in this article
Gene Pde6h phosphodiesterase 6H Rattus norvegicus

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