RGD Reference Report - Genetic Associations of Alexithymia in Predicting Interferon-Induced Depression in Chronic Hepatitis C. - Rat Genome Database

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Genetic Associations of Alexithymia in Predicting Interferon-Induced Depression in Chronic Hepatitis C.

Authors: Porcelli, P  Cozzolongo, R  Cariola, F  Giannuzzi, V  Lanzilotta, E  Gentile, M  Sonnante, G  Leandro, G 
Citation: Porcelli P, etal., Psychopathology. 2015;48(6):417-20. doi: 10.1159/000441682. Epub 2015 Nov 27.
RGD ID: 11352995
Pubmed: PMID:26609890   (View Abstract at PubMed)
DOI: DOI:10.1159/000441682   (Journal Full-text)

BACKGROUND: Previous studies have shown that alexithymia is associated with gene polymorphisms that regulate the availability of serotonin (5-HT) in the brain. Since the 5-HT network is involved in interferon (IFN)-induced depression, this paper aimed to investigate the role of alexithymia and the functional gene variants of the 5-HT1A receptor (HTR1A) and the 5-HT transporter (5-HTTLPR) in induction of depression during antiviral treatment. METHODS: The depressive symptoms of 130 consecutive patients with chronic hepatitis C and no current psychopathology were measured during treatment with IFN and ribavirin (6-12 months) and at a 6-month follow-up. At baseline, alexithymia and 2 genotypes (5-HTTLPR and HTR1A) were also assessed. RESULTS: Patients with homozygosity for HTR1A-G and 5-HTTLPR long alleles had significantly higher levels of alexithymia. After controlling for sociodemographic and disease-related factors, alexithymia and HTR1A-G polymorphism, both separately (20-22%) and jointly (14-16%), significantly and independently predicted the development of IFN-induced depression. CONCLUSIONS: Subjects carrying HTR1A-G and 5-HTTLRP double long alleles are more vulnerable to alexithymia. Also patients with a higher level of alexithymia and the HTR1A-G gene variant are more vulnerable to experiencing IFN-induced depressive symptoms. The clinical implications of targeting alexithymia and HTR1A receptors as a possible treatment option for mood disorders should be investigated in further studies.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SLC6A4Humanalexithymia susceptibilityIAGP associated with Chronic Hepatitis C and DNA:repeats:promoter:RGD 
Slc6a4Ratalexithymia susceptibilityISOSLC6A4 (Homo sapiens)associated wit Chronic Hepatitis C and DNA:repeats:promoter:RGD 
Slc6a4Mousealexithymia susceptibilityISOSLC6A4 (Homo sapiens)associated wit Chronic Hepatitis C and DNA:repeats:promoter:RGD 
SLC6A4HumanChronic Hepatitis C susceptibilityIAGP associated with alexithymia more ...RGD 
Slc6a4RatChronic Hepatitis C susceptibilityISOSLC6A4 (Homo sapiens)associated with alexithymia more ...RGD 
Slc6a4MouseChronic Hepatitis C susceptibilityISOSLC6A4 (Homo sapiens)associated with alexithymia more ...RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SLC6A4HumanAlexithymia susceptibilityIAGP associated with Chronic Hepatitis C and DNA:repeats:promoter:RGD 
Objects Annotated

Genes (Rattus norvegicus)
Slc6a4  (solute carrier family 6 member 4)

Genes (Mus musculus)
Slc6a4  (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4)

Genes (Homo sapiens)
SLC6A4  (solute carrier family 6 member 4)


Additional Information