RGD Reference Report - The nogo receptor family restricts synapse number in the developing hippocampus. - Rat Genome Database

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The nogo receptor family restricts synapse number in the developing hippocampus.

Authors: Wills, Zachary P  Mandel-Brehm, Caleigh  Mardinly, Alan R  McCord, Alejandra E  Giger, Roman J  Greenberg, Michael E 
Citation: Wills ZP, etal., Neuron. 2012 Feb 9;73(3):466-81. doi: 10.1016/j.neuron.2011.11.029.
RGD ID: 12790647
Pubmed: PMID:22325200   (View Abstract at PubMed)
PMCID: PMC3532882   (View Article at PubMed Central)
DOI: DOI:10.1016/j.neuron.2011.11.029   (Journal Full-text)

Neuronal development is characterized by a period of exuberant synaptic growth that is well studied. However, the mechanisms that restrict this process are less clear. Here we demonstrate that glycosylphosphatidylinositol-anchored cell-surface receptors of the Nogo Receptor family (NgR1, NgR2, and NgR3) restrict excitatory synapse formation. Loss of any one of the NgRs results in an increase in synapse number in vitro, whereas loss of all three is necessary for abnormally elevated synaptogenesis in vivo. We show that NgR1 inhibits the formation of new synapses in the postsynaptic neuron by signaling through the coreceptor TROY and RhoA. The NgR family is downregulated by neuronal activity, a response that may limit NgR function and facilitate activity-dependent synapse development. These findings suggest that NgR1, a receptor previously shown to restrict axon growth in the adult, also functions in the dendrite as a barrier that limits excitatory synapse number during brain development.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Rtn4rRatcell surface located_inIDA PMID:22325200UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Rtn4r  (reticulon 4 receptor)


Additional Information