RGD Reference Report - Myocardin is a master regulator of smooth muscle gene expression. - Rat Genome Database

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Myocardin is a master regulator of smooth muscle gene expression.

Authors: Wang, Z  Wang, DZ  Pipes, GC  Olson, EN 
Citation: Wang Z, etal., Proc Natl Acad Sci U S A 2003 Jun 10;100(12):7129-34. Epub 2003 May 19.
RGD ID: 1299358
Pubmed: PMID:12756293   (View Abstract at PubMed)
PMCID: PMC165841   (View Article at PubMed Central)
DOI: DOI:10.1073/pnas.1232341100   (Journal Full-text)

Virtually all smooth muscle genes analyzed to date contain two or more essential binding sites for serum response factor (SRF) in their control regions. Because SRF is expressed in a wide range of cell types, it alone cannot account for smooth muscle-specific gene expression. We show that myocardin, a cardiac muscle- and smooth muscle-specific transcriptional coactivator of SRF, can activate smooth muscle gene expression in a variety of nonmuscle cell types via its association with SRF. Homodimerization of myocardin is required for maximal transcriptional activity and provides a mechanism for cooperative activation of smooth muscle genes by SRF-myocardin complexes bound to different SRF binding sites. These findings identify myocardin as a master regulator of smooth muscle gene expression and explain how SRF conveys smooth muscle specificity to its target genes.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MyocdRatregulation of smooth muscle cell differentiation  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Myocd  (myocardin)


Additional Information